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1.发明申请公开(公告)号：US20060233838A1
公开(公告)日：2006-10-19
申请号：US11248552
申请日：2005-10-12
申请人： Harold Conkle , Joseph Schultz , Scott Blonigen , Fred Weber , David Kilanowski , Bruce Monzyk , Timothy Werner , Chad Cucksey , Hamish McArthur , Ted Tewksbury
发明人： Harold Conkle , Joseph Schultz , Scott Blonigen , Fred Weber , David Kilanowski , Bruce Monzyk , Timothy Werner , Chad Cucksey , Hamish McArthur , Ted Tewksbury
IPC分类号： A61K39/012 , C12N1/10
CPC分类号： A61K39/012 , C12N1/10 , Y10S435/947
摘要： A vaccine for in ovo vaccination against avian coccidiosis produced by a method including obtaining the coccidial oocysts from a fecal suspension, homogenizing the fecal suspension, separating the oocysts from the fecal debris by either salt flotation using sodium sulfate or gas flotation using air, sporulating the oocysts using hydrogen peroxide and air sparging, bleaching the sporulated oocysts, washing the bleached oocysts, concentrating the sterile washed oocysts and combining the concentrates of various species of coccidial oocysts, and producing a vaccine. The method in whole or in part can be applied to other kinds of encysted protozoa to produce vaccines for various types of animals.
摘要翻译： 一种用于通过包括从粪便悬浮液获得球虫卵囊，粪便悬浮液均质化，通过使用硫酸钠的盐浮选或使用空气气浮法从粪便碎片中分离卵囊的方法产生的针对禽类球虫病的疫苗的疫苗， 使用过氧化氢和空气喷射的卵囊，漂白孢子化的卵囊，洗涤漂白的卵囊，浓缩无菌洗涤的卵囊并组合各种球虫卵囊的浓缩物，并生产疫苗。 该方法全部或部分可应用于其他类型的包囊原生动物，以生产各种类型动物的疫苗。
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公开(公告)号：US20060269528A1
公开(公告)日：2006-11-30
申请号：US10492099
申请日：2002-10-17
摘要： A bioactive compound, or family of compounds, is biosynthesised by a cell using a plurality of enzymic activities. Host cells are provided that substantially lack the bioactivity, but possess at least a first one of the enzymic activities (or nucleic acid encoding a corresponding enzyme). The cells are transformed with nucleic acid expressible to provide at least a second enzymic activity which enables the cells to produce a bioactive compound. A family of cells may be transformed with a multiplicity of different nucleic acids, leading to a library of cells including cells producing different bioactive product, and cells not producing bioactive products. Transformed cells may be screened for bioactivity. Active cells may be isolated and cultured, and bioactive compounds may be isolated.
摘要翻译： 生物活性化合物或化合物家族由细胞使用多种酶活性生物合成。 提供了基本上缺乏生物活性但具有至少第一种酶活性（或编码相应酶的核酸）的宿主细胞。 用可表达的核酸转化细胞以提供使细胞产生生物活性化合物的至少第二酶活性。 可以用多种不同的核酸转化细胞家族，导致细胞文库，包括产生不同生物活性产物的细胞，以及不产生生物活性产物的细胞。 可以筛选转化细胞的生物活性。 可以分离和培养活性细胞，并且可以分离生物活性化合物。
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3.发明授权公开(公告)号：US06248579B1
公开(公告)日：2001-06-19
申请号：US09372934
申请日：1999-08-12
IPC分类号： C12N120
CPC分类号： C12N15/76 , C12N9/88 , C12P17/181 , C12P19/62 , C12P19/623
摘要： The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.
