公开(公告)号：US20070259807A1

公开(公告)日：2007-11-08

申请号：US11768441

申请日：2007-06-26

申请人： Daniel Soppet ,  Haodong Li

发明人： Daniel Soppet ,  Haodong Li

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C07K14/00 ,  C07K16/18 ,  C12N15/00 ,  C12N5/06 ,  C12P1/04 ,  G01N33/53

CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K14/495

摘要： The present invention discloses Growth Factor HTTER36 (GDF3) polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include the diagnosis, prevention, and treatment of wasting disorders. Also disclosed are antagonists against such polypeptide and their therapeutic uses which include the diagnosis, prevention, and treatment of obesity and obesity-related disorders. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.

摘要翻译： 本发明公开了生长因子HTTER36（GDF3）多肽和编码这种多肽的多核苷酸。 还提供了通过重组技术和包括诊断，预防和治疗消耗性疾病的多肽的治疗用途产生此类多肽的方法。 还公开了抗这种多肽及其治疗用途的拮抗剂，包括诊断，预防和治疗肥胖症和肥胖相关疾病。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。

公开(公告)号：US20070238644A1

公开(公告)日：2007-10-11

申请号：US11561963

申请日：2006-11-21

申请人： Haodong Li ,  Mark Adams ,  Solange Lima ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John White ,  Edward Appelbaum

发明人： Haodong Li ,  Mark Adams ,  Solange Lima ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John White ,  Edward Appelbaum

IPC分类号： A61K48/00 ,  A61K31/7052 ,  C07H21/04 ,  C07K14/00 ,  C07K16/18 ,  C12N15/00 ,  C12N5/06 ,  C12P1/04

CPC分类号： C07K14/52 ,  C07K14/523 ,  Y10S930/14

摘要： Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

摘要翻译： 公开了人趋化因子多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。

公开(公告)号：US07198944B2

公开(公告)日：2007-04-03

申请号：US11260166

申请日：2005-10-28

申请人： Haodong Li ,  Mark D. Adams

发明人： Haodong Li ,  Mark D. Adams

IPC分类号： C12N15/63

CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/523 ,  G01N33/564 ,  G01N33/57426 ,  G01N33/6863 ,  G01N2333/52

摘要： Human Ckβ-9 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Ckβ-9 polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the Ckβ-9 coding sequence and over-expression of the Ckβ-9 protein.

摘要翻译： 公开了人Ckbeta-9多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种Ckbeta-9多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了诊断测定法，其检测Ckbeta-9编码序列中突变的存在和Ckbeta-9蛋白的过表达。

公开(公告)号：US07138498B2

公开(公告)日：2006-11-21

申请号：US10646770

申请日：2003-08-25

申请人： Haodong Li ,  Mark D. Adams ,  Solange H. Gentz ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John R. White ,  Edward R. Appelbaum

发明人： Haodong Li ,  Mark D. Adams ,  Solange H. Gentz ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John R. White ,  Edward R. Appelbaum

