公开(公告)号：US07510706B2

公开(公告)日：2009-03-31

申请号：US10306949

申请日：2002-11-29

申请人： Yoshikazu Yonemitsu ,  Toshihiro Nakajima ,  Kenji Nakamaru ,  Masanori Kobayashi ,  Mamoru Hasegawa ,  Yasuji Ueda ,  Akihiro Iida ,  Hiroyuki Sakakibara

发明人： Yoshikazu Yonemitsu ,  Toshihiro Nakajima ,  Kenji Nakamaru ,  Masanori Kobayashi ,  Mamoru Hasegawa ,  Yasuji Ueda ,  Akihiro Iida ,  Hiroyuki Sakakibara

IPC分类号： A01N63/00 ,  A61K48/00 ,  C12N5/00 ,  C12N15/00 ,  A61K31/70

CPC分类号： C12N7/00 ,  A61K48/00 ,  C12N15/86 ,  C12N2740/15043 ,  C12N2740/15045 ,  C12N2740/15052 ,  C12N2810/60

摘要： The present invention provides a retroviral vector containing a membrane protein having a hemagglutinin activity. The present inventors constructed a retroviral vector pseudotyped by the membrane protein having a hemagglutinin activity. This viral vector showed gene transfer at a high efficiency into host cells. In particular, it was established that genes can be transferred thereby at a high efficiency into cells into which genes can hardly be transferred by the conventional techniques, for example, blood cells and hematopoietic cells including hematopoietic stem cells, and mucous cells including mucosa epithelial cells. The viral vector of the present invention is highly useful as a vector for gene therapy.

摘要翻译： 本发明提供含有血凝素活性的膜蛋白的逆转录病毒载体。 本发明人构建了具有血细胞凝集素活性的膜蛋白假型化的逆转录病毒载体。 该病毒载体以高效率显示宿主细胞的基因转移。 特别地，已经确定，通过常规技术，例如血细胞和包括造血干细胞在内的造血细胞和包括粘膜上皮细胞的粘液细胞在基因难以转移的细胞中，可以将高效转移基因 。 本发明的病毒载体作为基因治疗载体是非常有用的。

公开(公告)号：US07474864B2

公开(公告)日：2009-01-06

申请号：US11501743

申请日：2006-08-10

申请人： Masanori Kobayashi ,  Mitsuo Yamamoto ,  Yasutomo Ishii

发明人： Masanori Kobayashi ,  Mitsuo Yamamoto ,  Yasutomo Ishii

IPC分类号： G03G15/02

CPC分类号： G03G15/0225

摘要： An image forming apparatus includes a member to be cleaned, and a cleaning member, formed by foam material having plural foam cells, that cleans the member to be cleaned by contacting the member to be cleaned and rubbing against the member to be cleaned. In any one of the plural foam cells in a surface of the cleaning member, a maximum length A in a rubbing direction and a maximum length B in a direction orthogonal to the rubbing direction satisfy the relationship of A

摘要翻译： 图像形成装置包括待清洁的构件和由具有多个泡沫单元的泡沫材料形成的清洁构件，其通过使要清洁的构件接触并与待清洁的构件摩擦而清洁待清洁的构件。 在清洁部件的表面中的多个泡沫单体的任一个中，摩擦方向上的最大长度A和与摩擦方向正交的方向上的最大长度B满足A

公开(公告)号：US20080299642A1

公开(公告)日：2008-12-04

申请号：US12140715

申请日：2008-06-17

申请人： Hiroaki Kinoh ,  Makoto Inoue ,  Yasuji Ueda ,  Akihiro Iida ,  Mamoru Hasegawa ,  Masanori Kobayashi

发明人： Hiroaki Kinoh ,  Makoto Inoue ,  Yasuji Ueda ,  Akihiro Iida ,  Mamoru Hasegawa ,  Masanori Kobayashi

IPC分类号： C12N7/01 ,  C07H21/04 ,  C12N15/63

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/50 ,  C12N15/86 ,  C12N2760/18022 ,  C12N2760/18822 ,  C12N2760/18843 ,  C12N2800/30

摘要： The present invention provides cell fusogenic vectors having replicative ability, whose protease-dependent tropism has been modified. M gene-deficient viral vectors encoding modified F proteins, in which the cleavage site of the F protein of paramyxovirus is modified to be cleaved by different proteases, were produced. In cells transfected with these vectors, the genomic RNA present in the vectors is replicated, and cell fusogenic infection spreads to neighboring cells depending on the presence of other proteases; however, no viral particles are released. The vectors of this invention, encoding the F proteins which are cleaved by proteases whose activity is enhanced in cancer, show cancer growth suppressive effect in vivo.

