公开(公告)号：US4863859A

公开(公告)日：1989-09-05

申请号：US822494

申请日：1986-01-27

Applicant: Shigeki Hamaguchi ,  Takehisa Ohashi ,  Kiyoshi Watanabe

Inventor： Shigeki Hamaguchi ,  Takehisa Ohashi ,  Kiyoshi Watanabe

IPC: C12P11/00 ,  C12P41/00

CPC classification number: C12P41/004 ,  C12P11/00

Abstract: A process for preparing optically active glycerol derivatives by a biochemical resolution which comprises (i) subjecting an ester having the general formula [(R,S)-I]: ##STR1## wherein X is a halogen atom, R is an aliphatic hydrocarbon group of C.sub.1 to C.sub.8 and R' is an aromatic hydrocarbon group or an aliphatic hydrocarbon group of C.sub.1 to C.sub.2, to the action of enzymes derived from either microorganisms or animal organs, wherein said enzymes have a stereo selective esterase activity to asymmetrically hydrolyze the ester having the general formula [(R,S)-I] to give a mixture of an optically active alcohol having the general formula (II)*: ##STR2## wherein X and R' are as above and an optically active ester having the general formula (I)*: ##STR3## wherein X, R and R' are as above, and (ii) obtaining the optically active alcohol having the general formula (II)* and the optically active ester having the general formula (I)* by separating operations.In accordance with the present invention, there can be provided a process for preparing optically active glycerol derivatives, wherein the optically active ester having the general formula (I)* and the optically active alcohol having the general formula (II)* can be easily obtained.

Abstract translation: 一种通过生化分解制备光学活性甘油衍生物的方法，其包括（i）使具有通式[（R，S）-I]的酯：其中X为 卤素原子，R是C1至C8的脂族烃基，R'是C1至C2的芳族烃基或脂族烃基，来自微生物或动物器官的酶的作用，其中所述酶具有立体声 选择性酯酶活性以不对称地水解具有通式[（R，S）-I]的酯，得到具有通式（II）的光学活性醇的混合物：其中X和R （I）*：其中X，R和R'如上所述，和（ii）获得具有通式（I）的光学活性酯，其具有通式（I） II）*和具有通式（I）*的光学活性酯通过分离操作。 根据本发明，可以提供一种制备光学活性甘油衍生物的方法，其中可以容易地获得具有通式（I）*的光学活性酯和具有通式（II）*的光学活性醇 。

公开(公告)号：US4861877A

公开(公告)日：1989-08-29

申请号：US809

申请日：1987-01-06

Applicant: Takehisa Ohashi ,  Kazunori Kan ,  Noboru Ueyama ,  Isao Sada ,  Akimasa Miyama ,  Kiyoshi Watanabe

Inventor： Takehisa Ohashi ,  Kazunori Kan ,  Noboru Ueyama ,  Isao Sada ,  Akimasa Miyama ,  Kiyoshi Watanabe

IPC: C07D205/08 ,  C07F7/18

CPC classification number: C07D205/08 ,  C07F7/186 ,  Y02P20/55

Abstract: A process for preparing a 4-acetoxy-3-hydroxyethylazetidin-2-one derivative having the formula (II): ##STR1## wherein R.sup.1 is a protective group for the hydroxyl group, which comprises reacting a .beta.-lactam compound having the formula (I): ##STR2## wherein R.sup.1 is as defined above, R.sup.2, R.sup.3 and R.sup.4 are a lower alkyl group having 1 to 6 carbon atoms, phenyl group or an aralkyl group and R is a protective group for N, with acetic anhydride in an organic solvent in the presence of a base, and removing the protective group for N.4-Acetoxy-3-hydroxyethylazetidin-2-one derivatives are useful intermediates for preparing carbapenem .beta.-lactam antibiotics such as thienamycin and penem .alpha.-lactam antibiotics.

