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181 条记录 (耗时 0.031 秒)

    METHOD OF PRODUCING COMPOUND, COMPOUND, AND MIXTURE
    73.
    发明申请
    METHOD OF PRODUCING COMPOUND, COMPOUND, AND MIXTURE 审中-公开

    公开(公告)号：US20190144371A1

    公开(公告)日：2019-05-16

    申请号：US16099438

    申请日：2017-05-01

    申请人： ZEON CORPORATION

    发明人： Kei SAKAMOTO ,  Kumi OKUYAMA

    IPC分类号： C07C67/52 ,  C07C67/14 ,  C07C67/08

    摘要： Disclosed is a method of producing a compound which includes: obtaining a reaction product which contains a monoester compound represented by the following formula (I) and 1,4-cyclohexanedicarboxylic acid dichloride and/or 1,4-cyclohexanedicarboxylic acid, by reacting in an organic solvent a hydroxy compound represented by the formula Q-OH (where Q represents organic group which may have a substituent) with 1,4-cyclohexanedicarboxylic acid dichloride and/or 1,4-cyclohexanedicarboxylic acid; and mixing the reaction product with an acidic aqueous solution, where A represents hydroxyl group or chlorine atom and Q is as defined above.

    Crystalline form of chlorogenic acid and preparation method thereof
    74.
    发明授权
    Crystalline form of chlorogenic acid and preparation method thereof 有权

    公开(公告)号：US10246401B2

    公开(公告)日：2019-04-02

    申请号：US15308034

    申请日：2014-05-16

    申请人： SICHUAN JIUZHANG BIOLOGICAL SCIENCE AND TECHNOLOGY CO., LTD.

    发明人： Jie Zhang ,  Liang Zhang ,  Wang Huang

    IPC分类号： C07C67/52 ,  C07C69/618 ,  C07C69/732

    摘要： Provided is a crystalline form of chlorogenic acid. The crystalline form is an orthorhombic crystal system, the space group is P212121, the cell parameters are a=7.7291 (2) Å, b=10.9808 (2) Å, and c=3.5334 (7) Å, α=β=γ=90.00°, Z=8, and the cell volume is 3100.65 (11) Å3. Also provided is a preparation method for the crystalline form. The present crystalline form has good stability and does not significantly change during storage for 48 months in a cool, dark place, and the various indices all meet the relevant requirements for active pharmaceutical ingredients. The crystallization process provided by the present invention can not only use raw materials having different purities to prepare the same crystalline form of chlorogenic acid, but can also significantly reduce solvent residue in the raw materials, thereby improving product safety.

    Crystalline ingenol mebutate
    76.
    发明授权
    Crystalline ingenol mebutate 有权
    结晶西葫芦mebutate

    公开(公告)号：US09440906B2

    公开(公告)日：2016-09-13

    申请号：US14182274

    申请日：2014-02-17

    申请人： LEO Laboratories Limited

    发明人： Steven Martin Ogbourne

    IPC分类号： C07C67/52 ,  C07C69/533 ,  A61K9/00 ,  A61K9/06

    CPC分类号： C07C67/52 ,  A61K9/0014 ,  A61K9/0034 ,  A61K9/06 ,  C07B2200/13 ,  C07C69/533 ,  C07C2603/86 ,  Y02A50/463

    摘要： The present invention relates to a novel crystalline form of ingenol mebutate, methods of preparation thereof, and to its use. More specifically, the invention relates to the conversion of amorphous ingenol mebutate (ingenol-3-angelate, PEP005) to a crystalline form, which was characterized by single crystal X-Ray crystallography (XRC), attenuated total reflectance Fourier transform infrared (FTIR-ATR) spectroscopy and Differential Scanning calorimetry (DSC).