摘要翻译： 本发明提供具有复制能力的细胞融合载体，其蛋白酶依赖性向性已被修饰。 产生编码修饰的F蛋白的M基因缺陷型病毒载体，其中修饰了被不同蛋白酶切割的副粘病毒的F蛋白的切割位点。 在用这些载体转染的细胞中，载体中存在的基因组RNA被复制，并且根据其它蛋白酶的存在，细胞融合感染扩散到相邻细胞; 然而，没有病毒颗粒被释放。 本发明的编码由蛋白酶切割的F蛋白的载体，其活性在癌症中增强，在体内显示出癌症生长抑制作用。

公开(公告)号：US07438400B2

公开(公告)日：2008-10-21

申请号：US10892764

申请日：2004-07-16

申请人： Hitotoshi Kimura ,  Michinari Tsukahara ,  Masanori Kobayashi ,  Morio Sato ,  Kenji Ochiai ,  Yasuto Sakai

发明人： Hitotoshi Kimura ,  Michinari Tsukahara ,  Masanori Kobayashi ,  Morio Sato ,  Kenji Ochiai ,  Yasuto Sakai

IPC分类号： B41J2/175

CPC分类号： B41J2/17513 ,  B41J2/17543 ,  B41J2/17566

摘要： In a liquid container in which a liquid container case accommodates at least three liquid storing packs under a condition that the liquid storing pack partially overlaps the adjacent liquid storing pack, amounts of liquid stored in the respective liquid storing packs have a plurality of levels, and the liquid pack storing the most amount of the liquid is arranged at parts other than the center of arrangement.

摘要翻译： 在液体容器壳体容纳至少三个液体储存包装的液体容器中，在液体储存包部件与相邻的液体储存包部分重叠的状态下，存储在各个储液包中的液体量具有多个级别，并且 存储最多液体的液体组件布置在除了排列中心之外的部分。

公开(公告)号：US07402427B2

公开(公告)日：2008-07-22

申请号：US10513094

申请日：2003-04-30

申请人： Hiroaki Kinoh ,  Makoto Inoue ,  Yasuji Ueda ,  Akihiro Iida ,  Mamoru Hasegawa ,  Masanori Kobayashi

发明人： Hiroaki Kinoh ,  Makoto Inoue ,  Yasuji Ueda ,  Akihiro Iida ,  Mamoru Hasegawa ,  Masanori Kobayashi

IPC分类号： C12N15/86 ,  A01N63/00 ,  A61K39/155

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/50 ,  C12N15/86 ,  C12N2760/18022 ,  C12N2760/18822 ,  C12N2760/18843 ,  C12N2800/30

摘要： The present invention provides cell fusogenic vectors having replicative ability, whose protease-dependent tropism has been modified. M gene-deficient viral vectors encoding modified F proteins, in which the cleavage site of the F protein of paramyxovirus is modified to be cleaved by different proteases, were produced. In cells transfected with these vectors, the genomic RNA present in the vectors is replicated, and cell fusogenic infection spreads to neighboring cells depending on the presence of other proteases; however, no viral particles are released. The vectors of this invention, encoding the F proteins which are cleaved by proteases whose activity is enhanced in cancer, show cancer growth suppressive effect in vivo.

摘要翻译： 本发明提供具有复制能力的细胞融合载体，其蛋白酶依赖性向性已被修饰。 产生编码修饰的F蛋白的M基因缺陷型病毒载体，其中修饰了被不同蛋白酶切割的副粘病毒的F蛋白的切割位点。 在用这些载体转染的细胞中，载体中存在的基因组RNA被复制，并且根据其它蛋白酶的存在，细胞融合感染扩散到相邻细胞; 然而，没有病毒颗粒被释放。 本发明的编码由蛋白酶切割的F蛋白的载体，其活性在癌症中增强，在体内显示出癌症生长抑制作用。

公开(公告)号：US20080151020A1

公开(公告)日：2008-06-26

申请号：US12036754

申请日：2008-02-25

申请人： Hitotoshi Kimura ,  Yasuto Sakai ,  Satoshi Shinada ,  Michinari Tsukahara ,  Masanori Kobayashi ,  Taku Ishizawa

