公开(公告)号：US11110084B2

公开(公告)日：2021-09-07

申请号：US17142673

申请日：2021-01-06

申请人： Camurus AB

发明人： Fredrik Tiberg ,  Ian Harwigsson ,  Markus Johnsson

IPC分类号： A61K31/4748 ,  A61K31/485 ,  A61K47/10 ,  A61K47/24 ,  A61K47/34 ,  A61K9/00 ,  A61K47/14

摘要： A depot precursor formulation comprising:
a) a controlled-release matrix;
b) at least oxygen containing organic solvent;
c) at least 12% by weigh of at least one active agent selected from buprenorphine and salts thereof, calculated as buprenorphine free base.
Corresponding depot compositions and methods of treatment in pain management, by opioid maintenance and related methods are provided.

公开(公告)号：US11104915B2

公开(公告)日：2021-08-31

申请号：US15754598

申请日：2016-09-09

申请人： Trizell Ltd.

发明人： Nigel Parker ,  Hanna P. Lesch ,  Jenni Mykkanen ,  Sara Paulo ,  Minna Hassinen ,  Robert Shaw

IPC分类号： C12N15/86 ,  G01N33/50 ,  G01N33/569

摘要： A process for assaying viral vector manufactured by large-scale viral vector manufacturing processes to assure the resulting vector has acceptable purity and potency. The process entails three different types of assays, each one of which is optionally useful on a stand-alone basis, and which together provide the first system able to assure the quality of viral vector produced by large-scale vector manufacturing processes.

公开(公告)号：US11098061B2

公开(公告)日：2021-08-24

申请号：US16194577

申请日：2018-11-19

申请人： Celgene CAR LLC

发明人： Matthew David Alexander ,  Joseph John McDonald ,  Yike Ni ,  Deqiang Niu ,  Russell C. Petter ,  Lixin Qiao ,  Juswinder Singh ,  Tao Wang ,  Zhendong Zhu

IPC分类号： C07D487/04 ,  C07D519/00 ,  C07D213/74 ,  C07D213/75 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12 ,  C07D471/04 ,  C07D471/14 ,  C07D471/20 ,  C07D487/10 ,  C07D495/04 ,  C07D495/14 ,  A61K47/64 ,  C12N9/12 ,  C12N9/96 ,  C12N9/99 ,  G01N33/573

摘要： The present invention provides compounds of formula V: or pharmaceutically acceptable salts thereof, useful as inhibitors of MK2 kinases, compositions thereof, and methods of using the same.

公开(公告)号：US11091547B2

公开(公告)日：2021-08-17

申请号：US15526309

申请日：2015-11-12

申请人： Memorial Sloan Kettering Cancer Center ,  The General Hospital Corporation

发明人： Soldano Ferrone ,  Nai-Kong V. Cheung ,  Ming Cheng

IPC分类号： C07K16/00 ,  C07H21/04 ,  C12N5/12 ,  C07K16/28 ,  C07K16/30 ,  C07K16/44 ,  A61K39/00

摘要： Described herein are antibodies that bind chondroitin sulfate proteoglycan 4 (CSPG4) and, in particular, chimeric and humanized anti-CSPG4 antibodies and fragments thereof. Also provided herein are methods of using individual humanized antibodies or compositions thereof for the detection, prevention, and/or therapeutic treatment of CSPG4-related diseases, in particular, melanoma.

公开(公告)号：US11088007B1

公开(公告)日：2021-08-10

申请号：US16869152

申请日：2020-05-07

申请人： X-Celeprint Limited

发明人： Alin Mihai Fecioru

IPC分类号： H01L21/683

摘要： A component structure comprises a substrate and a sacrificial layer comprising a sacrificial material disposed on or in the substrate. The sacrificial layer defines sacrificial portions laterally spaced apart by anchors. A component is disposed entirely over each sacrificial portion and connected to at least one anchor by a tether. A spacer comprising a spacer material is disposed in or on the sacrificial portion at least partially between the tether and the substrate. For at least one etchant, the spacer material etches faster than the sacrificial material when exposed to the etchant.

