公开(公告)号：US07964406B2

公开(公告)日：2011-06-21

申请号：US11659921

申请日：2005-08-10

申请人： Hergen Spits ,  Benjamin Berkhout ,  Jurgen E. Seppen ,  David M. Markusic ,  Kees Weijer

发明人： Hergen Spits ,  Benjamin Berkhout ,  Jurgen E. Seppen ,  David M. Markusic ,  Kees Weijer

IPC分类号： C12N15/63 ,  C12N15/06 ,  C12N5/08

CPC分类号： A01K67/0271 ,  C07K14/4705 ,  C07K14/4746 ,  C07K14/4747 ,  C07K2319/01 ,  C12N5/0647 ,  C12N15/635 ,  C12N15/86 ,  C12N2517/02 ,  C12N2740/16043 ,  C12N2830/003 ,  C12N2830/006 ,  C12N2830/008 ,  C12N2830/48 ,  C12N2830/50 ,  C12N2830/85 ,  C12N2840/20 ,  C12N2840/203

摘要： The invention provides a method for producing a stabilized cell of interest, said method comprising providing a stem cell and/or a precursor cell of said cell of interest with a nucleic acid sequence which, when present in said cell of interest, is capable of stabilizing said cell of interest, providing a non-human animal with said stem cell and/or precursor cell, allowing generation of said cell of interest in said animal, and obtaining said cell of interest. Said animal is preferably provided with a human stem cell and/or human precursor cell, allowing production of a human cell line.

摘要翻译： 本发明提供了一种用于产生感兴趣的稳定化细胞的方法，所述方法包括用核酸序列提供所述目的细胞的干细胞和/或前体细胞，所述核酸序列当存在于感兴趣的细胞中时能够稳定 所述感兴趣的细胞，向非人动物提供所述干细胞和/或前体细胞，允许在所述动物中产生所述感兴趣的细胞，并获得所述感兴趣的细胞。 所述动物优选具有人干细胞和/或人前体细胞，允许产生人细胞系。

公开(公告)号：US20110003959A1

公开(公告)日：2011-01-06

申请号：US12744293

申请日：2008-11-19

申请人： Joost Nikolaas Hendrik Reek ,  Frederic William Patureau ,  Mark Kuil ,  Albertus Jacobus Sandee ,  Jurjen Meeuwissen

发明人： Joost Nikolaas Hendrik Reek ,  Frederic William Patureau ,  Mark Kuil ,  Albertus Jacobus Sandee ,  Jurjen Meeuwissen

IPC分类号： C07F15/00 ,  C07C231/12 ,  C07C67/303 ,  C07D209/08 ,  C07C45/69 ,  C08G69/08 ,  C07C5/10

CPC分类号： C07F15/008 ,  B01J31/2247 ,  B01J2231/321 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/822 ,  B01J2531/827 ,  B01J2531/828 ,  C07B2200/11 ,  C07C45/50 ,  C07C45/505 ,  C07C45/55 ,  C07C67/303 ,  C07C231/12 ,  C07C69/34 ,  C07C47/228 ,  C07C47/02 ,  C07C233/47 ,  C07C233/05

摘要： The invention relates to a coordination complex system comprising a ligand having the formula: R1—SO2—NH—P (XR2)2 (1a); or R1—SO2—N═PH (XR2)2 (1b); or R1—SO(OH)═N—P(XR2)2 (1c); wherein X is independently O, S, NH, or a bond; R1 and R2 are independently selected from hydrogen and substituted or unsubstituted alkyl or aryl; wherein at least one equivalent of the ligand is complexed to an equivalent of a metal selected from a transition metal and lanthanide. The invention also relates to the use of said coordination complexes as catalysts in the hydroformylation, hydrogenation, transfer hydrogenation, hydrocyanation, polymerization, isomerization, carbonylation, cross-coupling, metathesis, CH activation, allylic substitution, aldol condensation, or Michael addition.