摘要翻译： 本发明涉及包含编码aveC基因产物的核苷酸序列的多核苷酸分子，所述多核苷酸分子可用于改变阿维链霉菌发酵培养物中产生的2:1级阿凡曼菌素的比例或量。 本发明还涉及阿维链霉菌的载体，宿主细胞和突变菌株，其中aveC基因已被灭活，或突变以改变所产生的2:1级除虫菌素的比例或量。
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4.发明授权
公开(公告)号：US4767792A
公开(公告)日：1988-08-30
申请号：US16353
申请日：1987-02-19
IPC分类号： B01J21/04 , B01J23/30 , B01J23/83 , B01J23/888 , B01J37/02 , B01J37/08 , C07C1/04 , C07C5/27
CPC分类号： C07C1/0445 , B01J21/04 , B01J23/30 , B01J23/83 , B01J23/888 , B01J37/0207 , B01J37/08 , C07C1/044 , C07C5/2772 , C07C2521/04 , C07C2523/10 , C07C2523/30 , C07C2523/745 , C07C2523/83
摘要： A method of forming a support for use with a primary catalyst for conversion of a feed stream comprising carbon monoxide and hydrogen into hydrocarbons is disclosed.A primary catalyst and a method of manufacturing the catalyst is also disclosed.Furthermore, a secondary catalyst for the production of branched chain alkenes from straight chain alkenes is also disclosed, together with methods of manufacturing the secondary catalyst.
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公开(公告)号：US20050090461A1
公开(公告)日：2005-04-28
申请号：US10782257
申请日：2004-02-19
申请人： Peter Leadlay , James Staunton , Jesus Cortes , Hamish McArthur
发明人： Peter Leadlay , James Staunton , Jesus Cortes , Hamish McArthur
IPC分类号： A01H5/00 , A01K67/027 , A61K31/7042 , A61K31/7048 , A61P31/04 , C07H17/08 , C07K19/00 , C12N5/10 , C12N9/10 , C12N11/18 , C12N15/00 , C12N15/09 , C12N15/52 , C12P17/06 , C12P17/08 , C12P19/62
CPC分类号： C12N9/1029 , C07K2319/00 , C12N15/52 , C12P17/06 , C12P19/62
摘要： A polyketide synthase (“PKS”) of Type I is a complex multienzyme including a loading domain linked to a multiplicity of extension domains. The first extension module receives an acyl starter unit from the loading domain and each extension module adds a further ketide unit which may undergo processing (e.g. reduction). We have found that the Ksq domain possessed by some PKS's has decarboxylating activity, e.g. generating (substituted) acyl from (substituted) malonyl. The CLF domain of type II PKS's has similar activity. By inserting loading modules including such domains into PKS's not normally possessing them it is possible to control the starter units used.
摘要翻译： 类型I的聚酮化合物合酶（“PKS”）是复合多酶，其包括连接到多个延伸结构域的加载结构域。 第一扩展模块从加载域接收酰基起始单元，并且每个延伸模块加入可进行处理（例如还原）的另外的酮化单元。 我们发现一些PKS拥有的Ksq结构域具有脱羧活性，例如 从（取代的）丙二酰基产生（取代的）酰基。 II型PKS的CLF域具有类似的活动。 通过将包括这种域的加载模块插入通常不拥有它们的PKS，可以控制所使用的起动单元。
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6.发明授权公开(公告)号：US06833263B2
公开(公告)日：2004-12-21
申请号：US10306249
申请日：2002-11-27
IPC分类号： C12N988
CPC分类号： C12N15/76 , C12N9/88 , C12P17/181 , C12P19/62 , C12P19/623
摘要： The present invention relates to polynucleotide molecules comprising sequences encoding avec gene products, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of Streptomyces avermitilis. AveC genes, homologs and partial homologs thereof are described for S. avermitilis , S. hygroscopicus, and S. griseochromogenes, respectively. The present invention further relates to vectors, host cells, and mutant strains of Streptomyces avermitilis in which the avec gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.
摘要翻译： 本发明涉及包含编码avec基因产物的序列的多核苷酸分子，该多核苷酸分子可用于改变在阿维链霉菌的发酵培养物中产生的2:1级除虫菌素的比例或量。 AveC基因，同系物及其部分同系物分别描述了阿维链霉菌，吸湿链霉菌和灰质葡萄球菌。 本发明还涉及阿维链霉菌（Streptomyces avermitilis）的载体，宿主细胞和突变菌株，其中avec基因已被灭活或突变以改变所产生的2:1级除虫菌素的比例或量。
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7.发明授权Methods related to Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins 失效与阿维链霉菌基因相关的方法指导B2：B1阿凡曼菌素比例公开(公告)号：US07029887B2
公开(公告)日：2006-04-18
申请号：US10306247
申请日：2002-11-27
IPC分类号： C12N9/00
CPC分类号： C12N15/76 , C12N9/88 , C12P17/181 , C12P19/62 , C12P19/623
摘要： The present invention relates to polynucleotide molecules comprising sequences encoding avec gene products, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of Streptomyces avermitilis. AveC genes, homologs and partial homologs thereof are described for S. avermitilis, S. hygroscopicus, and S. griseochromogenes, respectively. The present invention further relates to vectors, host cells, and mutant strains of Streptomyces avermitilis in which the avec gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.
