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87 条记录 (耗时 0.091 秒)

    Nucleic acid encoding cytokine receptor ZCYTOR17
    71.
    发明授权
    Nucleic acid encoding cytokine receptor ZCYTOR17 有权
    核酸编码细胞因子受体ZCYTOR17

    公开(公告)号：US07947474B2

    公开(公告)日：2011-05-24

    申请号：US11551322

    申请日：2006-10-20

    申请人： Cindy A. Sprecher ,  Scott R. Presnell ,  Zeren Gao ,  Theodore E. Whitmore ,  Joseph L. Kuijper ,  Mark F. Maurer

    发明人： Cindy A. Sprecher ,  Scott R. Presnell ,  Zeren Gao ,  Theodore E. Whitmore ,  Joseph L. Kuijper ,  Mark F. Maurer

    IPC分类号： C12N15/12 ,  C12N15/64 ,  C12N5/10 ,  C12P21/02 ,  C07K14/47

    CPC分类号： C07K14/715

    摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zyctor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zyctor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

    摘要翻译： 新的多肽，编码多肽的多核苷酸以及相关组合物和方法公开于zyctor17，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zyctor17的多核苷酸位于染色体5上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。

    Growth factor homolog zvegf3
    74.
    发明授权
    Growth factor homolog zvegf3 有权
    生长因子同源物zvegf3

    公开(公告)号：US07691981B2

    公开(公告)日：2010-04-06

    申请号：US11552378

    申请日：2006-10-24

    申请人： Zeren Gao ,  Charles E. Hart ,  Christopher S. Piddington ,  Paul O. Sheppard ,  Kimberly E. Shoemaker

    发明人： Zeren Gao ,  Charles E. Hart ,  Christopher S. Piddington ,  Paul O. Sheppard ,  Kimberly E. Shoemaker

    IPC分类号： C12N15/00

    CPC分类号： C07K14/52 ,  A01K2217/05 ,  A61K38/1858 ,  C07K14/475 ,  C12N2799/022

    摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

    摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。

    Nucleic acid encoding cytokine receptor zcytor17
    78.
    发明授权
    Nucleic acid encoding cytokine receptor zcytor17 有权
    核酸编码细胞因子受体zcytor17

    公开(公告)号：US07427494B2

    公开(公告)日：2008-09-23

    申请号：US11551328

    申请日：2006-10-20

    申请人： Cindy A. Sprecher ,  Scott R. Presnell ,  Zeren Gao ,  Theodore E. Whitmore ,  Joseph L. Kuijper ,  Mark F. Maurer

    发明人： Cindy A. Sprecher ,  Scott R. Presnell ,  Zeren Gao ,  Theodore E. Whitmore ,  Joseph L. Kuijper ,  Mark F. Maurer

    IPC分类号： C12N15/24 ,  C12N15/12 ,  C12N15/64 ,  C12N5/10 ,  C12P21/02 ,  C07K14/47

    CPC分类号： C07K14/715

    摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

    摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zcytor17，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor17的多核苷酸位于染色体5上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。

    GROWTH FACTOR HOMOLOG ZVEGF3
    80.
    发明申请
    GROWTH FACTOR HOMOLOG ZVEGF3 有权
    生长因子HOMOLOG ZVEGF3

    公开(公告)号：US20070141056A1

    公开(公告)日：2007-06-21

    申请号：US11552362

    申请日：2006-10-24

    申请人： Zeren Gao ,  Charles Hart ,  Christopher Piddington ,  Paul Sheppard ,  Kimberly Shoemaker

    发明人： Zeren Gao ,  Charles Hart ,  Christopher Piddington ,  Paul Sheppard ,  Kimberly Shoemaker

    IPC分类号： A61K39/395 ,  C07K16/24

    CPC分类号： C07K14/52 ,  A01K2217/05 ,  A61K38/1858 ,  C07K14/475 ,  C12N2799/022

    摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO: 2 or residues 235-345 of SEQ ID NO: 2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

    摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。多肽的多聚体也被公开。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。