公开(公告)号：US11084627B2

公开(公告)日：2021-08-10

申请号：US15313467

申请日：2015-06-10

Applicant: CYTIVA SWEDEN AB

Inventor： Ralph Stankowski ,  Michael Miller

IPC: B65D30/20 ,  B65D33/02 ,  B65D33/16 ,  B65D75/00

Abstract: The invention discloses a plastic bag comprising: at least one longitudinal end weld, wherein the end weld comprises an elongate transversely-oriented weld bounded by a first pair and a second pair of coterminous oblique welds extending along an oblique angle from the first and second ends of transversely-oriented weld, respectively, such that each pair of oblique welds forms a first and second apex, respectively, adjacent its respective end of the transversely-oriented weld, a first and second planar gusset attached to the bag along or within the first and second pair of oblique welds so as to overlie the first and second apex, respectively.

公开(公告)号：US20210239662A1

公开(公告)日：2021-08-05

申请号：US16975324

申请日：2019-02-20

Applicant: Cytiva Sweden AB

Inventor： Jens Widehammar ,  Key Hyckenberg ,  Orjan Grelsson ,  Lars Mattsson ,  Kjell Karlsson

IPC: G01N30/86

Abstract: The present invention relates to a liquid chromatography system (90) configured to operate with at least one column and configured for purification of a sample comprising a target product using a predefined process. The liquid chromatography system comprises a controller (91) configured to: control the operation of the chromatography system to run the predefined process; retrieve column data accessible from a data storage, the column data being specific to each column; and adapt at least one process parameter of the predefined process for each column based on column data. Whereby the predefined process is adapted to each column to obtain the target product and maintain the performance of the liquid chromatography system.

公开(公告)号：US20210222681A1

公开(公告)日：2021-07-22

申请号：US16645022

申请日：2018-09-06

Applicant: Cytiva Sweden AB

Inventor： Andreas Torbjorn Lundin ,  Klas Marteleur ,  Mats Lundkvist ,  Andreas Marcstrom ,  David Gronowitz

IPC: F04B1/047 ,  F04B43/02

Abstract: A multiple cavity reciprocating positive displacement pump (200) comprises a plurality of pump cavities (222), each pump cavity (222) including at least an inlet valve (228) and an outlet valve (231), wherein respective inlet valves (228) are in fluid communication with a common inlet (224) and respective outlet valves (231) are in fluid communication with a common outlet (238), and wherein the pump cavities (222) are arranged about a pump axis (AR) and around said common inlet (224) and said common outlet (238).

公开(公告)号：US10954939B2

公开(公告)日：2021-03-23

申请号：US15769818

申请日：2016-10-28

Applicant: Cytiva Sweden AB

Inventor： Andreas Torbjorn Lundin

IPC: F04C2/08 ,  F04C15/00 ,  F04C2/18

Abstract: Disclosed is a gear pump (10) comprising a contra rotating gear element pair (30 and 40) mounted within a housing (20), each gear element having complementary gear teeth sets providing a pumping action in use, said teeth being formed from an annulus (34 and 44) of generally rigid construction mounted on a relatively flexible inner section (35 and 45), the gear pair being mounted such that their respective annuli are biased into resilient contact with the housing to provide a sliding seal.

公开(公告)号：US20210062923A1

公开(公告)日：2021-03-04

申请号：US16981114

申请日：2019-03-21

Applicant: Cytiva Sweden AB

Inventor： Klaus Gebauer

IPC: F16K7/04 ,  F16K7/12 ,  F16K31/12 ,  F16K31/122 ,  F16K31/126

Abstract: A method for controlling at least one valve provided to a tube in a bioprocess flow system, said method comprising the steps of: —controlling the at least one valve to be in a first state, which is an open state when a flow through the tube should be allowed; —controlling the at least one valve to be in a second state during some parts of a process run in the system, said second state is a closed state were a first closing force is provided; and—controlling the at least one valve to be in a third state during some parts of a process run in the system, said third state is a closed state were a second closing force is provided which is a higher force than the first closing force.

