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    Neural stimulation for arrhythmia recognition and therapy
    71.
    发明授权
    Neural stimulation for arrhythmia recognition and therapy 有权
    心律失常识别和治疗的神经刺激

    公开(公告)号：US08244350B2

    公开(公告)日：2012-08-14

    申请号：US12535332

    申请日：2009-08-04

    申请人： Yunlong Zhang ,  Dan Li

    发明人： Yunlong Zhang ,  Dan Li

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36114 ,  A61N1/3622 ,  A61N1/37288 ,  A61N1/3787 ,  A61N1/3962

    摘要： A system and method can sense a tachyarrhythmia, compare the sensed tachyarrhythmia with a ventricular tachyarrhythmia criterion, provide a ventricular tachyarrhythmia therapy when the sensed tachyarrhythmia satisfies the ventricular tachyarrhythmia criterion, provide a neural stimulation when the sensed tachyarrhythmia does not satisfy the ventricular tachyarrhythmia criterion, determine whether the tachyarrhythmia continues during or after the neural stimulation when the tachyarrhythmia is sustained, compare the tachyarrhythmia sensed during or after the neural stimulation with a supraventricular tachyarrhythmia (SVT) criterion, and provide a ventricular tachyarrhythmia therapy when the sensed tachyarrhythmia does not satisfy the SVT criterion.

    摘要翻译： 系统和方法可以感觉到快速性心律失常，将感觉到的快速性心律失常与室性快速性心律失常标准进行比较，当感觉到的快速性心律失常满足心室快速性心律失常标准时，提供室性快速性心律失常治疗，当感觉到的快速性心律失常不满足心室快速性心律失常标准时提供神经刺激， 确定当紧张性心律失常持续时神经刺激期间或之后快速性心律失常是否持续，将神经刺激期间或之后感觉到的快速性心律失常与室上性快速性心律失常（SVT）标准进行比较，并且当感觉到的快速性心律不齐不满足时，提供室性快速性心律失常治疗 SVT标准。

    Method and apparatus for selecting and timing anti-tachyarrhythmia pacing using cardiac cycle length stability
    73.
    发明授权
    Method and apparatus for selecting and timing anti-tachyarrhythmia pacing using cardiac cycle length stability 有权
    使用心脏周期长度稳定性选择和定时抗心动过速起搏的方法和装置

    公开(公告)号：US08050758B2

    公开(公告)日：2011-11-01

    申请号：US12829218

    申请日：2010-07-01

    申请人： Dan Li

    发明人： Dan Li

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3622 ,  A61B5/0452 ,  A61N1/3925 ,  A61N1/3962

    摘要： An implantable medical device delivers anti-tachyarrhythmia therapies including anti-tachyarrhythmia pacing (ATP). When a tachyarrhythmia episode is detected, the implantable medical device analyzes cardiac cycle length stability to determine whether and/or when to deliver an ATP. In one embodiment, the cardiac cycle length stability is measured by existence of stable ventricular tachyarrhythmia clusters (SVTCs) during the tachyarrhythmia episode. Each SVTC includes at least a specified minimum number of heart beats over which the cardiac cycle lengths meet a stability criterion.

    摘要翻译： 植入式医疗装置提供抗慢性心律失常疗法，包括抗快速性心律失常起搏（ATP）。 当检测到快速性心律失常发作时，可植入医疗装置分析心脏周期长度稳定性，以确定是否和/或何时递送ATP。 在一个实施例中，心动周期长度稳定性通过在快速性心律失常发作期间存在稳定的室性快速性心律失常簇（SVTC）来测量。 每个SVTC至少包括指定的最小心跳次数，其中心循环长度满足稳定性标准。

    Hypertension diagnosis and therapy using pressure sensor
    74.
    发明授权
    Hypertension diagnosis and therapy using pressure sensor 有权
    高血压诊断和治疗使用压力传感器

