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81.发明申请CARDIAC CONTRACTION DETECTION USING INFORMATION INDICATIVE OF LEAD MOTION 有权使用指示铅运动的信息进行CARDIAC承包检测公开(公告)号：US20110319776A1
公开(公告)日：2011-12-29
申请号：US13168507
申请日：2011-06-24
IPC分类号： A61B5/0245 , A61B5/042 , A61N1/365
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods for cardiac contraction detection using information indicative of lead motion are described. In an example, an implantable medical device can include a receiver circuit configured to be electrically coupled to conductor comprising a portion of an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The device can include a processor circuit configured to determine whether a cardiac mechanical contraction occurred during a specified interval included in the obtained information indicative of the movement of the implantable lead. The processor circuit can be configured to determine information about the cardiac mechanical contraction using the obtained information indicative of the movement of the implantable lead.
摘要翻译： 描述使用指示引导运动的信息进行心脏收缩检测的系统和方法。 在一个示例中，可植入医疗设备可以包括被配置为电耦合到导体的接收器电路，该导体包括可植入引线的一部分，并被配置为获得指示可植入引线的运动的信息，至少部分地由 一个心脏。 该装置可以包括处理器电路，该处理器电路被配置为确定在所获得的指示可植入引线的运动的信息中包括的指定间隔期间是否发生心脏机械收缩。 处理器电路可以被配置为使用获得的指示可植入引线的移动的信息来确定关于心脏机械收缩的信息。
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82.发明授权公开(公告)号：US08007442B2
公开(公告)日：2011-08-30
申请号：US12703533
申请日：2010-02-10
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.
摘要翻译： 一种用远程位置加速度计监测S1心音的可植入装置和方法。 该装置包括将心音转换为电信号的换能器。 控制电路耦合到换能器。 控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。 控制电路还从电信息生成形态数据。 形态学数据涉及血流动力学指标，如左心室收缩力。 壳体可以包围控制电路。 壳体限定与壳体的外表面共同延伸的体积。 传感器位于由外壳限定的体积中。
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83.发明授权Monitoring of chronobiological rhythms for disease and drug management using one or more implantable device 有权使用一个或多个可植入装置监测疾病和药物管理的计时生理节律公开(公告)号：US08005540B2
公开(公告)日：2011-08-23
申请号：US12836441
申请日：2010-07-14
申请人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
发明人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
IPC分类号： A61N1/02
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G06F19/00
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译： 使用至少一个可植入装置自动评估或预测受试者的健康状况。 在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。 也可以使用昼夜节律以外的其他时间生理节律。 可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。 预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。 还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。
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公开(公告)号：US20110077543A1
公开(公告)日：2011-03-31
申请号：US12964902
申请日：2010-12-10
IPC分类号： A61B5/02
CPC分类号： A61B7/04 , A61B7/00 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36585 , A61N1/368
摘要： A system and method provide heart sound tracking, including an input circuit, configured to receive heart sound information, and a heart sound recognition circuit. The heart sound recognition circuit can be coupled to the input circuit and can be configured to recognize, within a particular heart sound of a particular heart sound waveform, a first intra heart sound energy indication and a corresponding first intra heart sound time indication using the heart sound information from the particular heart sound waveform and the heart sound information from at least one other heart sound waveform. The particular heart sound can include at least a portion of one of S1, S2, S3, and S4. Further, the first intra heart sound energy indication and the corresponding first intra heart sound time indication can correspond to the at least a portion of one of S1, S2, S3, and S4, respectively.
