公开(公告)号：US08637700B2

公开(公告)日：2014-01-28

申请号：US13120561

申请日：2009-10-30

Applicant: Sang Min Yun ,  Dong Jin Hong ,  Weon Ki Yang ,  Jae Ho Yoo ,  Ji Sook Kim ,  Moon Sub Lee ,  Han Kyong Kim ,  Eun Jung Lim ,  Young Ho Moon ,  Young-Kil Chang ,  Gwan Sun Lee

Inventor： Sang Min Yun ,  Dong Jin Hong ,  Weon Ki Yang ,  Jae Ho Yoo ,  Ji Sook Kim ,  Moon Sub Lee ,  Han Kyong Kim ,  Eun Jung Lim ,  Young Ho Moon ,  Young-Kil Chang ,  Gwan Sun Lee

IPC: C07D319/08 ,  C07D305/08

CPC classification number: C07D305/12 ,  C07C51/09 ,  C07C51/353 ,  C07C59/29 ,  C07C59/72

Abstract: The present invention relates to a high-yield method for preparing highly pure (3S,4S)-4-((R)-2-(benzyloxy)tridecyl)-3-hexyl-2-oxetanone using a metal salt of (2S,3S,5R)-2-hexyl-3,5-dihydroxyhexadecanoic acid as an intermediate.

Abstract translation: 本发明涉及使用（2S，4S）-4 - （（R）-2-（苄氧基）十三烷基）-3-己基-2-氧杂环丁酮的金属盐制备高纯度 3S，5R）-2-己基-3,5-二羟基十六烷酸作为中间体。

公开(公告)号：US08569491B2

公开(公告)日：2013-10-29

申请号：US13501414

申请日：2010-09-15

Applicant: Jae Heon Lee ,  Gha Seung Park ,  Jin Hee Kim ,  Tae Jin Choi ,  Ji Eun Lee ,  Jung Hee Han ,  Hyo Jeong Bang ,  Sun Young Jung ,  Young Kil Chang ,  Gwan Sun Lee ,  Maeng Sup Kim

Inventor： Jae Heon Lee ,  Gha Seung Park ,  Jin Hee Kim ,  Tae Jin Choi ,  Ji Eun Lee ,  Jung Hee Han ,  Hyo Jeong Bang ,  Sun Young Jung ,  Young Kil Chang ,  Gwan Sun Lee ,  Maeng Sup Kim

IPC: C07D473/00

CPC classification number: C07D473/04

Abstract: Disclosed are a novel, high-yield method for preparing entecavir and intermediates used therein.

Abstract translation: 公开了用于制备恩替卡韦和中间体的新颖的高产率方法。

公开(公告)号：US08513426B2

公开(公告)日：2013-08-20

申请号：US12914032

申请日：2010-10-28

Applicant: Tae Hee Ha ,  Hee Sook Oh ,  Won Jeoung Kim ,  Chang Hee Park ,  Eun Young Kim ,  Young Hoon Kim ,  Kwee Hyun Suh ,  Gwan Sun Lee

Inventor： Tae Hee Ha ,  Hee Sook Oh ,  Won Jeoung Kim ,  Chang Hee Park ,  Eun Young Kim ,  Young Hoon Kim ,  Kwee Hyun Suh ,  Gwan Sun Lee

IPC: C07D401/12

CPC classification number: C07D401/12

Abstract: Disclosed are a crystalline S-omeprazole strontium hydrate for the prevention or treatment of gastric acid-related diseases, which has high optical purity, theremostability, solubility and nonhygroscopicity, a method for preparing same, and a pharmaceutical composition containing same.

公开(公告)号：US08426599B2

公开(公告)日：2013-04-23

申请号：US12674118

申请日：2008-10-01

Applicant: Chul-Hyun Park ,  Eun-Ju Park ,  Choong-Hahn Kim ,  Suk Man Jang ,  Eun Jung Lim ,  Young Kil Chang ,  Gwan Sun Lee ,  Jaeheon Lee

Inventor： Chul-Hyun Park ,  Eun-Ju Park ,  Choong-Hahn Kim ,  Suk Man Jang ,  Eun Jung Lim ,  Young Kil Chang ,  Gwan Sun Lee ,  Jaeheon Lee

IPC: C07D215/14

CPC classification number: C07D215/18

Abstract: The present invention relates to a method for preparing Montelukast acid or its sodium salt by reacting a thiol compound with a Montelukast intermediate in the presence of a base in a medium comprising an ionic liquid compound. In accordance with the inventive method, highly pure Montelukast acid or its sodium salt, which is advantageously used as a raw material in the preparation of Montelukast, a leukotriene antagonist, can be easily prepared in a high yield.

