公开(公告)号：US20060051370A1

公开(公告)日：2006-03-09

申请号：US11238025

申请日：2005-09-27

申请人： Aladar Szalay ,  Tatyana Timiryasova ,  Yong Yu ,  Qian Zhang

发明人： Aladar Szalay ,  Tatyana Timiryasova ,  Yong Yu ,  Qian Zhang

IPC分类号： A61K48/00 ,  A61K39/12

CPC分类号： A61K39/285 ,  A61K9/0019 ,  A61K35/74 ,  A61K35/744 ,  A61K35/768 ,  A61K39/00 ,  A61K45/06 ,  A61K48/00 ,  A61K2039/5254 ,  A61K2039/5256 ,  C07K16/30 ,  C07K16/40 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/24132 ,  C12N2710/24134 ,  C12N2710/24143 ,  C12N2710/24161 ,  C12P19/34 ,  C12P21/02 ,  Y02A50/472

摘要： Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.

摘要翻译： 提供了治疗方法和微生物。 与其他组织，细胞和器官相比，微生物被设计为在免疫缺陷组织和细胞中积累，例如在肿瘤和其他增殖组织和发炎组织中，使得它们对宿主生物体具有相对低的毒性。 微生物也被设计或修饰以导致其中积聚的细胞的泄漏的细胞膜，导致产生对蛋白质和其他细胞产物具有反应性的抗体，并且还允许开发促进增殖的组织，特别是肿瘤以产生选定的蛋白质等 产品。 提供含有微生物的疫苗。 还提供了微生物和抗癌剂的组合及其用于治疗癌症的用途。

公开(公告)号：US06999432B2

公开(公告)日：2006-02-14

申请号：US09895870

申请日：2001-06-28

申请人： Qian Zhang ,  Wenwu Zhu ,  Ya-Qin Zhang ,  Guijin Wang

发明人： Qian Zhang ,  Wenwu Zhu ,  Ya-Qin Zhang ,  Guijin Wang

IPC分类号： H04Q7/00

CPC分类号： H04W28/24 ,  H04L1/0001 ,  H04L1/0003 ,  H04L1/0009 ,  H04L1/0017 ,  H04L1/0018 ,  H04L1/007 ,  H04L1/1809 ,  H04L1/1812 ,  H04L1/1825 ,  H04L1/1877 ,  H04N21/234327 ,  H04N21/2383 ,  H04N21/2385 ,  H04N21/4126 ,  H04N21/43637 ,  H04N21/44209 ,  H04N21/6131 ,  H04N21/631 ,  H04N21/6375 ,  H04N21/6582 ,  H04W52/34 ,  H04W72/08 ,  H04W84/04

摘要： A cross-layer architecture is provided for delivering multiple media streams over 3G W-CDMA channels in adaptive multimedia wireless networks. A resource management mechanism dynamically allocates resources among different media streams adapted to channel status and Quality of Service (QoS) requirements. By taking the time-varying wireless transmission characteristics into account, an allocation of resources is performed based on a minimum-distortion or minimum-power criterion. Estimates of the time-varying wireless transmission conditions are made through measurements of throughput and error rate. Power and distortion minimized bit allocation schemes are used with the estimated wireless transmission conditions to for dynamically adaptations in transmissions.

公开(公告)号：US20050286523A1

公开(公告)日：2005-12-29

申请号：US11203954

申请日：2005-08-15

申请人： HongBin Liao ,  Qian Zhang ,  Wenwu Zhu ,  Ya-Qin Zhang

发明人： HongBin Liao ,  Qian Zhang ,  Wenwu Zhu ,  Ya-Qin Zhang

IPC分类号： H04L12/56 ,  H04L29/06 ,  H04L29/08 ,  H04L12/28

CPC分类号： H04L69/04 ,  H04L47/10 ,  H04L47/193 ,  H04L47/27 ,  H04L47/37 ,  H04L69/16 ,  H04L69/161 ,  H04L69/163 ,  H04L69/22 ,  H04L69/326

摘要： An implementation of a technology, described herein, for transmitting compressed network transport-layer-protocol headers in a speedy, efficient, inferentially synchronized, and robust manner. An implementation, described herein, models the transmission of compressed headers to the congestion procedure of the network transport-layer protocol (e.g., TCP's). Doing so, the sender of the compressed headers can infer whether the receiver correctly received them. Unlike the slow direct synchronization employed by conventional schemes, this implementation of the present claimed invention inferentially synchronizes by modeling after the congestion procedure of the network transport-layer protocol. This is inherently faster than direct synchronization. Since the implementation performs well over both noiseless and noisy links, it is particularly suited to use over wireless communications channels. This abstract itself is not intended to limit the scope of this patent. The scope of the present invention is pointed out in the appending claims.