发明人： Hitotoshi Kimura ,  Yasuto Sakai ,  Satoshi Shinada ,  Michinari Tsukahara ,  Masanori Kobayashi ,  Taku Ishizawa

IPC分类号： B41J2/175

CPC分类号： B41J2/17553 ,  B41J2/16523 ,  B41J2/175 ,  B41J2/17509 ,  B41J2/17513 ,  B41J2002/1728 ,  B41J2002/17516

摘要： Liquid packs 34 provided with liquid leading members 42 are stored in a container case 31 that is constituted by fitting a case main body portion 32 and a lid case 33 in fitting portions 27 and 28, support portions 13, which positions the liquid leading members 42 so as to be opposed to liquid introducing members 71 attached to a cartridge inserting portion 13, are provided on a front surface 32a of the container case 31, the fitting portions 27 and 28 are arranged in a state in which the fitting portions 27 and 28 traverses the support portions 43, and space portions 29 and 30 having a gap larger than a gap formed in the fitting portions 27 and 28 are formed near the support portions 43 in the fitting portions 27 and 28. In this way, liquid flowing through the fitting portions 27 and 28 due to the capillarity is retained by the space portions 29 and 30 and never flows to the fitting portions 27 and 28 further extending from the space portions 29 and 30.

摘要翻译： 设置有液体引导构件42的液体包34被存储在容器壳体31中，容器壳体31通过将壳体主体部分32和盖壳体33装配在装配部分27和28中，将液体引导构件42定位的支撑部分13 为了与安装在盒插入部13上的液体导入部件71相对，设置在容器壳体31的前面32a上，嵌合部27,28配置在嵌合部27和 28穿过支撑部43，并且在配合部27和28中的支撑部43的附近形成具有比形成在嵌合部27和28中的间隙大的间隙的空间部29,30。 以这种方式，由于毛细作用而流过装配部分27和28的液体被空间部分29和30保持，并且不会流向从空间部分29和30进一步延伸的装配部分27和28。

公开(公告)号：US20080097075A1

公开(公告)日：2008-04-24

申请号：US11661753

申请日：2005-08-31

申请人： Mitsuhiro Matsuzaki ,  Katsumi Horikoshi ,  Masanori Kobayashi

发明人： Mitsuhiro Matsuzaki ,  Katsumi Horikoshi ,  Masanori Kobayashi

IPC分类号： C08G75/14

CPC分类号： C08G75/0254 ,  C08G75/02

摘要： In a process for producing polyarylene sulfide, comprising: reacting an alkali sulfide source and an aromatic dihalide compound in a polar organic solvent to obtain a polymerizate slurry containing polyarylene sulfide particles, by-produced alkali metal salt fine particles and the polar organic solvent, and recovering the polyarylene sulfide particles washed from the polymerizate slurry; the polymerizate slurry is separated by sieving into the polyarylene sulfide particles and a slurry containing the alkali metal salt fine particles, and the separated polyarylene sulfide particles are subjected to a washing step wherein the polyarylene sulfides are introduced into a countercurrent washing apparatus enclosing a movable part and subjected therein to continuous countercurrent contact with a washing liquid. As a result, polyarylene sulfide particles of good quality are produced at a good yield, while pursuing process rationalization.

摘要翻译： 在制备聚芳硫醚的方法中，包括：将碱金属硫化物源和芳族二卤化物在极性有机溶剂中反应，得到含有聚芳硫醚颗粒，副产的碱金属盐微粒和极性有机溶剂的聚合物淤浆，以及 回收从聚合物浆料洗涤的聚芳硫醚颗粒; 将聚合物浆料通过筛分分离成聚芳硫醚颗粒和含有碱金属盐微粒的浆料，并将分离的聚芳硫醚颗粒进行洗涤步骤，其中将聚亚芳基硫化物引入到包围可动部分的逆流洗涤装置中 并与其进行与洗涤液的连续逆流接触。 结果，在追求工艺合理化的同时，以良好的产率生产质量好的聚芳硫醚颗粒。

公开(公告)号：US20070091129A1

公开(公告)日：2007-04-26

申请号：US11559187

申请日：2006-11-13

申请人： Michinari Tsukahara ,  Masanori Kobayashi ,  Morio Sato ,  Kenji Ochiai ,  Yasuto Sakai

发明人： Michinari Tsukahara ,  Masanori Kobayashi ,  Morio Sato ,  Kenji Ochiai ,  Yasuto Sakai