Abstract translation: 制备具有式（II）的4-乙酰氧基-3-羟乙基氮杂环丁-2-酮衍生物的方法：其中R1是羟基的保护基，其包括使具有 式（I）：其中R 1如上定义，其中R 1，R 3和R 4为具有1至6个碳原子的低级烷基，苯基或芳烷基，R为N的保护基 在乙酸酐的存在下，在有机溶剂中，在碱的存在下，除去N-（4-乙酰氧基-3-羟乙基氮杂环丁烷-2-酮）衍生物的保护基是制备碳青霉烯类β-内酰胺抗生素如噻吩霉素和青霉素的有用中间体 α-内酰胺抗生素。

公开(公告)号：US4786723A

公开(公告)日：1988-11-22

申请号：US844687

申请日：1986-03-27

Applicant: Mikio Kitahara ,  Kiyoto Ishii ,  Hajime Kawaharada ,  Kiyoshi Watanabe

Inventor： Mikio Kitahara ,  Kiyoto Ishii ,  Hajime Kawaharada ,  Kiyoshi Watanabe

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7076 ,  A61K31/708 ,  A61P35/00 ,  C07H19/16 ,  C07H19/167 ,  C07H19/173 ,  C12P19/40 ,  C12R1/01 ,  C12R1/025 ,  C12R1/07 ,  C12R1/13 ,  C12R1/18 ,  C12R1/19 ,  C12R1/22 ,  C12R1/37 ,  C12R1/38 ,  C07H17/00 ,  C07H15/12 ,  C07H19/06

CPC classification number: C07H19/16

Abstract: Novel 7-hydroxyguanine compounds of the formula: ##STR1## wherein R is hydrogen atom or hydroxy, and a salt thereof, which have excellent anti-tumor activity, process for preparing the compounds, and anti-tumor agent containing said compound as an active ingredient.

Abstract translation: 具有下式的新型7-羟基鸟嘌呤化合物：其中R是氢原子或羟基，其盐具有优异的抗肿瘤活性，制备该化合物的方法和含有所述化合物的抗肿瘤剂 作为活性成分。

公开(公告)号：US4690919A

公开(公告)日：1987-09-01

申请号：US826398

申请日：1986-02-05

Applicant: Takehiko Yamane ,  Takuji Hashizume ,  Katsuji Yamashita ,  Kiyoshi Watanabe

Inventor： Takehiko Yamane ,  Takuji Hashizume ,  Katsuji Yamashita ,  Kiyoshi Watanabe

IPC: C07D498/18 ,  C07D519/00 ,  A61K31/535

CPC classification number: C07D498/18 ,  C07D519/00

Abstract: A novel rifamycin derivative having the general formula (I): ##STR1## or salts thereof, a process for preparing the same and antibacterial agents containing the same as an effective component.The rifamycin derivative of the present invention having the general formula (I) shows a strong antibacterial activity against the Gram-positive bacteria and the acid-fast bacteria.

Abstract translation: 具有通式（I）的新型利福霉素衍生物或其盐，其制备方法和含有该有效成分的抗菌剂。 具有通式（I）的本发明的利福霉素衍生物显示出对革兰氏阳性菌和耐酸细菌的强抗菌活性。

公开(公告)号：US4540665A

公开(公告)日：1985-09-10

申请号：US475603

申请日：1983-03-15

Applicant: Junzo Hasegawa ,  Masahiro Ogura ,  Hiroshi Kanema ,  Hajime Kawaharada ,  Kiyoshi Watanabe

Inventor： Junzo Hasegawa ,  Masahiro Ogura ,  Hiroshi Kanema ,  Hajime Kawaharada ,  Kiyoshi Watanabe

IPC: C12P7/42 ,  C12N1/14 ,  C12N1/16 ,  C12N1/32 ,  C12N15/00 ,  C12P1/02 ,  C12R1/72

CPC classification number: C12P7/42 ,  Y10S435/921

Abstract: A process for producing D-.beta.-hydroxyalkanoic acids by utilizing microorganisms having an ability of stereospecifically converting alkanoic acids, 2-alkenoic acids or alcohols into D-.beta.-hydroxyalkanoic acids.

