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公开(公告)号：US06949649B2
公开(公告)日：2005-09-27
申请号：US10696477
申请日：2003-10-29
IPC分类号： A61K31/4745 , A61P31/02 , A61P31/12 , A61P37/02 , C07D471/04 , C07D487/02
CPC分类号： C07D471/04 , A61K31/4745
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06921826B2
公开(公告)日：2005-07-26
申请号：US10696684
申请日：2003-10-29
IPC分类号： A61K31/4745 , A61K31/506 , A61P1/16 , A61P7/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/02 , A61P17/12 , A61P17/14 , A61P25/00 , A61P31/02 , A61P31/04 , A61P31/06 , A61P31/08 , A61P31/10 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , A61P33/02 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/08 , A61P43/00 , C07D471/04
CPC分类号： C07D471/04 , A61K31/4745 , Y02A50/409
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US07288550B2
公开(公告)日：2007-10-30
申请号：US11132537
申请日：2005-05-19
IPC分类号： A61K31/4353 , C07D471/04
CPC分类号： C07D471/04 , A61K31/4745 , Y02A50/409
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译： 在1-位含有硫醚官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。
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公开(公告)号：US06667312B2
公开(公告)日：2003-12-23
申请号：US10165222
申请日：2002-06-07
IPC分类号： A61K314745
CPC分类号： C07D471/04 , A61K31/4745
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06670372B2
公开(公告)日：2003-12-30
申请号：US10013202
申请日：2001-12-06
申请人： Leslie J. Charles , Joseph F. Dellaria , Philip D. Heppner , Bryon A. Merrill , John W. Mickelson
发明人： Leslie J. Charles , Joseph F. Dellaria , Philip D. Heppner , Bryon A. Merrill , John W. Mickelson
IPC分类号： A61K314745
CPC分类号： C07D471/04 , A61K31/4745 , Y02A50/409
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and aryl or alkenyl functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06664264B2
公开(公告)日：2003-12-16
申请号：US10013059
申请日：2001-12-06
IPC分类号： A61K314745
CPC分类号： C07D471/04 , A61K31/4745 , Y02A50/409
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US07132429B2
公开(公告)日：2006-11-07
申请号：US11069033
申请日：2005-02-28
IPC分类号： A01N43/42 , A01N31/44 , C07D47/00 , C07D491/00 , C07D498/00
CPC分类号： C07D471/04 , A61K31/4745 , Y02A50/409
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and sulfonamide or sulfamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06989389B2
公开(公告)日：2006-01-24
申请号：US10696108
申请日：2003-10-29
申请人： Philip D. Heppner , Leslie J. Charles , Joseph F. Dellaria , Bryon A. Merrill , John W. Mickelson
发明人： Philip D. Heppner , Leslie J. Charles , Joseph F. Dellaria , Bryon A. Merrill , John W. Mickelson
IPC分类号： A61K31/4745 , C07D471/04 , A61P37/02 , A61P31/12
CPC分类号： C07D471/04
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and aryl or alkenyl functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06780873B2
公开(公告)日：2004-08-24
申请号：US10352604
申请日：2003-01-28
IPC分类号： A61K314745
CPC分类号： C07D471/04 , A61K31/4745
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain urea, thiourea, acylurea, or sulfonylurea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06541485B1
公开(公告)日：2003-04-01
申请号：US09589236
申请日：2000-06-07
IPC分类号： A61K314745
CPC分类号： C07D471/04 , A61K31/4745
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain urea, thiourea, acylurea, or sulfonylurea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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