IPC分类号： B41J2/195

CPC分类号： B41J2/175 ,  B41J2/17509 ,  B41J2/17513 ,  B41J2/17523

摘要： When ink is filled into an ink pack 13 including a bag part 20 and an outlet part 21, firstly, air in the bag 20 and outlet part 21 is sucked by a suction pump P2 provided for an ink pouring apparatus 30. Further, by a first measuring pipe 43, ink supplied from a main tank 31 is poured through the outlet part 21 into the bag part 20. Further, by a second measuring pipe 52, the ink poured into the bag part 20 of the ink pack 13 is sucked and exhausted. Furthermore, the ink in the second measuring pipe 52 is mixed into a mixing tank 34 with ink previously supplied to the mixing tank 34 from the main tank 31. Next, the ink is supplied from the mixing tank 34 to a third measuring pipe 59, and filled from the third measuring pipe 59 through the outlet part 21 into the bag part 20.

摘要翻译： 当墨水被填充到包括袋部分20和出口部分21的墨水包装13中时，首先，袋20和出口部分21中的空气被设置用于墨水注入装置30的抽吸泵P 2吸入。此外，通过 第一测量管43，从主容器31供应的油墨通过出口部分21注入到袋部分20中。此外，通过第二测量管52，将墨水组件13的袋部20中的油墨吸入 并耗尽。 此外，将第二测量管52中的墨水从预先从主罐31供给到混合罐34的墨水混合到混合罐34中。接下来，将墨从混合罐34供应到第三测量管59， 并通过出口部21从第三测量管59填充到袋部20中。

公开(公告)号：US07146942B2

公开(公告)日：2006-12-12

申请号：US11171881

申请日：2005-06-30

申请人： Tsuneyoshi Yuasa ,  Masanori Kobayashi

发明人： Tsuneyoshi Yuasa ,  Masanori Kobayashi

IPC分类号： F02B25/00

CPC分类号： F02M35/1019 ,  F02B25/22 ,  F02M35/1017

摘要： To provide an improved air scavenging type two-cycle combustion engine equipped with a pressure reducing device in which clogging of a decompressing hole can easily be removed, a two-cycle combustion engine includes a delivery passage (32) for introducing air into a combustion chamber (9) prior to an air-fuel mixture. This delivery passage (32) has a downstream opening (32c) through which the air is introduced into the combustion chamber by way of a scavenging port (40a). A decompressing hole (38) is defined for communicating the combustion chamber (9) to a portion of the delivery passage (32) and is closed by a piston (16) then ascending, at a timing delayed relative to closure of an exhaust port (31).

公开(公告)号：US07089891B2

公开(公告)日：2006-08-15

申请号：US10862667

申请日：2004-06-07

申请人： Tsuneyoshi Yuasa ,  Masanori Kobayashi

发明人： Tsuneyoshi Yuasa ,  Masanori Kobayashi

IPC分类号： F02B33/04

CPC分类号： F02B33/04 ,  F02B25/16 ,  F02B25/20 ,  F02B33/30

摘要： To provide a two-cycle combustion engine, in which the blow-off of the air-fuel mixture used as the scavenging gas is avoided and the combustion efficiency of the air-fuel mixture can be increased, the two-cycle combustion engine includes first and second scavenge passages (11, 12) for supplying the air-fuel mixture (M) from a crank chamber (2a) into the combustion chamber (1a) of the combustion engine. Each of the first and second scavenge passages (11, 12) has a lower end portion thereof extended to assume the position where it confronts an outer end face of a bearing (81) for the crankshaft (8), so that the air-fuel mixture (M) within the crank chamber (2a) can be introduced into the first and second scavenge passages (11, 12) through the bearing (81) and be then supplied into the combustion chamber (1a) through the first and second scavenge passages (11, 12).

摘要翻译： 为了提供避免用作清扫气体的空气 - 燃料混合物的吹扫的双循环内燃机，并且可以提高空气 - 燃料混合物的燃烧效率，所以双循环内燃机包括第一 以及用于将空气燃料混合物（M）从曲柄室（2a）供应到内燃机的燃烧室（1a）中的第二扫气通道（11,12）。 第一和第二清扫通道（11,12）中的每一个具有下端部，其延伸以呈现其与用于曲轴（8）的轴承（81）的外端面相对的位置，使得空气燃料 曲柄室（2a）内的混合物（M）可以通过轴承（81）被引入到第一和第二扫气通道（11,12）中，然后通过第一和第二 扫气通道（11,12）。