摘要翻译： 本文描述的用于以快速，有效，同步和稳健的方式发送压缩网络传输层协议报头的技术的实现。 这里描述的实现将压缩报头的传输建模到网络传输层协议（例如，TCP）的拥塞过程。 这样做，压缩报头的发送者可以推断接收机是否正确接收到它们。 与常规方案所采用的慢速直接同步不同，本发明的实施方式在网络传输层协议的拥塞过程之后通过建模同步。 这本质上比直接同步更快。 由于实现在无声和噪声链路上表现良好，特别适用于无线通信信道。 本摘要本身并不旨在限制本专利的范围。 在所附权利要求中指出了本发明的范围。

公开(公告)号：US20050250508A1

公开(公告)日：2005-11-10

申请号：US11168254

申请日：2005-06-27

申请人： Zihua Guo ,  Qian Zhang ,  Richard Yao ,  Wenwu Zhu

发明人： Zihua Guo ,  Qian Zhang ,  Richard Yao ,  Wenwu Zhu

IPC分类号： H04W36/04 ,  H04W36/14 ,  H04W36/22 ,  H04Q7/20

CPC分类号： H04W36/0088 ,  H04W36/04 ,  H04W36/14 ,  H04W36/22

摘要： A system and method for improved vertical handoff between different types of wireless network. Network allocation vector occupation and packet collision probability are used as quality of service measures, enabling vertical handoffs to be delayed until actually beneficial to quality of service. Improved wireless network cell boundary detection in vertical handoff scenarios is achieved with a Fourier-based technique in conjunction with an adaptively determined minimum operating signal strength threshold. Improved wireless network cell boundary detection enables vertical handoffs from high quality of service networks to be delayed as long as possible. Together, practical wireless network quality of service measures and improved detection of wireless network cell boundaries in vertical handoff scenarios reduce the rate of unnecessary vertical handoff resulting in higher overall quality of service experienced by a mobile computing device roaming between wireless network types.

公开(公告)号：US20050213542A1

公开(公告)日：2005-09-29

申请号：US11146965

申请日：2005-06-07

申请人： Zihua Guo ,  Qian Zhang ,  Richard Yao ,  Wenwu Zhu

发明人： Zihua Guo ,  Qian Zhang ,  Richard Yao ,  Wenwu Zhu

IPC分类号： H04B7/212 ,  H04B7/26 ,  H04J3/16 ,  H04J7/00 ,  H04J11/00 ,  H04L20060101 ,  H04L12/28 ,  H04W36/14 ,  H04W36/30 ,  H04Q7/00

CPC分类号： H04W36/30 ,  H04B2201/70702

摘要： A system and method for improved vertical handoff between different types of wireless network. Network allocation vector occupation and packet collision probability are used as quality of service measures, enabling vertical handoffs to be delayed until actually beneficial to quality of service. Improved wireless network cell boundary detection in vertical handoff scenarios is achieved with a Fourier-based technique in conjunction with an adaptively determined minimum operating signal strength threshold. Improved wireless network cell boundary detection enables vertical handoffs from high quality of service networks to be delayed as long as possible. Together, practical wireless network quality of service measures and improved detection of wireless network cell boundaries in vertical handoff scenarios reduce the rate of unnecessary vertical handoff resulting in higher overall quality of service experienced by a mobile computing device roaming between wireless network types.