Abstract translation: 本发明涉及一种通过在含有离子液体化合物的培养基中，在碱存在下使硫醇化合物与孟鲁司特中间体反应制备蒙特鲁卡斯特酸或其钠盐的方法。 根据本发明的方法，可以容易地以高产率制备高纯度的蒙特鲁卡斯特酸或其钠盐，其有利地用作孟鲁司特钠制剂中的原料，白细胞三烯拮抗剂。

公开(公告)号：US08263084B2

公开(公告)日：2012-09-11

申请号：US12744660

申请日：2008-11-28

Applicant: Dae Hae Song ,  Min Young Kim ,  Young Jin Park ,  Eun Hee Kang ,  Sung Youb Jung ,  Se Chang Kwon ,  Gwan Sun Lee

Inventor： Dae Hae Song ,  Min Young Kim ,  Young Jin Park ,  Eun Hee Kang ,  Sung Youb Jung ,  Se Chang Kwon ,  Gwan Sun Lee

IPC: A61K39/395 ,  A61P5/50

CPC classification number: C07K19/00 ,  A61K47/6811 ,  A61K47/6813 ,  A61K47/6835 ,  C07K2319/30

Abstract: The present invention relates to a composition for treating obesity-related diseases comprising an insulinotropic peptide conjugate, more particularly, to a composition for treating obesity-related diseases comprising a conjugate prepared by covalently linking the insulinotropic peptide with a carrier substance via a non-peptidyl linker, and a method for treating obesity-related diseases by using the same. In particular, the composition for treating obesity-related diseases according to the present invention remarkably improves the efficacy of suppressing food intake and its duration to reduce body weight and body fat, thereby being useful for the treatment of obesity-related diseases.

Abstract translation: 本发明涉及一种用于治疗肥胖相关疾病的组合物，其包括促胰岛素肽缀合物，更具体地，涉及用于治疗肥胖相关疾病的组合物，其包含通过非肽基共价连接促胰岛素肽与载体物质而制备的缀合物 接头，以及通过使用它们来治疗肥胖相关疾病的方法。 特别地，本发明的治疗肥胖相关疾病的组合物显着地提高了抑制食物摄取的效果及其减轻体重和体脂的持续时间，从而可用于治疗肥胖相关疾病。

公开(公告)号：US08163889B2

公开(公告)日：2012-04-24

申请号：US12603757

申请日：2009-10-22

Applicant: Young-Min Kim ,  Dae-Jin Kim ,  Sung-Min Bae ,  Chang-Ki Lim ,  Se-Chang Kwon ,  Gwan-Sun Lee

Inventor： Young-Min Kim ,  Dae-Jin Kim ,  Sung-Min Bae ,  Chang-Ki Lim ,  Se-Chang Kwon ,  Gwan-Sun Lee

IPC: C07K16/00

CPC classification number: C07K16/00 ,  A61K47/60 ,  A61K47/643 ,  A61K47/6811 ,  A61K47/6883

Abstract: A protein conjugate having a prolonged in vivo half-life of a physiological activity, comprising i) a physiologically active polypeptide, ii) a non-peptidic polymer, and iii) an immunoglobulin, is useful for the development of a polypeptide drug due to the enhanced in vivo stability and prolonged half-life in blood, while reducing the possibility of inducing an immune response.

Abstract translation: 具有延长的生理活性的体内半衰期的蛋白质缀合物，其包含i）生理活性多肽，ii）非肽聚合物和iii）免疫球蛋白，可用于开发多肽药物，因为 增强血液中的体内稳定性和延长的半衰期，同时降低诱导免疫应答的可能性。

公开(公告)号：US08110665B2

公开(公告)日：2012-02-07

申请号：US12759801

申请日：2010-04-14

Applicant: Young Min Kim ,  Dae Hae Song ,  Sung Youb Jung ,  Chang Hwan Kim ,  In Young Choi ,  Se Chang Kwon ,  Gwan Sun Lee

Inventor： Young Min Kim ,  Dae Hae Song ,  Sung Youb Jung ,  Chang Hwan Kim ,  In Young Choi ,  Se Chang Kwon ,  Gwan Sun Lee

IPC: C07K16/00

CPC classification number: C07K19/00 ,  A61K47/6811 ,  A61K47/6813 ,  A61K47/6835 ,  A61K2039/505 ,  C07K16/241 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2319/30

Abstract: Disclosed is a novel use of an immunoglobulin Fc fragment, and more particularly, a pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier. The pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier remarkably extends the serum half-life of a drug while maintaining the in vivo activity of the drug at relatively high levels. Also, when the drug is a polypeptide drug, the pharmaceutical composition has less risk of inducing immune responses compared to a fusion protein of the immunoglobulin Fc fragment and a target protein, and is thus useful for developing long-acting formulations of various polypeptide drugs.