公开(公告)号：US10927344B2

公开(公告)日：2021-02-23

申请号：US15574003

申请日：2016-05-27

Applicant: Cytiva Sweden AB

Inventor： Karin Molleryd ,  Karin Wernersson ,  Sarah Marie Stone ,  Claudia Nune ,  Rolf Kiessling ,  Tanja Lovgren ,  Lars Adamsson ,  Ulrica Eistrand

IPC: C12N5/0783 ,  A61K35/17 ,  A61K35/12

Abstract: The present invention relates to cell culture in bioreactors, such as flexible cellbag bioreactors. More specifically the present invention relates to methods for simplifying the production of clinically relevant cell products for use in cell therapy.

公开(公告)号：US12280168B2

公开(公告)日：2025-04-22

申请号：US17437097

申请日：2020-03-23

Applicant: Cytiva Sweden AB

Inventor： Johan Avallin ,  Anna Gronberg ,  Anders Nilsson ,  Henrik Ingvarsson ,  Linda Persson ,  Magnus Asplund ,  Reinhard Braaz

IPC: A61L2/18 ,  B01D15/20 ,  B01D15/38 ,  G01N30/50 ,  G01N30/56 ,  G01N30/60 ,  A61L101/36

Abstract: The invention discloses a method for sanitization of a bioprocess chromatography column, comprising the steps of: a) providing a bioprocess chromatography column with a packed bed of separation resin particles and a movable adapter, b) with the adapter in contact with the packed bed, conveying a sanitization fluid through the packed bed to a column outlet; c) raising the adapter to provide a gap between the packed bed and the adapter, d) lowering the adapter to close the gap; and e) conveying an equilibration liquid through the packed bed to a column outlet.

公开(公告)号：US20250092349A1

公开(公告)日：2025-03-20

申请号：US18962844

申请日：2024-11-27

Applicant: Cytiva Sweden AB

Inventor： Praveen Paul ,  Prashanth Hosabettu Mohan ,  Ajay Gore ,  Sahebagouda Alagur

IPC: C12M1/00 ,  B01D61/12 ,  B01D61/22 ,  C12M1/34

Abstract: A perfusion bioprocessing system (10) includes a bioreactor (12) and a recirculation flow path (14) provided with at least one first feed flow control device (46) and at least one second feed control device (48). The perfusion bioprocessing system (10) further includes a first tangential flow filter (16) coupled to the bioreactor (12) via the recirculation flow path (14) and a second tangential flow filter (18) coupled to the bioreactor (12) via the recirculation flow path (14). The first tangential flow filter and the second tangential flow filter are coupled to a permeate flow path and a retentate flow path.

公开(公告)号：US20250032998A1

公开(公告)日：2025-01-30

申请号：US18834983

申请日：2023-02-02

Applicant: Cytiva Sweden AB

Inventor： Martina Lorenzetti ,  Rodrigo Hernan-Dez Vera ,  Johan Alriksson

IPC: B01D69/10 ,  B01D69/02 ,  B01D69/12 ,  B29C64/124 ,  B29C64/30 ,  B29L31/14 ,  B33Y10/00 ,  B33Y40/20 ,  B33Y80/00

Abstract: A printed porous structure (500) fabricated using a multi-step absorption, MSA, process, said printed porous structure (500) comprising a support layer (520) that supports a filtration membrane (510), wherein said support layer (520) and said filtration membrane (510) are integrally formed.

公开(公告)号：US12196726B2

公开(公告)日：2025-01-14

申请号：US17767795

申请日：2020-10-15

Applicant: Cytiva Sweden AB

Inventor： Stephan Menzel

IPC: G01N30/02 ,  G01N15/08

Abstract: Disclosed is a system and a method for testing at least one filtration device. The system comprises a chromatography system (3) comprising at least one pair of inlet and outlet chromatography column connections (7a), 7b for at least one chromatography column, and at least one filtration device housing (21) comprising a filtration device (23) to be tested, whereby each filtration device housing (21) is connected to one of the at least one pair of inlet and outlet chromatography column connections (7a, 7b) instead of a chromatography column in the chromatography system.