公开(公告)号：US09448219B2

公开(公告)日：2016-09-20

申请号：US13893699

申请日：2013-05-14

申请人： William Jay Arora ,  Karen K. Gleason ,  George Barbastathis ,  Wyatt E. Tenhaeff

发明人： William Jay Arora ,  Karen K. Gleason ,  George Barbastathis ,  Wyatt E. Tenhaeff

IPC分类号： G01N27/04 ,  G01N33/00 ,  G01N27/12

CPC分类号： G01N33/0057 ,  G01N27/128 ,  Y10T436/147777 ,  Y10T436/163333 ,  Y10T436/173076 ,  Y10T436/173845

摘要： One aspect of the invention relates to an ultrathin micro-electromechanical chemical sensing device which uses swelling or straining of a reactive organic material for sensing. In certain embodiments, the device comprises a contact on-off switch chemical sensor. For example, the device can comprises a small gap separating two electrodes, wherein the gap can be closed as a result of the swelling or stressing of an organic polymer coating on one or both sides of the gap. In certain embodiments, the swelling or stressing is due to the organic polymer reacting with a target analyte.

公开(公告)号：US09409935B2

公开(公告)日：2016-08-09

申请号：US12884289

申请日：2010-09-17

申请人： Eric A. Haupfear

发明人： Eric A. Haupfear

IPC分类号： G01N31/00 ,  C07F9/38

CPC分类号： G01N31/22 ,  C07F9/3813 ,  G01N31/00 ,  Y10T436/163333 ,  Y10T436/204998

摘要： This invention relates to the preparation of N-(phosphonomethyl)glycine (“glyphosate”) from N-(phosphonomethyl)iminodiacetic acid (“PMIDA”), and more particularly to methods for control of the conversion of PMIDA, for the identification of reaction end points relating to PMIDA conversion and the preparation of glyphosate products having controlled PMIDA content.

摘要翻译： 本发明涉及从N-（膦酰基甲基）亚氨基二乙酸（“PMIDA”）制备N-（膦酰基甲基）甘氨酸（“草甘膦”），更具体地说，涉及用于控制PMIDA转化的方法，用于鉴定反应 关于PMIDA转化的终点和具有受控PMIDA含量的草甘膦产品的制备。

公开(公告)号：US20150355154A1

公开(公告)日：2015-12-10

申请号：US14707972

申请日：2015-05-08

申请人： CHUNG ANG UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

发明人： Tae Jung PARK ,  Myung-Sun KIM ,  Gi Wook KIM ,  Min Su HAN

IPC分类号： G01N33/18 ,  G01N21/82

CPC分类号： G01N33/1826 ,  B82Y15/00 ,  G01N21/80 ,  G01N31/22 ,  G01N2033/184 ,  Y10S977/773 ,  Y10S977/921 ,  Y10T436/163333

摘要： A sensor system detects organophosphorus pesticide residue by inducing the aggregation of gold nanoparticles. A method comprises aggregating gold nanoparticles by a reaction between an organophosphorus pesticide and imidazole or a green fluorescent protein (GFP), and detecting the organophosphorus pesticide based on a absorption spectral change resulting from the aggregation. The system for detecting pesticide residue is useful as a biosensor for analyzing pesticide residue in situ, because the optical change of the reagent by the presence of an organophosphorus pesticide is distinct, the detection speed is fast, and the range of detection limits is broad.

摘要翻译： 传感器系统通过诱导金纳米颗粒的聚集来检测有机磷农药残留。 一种方法包括通过有机磷农药和咪唑或绿色荧光蛋白（GFP）之间的反应聚集金纳米颗粒，并且基于由聚集引起的吸收光谱变化来检测有机磷农药。 检测农药残留的系统可用作原位分析农药残留的生物传感器，因为有机磷杀虫剂存在的试剂的光学变化不同，检测速度快，检测限范围广。

公开(公告)号：US20150268215A1

公开(公告)日：2015-09-24

申请号：US13748037

申请日：2013-01-23

申请人： Lindon Group, Inc.

