利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

87 条记录 (耗时 0.04 秒)

    Methods for the treatment of cellular proliferative disorders
    71.
    发明申请
    Methods for the treatment of cellular proliferative disorders 有权
    治疗细胞增殖性疾病的方法

    公开(公告)号：US20080057073A1

    公开(公告)日：2008-03-06

    申请号：US11807908

    申请日：2007-05-30

    申请人： Matthew Coffey

    发明人： Matthew Coffey

    IPC分类号： A61K39/395 ,  A61K35/00 ,  A61P43/00 ,  C12Q1/02 ,  C12Q1/48

    CPC分类号： G01N33/6872 ,  A61K35/765 ,  A61K45/06 ,  C12N2720/12232 ,  C12Q1/485 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57496 ,  G01N2333/135 ,  G01N2333/14 ,  A61K2300/00

    摘要： The present invention relates to methods of identifying the susceptibility of cells to reovirus infection by measuring constitutive ras-MAP signaling. The invention also pertains to methods using reovirus for the treatment of cellular proliferative disorders, and particularly cellular proliferative disorders wherein the proliferating cells exhibit constitutive MAPK phosphorylation, in mammals. In particular, the methods provide for reovirus treatment of mammals to treat proliferative disorders which include breast tumors, a subset of tumors in which mutation of the ras gene is not believed to play a significant role.

    摘要翻译： 本发明涉及通过测量组成型ras-MAP信号来鉴定细胞对呼肠孤病毒感染的易感性的方法。 本发明还涉及使用呼肠孤病毒治疗细胞增殖性疾病的方法，特别是哺乳动物中增殖细胞表现出组成型MAPK磷酸化的细胞增殖性疾病。 特别地，所述方法提供了呼肠孤病毒治疗哺乳动物以治疗增殖性疾病，包括乳腺肿瘤，其中ras基因的突变不被认为起重要作用的肿瘤的子集。

    Virus clearance of neoplastic cells from mixed cellular compositions
    72.
    发明申请
    Virus clearance of neoplastic cells from mixed cellular compositions 审中-公开
    来自混合细胞组合物的肿瘤细胞的病毒清除

    公开(公告)号：US20080038822A1

    公开(公告)日：2008-02-14

    申请号：US11807921

    申请日：2007-05-30

    申请人： Donald Morris ,  Bradley Thompson ,  Matthew Coffey

    发明人： Donald Morris ,  Bradley Thompson ,  Matthew Coffey

    IPC分类号： C12N5/00

    CPC分类号： C12N5/0093 ,  A61K35/28 ,  A61K35/765 ,  A61K48/00 ,  A61L2/00 ,  C12N5/0693 ,  C12N15/86 ,  C12N2500/70 ,  C12N2720/12232 ,  C12N2720/12243

    摘要： The present invention relates to a method for removing neoplastic cells from a mixed cellular composition, which is outside of a living organism, by using a virus which selectively infect and kill neoplastic cell. A variety of viruses can be used in this method to remove neoplastic cells for different purposes, for example, to purge hematopoietic stem cells prior to transplantation. Also provided are compositions prepared according to this method, and kits comprising a combination of viruses which are useful in this invention.

    摘要翻译： 本发明涉及通过使用选择性感染和杀死肿瘤细胞的病毒，从活体外部的混合细胞组合物中去除肿瘤细胞的方法。 在该方法中可以使用各种病毒以除去不同目的的肿瘤细胞，例如在移植前清除造血干细胞。 还提供了根据该方法制备的组合物，以及包含可用于本发明的病毒组合的试剂盒。

    Modified Reoviral Therapy
    74.
    发明申请
    Modified Reoviral Therapy 有权
    改良型病毒治疗

    公开(公告)号：US20070280952A1

    公开(公告)日：2007-12-06

    申请号：US11740985

    申请日：2007-04-27

    申请人： Jeffrey Tarrand ,  Xiang-Yang Han

    发明人： Jeffrey Tarrand ,  Xiang-Yang Han

    IPC分类号： A61K39/15 ,  A61K39/395 ,  A61P35/00

    CPC分类号： A61K35/765 ,  A61K47/6901 ,  C12N2720/12232

    摘要： The present invention relates to hyperproliferative diseases. Specifically, the present invention encompasses pharmaceutical compositions comprising a modified Reoviridae virus, wherein the Reoviridae virus is conjugated to a hydroxylated hydrocarbon or a polycationic polymer to reduce the clearance of the composition and reduce the immunogenicity of the composition. Yet further, the invention relates to methods of treating a hyperproliferative disease by administering to a patient an effective amount of the modified Reoviridae virus.

