公开(公告)号：US20240312773A1

公开(公告)日：2024-09-19

申请号：US18120677

申请日：2023-03-13

Applicant: W. Davis Lee

Inventor： W. Davis Lee

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/38 ,  H01J49/42

CPC classification number: H01J49/0031 ,  H01J49/0459 ,  H01J49/38 ,  H01J49/4285 ,  H01J49/0086

Abstract: The invention comprises a method for separating ions, comprising the steps of: providing an ion cyclotron resonance separator with a longitudinal axis; applying a magnetic field gradient along a length of the longitudinal axis; passing a single fixed radio frequency radially across the longitudinal axis; and spatially separating the ions at mass-to-charge ratio resonance locations along a length of the longitudinal axis, where the magnetic field gradient is within a range of 0 to 0.65 Tesla, where the single fixed radio frequency is maintained in a range of 40 kHz to 20 MHZ, and where the step of spatially separating further comprises the step of spiraling radially outward at a first resonance location a first set of ions, of the ions, the first set of ions comprising a first range of mass-to-charge ratios, the first resonance location comprising a first mass-to-charge ratio resonant with the applied radio frequency.

公开(公告)号：US11929246B2

公开(公告)日：2024-03-12

申请号：US17427386

申请日：2020-01-28

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Eric T Dziekonski

IPC: H01J49/42 ,  H01J49/38

CPC classification number: H01J49/422 ,  H01J49/38

Abstract: In one aspect, a mass analyzer is disclosed, which comprises a quadrupole having an input end for receiving ions and an output end through which ions can exit the quadrupole, said quadrupole having a plurality of rods to at least some of which a drive RF signal and an excitation signal can be applied. A fixed phase relationship is maintained between the drive RF signal and the excitation signal, thereby enhancing the signal-to-noise ratio of the mass detection signal.

公开(公告)号：US20220102133A1

公开(公告)日：2022-03-31

申请号：US17427386

申请日：2020-01-28

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Eric T Dziekonski

IPC: H01J49/42 ,  H01J49/38

Abstract: In one aspect, a mass analyzer is disclosed, which comprises a quadrupole having an input end for receiving ions and an output end through which ions can exit the quadrupole, said quadrupole having a plurality of rods to at least some of which a drive RF signal and an excitation signal can be applied. A fixed phase relationship is maintained between the drive RF signal and the excitation signal, thereby enhancing the signal-to-noise ratio of the mass detection signal.

公开(公告)号：US11016082B2

公开(公告)日：2021-05-25

申请号：US15223756

申请日：2016-07-29

Applicant: University of Louisville Research Foundation, Inc.

Inventor： Xiaoan Fu ,  Michael Nantz ,  Michael Bousamra ,  Victor van Berkel

IPC: G01N33/497 ,  A61B5/08 ,  H01J49/00 ,  H01J49/38 ,  G01N30/72 ,  G01N33/543 ,  G01N33/574 ,  G01N33/64 ,  A61B5/091

Abstract: Provided is a non-invasive method of detecting or screening for a cancer in a subject specimen originating in a tissue outside of the lung. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic compounds (VOCs) that are biomarkers for the cancer in exhaled breath from the subject specimen. The method may further include obtaining exhaled breath from the subject specimen; forming adducts of the carbonyl-containing VOCs with a reactive chemical compound; quantifying the adducts of the carbonyl-containing VOCs to establish a subject value for each of the adducts; and comparing each subject value to a threshold healthy specimen value for each of the adducts of the carbonyl-containing VOCs. One or more subject values at quantities greater than threshold healthy specimen values are also useful for screening for the cancer in the subject specimen.

公开(公告)号：US10804087B2

公开(公告)日：2020-10-13

申请号：US16274773

申请日：2019-02-13

Applicant: Takashi Hosaka

Inventor： Takashi Hosaka

IPC: H01J49/06 ,  H01J49/42 ,  H01J49/38 ,  H01J49/32 ,  H01J49/00 ,  H05H13/04 ,  H05H9/00 ,  H01J49/20 ,  H05H7/04 ,  H05H5/03 ,  G01N27/62 ,  H01J49/22 ,  H05H7/22

Abstract: A mass analyzer includes a main substrate, an upper substrate adhered to the main substrate, and a lower substrate. A mass analysis room (cavity) is formed in the main substrate and penetrates from an upper surface of the first main substrate to a lower surface of the first main substrate. A vertical direction (Z direction) to the main substrate by the upper substrate, both sides of the lower substrate, a travelling direction (X direction) of charged particles and a right angle to the Z direction by the main substrate, and both sides of a right-angled direction (Y to Z direction) and the X direction by a side surface of the main substrate are surrounded. A central hole is open in the side plate of the main substrate that the charged particles enter. The charged particles enter the mass analysis room through the central hole formed in the first main substrate.

