摘要:
The invention relates to pharmaceutical compositions comprising dihydromyricetin, methods for making such compositions, and methods for using such compositions to treat nicotine-related disorders and habits, such as nicotine addiction, nicotine withdrawal symptoms and the reduction and/or cessation of smoking, vaping, patch, and/or chewing tobacco products.
摘要:
An aqueous polyurethane dispersion compositions are disclosed. The compositions include a polyurethane prepolymer dispersed in an aqueous medium, the polyurethane prepolymer comprising an isocyanate and a crystalline polyester polyol having a hydroxyl content of 20 to 150 mg KOH/g and a melt temperature of less than or equal to 90° C. Methods of forming a laminate are also disclosed. The methods include providing an aqueous polyurethane dispersion, applying the polyurethane dispersion to a surface of the first substrate, bringing the side of the first substrate into contract with a surface of the second substrate, and curing the aqueous dispersion, thereby laminating the first substrate to the second substrate. Laminates formed by the methods and including the compositions are also disclosed.
摘要:
The subject invention concerns methods and compounds for inhibiting Shp2. In one embodiment, a compound of the invention has a chemical structure as shown in formula I or II: wherein X, Y, and Z are independently N or S; R1 is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, any of which can be optionally substituted with one or more of halogen; alkyl; heteroalkyl; —COOH; —C(R3)3, wherein R3 can independently be any of —H or halogen; or —OR4, wherein R4 can be any of H, alkyl, or heteroalkyl; R2 is alkyl, alkylcarbonyl, heteroalkylcarbonyl, aryl, arylcarbonyl, heterocycloalkylcarbonyl, cycloalkylcarbonyl, or —C(O)NR6R7, any of which can be optionally substituted with one or more of halogen; alkyl; heteroalkyl; carbonyl; —OR4, wherein R4 can be —H, alkyl, or heteroalkyl; —OH; —C(R3)3, wherein R3 can independently be any of —H or halogen; aryl, which can be substituted with one or more of halogen or —OR4; heterocycloalkyl; or —C(O)OR5, wherein R5 can be —H or alkyl; R6 and R7 are independently —H, alkyl, heteroalkyl, aryl, or heteroaryl; and R′ is H or alkyl; or a pharmaceutically acceptable salt or hydrate thereof.
摘要:
The present invention relates to methods of diagnosing, treating and prognosing mental disorders, such as Alzheimer's Disease. In one embodiment, the present invention provides a method of treating Alzheimer's Disease by inhibiting dysfunctional signaling of α7 nAChRs in the medial septum region of an individual.
摘要:
A method for preparing hydrorefining catalyst comprises the following steps: (1) mixing an aqueous ammonia solution with a polyamine complexing agent to form a mixed solvent; (2) adding a cobalt salt to the mixed solvent, dissolving the cobalt salt, and then adding a molybdenum salt and optional salts of other active components, and dissolving them to prepare an impregnating solution; and (3) impregnating a support with the impregnating solution, followed by aging, drying, and activating the impregnated support to form a hydrorefining catalyst. The hydrorefining catalyst prepared by this method has good activity, selectivity and stability in use.
摘要:
Techniques are provided which may be implemented using various methods and/or apparatuses in a device comprising a receiver to scan a spectral band of a received signal comprising a desired signal contribution to determine whether signal data associated with at least a sub-band of the spectral band further comprises at least one undesired signal contribution. In response to determining that the signal data comprises at least one undesired signal contribution, the mobile station may initiate at least one notch filter to affect the undesired signal contribution in subsequent signal data associated with the received signal.
摘要:
A coated ceramic cutting insert for removing material from a workpiece, as well as a method for making the same, that includes a ceramic substrate with a rake surface and at least one flank surface wherein a cutting edge is at the juncture therebetween. A wear-resistant coating scheme that includes an alumina-containing base coating layer region, which has at least one exposed alumina coating layer, deposited by chemical vapor deposition on the substantially all of the surfaces of the ceramic substrate that experience wear during removal of material from the workpiece. The exposed alumina coating layer exhibits a blasted stress condition ranging between about 50 MPa (tensile stress) and about −2 GPa (compressive) as measured by XRD using the Psi tilt method and the (024) reflection of alumina. The exposed alumina coating layer is the result of wet blasting a titanium-containing outer coating layer region from the surface of the alumina-containing base coating layer region.
摘要:
Methods and apparatuses are provided for use with mode switchable navigation radios and the like. The methods and apparatuses may be implemented to selectively switch between certain operating modes based, at least in part, a mode-switching test that takes into consideration one or more non-timed test conditions to determine if mode-switching may be enabled.
摘要:
A multipath detector includes an RF module receiving multiple signals, and a correlator module receiving the signals from the RF module. The correlator module correlates the signals to create a composite ACF, and produces samples of the composite autocorrelation function (ACF). The samples are time delayed relative to each other. The multipath detector also includes a carrier phase processor that receives the samples and estimates carrier phases associated with each of the samples. The carrier phase processor employs the estimated carrier phases to determine if one of the signals is subject to a multipath delay.
摘要:
Techniques are provided which may be implemented using various methods and/or apparatuses in a receiver of an electronic device to allow for a received signal to be demodulated using both coherent and non-coherent demodulation techniques and for selecting one of the demodulated data signals based, at least in part, on a drift rate measurement of a carrier frequency of the received signal.