    公开(公告)号：US08027724B2

    公开(公告)日：2011-09-27

    申请号：US11833435

    申请日：2007-08-03

    申请人： Xuan Wei ,  Cheng Zhang ,  Shantha Arcot-Krishnamurthy ,  Dan Li

    发明人： Xuan Wei ,  Cheng Zhang ,  Shantha Arcot-Krishnamurthy ,  Dan Li

    IPC分类号： A61N1/08

    CPC分类号： A61N1/36564 ,  A61B5/0031 ,  A61B5/0215 ,  A61N1/36114 ,  A61N1/36117

    摘要： An example relates to a method for sensing a pulmonary artery pressure (PAP) and providing a sensed PAP signal, detecting an abnormal blood pressure (BP) condition using information from the sensed PAP signal, delivering a pacing energy to a heart, and automatically altering at least one pacing characteristic in response to the detected abnormal BP condition. The detecting an abnormal BP condition can include detecting various forms of hypertension or hypotension. The automatically altering the at least one pacing characteristic can include automatically altering at least one of a pacing rate, a pacing waveform, an atriventricular (AV) delay, an interventricular (VV) delay, a pacing mode, or a pacing site. The method can also include delivering vagal nerve stimulation and automatically altering the vagal nerve stimulation in response to the detected abnormal BP condition. The detecting the abnormal BP condition can also include using a sensed auxiliary physiological parameter.

    摘要翻译： 一个例子涉及一种用于感测肺动脉压（PAP）并提供感测到的PAP信号的方法，使用来自感测到的PAP信号的信息检测异常血压（BP）状况，将起搏能量递送到心脏，并且自动改变 响应于检测到的异常BP状况的至少一个起搏特征。 检测异常BP病症可包括检测各种形式的高血压或低血压。 自动改变至少一个起搏特征可以包括自动改变起搏速率，起搏波形，房室（AV）延迟，心室间（VV）延迟，起搏模式或起搏部位中的至少一个。 该方法还可以包括递送迷走神经刺激并响应于检测到的异常BP状况自动改变迷走神经刺激。 检测异常BP状况还可以包括使用感测的辅助生理参数。

    Topic Word Generation Method and System
    75.
    发明申请
    Topic Word Generation Method and System 有权
    主题词生成方法与系统

    公开(公告)号：US20110231411A1

    公开(公告)日：2011-09-22

    申请号：US13058062

    申请日：2008-11-07

    申请人： Fraser Shein ,  Tom Nantais ,  Dan Li

    发明人： Fraser Shein ,  Tom Nantais ,  Dan Li

    IPC分类号： G06F17/30

    CPC分类号： G06F17/3071

    摘要： A method of, and system for, extracting topic words from a collection of documents across multiple and potentially very large number of domains. Documents are selected and ranked based on similarity with at least one seed word, which defines a topic. Seed words may be entered directly by a user or provided by another application. Keywords are extracted from documents determined to be a sufficiently good match to the topic and may be displayed to the user or used as input into word prediction or word analysis and display software. Documents are determined to be a sufficiently good match to the topic using an iterative algorithm starting with the best match and selecting documents containing keywords sufficiently similar to the previously selected documents.

    摘要翻译： 一种用于从跨越多个可能非常大数量的域的文档集合中提取主题词的方法和系统。 基于与定义主题的至少一个种子词的相似性来选择和排序文档。 种子字可以由用户直接输入或由另一应用提供。 从确定为与该主题足够好的匹配的文档中提取关键字，并且可以向用户显示或用作词预测或词分析和显示软件的输入。 文档被确定为与主题的足够好的匹配，使用从最佳匹配开始的迭代算法，并选择包含与先前选择的文档充分相似的关键字的文档。

    METHOD AND APPARATUS FOR MORPHOLOGY-BASED ARRHYTHMIA CLASSIFICATION USING CARDIAC AND OTHER PHYSIOLOGICAL SIGNALS
    76.
    发明申请
    METHOD AND APPARATUS FOR MORPHOLOGY-BASED ARRHYTHMIA CLASSIFICATION USING CARDIAC AND OTHER PHYSIOLOGICAL SIGNALS 有权
    使用心脏和其他生理信号进行形态学基于ARRHYTHMIA分类的方法和装置

