Indoline scaffold SHP-2 inhibitors and cancer treatment method
    73.
    发明授权
    Indoline scaffold SHP-2 inhibitors and cancer treatment method 有权
    吲哚酚支架SHP-2抑制剂和癌症治疗方法

    公开(公告)号:US09174969B2

    公开(公告)日:2015-11-03

    申请号:US13055113

    申请日:2009-07-21

    摘要: The subject invention concerns methods and compounds for inhibiting Shp2. In one embodiment, a compound of the invention has a chemical structure as shown in formula I or II: wherein X, Y, and Z are independently N or S; R1 is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, any of which can be optionally substituted with one or more of halogen; alkyl; heteroalkyl; —COOH; —C(R3)3, wherein R3 can independently be any of —H or halogen; or —OR4, wherein R4 can be any of H, alkyl, or heteroalkyl; R2 is alkyl, alkylcarbonyl, heteroalkylcarbonyl, aryl, arylcarbonyl, heterocycloalkylcarbonyl, cycloalkylcarbonyl, or —C(O)NR6R7, any of which can be optionally substituted with one or more of halogen; alkyl; heteroalkyl; carbonyl; —OR4, wherein R4 can be —H, alkyl, or heteroalkyl; —OH; —C(R3)3, wherein R3 can independently be any of —H or halogen; aryl, which can be substituted with one or more of halogen or —OR4; heterocycloalkyl; or —C(O)OR5, wherein R5 can be —H or alkyl; R6 and R7 are independently —H, alkyl, heteroalkyl, aryl, or heteroaryl; and R′ is H or alkyl; or a pharmaceutically acceptable salt or hydrate thereof.

    摘要翻译: 本发明涉及抑制Shp2的方法和化合物。 在一个实施方案中,本发明的化合物具有如式I或II所示的化学结构:其中X,Y和Z独立地为N或S; R 1是环烷基,杂环烷基,芳基或杂芳基,其中任何一个可以任选被一个或多个卤素取代; 烷基; 杂烷基; -COOH; -C(R 3)3,其中R 3可以独立地为-H或卤素; 或-OR 4,其中R 4可以是H,烷基或杂烷基中的任何一个; R 2是烷基,烷基羰基,杂烷基羰基,芳基,芳基羰基,杂环烷基羰基,环烷基羰基或-C(O)NR 6 R 7,其中任何一个可以任选被一个或多个卤素取代; 烷基; 杂烷基; 羰; -OR4,其中R4可以是-H,烷基或杂烷基; -哦; -C(R 3)3,其中R 3可以独立地为-H或卤素; 芳基,其可被一个或多个卤素或-OR 4取代; 杂环烷基; 或-C(O)OR 5,其中R 5可以是-H或烷基; R6和R7独立地是-H,烷基,杂烷基,芳基或杂芳基; 和R'是H或烷基; 或其药学上可接受的盐或水合物。

    DETECTION AND FILTERING OF AN UNDESIRED NARROWBAND SIGNAL CONTRIBUTION IN A WIRELESS SIGNAL RECEIVER
    76.
    发明申请
    DETECTION AND FILTERING OF AN UNDESIRED NARROWBAND SIGNAL CONTRIBUTION IN A WIRELESS SIGNAL RECEIVER 有权
    无线信号接收机中未受干扰的窄带信号贡献的检测和滤波

    公开(公告)号:US20130208838A1

    公开(公告)日:2013-08-15

    申请号:US13371311

    申请日:2012-02-10

    IPC分类号: H04B1/10

    CPC分类号: G01S19/21 H04B1/1036

    摘要: Techniques are provided which may be implemented using various methods and/or apparatuses in a device comprising a receiver to scan a spectral band of a received signal comprising a desired signal contribution to determine whether signal data associated with at least a sub-band of the spectral band further comprises at least one undesired signal contribution. In response to determining that the signal data comprises at least one undesired signal contribution, the mobile station may initiate at least one notch filter to affect the undesired signal contribution in subsequent signal data associated with the received signal.

