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    Arylmethyl triazolo- and imidazopyrazines as c-Met inhibitors
    1.
    发明授权
    Arylmethyl triazolo- and imidazopyrazines as c-Met inhibitors 失效
    芳基甲基三唑并 - 咪唑并吡嗪作为c-Met抑制剂

    公开(公告)号：US07250417B2

    公开(公告)日：2007-07-31

    申请号：US10875507

    申请日：2004-06-25

    申请人： Jingrong Cui ,  Iriny Botrous

    发明人： Jingrong Cui ,  Iriny Botrous

    IPC分类号： A01N43/58 ,  A01N43/60 ,  A61K31/50 ,  A61K31/495 ,  C07D47/00

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： The present invention relates to compounds of the Formulae (I)-(IV), wherein R1-R6, R11-R13, X and Y are defined herein, and their pharmaceutically acceptable salts. These compounds modulate the activity of c-Met and are therefore expected to be useful in the prevention and treatment of c-Met related disorders such as cancer

    摘要翻译： 本发明涉及式（I） - （IV）的化合物，其中R 1 -R 6，R 11 -R 本文定义X和Y以及它们的药学上可接受的盐。 这些化合物调节c-Met的活性，因此预期可用于预防和治疗c-Met相关疾病如癌症

    Hydrophilic permanent organosilicon compounds
    2.
    发明授权
    Hydrophilic permanent organosilicon compounds 失效
    亲水性永久性有机硅化合物

    公开(公告)号：US6043362A

    公开(公告)日：2000-03-28

    申请号：US888557

    申请日：1997-07-07

    申请人： Jochen Dauth ,  Guenter Mahr ,  Bernward Deubzer ,  Petra Gratzl ,  Hans-Juergen Lautenschlager

    发明人： Jochen Dauth ,  Guenter Mahr ,  Bernward Deubzer ,  Petra Gratzl ,  Hans-Juergen Lautenschlager

    IPC分类号： C07F7/10 ,  C07F7/18 ,  C08G77/10 ,  C08G77/26 ,  C08G77/388 ,  C08G77/46 ,  D06M13/02 ,  D06M13/148 ,  D06M13/322 ,  D06M13/35 ,  D06M13/355 ,  D06M13/358 ,  D06M13/364 ,  D06M13/50 ,  D06M13/51 ,  D06M13/513 ,  C07D47/00

    CPC分类号： C08G77/388 ,  C08G77/26 ,  C08G77/46

    摘要： The invention relates to oxyalkylene-group-containing organosilicon compounds having units of the formula ##STR1## where R is identical or different, and denotes a monovalent halogenated or nonhalogenated hydrocarbon radical, X is identical or different and is a chlorine atom or a radical of the formula --OR.sup.1, where R.sup.1 denotes an alkyl radical which can be substituted by an ether oxygen atom,a is 0 or 1,b is 0, 1, 2 or 3,c is 0, 1, 2 or 3 and the total a+b+c.ltoreq.4 andA is a radical of the formula ##STR2## where R.sup.2 signifies an unbranched or branched substituted or unsubstituted divalent hydrocarbon radical, which may or may not contain ether, amine, sulfide, ester, amide, carbonate, urea and urethane groups, B is identical or different, and denotes X, --NR.sub.2.sup.1, --O--C(.dbd.O)--R.sup.1, --SR.sup.1 or a radical of the formula--NR.sup.3 R.sup.2 [O--CH(CH.sub.3)--CH.sub.2 ].sub.d [OCH.sub.2 CH.sub.2 ].sub.e [O(CH.sub.2).sub.4 ].sub.f OR.sup.4 (III),where X, R.sup.1 and R.sup.2 have the meanings given for these above, R.sup.3 is identical or different and is a hydrogen atom or has the meaning of R, R.sup.4 has the meaning of R.sup.3 or signifies a radical of the formula--C(.dbd.O)--R, --R.sup.2 NR.sub.2.sup.3, --NR.sup.3 R.sup.2 --, --R.sup.2 NR.sub.2.sup.3 H.sup.+ X.sup.-,d, e and f are an integer from 0 to 200, with the proviso that the sum d+e+f.gtoreq.1 and B contains at least one radical of the formula (III) per polymer molecule.

