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    METHOD AND KIT FOR THE DETECTION OF HEPATITIS-SPECIFIC ANTIBODIES
    74.
    发明申请
    METHOD AND KIT FOR THE DETECTION OF HEPATITIS-SPECIFIC ANTIBODIES 审中-公开

    公开(公告)号：US20170285028A1

    公开(公告)日：2017-10-05

    申请号：US15485264

    申请日：2017-04-12

    申请人： Dror ATZMON ,  Dobroslav MELAMED

    发明人： Tamar JEHUDA-COHEN

    IPC分类号： G01N33/576

    CPC分类号： G01N33/576 ,  Y02A50/54

    摘要： Provided is an improved method for detecting antibodies to a hepatitis virus in a tissue sample from individuals, which can reliably detect antibodies in recently infected individuals and which provides much lower false positive results in individuals that have cleared their hepatitis infections. Further provided is an improved method and kit which utilizes an activator of (i) hepatitis virus-primed lymphocytes, (ii) memory cells specific for said hepatitis virus, (iii) hepatitis virus-specific antibody production, or (iv) a combination thereof in a tissue sample to stimulate the production of antibodies from newly primed B cells, if present.

    METHODS FOR DETERMINING VIRAL SENSITIVITY TO VIRAL INHIBITORS
    77.
    发明申请
    METHODS FOR DETERMINING VIRAL SENSITIVITY TO VIRAL INHIBITORS 审中-公开
    用于确定病毒感染性的方法

    公开(公告)号：US20140274935A1

    公开(公告)日：2014-09-18

    申请号：US14217410

    申请日：2014-03-17

    申请人： Laboratory Corporation of America Holdings

    发明人： Jacqueline Denise Reeves

    IPC分类号： C12Q1/70 ,  A61K31/7056 ,  C12Q1/68

    CPC分类号： C12Q1/707 ,  A61K31/7056 ,  A61K31/7072 ,  A61K31/7076 ,  C12Q1/6883 ,  C12Q1/6897 ,  C12Q2600/106 ,  G01N33/576 ,  G01N2333/186 ,  G01N2800/52

    摘要： Methods and compositions for the efficient and accurate determination of susceptibility of a hepatitis C virus (HCV) or HCV population to an HCV inhibitor. The inhibitor may include, for example, an interferon (IFN), ribavirin (RBV), one or more nucleos(t)ide inhibitors, including for example nucleoside inhibitor-1 (NI-1), 2′C-methyl adenosine (2′CMeA), sofosbuvir (SOF), or non-nucleoside inhibitor targeting site A or B (NNI-A or NNI-B) are provided. The methods may involve determining the genotype of the HCV or the phenotype of the HCV with respect to the inhibitor susceptibility. The methods may further include the selection of a suitable treatment based on the genotype or phenotype determined.

    摘要翻译： 用于有效和准确地测定丙型肝炎病毒（HCV）或HCV群体对HCV抑制剂的敏感性的方法和组合物。 抑制剂可以包括例如干扰素（IFN），利巴韦林（RBV），一种或多种核苷（t）ide抑制剂，包括例如核苷抑制剂-1（NI-1），2'C-甲基腺苷（2 “CMeA”，sofosbuvir（SOF）或非核苷抑制剂靶向部位A或B（NNI-A或NNI-B）。 所述方法可以涉及确定HCV的基因型或HCV的表型相对于抑制剂易感性。 所述方法还可以包括基于所确定的基因型或表型选择合适的治疗。

    METHODS FOR DETECTION OF BIOLOGICAL SUBSTANCES
    78.
    发明申请
    METHODS FOR DETECTION OF BIOLOGICAL SUBSTANCES 有权
    检测生物物质的方法

    公开(公告)号：US20140073654A1

    公开(公告)日：2014-03-13

    申请号：US13932613

    申请日：2013-07-01

    申请人： Robert I. Henkin

    发明人： Robert I. Henkin

    IPC分类号： G01N33/566 ,  A61K31/522

    CPC分类号： A61K31/522 ,  A61K9/0043 ,  A61K31/4709 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/118 ,  G01N33/566 ,  G01N33/57449 ,  G01N33/576 ,  G01N33/6893 ,  G01N2333/525 ,  G01N2333/70575 ,  G01N2800/042 ,  G01N2800/14 ,  G01N2800/52 ,  Y02A50/463 ,  Y02A50/54

    摘要： The invention is directed to a method of detecting a biological substance in the nasal secretion and diagnosing a disease following the detection of the biological substance wherein the biological substance is not related to a respiratory disease. The invention also provides treatment of the diseases following the detection of the biological substance and/or diagnosis of the disease. In some embodiments, the diseases are cancer, hepatitis, smell loss, taste loss, diabetes, and leprosy. The invention also provides a kit for diagnosing a disease.The present invention includes methods of analyzing samples from the nose for the detection of biological substances. In particular, nasal secretion or nasal mucus is collected and analyzed for biological substances. The results of this analysis are then suitable for use in diagnosis, prognosis, and determination of suitability of therapeutic interventions.

    摘要翻译： 本发明涉及一种检测鼻分泌物中的生物物质的方法，并且在检测到生物物质与生物物质与呼吸系统疾病无关之后诊断疾病。 本发明还提供了在检测生物物质和/或诊断疾病之后的疾病的治疗。 在一些实施方案中，疾病是癌症，肝炎，气味丧失，味觉丧失，糖尿病和麻风病。 本发明还提供了用于诊断疾病的试剂盒。 本发明包括分析来自鼻子的样品用于检测生物物质的方法。 特别地，收集鼻分泌物或鼻粘液并分析生物物质。 该分析结果适用于诊断，预后和治疗干预适合性的测定。