    摘要翻译: 提供了技术,其可以使用包括接收机的各种方法和/或装置来实现,该接收机扫描包括期望信号贡献的接收信号的频谱带,以确定与至少频谱的子带相关联的信号数据 频带还包括至少一个不需要的信号贡献。 响应于确定信号数据包括至少一个不需要的信号贡献,移动台可以启动至少一个陷波滤波器以影响与接收信号相关联的后续信号数据中的不期望的信号贡献。

    Coated ceramic cutting insert and method for making the same
    77.
    发明授权
    Coated ceramic cutting insert and method for making the same 有权
    涂层陶瓷切削刀片及其制造方法

    公开(公告)号:US08475944B2

    公开(公告)日:2013-07-02

    申请号:US12722015

    申请日:2010-03-11

    IPC分类号: B32B9/00

    摘要: A coated ceramic cutting insert for removing material from a workpiece, as well as a method for making the same, that includes a ceramic substrate with a rake surface and at least one flank surface wherein a cutting edge is at the juncture therebetween. A wear-resistant coating scheme that includes an alumina-containing base coating layer region, which has at least one exposed alumina coating layer, deposited by chemical vapor deposition on the substantially all of the surfaces of the ceramic substrate that experience wear during removal of material from the workpiece. The exposed alumina coating layer exhibits a blasted stress condition ranging between about 50 MPa (tensile stress) and about −2 GPa (compressive) as measured by XRD using the Psi tilt method and the (024) reflection of alumina. The exposed alumina coating layer is the result of wet blasting a titanium-containing outer coating layer region from the surface of the alumina-containing base coating layer region.

    摘要翻译: 一种用于从工件去除材料的涂覆陶瓷切削刀片及其制造方法,其包括具有前刀面和至少一个侧面的陶瓷基体,其中切削刃处于它们之间的接合处。 一种耐磨涂层方案,其包括含氧化铝的基底涂层区域,其具有至少一个暴露的氧化铝涂层,其通过化学气相沉积沉积在陶瓷基底的基本上所有的表面上,在去除材料期间经历磨损 从工件。 暴露的氧化铝涂层表现出通过使用Psi倾斜法和氧化铝的(024)反射通过XRD测量的约50MPa(拉伸应力)和约-2GPa(压缩)之间的喷砂应力条件。 暴露的氧化铝涂层是从含氧化铝的基底涂层区域的表面湿式喷射含钛外涂层区域的结果。

    Systems, computer program products, and methods using carrier phases to detect multipath signals
    79.
    发明授权
    Systems, computer program products, and methods using carrier phases to detect multipath signals 失效
    系统,计算机程序产品和使用载波相位的方法来检测多径信号

    公开(公告)号:US08279911B2

    公开(公告)日:2012-10-02

    申请号:US12410328

    申请日:2009-03-24

    IPC分类号: H04B1/707 H04L27/38

    摘要: A multipath detector includes an RF module receiving multiple signals, and a correlator module receiving the signals from the RF module. The correlator module correlates the signals to create a composite ACF, and produces samples of the composite autocorrelation function (ACF). The samples are time delayed relative to each other. The multipath detector also includes a carrier phase processor that receives the samples and estimates carrier phases associated with each of the samples. The carrier phase processor employs the estimated carrier phases to determine if one of the signals is subject to a multipath delay.

    摘要翻译: 多路径检测器包括接收多个信号的RF模块和从RF模块接收信号的相关器模块。 相关器模块将信号相关联以产生复合ACF,并且产生复合自相关函数(ACF)的样本。 样品相对于彼此是时间延迟的。 多径检测器还包括载波相位处理器,其接收采样并估计与每个采样相关联的载波相位。 载波相位处理器使用估计的载波相位来确定信号中的一个是否经受多径延迟。