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154 条记录 (耗时 0.103 秒)

    ZCYTOR19 POLYNUCLEOTIDES, POLYPEPTIDES, ANTIBODIES AND METHODS OF USE
    72.
    发明申请
    ZCYTOR19 POLYNUCLEOTIDES, POLYPEPTIDES, ANTIBODIES AND METHODS OF USE 审中-公开
    ZCYTOR19多核苷酸，多肽，抗体和使用方法

    公开(公告)号：US20120064571A1

    公开(公告)日：2012-03-15

    申请号：US13267430

    申请日：2011-10-06

    申请人： Scott R. Presnell ,  Francis J. Grant ,  Emily C. Costerison ,  Theodore E. Whitmore

    发明人： Scott R. Presnell ,  Francis J. Grant ,  Emily C. Costerison ,  Theodore E. Whitmore

    IPC分类号： C12P21/02 ,  C12N15/63 ,  C12N5/10 ,  C07H21/00

    CPC分类号： C07K14/47 ,  C07K14/715 ,  C07K2319/00 ,  Y10T436/143333

    摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor19, are located on chromosome 1p36.11, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

    摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zcytor19，一种新型的II类细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor19的多核苷酸位于染色体1p36.11上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。

    NUCLEIC ACID ENCODING CYTOKINE RECEPTOR ZCYTOR17
    74.
    发明申请
    NUCLEIC ACID ENCODING CYTOKINE RECEPTOR ZCYTOR17 有权
    核酸编码细胞因子受体ZCYTOR17

    公开(公告)号：US20110287012A1

    公开(公告)日：2011-11-24

    申请号：US13090316

    申请日：2011-04-20

    申请人： Cindy A. Sprecher ,  Scott R. Presnell ,  Zeren Gao ,  Theodore E. Whitmore ,  Joseph L. Kuijper ,  Mark F. Maurer

    发明人： Cindy A. Sprecher ,  Scott R. Presnell ,  Zeren Gao ,  Theodore E. Whitmore ,  Joseph L. Kuijper ,  Mark F. Maurer

    IPC分类号： A61K39/395 ,  A61P43/00 ,  C07K16/18

    CPC分类号： C07K14/715

    摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

    摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zcytor17，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor17的多核苷酸位于染色体5上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。

    ANTI-IL-TIF ANTIBODIES AND METHODS OF USE
    80.
    发明申请
    ANTI-IL-TIF ANTIBODIES AND METHODS OF USE 有权
    抗IL-TIF抗体及其使用方法

    公开(公告)号：US20100080802A1

    公开(公告)日：2010-04-01

    申请号：US12499636

    申请日：2009-07-08

    申请人： Scott R. Presnell ,  Wayne Kindsvogel

    发明人： Scott R. Presnell ,  Wayne Kindsvogel

    IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P29/00

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K39/00 ,  C07K14/54 ,  C07K2319/00 ,  C12N2799/026

    摘要： The present invention relates to ZCYTO18 polynucleotide and polypeptide molecules. The ZCYTO18 is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

    摘要翻译： 本发明涉及ZCYTO18多核苷酸和多肽分子。 ZCYTO18是一种新型细胞因子。 多肽可用于在体外和体内刺激造血细胞的增殖和/或发育的方法中。 本发明还包括生产蛋白质的方法，用途及其抗体。