DNA encoding an antigenic protein of Eimeria apical membrane antigen 1 and use thereof
    73.
    发明申请
    DNA encoding an antigenic protein of Eimeria apical membrane antigen 1 and use thereof 有权
    编码艾美球虫顶膜抗原1抗原蛋白的DNA及其应用

    公开(公告)号:US20060115498A1

    公开(公告)日:2006-06-01

    申请号:US11290422

    申请日:2006-01-20

    申请人: Takanori Sato

    发明人: Takanori Sato

    CPC分类号: C07K14/455 A61K39/00

    摘要: This invention provides a novel DNA for preventing avian coccidiosis and use thereof. The novel DNA encodes an antigenic protein of Eimeria apical membrane antigen 1, and is used for DNA vaccine and/or for vaccine comprising the recombinant protein deduced from the said DNA sequence as a main ingredient. The chickens immunized with vaccines described herein can be induced immunity against coccidiosis.

    摘要翻译: 本发明提供了用于预防禽类球虫病的新型DNA及其应用。 该新型DNA编码艾美球虫顶端膜抗原1的抗原性蛋白,并用于DNA疫苗和/或包含从所述DNA序列推导的重组蛋白作为主要成分的疫苗。 用本文所述的疫苗免疫的鸡可诱导针对球虫病的免疫。

    Coccidial vaccine and methods of making and using same
    76.
    发明授权
    Coccidial vaccine and methods of making and using same 有权
    球虫疫苗及其使用方法

    公开(公告)号:US06908620B2

    公开(公告)日:2005-06-21

    申请号:US10730206

    申请日:2003-12-08

    IPC分类号: A61K39/012

    摘要: The present invention relates to a vaccine for coccidiosis in chickens prepared from four attenuated Eimeria species: E. acervulina, E. maxima, E. mitis and E. tenella. The vaccine was similar to or superior to other anticoccidial drugs in stimulating protective immunity against coccidiosis.

    摘要翻译: 本发明涉及一种由四种减毒艾美球虫种类制备的鸡中的球虫病疫苗:大肠埃希氏菌(E.acervulina),大肠埃希氏菌(E. maxima),大肠杆菌(E.mitis)和大肠杆菌(E. tenella)。 该疫苗与其他抗球虫药物相似或优于刺激抗球虫病的保护性免疫。

    DNA encoding eimeria antigen
    78.
    发明授权
    DNA encoding eimeria antigen 失效
    编码艾美球虫抗原的DNA

    公开(公告)号:US6008342A

    公开(公告)日:1999-12-28

    申请号:US770035

    申请日:1996-12-19

    摘要: The invention provides an immunogenic polypeptide having the amino acid sequenceM A K S M L S G I V F A G L V A A A A A - S S A N S A A N V S V L E S G P A V Q E - V P A R T V T A R L A K P L L L L S A L - A A T L A A A F L V L Q C F N I I S S N - N Q Q T S V R R L A A G G A C G D E E D - A D E G T S Q Q A S R R R R K P D T P A - A D K Y D F V G G T P V S V T E P N V D - E V L I Q I R N K Q I F L K N P W T G Q - E E Q V L V L E R Q S E E P I L I V A R - T R Q T L E G Y L G S Q A L A Q D G K T - A K E E K V E G G K T H R R Y K V K S S - D P G Y G F P Y T T V L D G V P V G T D - E D G Y V V E V L M K T G P H G G V D M - M T S T A S Q G K F C G V L M D D G K G - N L V D G Q G R K I T A V I G M L T Q P - D T E F R S G P G D D E D D E (SEQ ID NO:1) and fragments thereof,which polypeptides are capable of inducing an immune response against Eimeria parasites, and the DNA encoding such polypeptides, as well as recombinant vectors and recombinant viruses containing the said DNA or fragments thereof and transformed microorganisms containing such vectors and viruses and coccidiosis vaccines comprising such polypeptides.

    摘要翻译: 本发明提供了具有氨基酸序列的免疫原性多肽 - MAKSMLSGIVFAGLVAAAAA - - SSANSAANVSVLESGPAVQE - - VPARTVTARLAKPLLLLSAL - - AATLAAAFLVLQCFNIISSN - - NQQTSVRRLAAGGACGDEED - - ADEGTSQQASRRRRKPDTPA - - ADKYDFVGGTPVSVTEPNVD - - EVLIQIRNKQIFLKNPWTGQ - - EEQVLVLERQSEEPILIVAR - - TRQTLEGYLGSQALAQDGKT - - AKEEKVEGGKTHRRYKVKSS - - DPGYGFPYTTVLDGVPVGTD - - EDGYVVEVLMKTGPHGGVDM - - MTSTASQGKFCGVLMDDGKG - - NLVDGQGRKITAVIGMLTQP - - DTEFRSGPGDDEDDE(SEQ ID NO:1)及其片段,其能够诱导针对艾美虫寄生虫的免疫应答,以及编码这些多肽的DNA,以及重组载体和重组病毒 将所述DNA或其片段和含有这样的载体和病毒的转化微生物以及包含这种多肽的球虫病疫苗。