摘要翻译： 一种系统和方法提供心脏跟踪，包括被配置为接收心脏声音信息的输入电路和心脏声音识别电路。 心脏声音识别电路可以耦合到输入电路，并且可以被配置为在特定心脏声音波形的特定心脏声音内识别第一心脏心脏声能指示和使用心脏的对应的第一心脏心脏音频指示 来自特定心脏声音波形的声音信息和来自至少一个其他心脏声音波形的心脏声音信息。 特定的心音可以包括S1，S2，S3和S4中的一个的至少一部分。 此外，第一心内心音能量指示和对应的第一心脏心音时间指示可以分别对应于S1，S2，S3和S4中的一个的至少一部分。
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公开(公告)号：US20110015702A1
公开(公告)日：2011-01-20
申请号：US12835288
申请日：2010-07-13
CPC分类号： A61N1/36139 , A61B5/0255 , A61B5/0816 , A61B5/0823 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61B2562/043 , A61N1/36053 , A61N1/36114 , A61N1/36117 , A61N1/36578
摘要： An embodiment uses an accelerometer to sense heart sounds, and determines heart rate info nation using the sensed heart sounds. An embodiment uses an accelerometer to sense respiratory activity. An embodiment delivers a programmed neural stimulation therapy with a programmed duty cycle, where the programmed duty cycle includes a stimulation ON portion followed by a stimulation OFF portion. An electrode electrically connected to the implanted neural stimulation device is used to remotely detect cardiac activity. The remotely detected cardiac activity is used to detect heart rate information during the stimulation ON portion and to detect heart rate information during the stimulation OFF portion. The detected heart rate information and/or the detected respiration information are used to control a neural stimulation therapy performed by the neural stimulator device and/or are used to provide diagnostic information for the patient's condition.
摘要翻译： 一个实施例使用加速度计来感测心脏声音，并且使用所感测到的心脏声音来确定心率信息国家。 一个实施例使用加速计来感测呼吸活动。 实施例以编程的占空比递送编程的神经刺激疗法，其中编程的占空比包括刺激开启部分，随后是刺激关闭部分。 电连接到植入的神经刺激装置的电极用于远程检测心脏活动。 远程检测到的心脏活动用于在刺激ON部分期间检测心率信息，并在刺激OFF部分期间检测心率信息。 检测到的心率信息和/或检测到的呼吸信息用于控制由神经刺激器装置执行的神经刺激治疗和/或用于提供患者状况的诊断信息。
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公开(公告)号：US20110009914A1
公开(公告)日：2011-01-13
申请号：US12886328
申请日：2010-09-20
IPC分类号： A61N1/36
CPC分类号： A61N1/3727 , A61B5/02405 , A61B5/4035 , A61B5/4839 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N1/362 , A61N1/37264
摘要： Described herein are methods and devices that utilize electrical neural stimulation to treat heart failure by modulating a patient's autonomic balance in a manner that inhibits sympathetic activity and/or augments parasympathetic activity. Because other therapies for treating heart failure may also affect a patient's autonomic balance, a device for delivering neural stimulation is configured to appropriately titrate such therapy in either an open-loop or closed-loop fashion.
摘要翻译： 本文描述了利用电神经刺激来以抑制交感神经活动和/或增加副交感神经活动的方式调节患者的自主神经平衡来治疗心力衰竭的方法和装置。 因为用于治疗心力衰竭的其它治疗也可能影响患者的自主平衡，用于递送神经刺激的装置被配置为以开环或闭环方式适当地滴定这种治疗。
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公开(公告)号：US07853327B2
公开(公告)日：2010-12-14
申请号：US11736055
申请日：2007-04-17
IPC分类号： A61N1/365
CPC分类号： A61B7/04 , A61B7/00 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36585 , A61N1/368
摘要： A system and method provide heart sound tracking, including an input circuit, configured to receive heart sound information, and a heart sound recognition circuit. The heart sound recognition circuit can be coupled to the input circuit and can be configured to recognize, within a particular heart sound of a particular heart sound waveform, a first intra heart sound energy indication and a corresponding first intra heart sound time indication using the heart sound information from the particular heart sound waveform and the heart sound information from at least one other heart sound waveform. The particular heart sound can include at least a portion of one of S1, S2, S3, and S4. Further, the first intra heart sound energy indication and the corresponding first intra heart sound time indication can correspond to the at least a portion of one of S1, S2, S3, and S4, respectively.
