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71.发明授权公开(公告)号：US07273721B2
公开(公告)日：2007-09-25
申请号：US10627476
申请日：2003-07-25
CPC分类号： C12Q1/689 , C07K14/34 , C12N9/00 , C12N9/18 , G01N33/56911
摘要： Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCT proteins, mutated MCT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCT genes in this organism.
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72.发明授权Polynucleotides encoding a 6-phosphogluconolactonase polypeptide from corynebacterium glutamicum 有权编码来自谷氨酸棒杆菌的6-磷酸葡萄糖聚糖酶多肽的多核苷酸公开(公告)号：US07270984B1
公开(公告)日：2007-09-18
申请号：US09602740
申请日：2000-06-23
CPC分类号： C12N9/18 , C07K14/34 , C07K2319/00 , C12N9/00 , C12N9/90 , C12P7/18 , C12P7/40 , C12P7/6409 , C12P7/6427 , C12P7/6463 , C12P7/6472 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/222 , C12P13/225 , C12P13/227 , C12P13/24 , C12P19/00 , C12P19/34 , C12Y301/01031
摘要： Isolated nucleic acid molecules, designated sugar metabolism and oxidative phosphorylation (SMP) nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum, are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SMP genes in this organism.
摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型SMP蛋白质的分离的核酸分子，称为糖代谢和氧化磷酸化（SMP）核酸分子。 本发明还提供了反义核酸分子，含有SMP核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还基于该生物体中的SMP基因的遗传工程，进一步提供了分离的SMP蛋白，突变的SMP蛋白，融合蛋白，抗原肽和用于从谷氨酸棒球菌（C.GM）生产所需化合物的方法。
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公开(公告)号：US07226762B2
公开(公告)日：2007-06-05
申请号：US10495291
申请日：2002-11-11
申请人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
发明人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
CPC分类号： C12N9/0006 , C07K14/415
摘要： The present invention relates to isolated nucleic acid molecules encoding mutants of glucose-6-phosphate dehydrogenase, and vectors and hosts cells including such nucleic acid molecules. These nucleic acid molecules are involved in the biosynthesis of a fine chemical, e.g., an amino acid such as lysine. The present invention also relates to methods of producing and modulating the production of fine chemicals, e.g., lysine, by culturing recombinant microorganisms containing these nucleic acid molecules under conditions such that the fine chemical is produced.
摘要翻译： 本发明涉及编码葡萄糖-6-磷酸脱氢酶突变体的分离的核酸分子，以及包含这种核酸分子的载体和宿主细胞。 这些核酸分子参与精细化学品的生物合成，例如氨基酸如赖氨酸。 本发明还涉及通过在产生精细化学品的条件下培养含有这些核酸分子的重组微生物来生产和调节精细化学品如赖氨酸的生产方法。
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74.发明授权公开(公告)号：US07223543B2
公开(公告)日：2007-05-29
申请号：US10480121
申请日：2002-06-10
申请人： Catherine Stanton , R. Paul Ross , Oskar Zelder , Bruno Kaesler
发明人： Catherine Stanton , R. Paul Ross , Oskar Zelder , Bruno Kaesler
CPC分类号： C12P7/6427 , A23K10/18 , A23L29/065 , A23V2002/00 , A23Y2300/59 , C12P7/6472 , A23V2250/1866
摘要： The present invention relates to a process for the production of conjugated linoleic acid and a process for the production of triglycerides with an increased content of conjugated linoleic acid. Moreover, the invention relates to a nucleic acid sequence; a nucleic acid construct, a vector and transgenic organisms comprising at least one nucleic acid sequence or one nucleic acid construct which encodes a polypeptide with conjugated linoleic isomerase activity. Furthermore, the invention relates to the use of a microorganism of the genus Bifidobacterium as a probiotic.
摘要翻译： 本发明涉及一种生产共轭亚油酸的方法和一种生产具有增加共轭亚油酸含量的甘油三酯的方法。 此外，本发明涉及核酸序列; 核酸构建体，载体和转基因生物体，其包含编码具有共轭亚油酸异构酶活性的多肽的至少一个核酸序列或一个核酸构建体。 此外，本发明涉及双歧杆菌属的微生物作为益生菌的用途。
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75.发明申请公开(公告)号：US20070117183A1
公开(公告)日：2007-05-24
申请号：US11511140
申请日：2006-08-28
CPC分类号： C12N9/18 , C07K14/34 , C12N9/00 , C12N9/1096 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/24 , C12Y206/01005
摘要： Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MP proteins, mutated MP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MP genes in this organism.
摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型MP蛋白的分离的核酸分子，称为MP核酸分子。 本发明还提供反义核酸分子，含有MP核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供分离的MP蛋白，突变的MP蛋白，融合蛋白，抗原肽和用于基于该生物体中MP基因的遗传工程改进谷氨酸棒球菌产生所需化合物的方法。
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76.发明申请Corynebacterium glutamicum genes encoding proteins involved in homeostasis and adaptation 审中-公开编码参与体内平衡和适应的蛋白质的谷氨酸棒杆菌基因公开(公告)号：US20070111232A1
公开(公告)日：2007-05-17
申请号：US11512384
申请日：2006-08-29
摘要： Isolated nucleic acid molecules, designated HA nucleic acid molecules, which encode novel HA proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HA nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated HA proteins, mutated HA proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of HA genes in this organism.
摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型HA蛋白质的分离的核酸分子，命名为HA核酸分子。 本发明还提供反义核酸分子，含有HA核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供分离的HA蛋白，突变的HA蛋白，融合蛋白，抗原肽以及用于基于该生物体中HA基因的遗传工程改进谷氨酸棒球菌产生所需化合物的方法。
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77.发明申请公开(公告)号：US20070082383A1
公开(公告)日：2007-04-12
申请号：US11505174
申请日：2006-08-15
CPC分类号： C12N9/18 , C07K14/34 , C07K2319/00 , C12N9/00 , C12N9/90 , C12P7/18 , C12P7/40 , C12P7/6409 , C12P7/6427 , C12P7/6463 , C12P7/6472 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/222 , C12P13/225 , C12P13/227 , C12P13/24 , C12P19/00 , C12P19/34 , C12Y301/01031
摘要： Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SMP genes in this organism.
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78.发明申请Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production 审中-公开编码参与碳代谢和能量产生的蛋白质的谷氨酸棒杆菌基因公开(公告)号：US20070077622A1
公开(公告)日：2007-04-05
申请号：US11505198
申请日：2006-08-15
IPC分类号： C07H21/04 , C12P21/06 , C12P13/04 , C12P13/24 , C12P13/22 , C12P13/20 , C12P13/14 , C12P13/18 , C12P13/16 , C12P13/12 , C12P13/10 , C12P13/08 , C12N9/10 , C12N1/21 , C12N15/74
CPC分类号： C12N9/18 , C07K14/34 , C07K2319/00 , C12N9/00 , C12N9/90 , C12P7/18 , C12P7/40 , C12P7/6409 , C12P7/6427 , C12P7/6463 , C12P7/6472 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/222 , C12P13/225 , C12P13/227 , C12P13/24 , C12P19/00 , C12P19/34 , C12Y301/01031
摘要： Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SMP genes in this organism.
摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型SMP蛋白质的分离的核酸分子，称为SMP核酸分子。 本发明还提供了反义核酸分子，含有SMP核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还基于该生物体中的SMP基因的遗传工程，进一步提供了分离的SMP蛋白，突变的SMP蛋白，融合蛋白，抗原肽和用于从谷氨酸棒球菌（C.GM）生产所需化合物的方法。
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公开(公告)号：US20070072274A1
公开(公告)日：2007-03-29
申请号：US11603384
申请日：2006-11-21
申请人： Oskar Zelder , Markus Pompejus , Hartwig Schroder , Burkhard Kroger , Corinna Klopprogge , Gregor Haberhauer
发明人： Oskar Zelder , Markus Pompejus , Hartwig Schroder , Burkhard Kroger , Corinna Klopprogge , Gregor Haberhauer
摘要： The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.
摘要翻译： 本发明涉及新颖的核酸分子，其用于构建遗传改良微生物的用途以及借助所述遗传改良的微生物制备精细化学品，特别是氨基酸的方法。
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公开(公告)号：US20070072273A1
公开(公告)日：2007-03-29
申请号：US11591868
申请日：2006-11-02
申请人： Oskar Zelder , Markus Pompejus , Hartwig Schroder , Burkhard Kroger , Corinna Klopprogge , Gregor Haberhauer
发明人： Oskar Zelder , Markus Pompejus , Hartwig Schroder , Burkhard Kroger , Corinna Klopprogge , Gregor Haberhauer
CPC分类号： C12N9/00 , C07K14/34 , C12N9/0006 , C12P13/08
摘要： The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.
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