公开(公告)号：US06929947B2

公开(公告)日：2005-08-16

申请号：US09944944

申请日：2001-08-31

申请人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Margaret Ann Roy ,  William I. Wood

发明人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Margaret Ann Roy ,  William I. Wood

IPC分类号： C07H21/04 ,  C07K14/47 ,  C12N5/06 ,  C12N9/00

CPC分类号： C07K14/47 ,  A61K38/1709

摘要： The present invention is directed to nucleic acids encoding a secreted polypeptide that inhibits neoplastic growth in tumor cells. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及编码抑制肿瘤细胞中肿瘤生长的分泌多肽的核酸。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07399834B2

公开(公告)日：2008-07-15

申请号：US10013912

申请日：2001-12-10

申请人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Margaret Ann Roy ,  Colin K. Watanabe ,  William I. Wood

发明人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Margaret Ann Roy ,  Colin K. Watanabe ,  William I. Wood

IPC分类号： C07K16/00 ,  C12P21/08

CPC分类号： C07K14/47 ,  C07K14/705

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07166282B2

公开(公告)日：2007-01-23

申请号：US09997585

申请日：2001-11-15

申请人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Margaret Ann Roy ,  Colin K. Watanabe ,  William I. Wood

发明人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Margaret Ann Roy ,  Colin K. Watanabe ,  William I. Wood

IPC分类号： A61K39/395

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  C07K14/52 ,  C07K14/705 ,  C07K16/18 ,  C07K2319/00 ,  C12N9/00 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/57484 ,  G01N33/68 ,  G01N33/6842 ,  Y10S530/866

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07070979B2

公开(公告)日：2006-07-04

申请号：US09906838

申请日：2001-07-16

申请人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Margaret Ann Roy ,  William I. Wood

发明人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Margaret Ann Roy ,  William I. Wood

IPC分类号： C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63

CPC分类号： C07K14/47

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07018811B2

公开(公告)日：2006-03-28

申请号：US09989726

申请日：2001-11-19

申请人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Margaret Ann Roy ,  William I. Wood

发明人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Margaret Ann Roy ,  William I. Wood

IPC分类号： C12P21/06 ,  C12N1/20 ,  C12N15/74 ,  C12N5/00 ,  C07H21/04

CPC分类号： C07H21/04 ,  C07K14/395 ,  C07K14/47

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US06913919B2

公开(公告)日：2005-07-05

申请号：US09991181

申请日：2001-11-16

申请人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Margaret Ann Roy ,  William I. Wood

发明人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Margaret Ann Roy ,  William I. Wood

IPC分类号： C07K5/10 ,  C07K5/16 ,  C07K15/12 ,  C07K15/63

CPC分类号： C07K14/705

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07189530B2

公开(公告)日：2007-03-13

申请号：US10015869

申请日：2001-12-11

申请人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Margaret Ann Roy ,  Colin K. Watanabe ,  William I. Wood

发明人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Margaret Ann Roy ,  Colin K. Watanabe ,  William I. Wood

IPC分类号： C12N15/12 ,  C12N5/10 ,  C12P21/02 ,  C07K14/47

CPC分类号： C07K14/47

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07109318B2

公开(公告)日：2006-09-19

申请号：US09990439

申请日：2001-11-16

申请人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Margaret Ann Roy ,  Colin K. Watanabe ,  William I. Wood

发明人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Margaret Ann Roy ,  Colin K. Watanabe ,  William I. Wood

IPC分类号： C07H21/04 ,  C12Q1/68 ,  C12N15/12 ,  C12N15/63 ,  C12N15/00

CPC分类号： C07K14/47

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US06974696B2

公开(公告)日：2005-12-13

申请号：US10017085

申请日：2001-10-24

申请人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Margaret Ann Roy ,  William I. Wood

发明人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Margaret Ann Roy ,  William I. Wood

IPC分类号： C07H21/04

CPC分类号： C07H21/04

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07294695B2

公开(公告)日：2007-11-13

申请号：US10243189

申请日：2002-09-12

申请人： Kevin P. Baker ,  Dan L. Eaton ,  Ellen Filvaroff ,  Audrey Goddard ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Victoria Smith ,  Jean Philippe Stephan ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang ,  Sherman Fong

发明人： Kevin P. Baker ,  Dan L. Eaton ,  Ellen Filvaroff ,  Audrey Goddard ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Victoria Smith ,  Jean Philippe Stephan ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang ,  Sherman Fong

IPC分类号： C07K14/00

CPC分类号： C07H21/04 ,  C07K14/435 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。