发明人： Dalita Tomellini ,  Melinda Penney ,  Phil Brooks

IPC分类号： G01N33/22 ,  B65D43/22 ,  B65D43/16 ,  G01N21/78

CPC分类号： G01N33/227 ,  A45C13/02 ,  A45C13/1084 ,  G01N21/78 ,  G01N21/8483 ,  G01N2201/0221 ,  G01N2201/0222 ,  Y10T436/142222 ,  Y10T436/145555 ,  Y10T436/147777 ,  Y10T436/163333 ,  Y10T436/170769 ,  Y10T436/171538 ,  Y10T436/173076 ,  Y10T436/173845

摘要： A personal-sized, portable explosive detection field test kit (ETK) and related methods of use. Embodiments of the disclosed ETK include a case having a closing system featuring three levels of closure which retain the case cover securely in a closed position until ready for use, while being easily opened when necessary. The ETK instructions are permanently attached to the case to prevent loss. The case includes retention features which retain the kit components until needed and protects them against loss or damage. The ETK includes one or more test tubes that are color coded and include abbreviated instructions.

摘要翻译： 个人尺寸便携式爆炸物检测现场测试套件（ETK）及相关使用方法。 所公开的ETK的实施例包括具有封闭系统的壳体，该封闭系统具有三级闭合，其将壳体盖牢固地保持在关闭位置，直到准备使用，同时在必要时容易打开。 ETK说明书永久附在案件上以防止损失。 这种情况包括保留功能，保留套件组件直到需要，并保护它们免受损失或损坏。 ETK包括一个或多个颜色编码的试管，并包括缩写说明。

公开(公告)号：US20150253245A1

公开(公告)日：2015-09-10

申请号：US14622281

申请日：2015-02-13

申请人： Commissariat a l'énergie atomique et aux énergies alternatives

发明人： Pierrick Buvat ,  Lucie Malosse ,  Alain Siove ,  Dominique Ades

IPC分类号： G01N21/64 ,  G01N33/00 ,  C08F220/68

CPC分类号： G01N21/64 ,  C08F220/68 ,  C09B57/02 ,  C09B69/109 ,  G01N33/0037 ,  G01N33/0047 ,  G01N33/0057 ,  G01N33/52 ,  G01N2201/06113 ,  G01N2201/068 ,  Y02A50/245 ,  Y10T428/2982 ,  Y10T436/163333 ,  Y10T436/173076

摘要： A polymer is obtained by polymerization of a polymerizable fluorescent monomer compound of 7-hydroxycoumarin having the following formula (I): G is a substituent including a polymerizable chemical group R, and optionally of at least one other polymerizable monomer. The polymer can be used as a sensitive material in an optical sensor.

摘要翻译： 通过聚合具有下式（I）的7-羟基香豆素的可聚合荧光单体化合物获得聚合物：G是包含可聚合化学基团R的取代基和任选的至少一种其它可聚合单体。 聚合物可以用作光学传感器中的敏感材料。

公开(公告)号：US20140356970A1

公开(公告)日：2014-12-04

申请号：US13906779

申请日：2013-05-31

申请人： Wisconsin Alumni Research Foundation

发明人： Nicholas Lawrence Abbott ,  Jacob Tyler Hunter

IPC分类号： G01N21/84 ,  G01N33/20

CPC分类号： G01N21/21 ,  G01N31/224 ,  G01N2021/8477 ,  Y10T436/163333

摘要： Methods and devices for determining a preferred composition of anions in a liquid crystal device, and methods and devices for detecting a targeted agent in a sample using such preferred compositions, are disclosed. Such methods include the steps of preparing a liquid crystal device including a liquid crystal, a metal cation, a strongly coordinating anion, and a weakly coordinating anion, contacting the liquid crystal device with a sample suspected of including the targeted agent, and observing the orientational ordering of the liquid crystal at the surface.

