公开(公告)号：US20110046893A1

公开(公告)日：2011-02-24

申请号：US12859429

申请日：2010-08-19

申请人： Arne HENGERER ,  Marcus Pfister ,  Sebastian Schmidt

发明人： Arne HENGERER ,  Marcus Pfister ,  Sebastian Schmidt

IPC分类号： G06F19/00 ,  G01N33/48

CPC分类号： A61B6/00 ,  G06T1/00

摘要： A method is disclosed for normalizing the results of an in-vitro analytical method for one or more diagnostically and/or prognostically relevant substances in an organism (biomarker) or one or more substances supplied to an organism from the outside. In at least one embodiment of the method a) one or more concentration values of the substance(s) in an organism, said concentration value(s) being obtained in an in-vitro analytical method is (are) provided, b) data obtained from an imaging study of the same organism are provided, c) from the data according to b), one or more quantitative values are determined as imaging value(s), d) from the values according to a) and c), one or more diagnostic parameters are determined by relating the values according to a) and c) to one another, and also to the use of this method for the type-correct dosage finding of drugs and for the in-vitro diagnosis, prognosis and monitoring the course of a disease. In addition, at least one embodiment of the invention relates to a program for a data processing system which, when carried out in a suitable computer system, carries out the above method, and also to an electronically readable data carrier having electronically readable control information stored thereon, which control information is configured in such a manner that they carry out the above method when a suitable data carrier is used in a suitable computer system.

摘要翻译： 公开了一种用于使生物体（生物标志物）中的一种或多种诊断和/或预后相关物质或从外部提供给生物体的一种或多种物质的体外分析方法的结果归一化的方法。 在方法的至少一个实施方案中a）提供生物体内物质的一个或多个浓度值，所述浓度值在体外分析方法中获得，b）得到的数据 提供来自相同生物体的成像研究，c）根据b）的数据，一个或多个定量值被确定为成像值，d）根据a）和c）的值，一个或多个 通过将根据a）和c）的值相互关联来确定更多的诊断参数，并且还使用该方法用于药物的类型正确剂量发现和用于体外诊断，预后和监测过程 的疾病 此外，本发明的至少一个实施例涉及一种用于数据处理系统的程序，当在合适的计算机系统中执行时，执行上述方法，并且还涉及具有存储的电子可读控制信息的电子可读数据载体 在其上配置有这样的控制信息，即当在合适的计算机系统中使用合适的数据载体时，它们执行上述方法。

公开(公告)号：US07868427B2

公开(公告)日：2011-01-11

申请号：US12353193

申请日：2009-01-13

申请人： Sebastian Schmidt ,  Hang-Yip Liu ,  Thomas Schafbauer ,  Yayi Wei

发明人： Sebastian Schmidt ,  Hang-Yip Liu ,  Thomas Schafbauer ,  Yayi Wei

IPC分类号： H01L21/76 ,  H01L21/4763 ,  H01L21/302 ,  H01L23/544

CPC分类号： H01L22/10 ,  B81C1/00539 ,  G06F17/5068 ,  H01L21/027 ,  H01L21/31053 ,  H01L21/3212 ,  H01L21/76229 ,  H01L21/82

摘要： A material layer on a substrate being processed, e.g. to form chips, includes one or more functional structures. In order to control pattern density during fabrication of the chip, dummy fill structures of different sizes and shapes are added to the chip at different distances from the functional structures of the material layer. In particular, the placement, size and shape of the dummy structures are determined as a function of a distance to, and density of, the functional structures of the material layer.