    公开(公告)号：US20110160551A1

    公开(公告)日：2011-06-30

    申请号：US13043346

    申请日：2011-03-08

    申请人： Dan Li ,  Shelley Cazares ,  Jaeho Kim ,  Kent Lee

    发明人： Dan Li ,  Shelley Cazares ,  Jaeho Kim ,  Kent Lee

    IPC分类号： A61B5/02

    CPC分类号： A61B5/0464 ,  A61B5/7264 ,  A61N1/3621 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/36571 ,  A61N1/36578 ,  A61N1/36585 ,  A61N1/3925 ,  A61N1/3962

    摘要： A tachyarrhythmia detection and classification system classifies tachyarrhythmias based on an analysis of morphological features of a cardiac signal enhanced by using one or more physiological parameters indicative of hemodynamic stability and/or activity level. The tachyarrhythmia detection and classification system computes a measure of similarity between an arrhythmic waveform of the cardiac signal, a template waveform for that cardiac signal, such as a correlation coefficient representative of the correlation between morphological features of the arrhythmic waveform and morphological features of the template waveform. A detected tachyarrhythmia episode is classified by comparing the measure of similarity to a threshold that is dynamically adjusted using the one or more physiological parameters.

    摘要翻译： 快速心律失常检测和分类系统基于通过使用指示血液动力学稳定性和/或活动水平的一个或多个生理参数来增强的心脏信号的形态学特征的分析来分类快速性心律失常。 快速心律失常检测和分类系统计算心脏信号的心律失常波形与该心脏信号的模板波形之间的相似性的度量，例如表示心律失常波形的形态特征与模板的形态特征之间的相关性的相关系数 波形 通过将相似性测量值与使用一个或多个生理参数动态调整的阈值进行比较来分类检测到的快速性心律失常发作。

    Patient characteristic based adaptive anti-tachy pacing programming
    78.
    发明授权
    Patient characteristic based adaptive anti-tachy pacing programming 有权
    基于患者特征的自适应反向起搏节奏

    公开(公告)号：US07873414B2

    公开(公告)日：2011-01-18

    申请号：US11736286

    申请日：2007-04-17

    申请人： Yanting Dong ,  Quan Ni ,  Xuan Wei ,  Dan Li ,  Qian Zhong

    发明人： Yanting Dong ,  Quan Ni ,  Xuan Wei ,  Dan Li ,  Qian Zhong

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3621

    摘要： A system including at least one implantable sensor circuit adapted to produce an electrical sensor signal related to one or more physiologic cardiovascular events of a subject, a therapy circuit configured to provide anti-tachycardia pacing (ATP) therapy, and a controller. The controller includes a tachyarrhythmia detection circuit and an efficacy circuit. The tachyarrhythmia detection circuit is configured to detect a tachyarrhythmia episode in the subject using the electrical sensor signal, and to determine whether the tachyarrhythmia episode is of a type that is treatable with ATP. The efficacy circuit is configured to estimate an efficacy of a currently configured ATP therapy for the subject, and the controller is configured to alter a delivery regimen of the currently configured ATP therapy when the estimated ATP therapy efficacy is deemed insufficient. Other systems and methods are described.

    摘要翻译： 一种系统，包括适于产生与受试者的一个或多个生理性心血管事件相关的电传感器信号的至少一个可植入传感器电路，被配置为提供抗心动过速起搏（ATP）治疗的治疗电路和控制器。 控制器包括快速性心律失常检测电路和功效电路。 快速心律失常检测电路被配置为使用电传感器信号检测受试者的快速性心律失常发作，并且确定快速性心律失常发作是否是可用ATP治疗的类型。 功效电路被配置为估计当前配置的ATP治疗对受试者的功效，并且当估计的ATP治疗功效被认为不足时，控制器被配置为改变当前配置的ATP治疗的递送方案。 描述其他系统和方法。