摘要翻译： 公开了用于确定液晶装置中阴离子的优选组成的方法和装置，以及用于使用这种优选组合物检测样品中靶向试剂的方法和装置。 这些方法包括制备包括液晶，金属阳离子，强配位阴离子和弱配位阴离子的液晶装置的步骤，使液晶装置与疑似包含目标试剂的样品接触，观察取向 在表面上排列液晶。

公开(公告)号：US08898069B2

公开(公告)日：2014-11-25

申请号：US12584055

申请日：2009-08-28

申请人： Leroy E. Hood ,  Edward K. Y. Jung ,  Elizabeth A. Sweeney ,  Clarence T. Tegreene ,  Lowell L. Wood, Jr.

发明人： Leroy E. Hood ,  Edward K. Y. Jung ,  Elizabeth A. Sweeney ,  Clarence T. Tegreene ,  Lowell L. Wood, Jr.

IPC分类号： G06Q10/00 ,  G06Q50/00 ,  G06Q50/24 ,  A61B5/00

CPC分类号： A61B5/0002 ,  A61B5/00 ,  A61B5/411 ,  G01N33/14 ,  G06F19/00 ,  G06Q50/24 ,  Y02A90/22 ,  Y02A90/26 ,  Y10T436/163333

摘要： Methods and systems are described herein for detecting one or more analyte in salivary fluid. Systems include: a discrete oral component configured for complete enclosure in a human oral cavity; at least one sensor configured to detect one or more analyte in salivary fluid; and an external device including a port configured for communication with the discrete oral component. Methods include: detecting one or more analyte within salivary fluid with at least one sensor integral to a discrete oral component, wherein the discrete oral component is configured to be completely enclosed in the oral cavity and includes one or more flavorant; and communicating information from the discrete oral component to at least one external device.

摘要翻译： 本文描述了用于检测唾液中一种或多种分析物的方法和系统。 系统包括：配置成完全封闭在人类口腔中的离散口腔部件; 至少一个传感器被配置成检测唾液中的一种或多种分析物; 以及包括被配置为与离散口头部件通信的端口的外部设备。 方法包括：用至少一个与离散的口服组分成一体的传感器检测唾液中的一种或多种分析物，其中所述离散的口服组分构造成完全封闭在口腔中，并且包括一种或多种调味剂; 以及将信息从离散口头部件传送到至少一个外部装置。

公开(公告)号：US08859291B2

公开(公告)日：2014-10-14

申请号：US11148478

申请日：2005-06-09

申请人： Roger Bossé ,  Wayne F. Patton ,  Philippe Roby

发明人： Roger Bossé ,  Wayne F. Patton ,  Philippe Roby

IPC分类号： G01N33/00 ,  G01N25/18 ,  G01N27/00 ,  G01N21/62 ,  G01N21/76 ,  G01N24/00

CPC分类号： G01N33/6842 ,  Y10T436/16 ,  Y10T436/163333 ,  Y10T436/166666 ,  Y10T436/17 ,  Y10T436/170769 ,  Y10T436/176152 ,  Y10T436/176921 ,  Y10T436/18 ,  Y10T436/182 ,  Y10T436/188 ,  Y10T436/24

摘要： The invention provides methods for isolating a target molecule from a sample. In an embodiment, the method involves contacting a sample with a capture agent, the agent comprising a siderophore and a transition metal cation, under conditions wherein the agent is capable of binding a target molecule to form a target molecule-capture agent complex, wherein the target molecule is selected from the group consisting of a phosphorylated molecule, a nitrotyrosine-containing molecule and a sulfated molecule, and separating the target molecule-capture agent complex from the sample, thereby isolating the target molecule from the sample. Also provided are methods for determining the presence of a target molecule in a sample, that involve contacting a sample with a capture agent, the agent comprising a siderophore and a transition metal cation.