摘要翻译： 正在处理的衬底上的材料层，例如， 以形成芯片，包括一个或多个功能结构。 为了在制造芯片期间控制图案密度，将不同尺寸和形状的虚拟填充结构添加到与材料层的功能结构不同距离的芯片。 特别地，虚拟结构的布置，尺寸和形状被确定为材料层的功能结构的距离和密度的函数。

公开(公告)号：US07807342B2

公开(公告)日：2010-10-05

申请号：US11303301

申请日：2005-12-16

申请人： Hang Yip Liu ,  Sebastian Schmidt ,  Benjamin Szu-Min Lin

发明人： Hang Yip Liu ,  Sebastian Schmidt ,  Benjamin Szu-Min Lin

IPC分类号： G03F7/20 ,  G03F1/08

CPC分类号： G03F1/36 ,  G03F1/50 ,  G03F7/70283

摘要： An apparatus, system and method to compensate for the proximity effects in the imaging of patterns in a photolithography process. A light exposure of a photoresist layer is effectuated in predetermined patterns through an exposure mask having light-transmissive openings in correspondence to the predetermined patterns. The exposure mask has areas densely populated with the light-transmissive openings and areas sparsely populated with the light-transmissive openings. Light is attenuated through the densely populated light-transmissive openings by a different amount than through the sparsely populated light-transmissive openings.

摘要翻译： 一种用于补偿光刻工艺中图案成像中的邻近效应的装置，系统和方法。 通过具有对应于预定图案的透光开口的曝光掩模，以预定图案实现光致抗蚀剂层的曝光。 曝光掩模具有由透光开口和由透光开口稀疏地填充的区域密集地区域。 光通过密集居住的透光开口被衰减不同于通过疏散人口的透光开口的量。

公开(公告)号：US20100225318A1

公开(公告)日：2010-09-09

申请号：US12718295

申请日：2010-03-05

申请人： Sebastian Schmidt

发明人： Sebastian Schmidt

IPC分类号： G01R33/48

CPC分类号： G01R33/56308 ,  G01R33/5608 ,  G01R33/56333

摘要： A method for spatially resolved detection and display of movement processes in an examination subject by means of magnetic resonance tomography includes the steps of imposing a magnetization pattern on at least a portion of a fluid medium located in the intestine of the examination subject, acquiring at least one image data set or a portion of an image data set that images the region of the examination subject on which the magnetization pattern was imposed, determining at least one item of movement information from the at least one image data set or portion of an image data set, by an analysis of the magnetization pattern in a processor, and presenting the at least one item of movement information through presentation device in communication with the processor.

摘要翻译： 用于通过磁共振断层摄影在空间上分辨检测和检查检查对象中的移动过程的方法包括以下步骤：在位于检查对象的肠中的流体介质的至少一部分上施加磁化模式，至少获取 一个图像数据集或图像数据集的对其施加了磁化模式的检查对象的区域进行成像的部分，从至少一个图像数据集或图像数据的一部分确定至少一个移动信息项 通过分析处理器中的磁化模式来设置，并且通过与处理器通信的呈现设备呈现至少一个移动信息项。

公开(公告)号：US07745794B2

公开(公告)日：2010-06-29

申请号：US12149208

申请日：2008-04-29

申请人： Sebastian Schmidt

发明人： Sebastian Schmidt

IPC分类号： G01T1/164 ,  A61B5/05

CPC分类号： A61B5/055 ,  A61B5/0035 ,  A61B6/037 ,  A61B6/4417

摘要： A positron emission tomography module is disclosed. In at least one embodiment, the positron emission tomography module includes a gamma ray detector arrangement designed such that it can alternately be combined with a magnetic resonance tomograph and with a computed tomograph.

摘要翻译： 公开了正电子发射断层摄影模块。 在至少一个实施例中，正电子发射断层摄影模块包括设计成可以与磁共振断层摄影机和计算机断层摄影机组合的伽马射线检测器装置。

公开(公告)号：US20100087726A1

公开(公告)日：2010-04-08

申请号：US12572374

申请日：2009-10-02

申请人： Jan Ruff ,  Stefan Roell ,  Sebastian Schmidt

发明人： Jan Ruff ,  Stefan Roell ,  Sebastian Schmidt

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  A61B5/201 ,  A61B5/204 ,  A61B2560/0223 ,  A61B2560/0228

摘要： In a method to determine a kidney function parameter of kidneys of an examination person with the aid of magnetic resonance tomography, at least one magnetic resonance measurement is implemented for an examination region of the examination person that comprises a urinary bladder of the examination person, to acquire magnetic resonance data from the examination region that include at least image data. The concentration of a urophanic substance in the urinary bladder of the examination person is automatically determined based on the acquired magnetic resonance data. A volume of the urinary bladder is automatically determined based on the acquired image data. A kidney function parameter of the kidneys of the examination person is automatically determined on the basis of the determined concentration of the urophanic substance in the urinary bladder and of the specific volume of the urinary bladder.