摘要翻译： 本发明涉及包含具有下式的配体的配位络合物体系：R1-SO2-NH-P（XR2）2（1a）; 或R1-SO2-N = PH（XR2）2（1b）; 或R1-SO（OH）= N-P（XR2）2（1c）; 其中X独立地为O，S，NH或键; R 1和R 2独立地选自氢和取代或未取代的烷基或芳基; 其中至少一当量的配体与选自过渡金属和镧系元素的金属的当量络合。 本发明还涉及所述配位络合物在加氢甲酰化，氢化，转移氢化，氢氰化，聚合，异构化，羰基化，交叉偶联，复分解，CH活化，烯丙基取代，醛醇缩合或迈克尔加成中的用途。

公开(公告)号：US20100144008A1

公开(公告)日：2010-06-10

申请号：US12524209

申请日：2007-12-21

申请人： Johannes Maria Franciscus Gerardus Aerts

发明人： Johannes Maria Franciscus Gerardus Aerts

IPC分类号： C12N9/00

CPC分类号： A61K38/47

摘要： A pathogenic factor in plasma as an improved therapy for Fabry disease.

摘要翻译： 血浆中的致病因子是法布里病改进疗法。

公开(公告)号：US20100093038A1

公开(公告)日：2010-04-15

申请号：US12086269

申请日：2005-12-09

申请人： Hergen Spits

发明人： Hergen Spits

IPC分类号： C12P21/00 ,  C12N5/16 ,  C07K16/00

CPC分类号： C12N5/0635 ,  C07K16/00 ,  C12N2501/23 ,  C12N2501/60

摘要： The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.

摘要翻译： 本发明提供了影响抗体产生细胞的稳定性的方法，其包括直接或间接地影响所述抗体产生细胞内的BCL6和/或Blimp1表达产物的量。 还提供稳定的抗体产生细胞和细胞系，以及使用这种细胞和/或细胞系产生抗体的方法。

公开(公告)号：US20090130769A1

公开(公告)日：2009-05-21

申请号：US12067758

申请日：2005-09-21

申请人： Luitzen de Jong ,  Piotr Thomasz Kasper ,  Jaap Willem Back ,  Jan Herman van Maarseveen ,  Chris Gerdinus de Koster

发明人： Luitzen de Jong ,  Piotr Thomasz Kasper ,  Jaap Willem Back ,  Jan Herman van Maarseveen ,  Chris Gerdinus de Koster

IPC分类号： G01N33/68 ,  C07D403/12 ,  C07D403/06 ,  C07K1/107

CPC分类号： C07D207/333 ,  C07D207/416 ,  C07D307/33

摘要： The present invention describes a novel cross-linker, a method for preparing one or more cross-linked biomolecules, biomolecular complexes of two or more biomolecules, a method for preparing cross-linked fragments from such cross-linked biomolecules and/or biomolecular complexes, a method for cleavage and reduction of such cross-linked biomolecules and/or biomolecular complexes, a method for identifying cross-links in such cross-linked biomolecules and/or biomolecular complexes, as well as a method for determining relative amounts of cross-links in a biomolecule or biomolecular complex in two or more samples.

摘要翻译： 本发明描述了一种新的交联剂，一种或多种交联生物分子的制备方法，两种或多种生物分子的生物分子复合物，从这种交联的生物分子和/或生物分子复合物制备交联片段的方法， 用于切割和还原这种交联的生物分子和/或生物分子复合物的方法，用于鉴定这种交联的生物分子和/或生物分子复合物中的交联的方法，以及用于确定交联的相对量的方法 在两个或更多个样品中的生物分子或生物分子复合物中。

公开(公告)号：US20060117758A1

公开(公告)日：2006-06-08

申请号：US10543673

申请日：2003-01-29

申请人： Ekkehard Brück ,  Ojiyed Tegusi ,  Frank De Boer

发明人： Ekkehard Brück ,  Ojiyed Tegusi ,  Frank De Boer

IPC分类号： F25B21/00 ,  C04B35/26 ,  H01F1/00 ,  C04B35/00

CPC分类号： H01F1/015 ,  B22F2003/248 ,  B22F2009/041 ,  B22F2998/10 ,  C04B35/5154 ,  C04B2235/40 ,  C04B2235/405 ,  C04B2235/428 ,  C22C1/0491 ,  F25B21/00 ,  Y02B30/66 ,  B22F1/0003 ,  B22F9/04 ,  B22F3/02 ,  B22F3/10 ,  B22F3/24

摘要： The invention relates to a material that can be used for magnetic refrigeration, wherein the material substantially has the general formula (AYB1-Y)2+δCWDXEZ Wherein: A is selected from Mn and Co; B is selected from Fe and Cr; of C, D and E at least two are different, have a non-vanishing concentration and are selected from P, B. Se, Ge, Ga, Si, Sn and Sb; wherein at least one of C, D and E is Ge or Si; W, X, Y and Z each is a number in the range 0-1, and W+X+Z=1; andδas a number from (−0.1)-(+0.1).