摘要翻译： 一种系统和方法提供心脏跟踪，包括被配置为接收心脏声音信息的输入电路和心脏声音识别电路。 心脏声音识别电路可以耦合到输入电路，并且可以被配置为在特定心脏声音波形的特定心脏声音内识别第一心脏心脏声能指示和使用心脏的对应的第一心脏心脏音频指示 来自特定心脏声音波形的声音信息和来自至少一个其他心脏声音波形的心脏声音信息。 特定的心音可以包括S1，S2，S3和S4中的一个的至少一部分。 此外，第一心内心音能量指示和对应的第一心脏心音时间指示可以分别对应于S1，S2，S3和S4中的一个的至少一部分。
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公开(公告)号：US20100222653A1
公开(公告)日：2010-09-02
申请号：US12776557
申请日：2010-05-10
IPC分类号： A61B5/00
CPC分类号： A61B5/00 , A61B5/053 , A61B5/746 , A61B7/023 , A61N1/3627 , A61N1/36514
摘要： Systems and methods using constant false alarm rate techniques for event detection. One example of an event detection method includes collecting a first distribution of measurements for a first physiological parameter. In another example, the first distribution of measurements includes only non-event measurements. One or more values are determined corresponding to at least a first tail area of the first distribution from at least one measurement of the first physiological parameter toward an end point of the distribution. A threshold is established based on a specified false alarm rate. The one or more values are compared to the threshold. The method includes determining if the measurement is representative of a detected event using the comparison.
摘要翻译： 用于事件检测的常数误报率技术的系统和方法。 事件检测方法的一个示例包括收集第一生理参数的测量的第一分布。 在另一示例中，测量的第一分布仅包括非事件测量。 从第一生理参数的至少一个测量到分布的终点，确定对应于第一分布的至少第一尾区的一个或多个值。 基于指定的虚警率建立阈值。 将一个或多个值与阈值进行比较。 该方法包括使用比较来确定测量是否表示检测到的事件。
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89.发明授权Monitoring of chronobiological rhythms for disease and drug management using one or more implantable device 有权使用一个或多个可植入装置监测疾病和药物管理的计时生理节律公开(公告)号：US07764996B2
公开(公告)日：2010-07-27
申请号：US11554986
申请日：2006-10-31
申请人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
发明人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
IPC分类号： A61B5/00
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G06F19/00
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译： 使用至少一个可植入装置自动评价或预测受试者的健康状况。 在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。 也可以使用昼夜节律以外的其他时间生理节律。 可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。 预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。 还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。
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公开(公告)号：US07713213B2
公开(公告)日：2010-05-11
申请号：US11276735
申请日：2006-03-13
IPC分类号： A61B5/02
CPC分类号： A61B5/00 , A61B5/053 , A61B5/746 , A61B7/023 , A61N1/3627 , A61N1/36514
摘要： Systems and methods using constant false alarm rate techniques for event detection. One example of an event detection method includes collecting a first distribution of measurements for a first physiological parameter. In another example, the first distribution of measurements includes only non-event measurements. One or more values are determined corresponding to at least a first tail area of the first distribution from at least one measurement of the first physiological parameter toward an end point of the distribution. A threshold is established based on a specified false alarm rate. The one or more values are compared to the threshold. The method includes determining if the measurement is representative of a detected event using the comparison.
摘要翻译： 用于事件检测的常数误报率技术的系统和方法。 事件检测方法的一个示例包括收集第一生理参数的测量的第一分布。 在另一示例中，测量的第一分布仅包括非事件测量。 从第一生理参数的至少一个测量到分布的终点，确定对应于第一分布的至少第一尾区的一个或多个值。 基于指定的虚警率建立阈值。 将一个或多个值与阈值进行比较。 该方法包括使用比较来确定测量是否表示检测到的事件。
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