    SYSTEM AND METHOD FOR RHYTHM IDENTIFICATION AND THERAPY DISCRIMINATION USING HEMODYNAMIC STATUS INFORMATION
    79.
    发明申请
    SYSTEM AND METHOD FOR RHYTHM IDENTIFICATION AND THERAPY DISCRIMINATION USING HEMODYNAMIC STATUS INFORMATION 审中-公开
    使用血液动力学状态信息进行RHYTHM识别和治疗分离的系统和方法

    公开(公告)号：US20100305635A1

    公开(公告)日：2010-12-02

    申请号：US12786074

    申请日：2010-05-24

    申请人： Lili Liu ,  Dan Li ,  Allan C. Shuros ,  James O. Gilkerson

    发明人： Lili Liu ,  Dan Li ,  Allan C. Shuros ,  James O. Gilkerson

    IPC分类号： A61N1/365 ,  A61N1/39

    CPC分类号： A61N1/36564 ,  A61B5/02028 ,  A61B5/0452 ,  A61N1/3622 ,  A61N1/36585 ,  A61N1/3962

    摘要： A system and method for controlling cardiac ventricular tachyarrhythmias by acquiring a pressure signal representative of coronary venous pressure (CVP) from a pressure sensor implanted within a coronary vein of the patient. A CVP index is derived based on the pressure signal. The onset of a ventricular tachyarrhythmia episode is detected based on a cardiac rates signal. The CVP index and the rate signal are monitored and, responsive to the rate signal indicating a sustained tachycardia episode during the episode monitoring period, anti-tachycardia therapy selectively withheld and the episode monitoring period is extended based on the CVP index.

    摘要翻译： 一种用于通过从植入在患者的冠状静脉内的压力传感器获取代表冠状静脉压（CVP）的压力信号来控制心室性心律失常的系统和方法。 基于压力信号导出CVP指数。 基于心率信号检测心室快速性心律失常事件的发作。 监测CVP指数和速率信号，并且响应于在发作监测期间指示持续性心动过速发作的速率信号，选择性地保留抗心动过速治疗，并且基于CVP指数扩大发作监测期。

    NEURAL STIMULATION FOR ARRHYTHMIA RECOGNITION AND THERAPY
    80.
    发明申请
    NEURAL STIMULATION FOR ARRHYTHMIA RECOGNITION AND THERAPY 有权
    神经刺激ARRHYTHMIA识别和治疗

    公开(公告)号：US20100036447A1

    公开(公告)日：2010-02-11

    申请号：US12535332

    申请日：2009-08-04

    申请人： Yunlong Zhang ,  Dan Li

    发明人： Yunlong Zhang ,  Dan Li

    IPC分类号： A61N1/365 ,  A61N1/39

    CPC分类号： A61N1/36114 ,  A61N1/3622 ,  A61N1/37288 ,  A61N1/3787 ,  A61N1/3962

    摘要： A system and method can sense a tachyarrhythmia, compare the sensed tachyarrhythmia with a ventricular tachyarrhythmia criterion, provide a ventricular tachyarrhythmia therapy when the sensed tachyarrhythmia satisfies the ventricular tachyarrhythmia criterion, provide a neural stimulation when the sensed tachyarrhythmia does not satisfy the ventricular tachyarrhythmia criterion, determine whether the tachyarrhythmia continues during or after the neural stimulation when the tachyarrhythmia is sustained, compare the tachyarrhythmia sensed during or after the neural stimulation with a supraventricular tachyarrhythmia (SVT) criterion, and provide a ventricular tachyarrhythmia therapy when the sensed tachyarrhythmia does not satisfy the SVT criterion.

    摘要翻译： 系统和方法可以感觉到快速性心律失常，将感觉到的快速性心律失常与室性快速性心律失常标准进行比较，当感觉到的快速性心律失常满足心室快速性心律失常标准时，提供室性快速性心律失常治疗，当感觉到的快速性心律失常不满足心室快速性心律失常标准时提供神经刺激， 确定当紧张性心律失常持续时神经刺激期间或之后快速性心律失常是否持续，将神经刺激期间或之后感觉到的快速性心律失常与室上性快速性心律失常（SVT）标准进行比较，并且当感觉到的快速性心律不齐不满足时，提供室性快速性心律失常治疗 SVT标准。