Abstract translation: 公开了免疫球蛋白Fc片段的新用途，更具体地，涉及包含免疫球蛋白Fc片段作为载体的药物组合物。 包含作为载体的免疫球蛋白Fc片段的药物组合物显着延长了药物的血清半衰期，同时保持药物的体内活性在相对高的水平。 此外，当药物是多肽药物时，与免疫球蛋白Fc片段和靶蛋白质的融合蛋白相比，药物组合物诱导免疫应答的风险较小，因此可用于开发各种多肽药物的长效制剂。

公开(公告)号：US08003658B2

公开(公告)日：2011-08-23

申请号：US11722096

申请日：2005-12-20

Applicant: Young Jin Ham ,  Ji Hyeon Gong ,  Mi Young Cha ,  Jong Woo Kim ,  Maeng Sup Kim ,  Eun Young Kim ,  Ji Yeon Song ,  Chang In Kim ,  Se Young Kim ,  Gwan Sun Lee

Inventor： Young Jin Ham ,  Ji Hyeon Gong ,  Mi Young Cha ,  Jong Woo Kim ,  Maeng Sup Kim ,  Eun Young Kim ,  Ji Yeon Song ,  Chang In Kim ,  Se Young Kim ,  Gwan Sun Lee

IPC: A61K31/517 ,  C07D239/72

CPC classification number: C07D403/12 ,  C07D239/94 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

Abstract: The present invention relates to a novel quinazoline derivative and a pharmaceutically acceptable salt thereof for inhibiting the growth of cancer cells, a method for the preparation thereof and a pharmaceutical composition comprising same as an active ingredient.

Abstract translation: 本发明涉及用于抑制癌细胞生长的新型喹唑啉衍生物及其药学上可接受的盐，其制备方法和包含该活性成分的药物组合物。

公开(公告)号：US20110071262A1

公开(公告)日：2011-03-24

申请号：US12993336

申请日：2009-05-19

Applicant: Pyeong-uk Park ,  Seong-Nyun Kim ,  Woo-Hyuk Choi ,  Hak-Sun Jang ,  Gwan-Sun Lee ,  Se-Chang Kwon

Inventor： Pyeong-uk Park ,  Seong-Nyun Kim ,  Woo-Hyuk Choi ,  Hak-Sun Jang ,  Gwan-Sun Lee ,  Se-Chang Kwon

IPC: C08G65/48

CPC classification number: C08G65/326 ,  C08G65/323 ,  C08G65/324 ,  C08G65/3312 ,  C08G65/33317 ,  C08G65/33337 ,  C08G65/33365 ,  C08G65/33368 ,  C08G65/3346 ,  C08G65/337 ,  C08G65/338

Abstract: A method for preparing high-purity polyethyleneglycol-alkylenealdehydes and derivatives thereof is provided.

Abstract translation: 提供了制备高纯度聚乙二醇 - 亚烷基醛及其衍生物的方法。

公开(公告)号：US20100120888A1

公开(公告)日：2010-05-13

申请号：US12524807

申请日：2008-01-21

Applicant: Eun Sook Kim ,  Sun Young Jang ,  Bo Sung Kwon ,  Sangmin Yun ,  Kwee Hyun Suh ,  Gwan Sun Lee

Inventor： Eun Sook Kim ,  Sun Young Jang ,  Bo Sung Kwon ,  Sangmin Yun ,  Kwee Hyun Suh ,  Gwan Sun Lee

IPC: A61K31/40 ,  C07D207/323 ,  A61P3/06 ,  A61P3/00

CPC classification number: C07D207/416

Abstract: This invention provides atorvastatin strontium salt or its hydrates or polymorphs having improved water solubility, which is useful for the prevention or treatment of hyperlipidemia and hypercholesterolemia, and a pharmaceutical composition comprising same.

Abstract translation: 本发明提供了可用于预防或治疗高脂血症和高胆固醇血症的具有改善的水溶性的阿托伐他汀锶盐或其水合物或多晶型物，以及包含其的药物组合物。