摘要翻译： 本发明涉及包含编码avec基因产物的序列的多核苷酸分子，该多核苷酸分子可用于改变在阿维链霉菌的发酵培养物中产生的2:1级除虫菌素的比例或量。 AveC基因，同系物及其部分同系物分别描述了阿维链霉菌，吸湿链霉菌和灰质葡萄球菌。 本发明还涉及阿维链霉菌（Streptomyces avermitilis）的载体，宿主细胞和突变菌株，其中avec基因已被灭活或突变以改变所产生的2:1级除虫菌素的比例或量。
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8.发明申请公开(公告)号：US20050196777A1
公开(公告)日：2005-09-08
申请号：US11011960
申请日：2004-12-14
申请人： Hamish McArthur , Yoshihiro Katoh
发明人： Hamish McArthur , Yoshihiro Katoh
IPC分类号： C12N15/09 , A01N43/90 , C12N20060101 , C12N1/21 , C12N9/88 , C12N15/60 , C12N15/76 , C12P20060101 , C12P17/18 , C12P19/44 , C12P19/62 , C12R20060101 , C12R1/465 , C12Q1/68 , C07H21/04 , C12N9/10 , C12N15/74
CPC分类号： C12N15/76 , C12N9/88 , C12P17/181 , C12P19/62 , C12P19/623
摘要： The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.
摘要翻译： 本发明涉及包含编码aveC基因产物的核苷酸序列的多核苷酸分子，所述多核苷酸分子可用于改变阿维链霉菌发酵培养物中产生的2:1级阿凡曼菌素的比例或量。 本发明还涉及阿维链霉菌的载体，宿主细胞和突变菌株，其中aveC基因已被灭活，或突变以改变所产生的2:1级除虫菌素的比例或量。
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公开(公告)号：US06777543B2
公开(公告)日：2004-08-17
申请号：US10441347
申请日：2003-05-19
申请人： Yong-Jin Wu , Wei-Guo Su , Takushi Kaneko , Hamish McArthur
发明人： Yong-Jin Wu , Wei-Guo Su , Takushi Kaneko , Hamish McArthur
IPC分类号： C07H1708
CPC分类号： C07H17/08
摘要： The invention relates to compounds of the formula and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3, R4, R5, R17, Rf, A, X, and Y are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formulas 1, methods of using the compounds of formula 1 in the treatment of infections and methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及下式的化合物及其药学上可接受的盐，前药和溶剂化物，其中R 1，R 2，R 3，R 4，R 5，R 17，R A，X和Y如本文所定义。 本发明还涉及含有式1化合物，使用式1化合物治疗感染的方法和制备式1化合物的方法的药物组合物。
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公开(公告)号：US4610975A
公开(公告)日：1986-09-09
申请号：US604655
申请日：1984-04-19
IPC分类号： B01J21/04 , B01J23/30 , B01J23/83 , B01J23/888 , B01J37/02 , B01J37/08 , C07C1/04 , C07C5/27 , B01J23/10 , B01J23/76
CPC分类号： C07C1/0445 , B01J21/04 , B01J23/30 , B01J23/83 , B01J23/888 , B01J37/0207 , B01J37/08 , C07C1/044 , C07C5/2772 , C07C2521/04 , C07C2523/10 , C07C2523/30 , C07C2523/745 , C07C2523/83
摘要： A method of forming a support for use with a primary catalyst for conversion of a feed stream comprising carbon monoxide and hydrogen into hydrocarbons is disclosed.A primary catalyst and a method of manufacturing the catalyst is also disclosed.Furthermore, a secondary catalyst for the production of branched chain alkenes from straight chain alkenes is also disclosed, together with methods of manufacturing the secondary catalyst.
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