摘要:
The invention provides methods and composition developed to be used with imaging techniques and useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degeneration include markers of neuronal, vascular, immune and matrix elements.
摘要:
The invention provides kits developed to analyze ex vivo, a sample retrieved from the area of the pathological condition for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degenerating disc include markers of neuronal, vascular, immune and matrix elements.
摘要:
An intervertebral prosthetic disc is disclosed and can be installed within an intervertebral space between a superior vertebra and an inferior vertebra. The intervertebral prosthetic disc can include an inferior component having a depression formed therein and a superior component having a projection extending therefrom. The projection can be configured to movably engage the depression and allow relative motion between the inferior component and the superior component. Further, the projection can include a superior wear resistant layer configured to engage the depression.
摘要:
A method comprises selecting an intervertebral implant having a predetermined shape with a height dimension and a width dimension. The implant further comprises an empty or partially filled reservoir. The method further comprises selecting a deformation instrument and inserting the intervertebral implant into the deformation instrument. The deformation instrument comprises at least one joint for moving the deformation instrument between an expanded state and a collapsed state. The method further comprises placing the intervertebral implant in the deformation instrument while in the expanded state and activating the at least one joint to move the deformation instrument into a collapsed state. The method further comprises collapsing the reservoir to reduce one of the dimensions of the implant and moving the implant from the deformation instrument into an intervertebral disc space. The implant is allowed to expand substantially to the predetermined shape within the intervertebral disc space. The method further comprises filling the reservoir and maintaining within the reservoir a volume of filling material.
摘要:
A method is provided for treating a spinal condition. The method includes introducing a biological treatment into an area of a vertebral column, and mechanically unloading the treated area by applying a load-bearing device to the anterior region, the anterior column region, the posterior region, or the spinous process region of the vertebral column.
摘要:
An intervertebral prosthetic disc is disclosed and can be installed within an intervertebral space between a superior vertebra and an inferior vertebra. The intervertebral prosthetic disc can include a superior component and an inferior component that can have an inferior bearing surface. A hydrophilicity of the inferior bearing surface can be greater-than an average hydrophilicity of the inferior component.
摘要:
A spinal rod includes an elongated tubular member that is inflatable from a first insertion profile to a second enlarged profile. An expandable tubular reinforcement sleeve is concentrically positioned adjacent to the balloon. The balloon may be bonded to the sleeve. The spinal rod may also have longitudinal reinforcement members. A joining member may join two or more of the longitudinal reinforcing members at a discrete point along each. The spinal rod may further include end portions on either side of an inflatable portion.
摘要:
The present application is directed to vertebral rods and methods of use. In one embodiment, the rod includes upper and lower sections that are separated by an intermediate section. The intermediate section may include one or more members, and may have a variety of configurations. An elastic member may be positioned within the intermediate section. The intermediate section and the elastic member may provide for variable resistance during movement of the upper and lower sections. In one embodiment, the resistance increases the further away the upper and lower sections move from a first orientation. In one embodiment, the extent of movement of the upper and lower sections is limited.
摘要:
Protectors and methods of mounting protectors to features on implants within patients. The protectors attach to the features and provide protection to the patient by preventing or reducing injury that may be caused by the feature. The protectors may also be removable such that the feature can be exposed during future revision procedures. A variety of attachment methods may also be used to attach the protector to the feature. Insertion tools may be used for attaching the protectors to the features.
摘要:
The embodiments provide a method for treating an intervertebral disc having a nucleus pulposus and an annulus fibrosis, using one or more superabsorbent polymers. Additionally, the embodiments provide a method for bulking up an intervertebral disc having a nucleus pulposus and an annulus fibrosis, using one or more superabsorbent polymers. The methods comprise introducing an amount of the superabsorbent polymers into the intervertebral disc space without removing nucleus pulposus or annulus fibrosis material.