    摘要翻译： 本发明涉及具有下式的单元的含氧化烯基的有机硅化合物，其中R相同或不同，表示一价卤代或非卤代烃基，X相同或不同，为氯原子或式 - OR1，其中R1表示可被醚氧原子取代的烷基，a为0或1，b为0,1,2或3，c为0,1,2或3，总计a + b + C 4和A是下式的基团，其中R 2表示无支链或支链的取代或未取代的二价烃基，其可以含有或不含有醚，胺，硫醚，酯，酰胺，碳酸酯，脲和氨基甲酸酯基团， B表示相同或不同的表示X，-NR 21，-OC（= O）-R 1，-SR 1或-NR 3 R 2基团的基团[O-CH（CH 3）-CH 2] d [OCH 2 CH 2] CH 2）4] fOR 4（III），其中X，R 1和R 2具有上述含义，R 3相同或不同，为氢原子或具有R的含义，R 4具有平均 或表示式-C（= O）-R，-R2NR23，-NR3R2-，-R2NR23H + X，D，e和f的基团为0至200的整数，条件是 总和d + e + f> / = 1，B包含每个聚合物分子中至少一个式（III）的基团。

    1-aryl-3-alkyluretidinediones
    3.
    发明授权
    1-aryl-3-alkyluretidinediones 失效
    1-亚芳基-3-烷基

    公开(公告)号：US3579500A

    公开(公告)日：1971-05-18

    申请号：US3579500D

    申请日：1968-05-28

    申请人： DU PONT

    发明人： JELINEK ARTHUR G

    IPC分类号： C07D229/00 ,  C07D47/00

    CPC分类号： C07D229/00

    摘要： COMPOUNDS USEFUL AS HERBICIDES OF THE FORMULA:

    1-R,3-(A,(Z)M-PHENYL)URETIDINE-2,4-DIONE

    WHERE A IS HYDROGEN, HALOGEN, ALKYL, ALKOXY, NITRO, CYANO, TRIFLUOROMETHYL, P-CHLOROPHENOXY OR M-(TERTIARY BUTYLCARBAMOYLOXY); Z IS HYDROGEN OR HALOGEN; M IS 1 OR 2, AND R IS ALKYL, CYCLOALKYL, METHYLCYCLOHEXYL, CYCLOHEXYLMETHYL, CYCLOPENTYLMETHYL, ALLYL, METHALLYL. TYPICAL IS 1-(O,4-DICHLOROPHENYL)-3-METHYLURETIDINEDIONE.

    Method for preparing oxytitanium phthalocyanine charge generating material and apparatus for preparing the same
    4.
    发明授权
    Method for preparing oxytitanium phthalocyanine charge generating material and apparatus for preparing the same 失效
    制备氧钛酞菁电荷产生材料的方法及其制备方法

    公开(公告)号：US07812154B2

    公开(公告)日：2010-10-12

    申请号：US10574797

    申请日：2004-10-07

    申请人： Jong Ho Kwon ,  Ki Suck Jung ,  Woo Ho Son ,  Seong Soo Park ,  Jin Phil Ko ,  Hyun Suk Jung

    发明人： Jong Ho Kwon ,  Ki Suck Jung ,  Woo Ho Son ,  Seong Soo Park ,  Jin Phil Ko ,  Hyun Suk Jung

    IPC分类号： C09B47/08 ,  C07D47/00

    CPC分类号： C09B67/0026 ,  C07D487/22 ,  G03G5/051 ,  G03G5/0525 ,  G03G5/0696 ,  H05B6/74

    摘要： Disclosed herein are a method and an apparatus for preparing oxytitanium phthalocyanine as a charge generating material. The method comprises the steps of homogeneously mixing an oxytitanium phthalocyanine crude with an organic solvent while microwave energy having a frequency of 0.1˜100 GHz and a power of 10˜3,000 W and ultrasonic wave energy having a frequency of 1˜1,000 kHz and a power of 10˜5,000 W are applied thereto, and reacting the mixture at 30˜100° C. for 0.5˜5 hours. The apparatus comprises: a magnetron 1 capable of generating a frequency of 0.1˜100 GHz and a power of 100˜3,000 W; a mode stirrer 3 for making the wavelength of microwaves uniform in a microwave container 2; a PID type temperature controller 9 for accurately measurement and controlling the temperature of reactants; a K-type thermocouple shielded from microwaves 4; a condenser 5; an agitator 6, the thermocouple 4, the condenser 5 and the agitator 6 being inserted into three openings formed at a top of the microwave container 2; an ultrasonic tip 7 inserted into an opening formed at a bottom of the microwave container 2; a Pyrex container 9 into which the reactants are introduced; and a solvent tank 10. According to the method and the apparatus, an oxytitanium phthalocyanine charge generating material having superior thermal stability and crystal stability can be prepared in an efficient manner.

