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    Methods for targeting pulmonary diseases with agents that bind a target in pulmonary tissue
    81.
    发明授权
    Methods for targeting pulmonary diseases with agents that bind a target in pulmonary tissue 有权
    用于结合肺组织中靶标的试剂靶向肺部疾病的方法

    公开(公告)号：US08497244B2

    公开(公告)日：2013-07-30

    申请号：US13356228

    申请日：2012-01-23

    申请人： Rudolf M. T. de Wildt ,  Steve Holmes ,  Ian M. Tomlinson ,  Gregory P. Winter ,  Mary F. Fitzgerald ,  Justian Craig Fox ,  Armin Sepp ,  Jennifer Luckett ,  Benjamin P. Woolven

    发明人： Rudolf M. T. de Wildt ,  Steve Holmes ,  Ian M. Tomlinson ,  Gregory P. Winter ,  Mary F. Fitzgerald ,  Justian Craig Fox ,  Armin Sepp ,  Jennifer Luckett ,  Benjamin P. Woolven

    IPC分类号： A61K38/00

    CPC分类号： C07K16/2875 ,  A61K9/0043 ,  A61K9/007 ,  A61K39/3955 ,  C07K16/28 ,  C07K16/2878 ,  C07K2317/31 ,  C07K2317/569 ,  C07K2317/76

    摘要： Disclosed is the use of an agent (e.g., antibody fragment, antagonist, ligand, dAb monomer) that binds a target in pulmonary tissue for the manufacture of a long action or long therapeutic window formulation for local delivery to pulmonary tissue, and methods for administering an agent that binds a target in pulmonary tissue to a subject to produce a long therapeutic window in pulmonary tissue. The formulation is for, and the method comprises, administering locally to pulmonary tissue. Also disclosed is the use of antagonists of TNFR1 for the manufacture of a formulation or medicament for treating, preventing or suppressing lung inflammation or a respiratory disease, and methods of treating such diseases. Also disclosed are the use of agents a for the manufacture of a delivery device (e.g., inhaler, intranasal delivery device) for the treatment or prevention of lung inflammation or a respiratory disease, and a delivery device for the treatment or prevention of lung inflammation or a respiratory disease that contains an agent as described herein.

    摘要翻译： 公开了结合肺组织中的靶标以制备用于局部递送至肺组织的长效或长治疗窗口制剂的试剂（例如，抗体片段，拮抗剂，配体，dAb单体）的用途，以及用于施用 将肺组织中的靶标结合到受试者以在肺组织中产生长治疗窗的药剂。 该制剂用于，并且该方法包括局部给予肺组织。 还公开了使用TNFR1的拮抗剂来制造用于治疗，预防或抑制肺部炎症或呼吸系统疾病的制剂或药物，以及治疗这些疾病的方法。 还公开了使用试剂a来制造用于治疗或预防肺部炎症或呼吸系统疾病的输送装置（例如，吸入器，鼻内递送装置），以及用于治疗或预防肺部炎症或 包含本文所述的药剂的呼吸系统疾病。

    Compositions monovalent for CD28 binding and methods of use
    82.
    发明申请
    Compositions monovalent for CD28 binding and methods of use 审中-公开
    用于CD28结合的单价组合物和使用方法

    公开(公告)号：US20110097339A1

    公开(公告)日：2011-04-28

    申请号：US12456703

    申请日：2009-06-18

    申请人： Steven Holmes ,  Carrie Enever ,  Steven Grant ,  David Sansom

    发明人： Steven Holmes ,  Carrie Enever ,  Steven Grant ,  David Sansom

    IPC分类号： A61K39/395 ,  C07K16/28 ,  C07H21/00 ,  C12N15/63 ,  C12N5/10 ,  C12P21/02 ,  A61P11/06 ,  A61P37/08 ,  A61P35/00 ,  A61P31/00

    CPC分类号： C07K16/2896 ,  C07K16/2818 ,  C07K2317/569

    摘要： The disclosure relates to a monovalent polypeptide domain which specifically binds CD28, as well as to an antagonist of CD28, where the antagonist comprises a monovalent polypeptide domain which specifically binds CD28. This disclosure encompasses monovalent polypeptide domains comprising an antibody single variable domain that monovalently binds CD28. An antibody single variable domain that is monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a monovalent anti-CD28 antibody single variable domain consists of or comprises an antibody single variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the monovalent anti-CD28 antibody single variable domain is a human antibody single variable domain. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a monovalent anti-CD28 antibody single variable domain to the individual.