摘要翻译： 在通过磁共振断层扫描技术确定检查者的肾脏的肾功能参数的方法中，对包括检查者的膀胱的检查者的检查区域进行至少一次磁共振测量， 从检查区域获取至少包括图像数据的磁共振数据。 检查人员尿膀胱中的urophanic物质的浓度根据获得的磁共振数据自动确定。 基于获取的图像数据自动确定膀胱的体积。 检查人员肾脏的肾功能参数是根据确定的膀胱尿液含量和膀胱体积的确定浓度自动确定的。

公开(公告)号：US20090124027A1

公开(公告)日：2009-05-14

申请号：US12353193

申请日：2009-01-13

申请人： Sebastian Schmidt ,  Thomas Schafbauer ,  Hang Yip Liu ,  Yayi Wei

发明人： Sebastian Schmidt ,  Thomas Schafbauer ,  Hang Yip Liu ,  Yayi Wei

IPC分类号： H01L21/66

CPC分类号： H01L22/10 ,  B81C1/00539 ,  G06F17/5068 ,  H01L21/027 ,  H01L21/31053 ,  H01L21/3212 ,  H01L21/76229 ,  H01L21/82

摘要： A material layer on a substrate being processed, e.g. to form chips, includes one or more functional structures. In order to control pattern density during fabrication of the chip, dummy fill structures of different sizes and shapes are added to the chip at different distances from the functional structures of the material layer. In particular, the placement, size and shape of the dummy structures are determined as a function of a distance to, and density of, the functional structures of the material layer.

摘要翻译： 正在处理的衬底上的材料层，例如， 以形成芯片，包括一个或多个功能结构。 为了在制造芯片期间控制图案密度，将不同尺寸和形状的虚拟填充结构添加到与材料层的功能结构不同距离的芯片。 特别地，虚拟结构的布置，尺寸和形状被确定为材料层的功能结构的距离和密度的函数。

公开(公告)号：US07522952B2

公开(公告)日：2009-04-21

申请号：US11395267

申请日：2006-04-03

申请人： Robert Krieg ,  Rainer Kuth ,  Ralf Ladebeck ,  Ralph Oppelt ,  Wolfgang Renz ,  Sebastian Schmidt ,  Markus Vester

发明人： Robert Krieg ,  Rainer Kuth ,  Ralf Ladebeck ,  Ralph Oppelt ,  Wolfgang Renz ,  Sebastian Schmidt ,  Markus Vester

IPC分类号： A61B5/055

CPC分类号： G01T1/1603 ,  A61B6/037 ,  A61B6/4417 ,  A61B6/5247 ,  G01R33/481 ,  G01T1/2985

摘要： A combined PET/MRI tomography unit has a PET unit with a unit part assigned to the examination space, and a first evaluation unit for evaluating the PET electric signals. The unit part has a gamma ray detector. The combined unit has an MRI unit and a second evaluation unit for evaluating MRI signals. The MRI unit has a high frequency antenna as well as a gradient coil system, the high frequency antenna device being arranged nearer to the examination space than the gradient coil system, as well as a high frequency shield arranged between the gradient coil system and the high frequency antenna device. The PET unit part is arranged between the high frequency shield and the high frequency antenna device. A shielding cover for the high frequency antenna device faces the high frequency antenna device. The shielding cover is opaque to high frequency radiation.