    摘要翻译： 本发明涉及过度增生性疾病。 具体地说，本发明包括包含修饰的呼肠弧病毒病毒的药物组合物，其中病毒科病毒与羟基化烃或聚阳离子聚合物结合以减少组合物的清除率并降低组合物的免疫原性。 此外，本发明涉及通过向患者施用有效量的经修饰的病毒科病毒来治疗过度增殖性疾病的方法。

    Modified reoviral therapy
    75.
    发明授权
    Modified reoviral therapy 有权
    改良的呼肠孤病毒治疗

    公开(公告)号：US07223388B2

    公开(公告)日：2007-05-29

    申请号：US10211218

    申请日：2002-08-02

    申请人： Jeffrey Tarrand ,  Xiang-Yang Han

    发明人： Jeffrey Tarrand ,  Xiang-Yang Han

    IPC分类号： A61K39/15 ,  A61K48/00 ,  A61K47/00 ,  A61K47/02 ,  A61K39/00 ,  A61B5/055

    CPC分类号： A61K35/765 ,  A61K47/6901 ,  C12N2720/12232

    摘要： The present invention relates to hyperproliferative diseases. Specifically, the present invention encompasses pharmaceutical compositions comprising a modified Reoviridae virus, wherein the Reoviridae virus is conjugated to a hydroxylated hydrocarbon or a polycationic polymer to reduce the clearance of the composition and reduce the immunogenicity of the composition. Yet further, the invention relates to methods of treating a hyperproliferative disease by administering to a patient an effective amount of the modified Reoviridae virus.

    摘要翻译： 本发明涉及过度增生性疾病。 具体地说，本发明包括包含修饰的呼肠弧病毒病毒的药物组合物，其中病毒科病毒与羟基化烃或聚阳离子聚合物结合以减少组合物的清除率并降低组合物的免疫原性。 此外，本发明涉及通过向患者施用有效量的经修饰的病毒科病毒来治疗过度增殖性疾病的方法。

    Method of extracting virus from cell culture
    78.
    发明申请
    Method of extracting virus from cell culture 有权
    从细胞培养中提取病毒的方法

    公开(公告)号：US20050095692A1

    公开(公告)日：2005-05-05

    申请号：US10916378

    申请日：2004-08-10

    申请人： Matthew Coffey ,  Bradley Thompson

    发明人： Matthew Coffey ,  Bradley Thompson

    IPC分类号： A61K35/76 ,  A61P35/00 ,  A61P35/02 ,  C12N7/02 ,  C12R1/93

    CPC分类号： C12N7/00 ,  A61K35/765 ,  C12N2720/12232 ,  C12N2720/12251

    摘要： The present invention is directed to a method of extracting virus, particularly reovirus, from a culture of cells. Infectious virus can be extracted from the culture with a detergent at a convenient temperature such as 25° C. or 37° C. to produce high virus titers. Both ionic and non-ionic detergents can be used in the present invention.

    摘要翻译： 本发明涉及从细胞培养物中提取病毒，特别是呼肠弧病毒的方法。 感染性病毒可以用诸如25℃或37℃的方便温度的洗涤剂从培养物中提取，以产生高病毒效价。 离子和非离子洗涤剂都可用于本发明。

    Reovirus for the treatment of neoplasia
    79.
    发明申请
    Reovirus for the treatment of neoplasia 有权
    呼肠孤病毒治疗瘤形成

    公开(公告)号：US20040265271A1

    公开(公告)日：2004-12-30

    申请号：US10403528

    申请日：2003-04-01

    申请人： Oncolytics Biotech Inc.

    发明人： Patrick W.K. Lee ,  James Strong ,  Matthew C. Coffey

    IPC分类号： A61K048/00 ,  C12N015/86

    CPC分类号： C12N9/1205 ,  A61K35/765 ,  C12N7/00 ,  C12N2720/12232 ,  C12N2720/12261

    摘要： Methods for treating neoplasia, by administering reovirus to a Ras-mediated neoplasm, and use of reovirus for manufacture of a medicament for the treatment of neoplasia, are disclosed. The reovirus is administered so that it ultimately directly contacts cells of the neoplasm. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, type 1 (e.g., strain Lang), type 2 (e.g., strain Jones), type 3 (e.g., strain Dearing or strain Abney), as well as other sterotypes or strains of reovirus can be used. Combinations of more than one type and/or strain or reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.