    摘要翻译： 本公开涉及特异性结合CD28的单价多肽结构域以及CD28拮抗剂，其中拮抗剂包含特异性结合CD28的单价多肽结构域。 本公开内容涵盖包含单价结合CD28的抗体单可变结构域的单价多肽结构域。 用于结合CD28的单价抗体单可变区可抑制CD28活性。 在一个方面，单价抗CD28抗体单可变结构域由一个方面组成或包含特异性结合和拮抗CD28的活性的抗体单可变结构域，而不具有实质上激动的CD28活性。 另一方面，单价抗CD28抗体单可变结构域是人抗体单可变结构域。 本公开还包括在个体中拮抗CD80和/或CD86相互作用的方法以及涉及CD80和/或CD86与CD28相互作用的疾病或病症的方法，涉及向单克隆抗CD28抗体单可变结构域施用的方法 个人。

    Methods of antagonizing binding of CD40 to CD40L with CD40L-specific monovalent polypeptides
    83.
    发明授权
    Methods of antagonizing binding of CD40 to CD40L with CD40L-specific monovalent polypeptides 有权
    拮抗CD40与CD40L与CD40L特异性单价多肽的结合的方法

    公开(公告)号：US07927596B2

    公开(公告)日：2011-04-19

    申请号：US12387423

    申请日：2009-05-01

    申请人： Steven Grant ,  Haiqun Liu ,  Kevin Moulder

    发明人： Steven Grant ,  Haiqun Liu ,  Kevin Moulder

    IPC分类号： A61K39/395 ,  C07K16/28

    CPC分类号： C07K16/2875 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/76

    摘要： The invention relates to antibody polypeptides that monovalently bind CD40L. Antibody polypeptides that are monovalent for binding of CD40L can inhibit CD40L activity while avoiding potential undesirable effects that can occur with antibodies capable of divalent or multivalent binding of DC40L. in one aspect, a monovalent anti-CD40L antibody polypeptide consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of DC40L, preferably without substantially agonizing CD40 activity. In another aspect, the monovalent anti-CD40L antibody polypeptide is a human antibody polypeptide. The invention further encompasses methods of antagonizing CD40/CD40L interactions in an individual and methods of treating diseases or disorders involving CD40/DC40L interactions, the methods involving administering a monovalent anti-CD40L antibody polypeptide to the individual.

    摘要翻译： 本发明涉及单价结合CD40L的抗体多肽。 CD40L结合的一价抗体多肽可以抑制CD40L活性，同时避免可能发生在能够进行DC40L二价或多价结合的抗体的潜在的不良作用。 在一个方面，单价抗CD40L抗体多肽由特异性结合并拮抗DC40L的活性的单个免疫球蛋白可变区组成或包含，优选不具有实质上激动的CD40活性。 另一方面，单价抗CD40L抗体多肽是人抗体多肽。 本发明还包括拮抗个体中CD40 / CD40L相互作用的拮抗作用的方法以及治疗涉及CD40 / DC40L相互作用的疾病或病症的方法，涉及向个体施用单价抗CD40L抗体多肽的方法。

    Monovalent anti-CD40L antibody polypeptides and compositions thereof
    87.
    发明授权
    Monovalent anti-CD40L antibody polypeptides and compositions thereof 有权
    单价抗CD40L抗体多肽及其组合物

    公开(公告)号：US07563443B2

    公开(公告)日：2009-07-21

    申请号：US11102512

    申请日：2005-04-08

    申请人： Steven Grant ,  Haiqun Liu ,  Kevin Moulder

    发明人： Steven Grant ,  Haiqun Liu ,  Kevin Moulder

    IPC分类号： A61K39/395 ,  C07K16/28

    CPC分类号： C07K16/2875 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/76

    摘要： The invention relates to antibody polypeptides that monovalently bind CD40L. Antibody polypeptides that are monovalent for binding of CD40L can inhibit CD40L activity while avoiding potential undesirable effects that can occur with antibodies capable of divalent or multivalent binding of CD40L. In one aspect, a monovalent anti-CD40L antibody polypeptide consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD40L, preferably without substantially agonizing CD40 activity. In another aspect, the monovalent anti-CD40L antibody polypeptide is a human antibody polypeptide. The invention further encompasses methods of antagonizing CD40/CD40L interactions in an individual and methods of treating diseases or disorders involving CD40/CD40L interactions, the methods involving administering a monovalent anti-CD40L antibody polypeptide to the individual.

    摘要翻译： 本发明涉及单价结合CD40L的抗体多肽。 针对CD40L结合的单价抗体多肽可以抑制CD40L活性，同时避免可能与能够进行CD40L二价或多价结合的抗体发生的不良反应。 在一个方面，单价抗CD40L抗体多肽由特异性结合并拮抗CD40L的活性的单个免疫球蛋白可变区组成或包含，优选不具有实质上激动的CD40活性。 另一方面，单价抗CD40L抗体多肽是人抗体多肽。 本发明还包括拮抗个体中CD40 / CD40L相互作用的拮抗作用的方法以及治疗涉及CD40 / CD40L相互作用的疾病或病症的方法，涉及向个体施用单价抗CD40L抗体多肽的方法。