Abstract translation: 通过利用具有立体选择性将链烷酸，2-链烯酸或醇转化为D-β-羟基链烷酸的能力的微生物来生产D-β-羟基链烷酸的方法。

公开(公告)号：US4431656A

公开(公告)日：1984-02-14

申请号：US337168

申请日：1982-01-05

Applicant: Ikuo Katsumi ,  Hideo Kondo ,  Katsuji Yamashita ,  Takayoshi Hidaka ,  Kazunori Hosoe ,  Yutaka Ariki ,  Toshiaki Yamashita ,  Kiyoshi Watanabe

Inventor： Ikuo Katsumi ,  Hideo Kondo ,  Katsuji Yamashita ,  Takayoshi Hidaka ,  Kazunori Hosoe ,  Yutaka Ariki ,  Toshiaki Yamashita ,  Kiyoshi Watanabe

IPC: C07C49/248 ,  C07C49/747 ,  C07C49/753 ,  C07C49/835 ,  C07C59/52 ,  C07C59/90 ,  C07D233/96 ,  C07D307/58 ,  A61K31/415 ,  C07D307/26

CPC classification number: C07C255/00 ,  C07C49/248 ,  C07C49/747 ,  C07C49/753 ,  C07C49/835 ,  C07C59/52 ,  C07C59/90 ,  C07D233/96 ,  C07D307/58 ,  Y10S514/825 ,  Y10S514/916

Abstract: Novel compounds, 3,5-di-tert-butylstyrene derivatives and their salts, are disclosed, which derivatives are represented by the general formula: ##STR1## wherein R.sup.1 stands for an acyloxy group represented by R.sup.3 COO (R.sup.3 is a hydrogen atom or an alkyl group with C.sub.1 -C.sub.6), an alkoxyl group of R.sub.4 O (R.sup.4 is an alkyl group with C.sub.1 -C.sub.4), a hydroxyl group, or a hydrogen atom; R.sup.2 stands for ##STR2## (R.sup.5 is a hydrogen atom or an alkyl group with C.sub.1 -C.sub.3 and X.sup.1 is CH.sub.2 or an oxygen atom), ##STR3## (R.sup.5 and X.sup.1 are each the same as defined above), or ##STR4## (X.sup.2 is an oxygen or sulfur atom). There are also disclosed an anti-inflammatory, analgesic, and antipyretic pharmaceutical composition and an anti-platelet aggregation pharmaceutical composition, both pharmaceutical compositions comprising the foregoing 3,5-di-tert-butylstyrene derivative or its pharmaceutically acceptable salt as an active ingredient in association with pharmaceutical excipients.

Abstract translation: 公开了新的化合物，3,5-二叔丁基苯乙烯衍生物及其盐，该衍生物由以下通式表示：其中R1代表由R3COO表示的酰氧基（R3是氢原子或 具有C1-C6的烷基），R4O的烷氧基（R4是具有C1-C4的烷基），羟基或氢原子; R2代表（R5是氢原子或具有C1-C3和X1是CH2的烷基或氧原子），＆lt; IMAGE＆gt;（R5和X1各自与上述相同）或 （X2是氧或硫原子）。 还公开了抗炎，镇痛和解热药物组合物和抗血小板聚集药物组合物，两种药物组合物包含前述3,5-二叔丁基苯乙烯衍生物或其药学上可接受的盐作为活性成分 与药物赋形剂的关联。

公开(公告)号：US4403317A

公开(公告)日：1983-09-06

申请号：US256112

申请日：1981-04-21

Applicant: Hiroyuki Suzuki ,  Masayuki Taoka ,  Kiyoshi Watanabe

Inventor： Hiroyuki Suzuki ,  Masayuki Taoka ,  Kiyoshi Watanabe

IPC: G11B17/032 ,  G11B17/04 ,  G11B1/00

CPC classification number: G11B17/0545 ,  G11B17/032

Abstract: There is disclosed a disk mount assembly for a disk player with a turntable and a front cover, especially for use in a vertical player. The disk mount assembly includes a disk mount so disposed in front of the turntable as to be movable upon opening or closing the front cover. A disk is first placed on the disk mount and brought into contact with the turntable upon closure of the front cover. Preferably, the disk mount bears an EP record disk mounting recess and an LP record disk mounting recess which are axially displaced on different levels with respect to each other.