    摘要翻译： 公开了通过向Ras介导的肿瘤施用呼肠孤病毒和使用呼肠孤病毒来制造用于治疗肿瘤的药物的方法。 呼肠病毒的施用使其最终直接接触肿瘤细胞。 可以使用人呼肠病毒，非人哺乳动物呼肠病毒和/或禽呼肠孤病毒。 如果呼肠孤病毒是人呼肠病毒，可以使用1型（例如，菌株Lang），2型（例如菌株琼斯），3型（例如，菌株Dearing或菌株Abney）以及其它定向型或呼肠孤病毒菌株。 可以使用多于一种类型和/或菌株或呼肠孤病毒的组合，以及来自不同动物种的呼肠病毒。 可以治疗实体肿瘤或造血赘生物。

    Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders
    80.
    发明申请
    Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders 失效
    用于预防呼肠孤病毒识别用于治疗细胞增殖性疾病的方法

    公开(公告)号：US20030215443A1

    公开(公告)日：2003-11-20

    申请号：US10401032

    申请日：2003-03-28

    申请人： Oncolytics Biotech Inc.

    发明人： Matthew C. Coffey ,  Bradley G. Thompson

    IPC分类号： A61K039/395

    CPC分类号： A61K35/765 ,  A61K38/13 ,  C07K16/081 ,  C07K16/10 ,  C07K16/4216 ,  C12N9/1205 ,  C12N2720/12232 ,  Y10S435/948 ,  Y10S435/975 ,  A61K2300/00

    摘要： The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The mammal may be selected from dogs, cats, sheep, goats, cattle, horses, pigs, mice, humans and non-human primates. The method comprises suppressing or otherwise inhibiting the immune system of the mammal and, concurrently or subsequently, administering to the proliferating cells an effective amount of one or more reoviruses under conditions which result in substantial lysis of the proliferating cells. In particular, the methods provide for reovirus treatment of immunosuppressed or immuno-deficient mammals to treat the proliferative disorders. Immunosuppression, immunoinhibition or otherwise inducing an immunodeficient state in a mammal renders the reovirus more effective. The methods may include the selective removal of immune constituents that may interfere with the systemic delivery of the virus; preventing reovirus recognition by the host immune system; and removal of the virus from an immune suppressed or immune incompetent host following treatment with reovirus. Alternatively, reovirus may be administered to a mammal with a diminished immune response system under conditions which result in substantial lysis of the proliferating cells. Immune systems may be compromised by one or more of the following: an HIV infection; as a side effect of chemotherapy or radiation therapy; by selective removal of B and/or T cell populations; by removal of antibodies (anti-antireovirus antibodies or all antibodies), and the like.

    摘要翻译： 本发明涉及在哺乳动物中治疗细胞增殖性疾病，特别是ras介导的细胞增殖性疾病中预防呼肠孤病毒识别的方法。 哺乳动物可以选自狗，猫，绵羊，山羊，牛，马，猪，小鼠，人和非人灵长类动物。 该方法包括抑制或以其他方式抑制哺乳动物的免疫系统，并且同时或随后在导致增殖细胞的实质性裂解的条件下向增殖细胞施用有效量的一种或多种呼吸道病毒。 特别地，该方法提供了呼肠孤病毒治疗免疫抑制或免疫缺陷型哺乳动物以治疗增殖性疾病。 在哺乳动物中的免疫抑制，免疫抑制或其他诱导免疫缺陷状态使呼肠孤病毒更有效。 所述方法可以包括选择性去除可能干扰病毒的全身递送的免疫组分; 预防宿主免疫系统的呼肠孤病毒识别; 并在用呼肠孤病毒治疗后从免疫抑制或免疫不称职的宿主中除去病毒。 或者，呼肠孤病毒可以在导致增殖细胞的实质性裂解的条件下给予具有减少的免疫应答系统的哺乳动物。 免疫系统可能受到以下一种或多种感染：HIV感染; 作为化疗或放射治疗的副作用; 通过选择性去除B和/或T细胞群体; 通过除去抗体（抗 - 抗病毒抗体或全部抗体）等。