    摘要翻译： 本文公开了一种制备氧钛酞菁作为电荷产生材料的方法和装置。 该方法包括以下步骤：将氧钛酞菁粗品与有机溶剂均匀混合，同时具有频率为0.1〜100GHz，功率为10〜3000W的微波能量，频率为1〜1000kHz的超声波能量和功率 施加10〜5000W，并使混合物在30〜100℃下反应0.5〜5小时。 该装置包括：能够产生0.1〜100GHz的频率和100〜3000W的功率的磁控管1; 用于使微波波长在微波容器2中均匀的模式搅拌器3; 用于精确测量和控制反应物温度的PID型温度控制器9; 与微波屏蔽的K型热电偶4; 冷凝器5; 搅拌器6，热电偶4，冷凝器5和搅拌器6插入形成在微波容器2的顶部的三个开口中; 插入到形成在微波容器2的底部的开口中的超声波尖端7; 其中引入反应物的Pyrex容器9; 和溶剂罐10.根据该方法和装置，可以有效地制备具有优异的热稳定性和晶体稳定性的氧钛酞菁电荷产生材料。

    Compounds for PDT
    5.
    发明授权
    Compounds for PDT 失效
    PDT化合物

    公开(公告)号：US07375215B2

    公开(公告)日：2008-05-20

    申请号：US10221218

    申请日：2001-03-08

    申请人： Paul Bradley ,  Mehar Manku

    发明人： Paul Bradley ,  Mehar Manku

    IPC分类号： C07D487/22 ,  C07D47/00 ,  C08G18/08 ,  A01N55/02 ,  A61K31/409 ,  A61K31/555

    CPC分类号： C07D487/22 ,  A61K41/0071

    摘要： A tetrakis(hydroxyphenyl)chlorin, bacteriochlorin or isobacteriochlorin, derivatised at one or more of the hydroxy groups by addition reaction with a diisocyanate, diisothiocyanate or isocyanate-isothiocyanate at one isocyanate or isothiocyanate group thereof, the other isocyanate or isothiocyanate group being itself derivatised by addition reaction with the hydroxy group of an w-alkylated or acylated poly(alkylene oxide) or to a hydroxy group of a link residue itself carrying a residue of such poly(alkylene oxide).

    摘要翻译： 通过与二异氰酸酯，二异硫氰酸酯或异氰酸酯 - 异硫氰酸酯在一个异氰酸酯或异硫氰酸酯基团的加成反应，在一个或多个羟基衍生的四（羟基苯基）二氢卟酚，细菌二氢卟酚或异细菌素，其它异氰酸酯或异硫氰酸酯基团本身由 与w-烷基化或酰化的聚（环氧烷）的羟基或本身携带这种聚（环氧烷）的残基的连接残基的羟基的加成反应。

    Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity
    7.
    发明授权
    Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity 有权

    公开(公告)号：US07189723B2

    公开(公告)日：2007-03-13

    申请号：US10776002

    申请日：2004-02-10

    申请人： Scott A. Mitchell ,  Kevin S. Currie ,  Robert W. DeSimone ,  Douglas A. Pippin

    发明人： Scott A. Mitchell ,  Kevin S. Currie ,  Robert W. DeSimone ,  Douglas A. Pippin

    IPC分类号： A01N43/58 ,  A01N43/60 ,  A61K31/50 ,  A61K31/495 ,  C07D47/00

    CPC分类号： C07D487/04

    摘要： This invention pertains to compounds of Formula I: and all pharmaceutically-acceptable forms thereof. The variables R1, R2, R3, Z1, Z2, W, and X shown in Formula I are defined herein.The invention also provides pharmaceutical compositions containing one or more compound of Formula I, or a pharmaceutically acceptable form of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents.The invention further comprises methods of treating patients suffering from certain diseases and disorders responsive to EphB4 kinase modulation, which comprise administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease or disorder. These diseases include cancer, including of breast neoplasma, endometrial cancer, colon cancer, and neck squamous cell carcinoma. Thus methods of treatment include administering a sufficient amount of a compound or salt of the invention to decrease the symptoms or slow the progression of these diseases or disorders.The invention also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an disease or disorder responsive to EphB4 modulation.Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with one or more other therapeutic agent.The invention also includes a method for determining the presence of EphB4 kinase in a sample, comprising contacting the sample with a compound of Formula I, or form thereof, and the detecting the amount of compound or form bound to EphB4 kinase, and therefrom determining the presence or absence of EphB4 kinase in the sample.