公开(公告)号：US11065350B2

公开(公告)日：2021-07-20

申请号：US16845372

申请日：2020-04-10

申请人： Memorial Sloan Kettering Cancer Center

发明人： Mark Dunphy ,  Gabriela Chiosis

IPC分类号： A61K51/04 ,  A61P35/00 ,  A61K49/00 ,  A61B5/00 ,  A61K31/52 ,  A61B5/318 ,  A61B5/0275 ,  A61B5/08 ,  A61B6/03 ,  A61B6/00 ,  A61K49/18

摘要： The present invention provides new methods for inflammation and infection imaging and related medical applications thereof. In some embodiments, the present invention provides a method for the diagnosis of inflammation and/or infection. In some embodiments, the present invention provides a method for the treatment or prevention of inflammation and/or infection. In some embodiments, the present invention provides methods for monitoring the effect of inflammation and/or infection treatment, and/or methods for monitoring an inflammation and/or infection treatment regimen. In some embodiments, the present invention provides a method for selecting subjects for an inflammation and/or infection treatment. In some embodiments, the present invention provides a method for determining the dosage of a drug for the treatment of inflammation and/or infection.

公开(公告)号：US11059969B2

公开(公告)日：2021-07-13

申请号：US16151576

申请日：2018-10-04

申请人： Saudi Aramco Technologies Company

发明人： Scott D. Allen ,  Christopher A. Simoneau ,  Jay J. Farmer

IPC分类号： C08L69/00 ,  C08G64/02 ,  C08G64/42 ,  B32B17/10 ,  C08G18/44 ,  C08K7/14 ,  C08L61/06

摘要： The present invention encompasses polymer compositions comprising aliphatic polycarbonate chains containing functional groups that increase the polymer's ability to wet or adhere to inorganic materials. In certain embodiments, chain ends of the aliphatic polycarbonates are modified to introduce silicon-containing functional groups, boron-containing functional groups, phosphorous-containing functional groups, sulfonic acid groups or carboxylic acid groups.

公开(公告)号：US11051498B2

公开(公告)日：2021-07-06

申请号：US16209820

申请日：2018-12-04

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Andrew J. Murphy ,  Lynn Macdonald ,  Chunguang Guo ,  John McWhirter

IPC分类号： A01K67/027 ,  C07K16/00 ,  C07K16/46 ,  C12N9/12

摘要： Non-human animals (and/or non-human cells) and methods of using the same are provided, which non-human animals (and/or non-human cells) have a genome comprising human antibody-encoding sequences (i.e., immunoglobulin genes). Non-human animals described herein express antibodies that contain immunoglobulin (Ig) light chains characterized by the presence of human Vλ domains. Non-human animals provided herein are, in some embodiments, characterized by expression of antibodies that contain human Vλ light chains that are encoded by human Igλ light chain-encoding sequences inserted into an endogenous Igκ light chain locus of said non-human animals. Methods for producing antibodies from non-human animals are also provided, which antibodies contain human variable regions and mouse constant regions.

公开(公告)号：US11047204B2

公开(公告)日：2021-06-29

申请号：US16797538

申请日：2020-02-21

申请人： Saudi Arabian Oil Company

发明人： Sergei Kozodeev ,  Pavel Golikov

IPC分类号： E21B33/138 ,  C09K8/40 ,  C09K8/50 ,  C09K8/42

摘要： An example method includes pumping fluid into a wellbore to fill, at least partly, a region in a lost circulation zone, with the fluid having a first density; and after pumping the fluid, pumping cement slurry into the wellbore. The cement slurry has a second density. The first density is greater than, or equal to, the second density, which causes the fluid to prevent, at least partly, the cement slurry from mixing with other fluid in the lost circulation zone for at least a period of time.

公开(公告)号：US11046969B2

公开(公告)日：2021-06-29

申请号：US15603894

申请日：2017-05-24

申请人： EPIPLANTA BIOTECH LTD.

发明人： Guifang Jia ,  Chuan He

IPC分类号： C12N15/82 ,  A01H4/00

摘要： The present invention is directed to a transgenic plant and a method for producing the same. In particular, the present invention is directed to a transgenic plant or a plant cell in which a nucleic acid molecule encoding an m6A demethylase is introduced, wherein said m6A demethylase has the following two domains: i) N-terminal domain (NTD) having the function of AlkB oxidation demethylase; and ii) C-terminal domain (CTD). The present invention is also directed to a method for producing said plant, comprising introducing a nucleic acid molecule encoding an m6A demethylase into a regenerable plant cell, and regenerating a transgenic plant from the regenerable plant cell.