摘要翻译： 本发明涉及可用于磁性制冷的材料，其中该材料基本上具有通式（A 1 Y 1 B 1 -Y 2）2 +δ 其中A选自Mn和Co;其中A选自Mn和Co; B选自Fe和Cr; C，D和E中至少有两个不同，具有非消失浓度，选自P，B，Se，Ge，Ga，Si，Sn和Sb; 其中C，D和E中的至少一个是Ge或Si; W，X，Y和Z分别为0-1，W + X + Z = 1的范围内的数字。 和（ - 0.1） - （+ 0.1）的数字。

公开(公告)号：US06838435B1

公开(公告)日：2005-01-04

申请号：US09509391

申请日：1998-09-25

申请人： Jeroen Krijgsveld ,  Sebastianus Antonius Johannes Zaat ,  Jacob Dankert ,  Alma Johanna Kuijpers ,  Gerardus Henricus Maria Engbers ,  Jan Feijen

发明人： Jeroen Krijgsveld ,  Sebastianus Antonius Johannes Zaat ,  Jacob Dankert ,  Alma Johanna Kuijpers ,  Gerardus Henricus Maria Engbers ,  Jan Feijen

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/19 ,  A61P9/00 ,  A61P31/04 ,  A61P31/10 ,  C07K14/52

CPC分类号： C07K14/521 ,  A61K38/00

摘要： The present invention relates to isolated and recombinant antimicrobial peptides thrombocidin-1 (TC-1) and thrombocidin-2 (TC-2), or variants thereof, which comprise at least in part the sequence as shown in FIG. 1 indicated by the label TC-1 and TC-2, and have antimicrobial activity against gram-positive and gram-negative bacteria, for example Escherichia coli, Bacillus subtilis, Streptococcus sanguis, Streptococcus pneumoniae, Staphylococcus epidermis, and Staphylococcus aureus, and/or against fungi, for example Candida albicans, C. glabarata, Cryptococcus neoformans, Aspergillus flavus, A. fumigatus, and Pseudoallescheria spec. The invention further relates to the use of said peptides, or variants thereof, for the preparation of a medicament for the treatment of bacterial or fungal infections, such as endocarditis, in humans and animals and the use of said peptides, or variants thereof, in release systems for prevention of bacterial or fungal infections in humans and animals.

公开(公告)号：US11518088B2

公开(公告)日：2022-12-06

申请号：US17604870

申请日：2020-04-20

申请人： UNIVERSITEIT VAN AMSTERDAM

发明人： Suhas Nawada

IPC分类号： B29C64/286 ,  B29C64/129 ,  B33Y10/00 ,  B33Y30/00

摘要： The invention provides a stereo lithographic 3D printing assembly comprising a digital projection system for projecting a first pattern having a first resolution at a projection location, and a photo mask system for projecting a second pattern having a second resolution at said projection location. This provides a fast 3D printing assembly allowing high resolution details.

公开(公告)号：US20220098232A1

公开(公告)日：2022-03-31

申请号：US17494149

申请日：2021-10-05

申请人： Stichting voor de Technische Wetenschappen ,  Universiteit van Amsterdam

发明人： Gaston Julia Johannes Richelle ,  Dieuwertje Emma Streefkerk ,  Jan Herman Van Maarseveen ,  Peter Timmerman

IPC分类号： C07K1/04 ,  C07K1/107 ,  C07K7/56 ,  C07K7/64 ,  C40B30/04 ,  G01N33/543

摘要： The invention relates to methods for preparing a compound comprising a peptide attached to a molecular scaffold whereby multiple peptide loops are formed, to compounds that can be obtained with such methods and uses thereof.

公开(公告)号：US11268021B2

公开(公告)日：2022-03-08

申请号：US16331704

申请日：2017-09-08

申请人： UNIVERSITEIT VAN AMSTERDAM

发明人： Katerina Newell ,  Benjamin Bruhn ,  Benjamin Brenny

IPC分类号： C09K11/59 ,  C09K11/02 ,  B82Y20/00 ,  B82Y40/00

摘要： Multi-chromatic photoluminescent, oxide-capped semiconductor nanocrystals and methods for forming such semiconductor nanocrystals. The method includes exposing one or more oxide-capped semiconductors, preferably type IV semiconductor nanocrystals, to electron beam radiation, wherein the radiation has an energy between 1 and 30 keV, the radiation introducing color centers in the oxide that exhibit photoluminescence in at least the green band of the visible spectrum.