摘要翻译： 组合的PET / MRI断层摄影单元具有分配给检查空间的单位部分的PET单元和用于评估PET电信号的第一评估单元。 单位部件具有伽马射线检测器。 组合单元具有用于评估MRI信号的MRI单元和第二评估单元。 MRI单元具有高频天线以及梯度线圈系统，高频天线装置布置成比梯度线圈系统更靠近检查空间，以及布置在梯度线圈系统和高电平之间的高频屏蔽 频率天线装置。 PET单元部分布置在高频屏蔽和高频天线装置之间。 用于高频天线装置的屏蔽罩面向高频天线装置。 屏蔽罩对高频辐射是不透明的。

公开(公告)号：US07494930B2

公开(公告)日：2009-02-24

申请号：US11441649

申请日：2006-05-26

申请人： Sebastian Schmidt ,  Thomas Schafbauer ,  Hang Yip Liu ,  Yayi Wei

发明人： Sebastian Schmidt ,  Thomas Schafbauer ,  Hang Yip Liu ,  Yayi Wei

IPC分类号： H01L21/302

CPC分类号： H01L22/10 ,  B81C1/00539 ,  G06F17/5068 ,  H01L21/027 ,  H01L21/31053 ,  H01L21/3212 ,  H01L21/76229 ,  H01L21/82

摘要： A material layer on a substrate being processed, e.g. to form chips, includes one or more functional structures. In order to control pattern density during fabrication of the chip, dummy fill structures of different sizes and shapes are added to the chip at different distances from the functional structures of the material layer. In particular, the placement, size and shape of the dummy structures are determined as a function of a distance to, and density of, the functional structures of the material layer.

摘要翻译： 正在处理的衬底上的材料层，例如， 以形成芯片，包括一个或多个功能结构。 为了在制造芯片期间控制图案密度，将不同尺寸和形状的虚拟填充结构添加到与材料层的功能结构不同距离的芯片。 特别地，虚拟结构的布置，尺寸和形状被确定为材料层的功能结构的距离和密度的函数。

公开(公告)号：US20090048507A1

公开(公告)日：2009-02-19

申请号：US12222210

申请日：2008-08-05

申请人： Thorsten Feiweier ,  Diana Martin ,  Gunther Platsch ,  Sebastian Schmidt ,  Kristin Schmiedehausen ,  Michael Szimtenings

发明人： Thorsten Feiweier ,  Diana Martin ,  Gunther Platsch ,  Sebastian Schmidt ,  Kristin Schmiedehausen ,  Michael Szimtenings

IPC分类号： A61B5/055 ,  A61B5/0476 ,  G01V3/00 ,  A61B6/00

CPC分类号： A61B6/037 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/4094 ,  A61B6/032 ,  A61B6/501 ,  A61B6/5247 ,  G06T7/30

摘要： A method and an apparatus for imaging functional and electrical activities of the brain are disclosed. In order to allow improved relative positional determination of the epileptogenic focus with reference to the EEG electrodes, a positron emission tomography measurement using at least one radiation detector, and a magnetic resonance imaging measurement using at least one coil for generating a basic magnetic field, at least one gradient coil and a radio-frequency antenna device are undertaken in at least one embodiment. In addition, in at least one embodiment an electroencephalography measurement using a plurality of electrodes for acquiring spatial and temporal changes of the electrical activities of the brain and a computed tomography measurement using at least one x-ray source and at least one x-ray detector are carried out. By way of an evaluation apparatus in at least one embodiment, a spatial correlation between the computed tomography measurement and the magnetic resonance imaging measurement is undertaken, so as to result in registration between the electroencephalography measurement and the positron emission tomography measurement.

摘要翻译： 公开了一种用于成像大脑的功能和电活动的方法和装置。 为了允许参考EEG电极改进癫痫发生焦点的相对位置确定，使用至少一个辐射检测器的正电子发射断层摄影测量和使用至少一个线圈产生基本磁场的磁共振成像测量，在 至少一个实施例中进行至少一个梯度线圈和射频天线装置。 另外，在至少一个实施例中，使用多个电极获取脑的电活动的空间和时间变化以及使用至少一个X射线源和至少一个X射线检测器的计算机断层摄影测量的脑电图测量 被执行。 通过至少一个实施例中的评估装置，进行计算机断层摄影测量和磁共振成像测量之间的空间相关性，以便导致脑电图测量与正电子发射断层摄影测量之间的对准。