    摘要翻译： 本发明涉及新戊烯酮甲酸酯的结晶形式，其制备方法及其用途。 更具体地说，本发明涉及以单结晶X射线晶体学（XRC），衰减全反射傅里叶变换红外（FTIR-3）为特征的无定形内酯酚酸酯（茚满醇-3-当归，PEP005）转化为结晶形式， ATR）光谱和差示扫描量热法（DSC）。

    CRYSTALLINE INGENOL MEBUTATE
    77.
    发明申请
    CRYSTALLINE INGENOL MEBUTATE 有权
    晶体金刚石粉末

    公开(公告)号：US20150025265A1

    公开(公告)日：2015-01-22

    申请号：US14182274

    申请日：2014-02-17

    申请人： LEO LABORATORIES LIMITED

    发明人： Steven Martin Ogbourne

    IPC分类号： C07C67/52

    CPC分类号： C07C67/52 ,  A61K9/0014 ,  A61K9/0034 ,  A61K9/06 ,  C07B2200/13 ,  C07C69/533 ,  C07C2603/86 ,  Y02A50/463

    摘要： The present invention relates to a novel crystalline form of ingenol mebutate, methods of preparation thereof, and to its use. More specifically, the invention relates to the conversion of amorphous ingenol mebutate (ingenol-3-angelate, PEP005) to a crystalline form, which was characterized by single crystal X-Ray crystallography (XRC), attenuated total reflectance Fourier transform infrared (FTIR-ATR) spectroscopy and Differential Scanning calorimetry (DSC).

    摘要翻译： 本发明涉及新戊烯酮甲酸酯的结晶形式，其制备方法及其用途。 更具体地说，本发明涉及以单结晶X射线晶体学（XRC），衰减全反射傅立叶变换红外（FTIR-3）为特征的无定形内酯酚酸酯（茚满醇-3-当归，PEP005）转化为结晶形式， ATR）光谱和差示扫描量热法（DSC）。

    Recovery method of pyrolysis product of resin
    78.
    发明授权
    Recovery method of pyrolysis product of resin 有权
    树脂热解产物的回收方法

    公开(公告)号：US08304573B2

    公开(公告)日：2012-11-06

    申请号：US12529725

    申请日：2008-03-07

    申请人： Akinobu Sasaki ,  Nobuyuki Kikuya ,  Takashi Ookubo ,  Masahiro Hayashida

    发明人： Akinobu Sasaki ,  Nobuyuki Kikuya ,  Takashi Ookubo ,  Masahiro Hayashida

    IPC分类号： C07C67/333 ,  C07C67/52 ,  C07C69/54

    CPC分类号： C08J11/12 ,  C07C67/333 ,  C08J2333/06 ,  C10G1/02 ,  Y02W30/703 ,  C07C69/54

    摘要： A method of recovering pyrolysis products of resin of the present invention includes cooling gaseous pyrolysis products generated from pyrolysis of the resin in a pyrolysis tank to recover the resin as liquid pyrolysis products. The method includes the following steps (1) to (4): (1) continuously feeding fluidization gas, heated solid particles, and a resin into the pyrolysis tank to fluidize the solid particles and the resin by the fluidization gas; (2) continuously feeding the resin into the pyrolysis tank from a position which is ½ or less of the height of a solid particle layer in the pyrolysis tank in a stationary state; (3) continuously discharging the solid particles from a position lower than the height of a feeding position of the resin; and (4) heating the discharged solid particles in a heating furnace and then feeding the heated solid particles into the pyrolysis tank.

    摘要翻译： 回收本发明树脂热解产物的方法包括冷却由热解槽中的树脂热分解产生的气态热解产物，以回收作为液体热解产物的树脂。 该方法包括以下步骤（1）至（4）：（1）将流化气体，加热的固体颗粒和树脂连续供入热解槽中，以使流化气体使固体颗粒和树脂流态化; （2）从处于静止状态的热解槽中的固体颗粒层的高度的1/2以下的位置将树脂连续进料到热解槽中; （3）从低于树脂供给位置的高度的位置连续排出固体颗粒; 和（4）在加热炉中加热排出的固体颗粒，然后将加热的固体颗粒进料到热解槽中。