摘要翻译： 本发明提供了从样品中分离靶分子的方法。 在一个实施方案中，所述方法包括在其中所述试剂能够结合靶分子以形成靶分子捕获剂复合物的条件下使样品与捕获剂接触，所述捕获剂包含铁载体和过渡金属阳离子，其中 靶分子选自磷酸化分子，含硝基酪氨酸的分子和硫酸化分子，并从样品中分离靶分子捕获剂复合物，从而从样品中分离靶分子。 还提供了确定样品中靶分子存在的方法，其涉及使样品与捕获剂接触，所述试剂包含铁载体和过渡金属阳离子。

公开(公告)号：US20130244334A1

公开(公告)日：2013-09-19

申请号：US13809092

申请日：2011-07-04

申请人： Simon Clavaguera ,  Alexandre Carella ,  Caroline Celle ,  Jean-Pierre Simonato

发明人： Simon Clavaguera ,  Alexandre Carella ,  Caroline Celle ,  Jean-Pierre Simonato

IPC分类号： G01N33/00

CPC分类号： G01N33/00 ,  G01N27/4141 ,  G01N33/0057 ,  Y10T436/163333

摘要： The present invention relates to a method and device for the detecting and/or electrically quantifying organophosphorus compounds as a gas or solution. The device includes: an electrical device including a source electrode and a drain electrode, separated by a semiconductor material; and a device for detecting positive charges between the two electrodes. One surface of the semiconductor material is in contact with a polymer material having at least one receptor group including: 1) a function X capable of reacting with the detectable organophosphorus compound, to form an intermediate grouping —Z; and 2) a function Y capable of reacting with —Z to form a positively charged ring. The polymer material includes molecular imprint cavities, with geometrical and chemical configuration allowing the detectable organophosphorus compounds to penetrate into said polymer material. The invention can be used in the field of detecting and/or quantifying organophosphorus compounds.

摘要翻译： 本发明涉及一种用于检测和/或电定量有机磷化合物作为气体或溶液的方法和装置。 该装置包括：由半导体材料分离的包括源电极和漏电极的电气装置; 以及用于检测两个电极之间的正电荷的装置。 半导体材料的一个表面与具有至少一个受体基团的聚合物材料接触，包括：1）能够与可检测的有机磷化合物反应的功能X，以形成中间体组合-Z; 和2）能够与-Z反应形成带正电荷的环的官能度Y。 聚合物材料包括具有几何和化学构型的分子印迹腔，允许可检测的有机磷化合物渗入所述聚合物材料。 本发明可用于检测和/或定量有机磷化合物领域。

公开(公告)号：US08441081B2

公开(公告)日：2013-05-14

申请号：US12507283

申请日：2009-07-22

申请人： William Jay Arora ,  Karen K. Gleason ,  George Barbastathis ,  Wyatt E. Tenhaeff

发明人： William Jay Arora ,  Karen K. Gleason ,  George Barbastathis ,  Wyatt E. Tenhaeff

IPC分类号： G01P15/08

CPC分类号： G01N33/0057 ,  G01N27/128 ,  Y10T436/147777 ,  Y10T436/163333 ,  Y10T436/173076 ,  Y10T436/173845

摘要： One aspect of the invention relates to an ultrathin micro-electromechanical chemical sensing device which uses swelling or straining of a reactive organic material for sensing. In certain embodiments, the device comprises a contact on-off switch chemical sensor. For example, the device can comprises a small gap separating two electrodes, wherein the gap can be closed as a result of the swelling or stressing of an organic polymer coating on one or both sides of the gap. In certain embodiments, the swelling or stressing is due to the organic polymer reacting with a target analyte.

摘要翻译： 本发明的一个方面涉及使用用于感测的反应性有机材料的溶胀或应变的超薄微机电化学感测装置。 在某些实施例中，该装置包括接触开 - 关开关化学传感器。 例如，该装置可以包括分开两个电极的小间隙，其中间隙可以由于间隙的一侧或两侧上的有机聚合物涂层的膨胀或应力而封闭。 在某些实施方案中，溶胀或应激是由于有机聚合物与靶分析物反应。