摘要翻译： 一种用于改善不同类型无线网络之间的垂直切换的系统和方法。 网络分配向量占用和分组冲突概率被用作服务质量度量，使得垂直切换被延迟，直到实际上有益于服务质量。 利用基于傅里叶的技术结合自适应确定的最小操作信号强度阈值来实现垂直切换场景中改进的无线网孔单元边界检测。 改进的无线网络小区边界检测能够使来自高质量服务网络的垂直切换尽可能延迟。 总而言之，在垂直切换场景中实际的无线网络服务质量测量和无线网络小区边界的改进检测降低了不必要的垂直切换速率，从而导致移动计算设备在无线网络类型之间漫游所遇到的更高的整体服务质量。

公开(公告)号：US06944144B2

公开(公告)日：2005-09-13

申请号：US10377494

申请日：2003-02-28

申请人： Zihua Guo ,  Qian Zhang ,  Richard Yao ,  Wenwu Zhu

发明人： Zihua Guo ,  Qian Zhang ,  Richard Yao ,  Wenwu Zhu

IPC分类号： H04W36/04 ,  H04W36/14 ,  H04W36/22 ,  H04Q7/00 ,  H04B7/212 ,  H04J3/00 ,  H04L12/43

CPC分类号： H04W36/0088 ,  H04W36/04 ,  H04W36/14 ,  H04W36/22

摘要： A system and method for improved vertical handoff between different types of wireless network. Network allocation vector occupation and packet collision probability are used as quality of service measures, enabling vertical handoffs to be delayed until actually beneficial to quality of service. Improved wireless network cell boundary detection in vertical handoff scenarios is achieved with a Fourier-based technique in conjunction with an adaptively determined minimum operating signal strength threshold. Improved wireless network cell boundary detection enables vertical handoffs from high quality of service networks to be delayed as long as possible. Together, practical wireless network quality of service measures and improved detection of wireless network cell boundaries in vertical handoff scenarios reduce the rate of unnecessary vertical handoff resulting in higher overall quality of service experienced by a mobile computing device roaming between wireless network types.

公开(公告)号：US20050198350A1

公开(公告)日：2005-09-08

申请号：US10758510

申请日：2004-01-15

申请人： Kun Tan ,  Hongbin Liao ,  Chuanxiong Guo ,  Qian Zhang ,  Wenwu Zhu

发明人： Kun Tan ,  Hongbin Liao ,  Chuanxiong Guo ,  Qian Zhang ,  Wenwu Zhu

IPC分类号： G06F15/16

CPC分类号： H04L69/16 ,  H04L69/163

摘要： A method for detecting a spurious timeout in a TCP network which can be used to avoid unnecessarily triggering the TCP rate adaptation is disclosed. Upon detection of a timeout on a given packet, a shortened packet version of the possibly lost packet is retransmitted. The retransmitted packet is at least one byte shorter than the original packet. The node receiving this retransmitted packet will acknowledge the receipt of the packet as specified in the TCP protocol. The acknowledgment will contain the sequence number of the lowest byte the receiving node has not yet received. Because the retransmitted packet is shorter than the original packet, the sequence number of this as yet not received byte will be less than or equal to the last byte of the original packet if the original packet was not received indicating a valid timeout. If the sequence number in the acknowledgment is greater than the last byte of the original packet than the original packet was received correctly and the timeout was caused by a lost acknowledgment and is considered a spurious timeout. In the case of a spurious timeout the congestion control mechanisms in the TCP protocol need not be used.

摘要翻译： 公开了一种用于检测可以用于避免不必要地触发TCP速率适配的TCP网络中的虚假超时的方法。 在检测到给定分组上的超时时，重传可能丢失的分组的缩短的分组版本。 重传的分组比原始分组短至少一个字节。 接收该重发分组的节点将确认在TCP协议中指定的分组的接收。 确认将包含接收节点尚未接收的最低字节的序列号。 由于重传的分组比原始分组短，因此未接收到的字节的序列号将小于或等于原始分组的最后一个字节，如果未收到指示有效超时的原始分组。 如果确认中的序列号大于原始数据包的最后一个字节，而不是原始数据包被正确接收，并且超时是由丢失的确认引起的，并且被认为是虚假超时。 在虚假超时的情况下，不需要使用TCP协议中的拥塞控制机制。

公开(公告)号：US20050128944A1

公开(公告)日：2005-06-16

申请号：US11044685

申请日：2005-01-27

申请人： Qian Zhang ,  Wenwu Zhu ,  Jiangchuan Liu

发明人： Qian Zhang ,  Wenwu Zhu ,  Jiangchuan Liu

IPC分类号： H04L12/28 ,  H04L12/56 ,  H04W28/24 ,  H04W48/16 ,  H04W72/00 ,  H04W84/18 ,  H04L12/26

CPC分类号： H04W48/16 ,  H04W28/24 ,  H04W72/00 ,  H04W84/18

摘要： A framework and method for quality of service (QoS) aware resource discovery in mobile ad hoc networks are presented. Self-organized discovery agents manage the directory information that describes the network resources available for use by clients. In one embodiment, hash indexing of available resources is utilized. The discovery agents also partition the network into domains and collect intra- and inter-domain QoS information. This information is used to allow clients to select appropriate resource providers. This framework and method has low discovery latency and cost in terms of the number of packets for each resource discovery query.