公开(公告)号：US20190198306A1

公开(公告)日：2019-06-27

申请号：US16274773

申请日：2019-02-13

Applicant: Takashi HOSAKA

Inventor： Takashi HOSAKA

IPC: H01J49/06 ,  H01J49/42 ,  H01J49/38 ,  H01J49/32 ,  H01J49/00 ,  H05H13/04 ,  H05H9/00 ,  H01J49/20 ,  H05H7/04 ,  H05H5/03 ,  G01N27/62 ,  H01J49/22 ,  H05H7/22

Abstract: A mass analyzer includes a main substrate, an upper substrate adhered to the main substrate, and a lower substrate. A mass analysis room (cavity) is formed in the main substrate and penetrates from an upper surface of the first main substrate to a lower surface of the first main substrate. A vertical direction (Z direction) to the main substrate by the upper substrate, both sides of the lower substrate, a travelling direction (X direction) of charged particles and a right angle to the Z direction by the main substrate, and both sides of a right-angled direction (Y to Z direction) and the X direction by a side surface of the main substrate are surrounded. A central hole is open in the side plate of the main substrate that the charged particles enter. The charged particles enter the mass analysis room through the central hole formed in the first main substrate.

公开(公告)号：US10249483B2

公开(公告)日：2019-04-02

申请号：US15329153

申请日：2015-07-29

Applicant: Takashi Hosaka

Inventor： Takashi Hosaka

IPC: H01J49/06 ,  H01J49/20 ,  H01J49/22 ,  H01J49/42 ,  G01N27/62 ,  H05H5/03 ,  H05H7/04 ,  H05H7/22 ,  H05H9/00 ,  H05H13/04 ,  H01J49/00 ,  H01J49/32 ,  H01J49/38

Abstract: A mass analyzer includes a main substrate, an upper substrate adhered to the main substrate, and a lower substrate. A mass analysis room (cavity) is formed in the main substrate and penetrates from an upper surface of the first main substrate to a lower surface of the first main substrate. A vertical direction (Z direction) to the main substrate by the upper substrate, both sides of the lower substrate, a travelling direction (X direction) of charged particles and a right angle to the Z direction by the main substrate, and both sides of a right-angled direction (Y to Z direction) and the X direction by a side surface of the main substrate are surrounded. A central hole is open in the side plate of the main substrate that the charged particles enter. The charged particles enter the mass analysis room through the central hole formed in the first main substrate.

公开(公告)号：US10242854B2

公开(公告)日：2019-03-26

申请号：US15524373

申请日：2015-10-30

Applicant: SHIMADZU CORPORATION

Inventor： Aleksandr Rusinov ,  Li Ding

IPC: H01J49/00 ,  H01J49/38 ,  H01J49/42

Abstract: Disclosed is a method of quantification of one or more ion species, in a sample of ions, using a mass spectrometer, the method including the steps of: obtaining a time domain data set corresponding to a signal induced by motion of the ions in the mass spectrometer; adjusting the data set by applying an asymmetric window function thereto; generating an absorption mode mass spectrum in the frequency domain including the step of applying a Fourier transform to the adjusted data set; determining peak ranges for one or more peaks in the mass spectrum associated with the one or more ion species; integrating, for each determined peak range, the spectral data within the respective peak range to generate a respective peak intensity value; and quantifying each of the one or more ion species on the basis of the respective peak intensity values.

公开(公告)号：US10141174B2

公开(公告)日：2018-11-27

申请号：US15795405

申请日：2017-10-27

Applicant: Carl Zeiss SMT GmbH

Inventor： Michel Aliman ,  Alexander Laue ,  Hin Yiu Anthony Chung ,  Gennady Fedosenko ,  Ruediger Reuter ,  Leonid Gorkhover ,  Martin Antoni ,  Andreas Gorus ,  Valerie Derpmann

IPC: H01J49/38 ,  H01J49/42 ,  H01J49/00 ,  H01J49/02

Abstract: A method for examining a gas by mass spectrometry includes: ionizing the gas for producing ions; and storing, exciting and detecting at least some of the produced ions in an FT ion trap. Producing and storing the ions in the FT ion trap and/or exciting the ions prior to the detection of the ions in the FT ion trap includes at least one selective IFT excitation, such as a SWIFT excitation, which is dependent on the mass-to-charge ratio of the ions. The disclosure further relates to a mass spectrometer. A mass spectrometer includes: an FT ion trap; and an excitation device for storing, exciting, and detecting ions in the FT ion trap.

公开(公告)号：US20180277346A1

公开(公告)日：2018-09-27

申请号：US15524373

申请日：2015-10-30

Applicant: SHIMADZU CORPORATION

Inventor： Aleksandr RUSINOV ,  Li DING

IPC: H01J49/00 ,  H01J49/42 ,  H01J49/38

CPC classification number: H01J49/0036 ,  H01J49/38 ,  H01J49/4245

Abstract: Disclosed is a method of quantification of one or more ion species, in a sample of ions, using a mass spectrometer, the method including the steps of: obtaining a time domain data set corresponding to a signal induced by motion of the ions in the mass spectrometer; adjusting the data set by applying an asymmetric window function thereto; generating an absorption mode mass spectrum in the frequency domain including the step of applying a Fourier transform to the adjusted data set; determining peak ranges for one or more peaks in the mass spectrum associated with the one or more ion species; integrating, for each determined peak range, the spectral data within the respective peak range to generate a respective peak intensity value; and quantifying each of the one or more ion species on the basis of the respective peak intensity values.