IPC分类号： C07K16/24

CPC分类号： C07K14/52 ,  C07K14/523 ,  Y10S930/14

摘要： Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

摘要翻译： 公开了人趋化因子多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。

公开(公告)号：US20060159686A1

公开(公告)日：2006-07-20

申请号：US11378243

申请日：2006-03-20

申请人： Jian Ni ,  Haodong Li ,  Guo-Liang Yu ,  Reiner Gentz

发明人： Jian Ni ,  Haodong Li ,  Guo-Liang Yu ,  Reiner Gentz

IPC分类号： A61K39/395 ,  G01N33/567 ,  G01N33/53 ,  C07K16/28

CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/52

摘要： The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

公开(公告)号：US20060068463A1

公开(公告)日：2006-03-30

申请号：US10192611

申请日：2002-07-11

申请人： Jian Ni ,  Haodong Li ,  Guo-Liang Yu ,  Reiner Gentz

发明人： Jian Ni ,  Haodong Li ,  Guo-Liang Yu ,  Reiner Gentz

IPC分类号： C12N9/12 ,  C07H21/04 ,  C12P21/02 ,  C12N5/06

CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/52

摘要： The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

摘要翻译： 本发明涉及NKAF II多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

公开(公告)号：US20060035337A1

公开(公告)日：2006-02-16

申请号：US11247235

申请日：2005-10-12

申请人： Haodong Li ,  Brent Kreider

发明人： Haodong Li ,  Brent Kreider

IPC分类号： C07H21/04 ,  C12P21/06 ,  C07K14/52 ,  C07K16/24

CPC分类号： C07K14/521 ,  A61K38/00 ,  C07K14/522 ,  C07K14/523 ,  C07K14/5421 ,  Y02A50/473 ,  Y10S930/14

摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta-11 (Ck beta-11) polypeptide and a human leukocyte adhesion inhibitor-1 (LAI-1) polypeptide (previously termed chemokine α1 (CKα1 or cka-1), as well as Ck beta-11 and/or LAI-1 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.

摘要翻译： 公开了使用编码人趋化因子β-11（Ckβ-11）多肽和人白细胞粘附抑制剂-1（LAI-1）多肽的分离的核酸分子的治疗组合物和方法（先前称为趋化因子α1（CKalpha1或cka- 1）以及Ckβ-11和/或LAI-1多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。

公开(公告)号：US20050118680A1

公开(公告)日：2005-06-02

申请号：US11035998

申请日：2005-01-18

申请人： Haodong Li ,  Steven Ruben ,  Granger Sutton

发明人： Haodong Li ,  Steven Ruben ,  Granger Sutton

IPC分类号： A61K38/00 ,  C07K14/52 ,  C12N15/12 ,  C12N15/19 ,  A61K38/19 ,  C07H21/04 ,  C07K14/705

CPC分类号： C07K14/523 ,  A61K38/00

摘要： A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

摘要翻译： 公开了人趋化多肽，编码它的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了将多肽用于多种目的的方法，包括：干细胞动员，髓过保护，神经元保护，治疗肿瘤，伤口愈合，治疗寄生虫感染和调节造血。 还公开了多肽拮抗剂和用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。

公开(公告)号：US06485719B1

公开(公告)日：2002-11-26

申请号：US09635899

申请日：2000-08-11

申请人： Haodong Li ,  Brent L. Kreider

发明人： Haodong Li ,  Brent L. Kreider

IPC分类号： A61K3819

CPC分类号： C07K14/521 ,  A61K38/00 ,  C07K14/522 ,  C07K14/523 ,  C07K14/5421 ,  Y02A50/473 ,  Y10S930/14

摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta-11 (Ck beta-11) polypeptide and a human leukocyte adhesion inhibitor-1 (LAI-1) polypeptide (previously termed chemokine &agr;1(CK&agr;1 or cka-1), as well as Ck beta-11 and/or LAI-1 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.

摘要翻译： 公开了使用编码人趋化因子β-11（Ckβ-11）多肽和人白细胞粘附抑制剂-1（LAI-1）多肽的分离的核酸分子的治疗组合物和方法（先前称为趋化因子α1（CKalpha1或cka- 1）以及Ckβ-11和/或LAI-1多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。

公开(公告)号：US06391589B1

公开(公告)日：2002-05-21

申请号：US09479729

申请日：2000-01-07

申请人： Henrik S. Olsen ,  Haodong Li ,  Mark D. Adams ,  Solange H. L. Gentz ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John R. White ,  Edward R. Appelbaum

发明人： Henrik S. Olsen ,  Haodong Li ,  Mark D. Adams ,  Solange H. L. Gentz ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John R. White ,  Edward R. Appelbaum

IPC分类号： C12N510

CPC分类号： C07K14/523 ,  A61K38/00 ,  C07K2319/00

摘要： Human chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

摘要翻译： 公开了人趋化因子β-10多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。