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    FGF9 as a specific ligand for FGFR3
    792.
    发明申请
    FGF9 as a specific ligand for FGFR3 审中-公开
    FGF9作为FGFR3的特异性配体

    公开(公告)号：US20020193309A1

    公开(公告)日：2002-12-19

    申请号：US10212357

    申请日：2002-08-02

    Applicant: Yeda Research and Development Co., Ltd., an Israel corporation

    Inventor： Avner Yayon

    IPC: G01N033/567 ,  C12P021/02 ,  C12N005/06 ,  A61K038/18 ,  C07K014/50

    CPC classification number: G01N33/566 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/50 ,  C07K16/2863 ,  G01N33/53 ,  G01N33/56966 ,  G01N33/6887 ,  G01N33/74 ,  G01N2333/50 ,  G01N2333/9121

    Abstract: The present invention concerns fibroblast growth factor 9 (FGF9) as a high affinity ligand for fibroblast growth factor receptor 3 (FGFR3) which ligand is capable of binding and activating FGFR3 in a specific manner. The present invention is also directed to methods for detection of FGFR3 by utilizing FGF9, as well as to pharmaceutical compositions for modulating the activity of FGFR3 comprising as an active ingredient FGF9, antagonists thereof or FGF binding agents which are capable of neutralizing native circulating FGF9. The present invention further concerns novel recombinant mouse and chicken FGF9, expression vectors comprising these recombinant FGF9s and a transgenic animal transformed with said expression vectors.

    Abstract translation: 本发明涉及作为成纤维细胞生长因子受体3（FGFR3）的高亲和力配体的成纤维细胞生长因子9（FGF9），该配体能够以特异性方式结合并活化FGFR3。 本发明还涉及通过利用FGF9检测FGFR3的方法，以及用于调节FGFR3活性成分的药物组合物，其包含能够中和天然循环FGF9的活性成分FGF9，其拮抗剂或FGF结合剂。 本发明还涉及新型重组小鼠和鸡FGF9，包含这些重组FGF9的表达载体和用所述表达载体转化的转基因动物。

    Method and system for semantic appearance transfer using splicing ViT features
    799.
    发明授权
    Method and system for semantic appearance transfer using splicing ViT features 有权

    公开(公告)号：US12282696B2

    公开(公告)日：2025-04-22

    申请号：US18723429

    申请日：2022-12-18

    Applicant: Yeda Research and Development Co. Ltd.

    Inventor： Tali Dekel ,  Shai Bagon ,  Omer Bar Tal ,  Narek Tumanyan

    IPC: G06F3/14 ,  G06T7/11 ,  G06V10/54 ,  G06V10/56 ,  G06V10/74 ,  G06V20/70

    Abstract: Using a pre-trained and fixed Vision Transformer (ViT) model as an external semantic prior, a generator is trained given only a single structure/appearance image pair as input. Given two input images, a source structure image and a target appearance image, a new image is generated by the generator in which the structure of the source image is preserved, while the visual appearance of the target image is transferred in a semantically aware manner, so that objects in the structure image are “painted” with the visual appearance of semantically related objects in the appearance image. A self-supervised, pre-trained ViT model, such as a DINO-VIT model, is leveraged as an external semantic prior, allowing for training of the generator only on a single input image pair, without any additional information (e.g., segmentation/correspondences), and without adversarial training. The method may generate high quality results in high resolution (e.g., HD).

    PHOTODYNAMIC THERAPY SYSTEM AND METHOD
    800.
    发明申请
    PHOTODYNAMIC THERAPY SYSTEM AND METHOD 有权

    公开(公告)号：US20250082957A1

    公开(公告)日：2025-03-13

    申请号：US18726614

    申请日：2023-01-05

    Applicant: STEBA BIOTECH S.A. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

    Inventor： Zachary Sacks ,  Yaniv Cohen ,  Avigdor Scherz

    IPC: A61N5/06

    Abstract: An assembly, system, and method for photodynamic therapy (PDT) of a target tissue utilizing a delivery apparatus and a displacement control arrangement. The delivery apparatus comprises a flexible needle device with an elongated flexible tube having a fiber-receiving lumen, extendable in a proximal-distal direction along a delivery axis, and with a pointed, needle-like distal tip for penetrating said tissue. An optical fiber is insertable and axially displaceable within said lumen and couplable at its proximal end to a light source, emitting a PDT-effective light at a wavelength applicable for said PDT. The fiber's distal end portion has a light-diffusing section for emitting light from within the fiber in one or more directions and has one or more X-ray markers. The displacement-control arrangement is couplable to a proximal portion of the flexible needle device and to a proximal portion of the optical fiber accommodated within the flexible needle device with the proximal portion projecting out of the proximal end of the flexible needle device, and comprises an axial displacement arrangement configured for controlled axial displacement of said delivery apparatus. The delivery apparatus may also comprise a delivery catheter extending in a proximal-to-distal direction and has a working channel that can accommodate the flexible needle device.

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