Abstract translation: 公开了一种用于具有转台和前盖的盘播放器的盘安装组件，特别是用于垂直播放器中。 盘安装组件包括一个安装在转盘前面的盘形支架，以便在打开或关闭前盖时可移动。 首先将磁盘放置在磁盘安装座上，并在封盖前盖与转盘接触。 优选地，盘安装件具有EP记录盘安装凹部和LP记录盘安装凹部，其相对于彼此在不同的水平上轴向移位。

公开(公告)号：US4242373A

公开(公告)日：1980-12-30

申请号：US910344

申请日：1978-05-30

Applicant: Kiyoshi Watanabe ,  Kazuo Sunahara ,  Tsutomu Fujita

Inventor： Kiyoshi Watanabe ,  Kazuo Sunahara ,  Tsutomu Fujita

IPC: C23C14/08 ,  B05D1/00 ,  H01J31/26

CPC classification number: C23C14/08 ,  H01J9/233

Abstract: A method for forming a thin film of cerium oxide as a blocking layer which constitutes a portion of a photoelectric film of a blocking type image pickup tube is disclosed. A substrate deposition rate in a vacuum deposition process is established in a range between 0.01 to 0.6 A/sec to prevent the deposition of particles which result in black or white spots in a picture image. It is more effective to select a particle size of 5 .mu. or more for the primary particles to be deposited.

Abstract translation: 公开了一种形成作为阻挡层的氧化铈薄膜的方法，该阻挡层构成了封闭型图像拾取管的光电膜的一部分。 在真空沉积工艺中的衬底沉积速率建立在0.01至0.6A / sec的范围内，以防止在图像中产生黑色或白色斑点的颗粒沉积。 对于要沉积的一次颗粒选择5μm或更大的粒径是更有效的。

公开(公告)号：US4043748A

公开(公告)日：1977-08-23

申请号：US715716

申请日：1976-08-19

Applicant: Kiyoshi Watanabe ,  Kazuo Sunahara ,  Motoyasu Terao ,  Tsutomu Fujita

Inventor： Kiyoshi Watanabe ,  Kazuo Sunahara ,  Motoyasu Terao ,  Tsutomu Fujita

IPC: C23C14/24 ,  C23C14/26 ,  F27B21/04

CPC classification number: C23C14/243

Abstract: The evaporation boat comprises superposed upper and lower sheets. The upper sheet includes a upwardly convexed central section and a pair of side sections bent back toward the central section and the lower sheet includes a downwardly convexed central section and a pair of side sections bent inwardly toward the upper sheet. The upper and lower sheets are superposed each other such that the central sections of the upper and lower sheets define a substantially closed chamber for accomodating source material to be evaporated, that slit shaped vapor passages are formed between the upper and lower sheets or the opposite sides of the chamber and that any straight line drawn between any point on the surface of the source material and any point in the passages intersects the inner wall of the upper or lower sheets.

Abstract translation: 蒸发舟包括叠加的上下板。 上片包括向上凸起的中心部分和朝向中心部分向后弯曲的一对侧部，并且下片包括向下凸出的中心部分和朝向上片向内弯曲的一对侧部。 上下板叠合，使得上板和下板的中心部分限定了用于容纳要蒸发的源材料的基本上封闭的室，在上板和下板或相对侧之间形成狭缝形蒸汽通道 并且在源材料表面上的任何点和通道中的任何点之间绘制的任何直线与上部或下部片材的内壁相交。

公开(公告)号：US08809684B2

公开(公告)日：2014-08-19

申请号：US13075286

申请日：2011-03-30

Applicant: Takanori Yamazaki ,  Kiyoshi Watanabe ,  Junichi Abe ,  Hideyuki Kikuchi ,  Daisuke Hino

Inventor： Takanori Yamazaki ,  Kiyoshi Watanabe ,  Junichi Abe ,  Hideyuki Kikuchi ,  Daisuke Hino

IPC: H01B7/00

CPC classification number: H01B3/305 ,  H01B3/301

Abstract: There is provided an insulated wire including a wire conductor and an insulation coating formed on the wire conductor by extrusion coating a resin composition. The resin composition is a mixture of a polyphenylene sulfide-based resin (A) and a polyamide-based resin (B), in which a ratio of parts by mass of the resin (B) to that of the resin (A), i.e. (B)/(A), is not less than 5/95 and not more than 30/70.

Abstract translation: 提供了一种绝缘电线，其包括线导体和通过挤出涂覆树脂组合物形成在导线导体上的绝缘涂层。 树脂组合物是聚苯硫醚类树脂（A）和聚酰胺类树脂（B）的混合物，其中树脂（B）与树脂（A）的质量份的比例，即 （B）/（A），不小于5/95且不大于30/70。