摘要翻译： 提出了移动自组织网络中服务质量（QoS）感知资源发现的框架和方法。 自组织发现代理管理描述可供客户使用的网络资源的目录信息。 在一个实施例中，利用可用资源的哈希索引。 发现代理还将网络划分为域，并收集域内和域间QoS信息。 此信息用于允许客户端选择适当的资源提供者。 该框架和方法在每个资源发现查询的数据包数量方面具有较低的发现延迟和成本。

公开(公告)号：US20050122902A1

公开(公告)日：2005-06-09

申请号：US11035291

申请日：2005-01-12

申请人： Zihua Guo ,  Wenwu Zhu ,  Qian Zhang ,  Jun Zhao

发明人： Zihua Guo ,  Wenwu Zhu ,  Qian Zhang ,  Jun Zhao

IPC分类号： H04L12/28 ,  H04L12/56 ,  H04W28/18 ,  H04W28/24 ,  H04W74/00 ,  H04W74/08 ,  H04L12/26

CPC分类号： H04W74/0816 ,  H04W28/18 ,  H04W28/24 ,  H04W74/006 ,  H04W74/0833

摘要： A method provides differentiated quality of service (QoS) by providing adaptive updates to media access control (MAC) layer parameters on a distributed basis. The method includes calculating a failure probability for a transmission over the network, determining a target value for determining a contention window according to a mapped function of the failure probability, and altering the contention window according to a scaling function of the target value. The mapped function and the scaling can provide QoS differentiation. A wireless device ensures fairness in a wireless time slotted network and includes a network interface card (NIC), a network driver interface, a network monitor, a statistics engine, and an adaptive parameter engine for determining a target value for determining a contention window according to a mapped function of the one or more probabilities to enable an alteration of the contention window and provide new parameters for the MAC layer.

公开(公告)号：US20050015496A1

公开(公告)日：2005-01-20

申请号：US10619330

申请日：2003-07-14

申请人： Chuanxiong Guo ,  Jun Yuan ,  Qian Zhang ,  Wenwu Zhu

发明人： Chuanxiong Guo ,  Jun Yuan ,  Qian Zhang ,  Wenwu Zhu

IPC分类号： G06F15/00 ,  H04L12/28 ,  H04L12/56 ,  H04L29/06 ,  H04L29/08 ,  H04L29/12 ,  G06F15/16

CPC分类号： H04L63/12 ,  H04L29/06 ,  H04L29/12009 ,  H04L29/12518 ,  H04L61/2571 ,  H04L69/32 ,  H04W8/14 ,  H04W36/0011 ,  H04W80/04

摘要： A middle layer network protocol enhancement, virtual connectivity (VC) makes the network attachment point changes of local and remote peers transparent to applications that use network services. A virtual connectivity module local to each peer translates communication connection parameters from apparent to real and vice versa, as well as sending and receiving secure connection updates directly to and from peers. Unlike Mobile IP, no routing infrastructure modifications are required. A subscribe-notify service provides connection update notifications when direct peer-to-peer connection updates are not possible, for example, when two communicating peers move simultaneously or when the moving peer is communicating with a peer behind network address translation (NAT). Methods for detecting these conditions are disclosed, as is a virtual connectivity protocol and virtual connectivity module architecture.

摘要翻译： 中间层网络协议增强，虚拟连接（VC）使本地和远程对等体的网络连接点更改对使用网络服务的应用程序透明化。 每个对等体本地的虚拟连接模块将通信连接参数从明显转换为实际，反之亦然，以及直接向对方发送和接收安全连接更新。 与移动IP不同，不需要进行路由基础架构修改。 当直接对等连接更新不可行时，例如当两个通信对等体同时移动或当移动对等体与网络地址转换（NAT）之后的对等体通信时，订阅通知服务提供连接更新通知。 公开了用于检测这些条件的方法，以及虚拟连接协议和虚拟连接模块架构。