公开(公告)号：US20230202725A1

公开(公告)日：2023-06-29

申请号：US17998755

申请日：2021-05-14

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Slavi MIRTCHEV ,  Noel LAWRENCE ,  Manish KOCHAR

IPC: B65D51/24 ,  B65D43/02 ,  B65D43/26 ,  G01N35/00 ,  B01L3/00

CPC classification number: B65D51/243 ,  B65D43/0214 ,  B65D43/26 ,  G01N35/0099 ,  B01L3/50853 ,  B65D2543/00296 ,  B65D2543/00333 ,  B65D2543/0037 ,  B65D2543/00824 ,  B01L2200/026 ,  B01L2300/044

Abstract: Automation compatible removable lids are provided. The removable lids include a top surface surrounded by a peripheral rim. The removable lids further include septal portions configured to receive an extractor, such as a pipette tip, inserted therethrough. The septal portions are further configured to grip the extractor to facilitate lid removal.

公开(公告)号：US11686013B2

公开(公告)日：2023-06-27

申请号：US16971752

申请日：2019-02-22

Applicant: Meso Scale Technologies, LLC.

Inventor： Ka Y. Kwong ,  Ilia V. Davydov

IPC: C40B30/04 ,  C07K16/00 ,  C07K16/26 ,  C12N15/10

CPC classification number: C40B30/04 ,  C07K16/005 ,  C07K16/26 ,  C12N15/1037

Abstract: The invention provides singleplex and multiplex assays for screening of antigen-binding molecules for their affinity to antigens by normalizing for the concentration of the antigen-binding molecule.

公开(公告)号：US20230020070A1

公开(公告)日：2023-01-19

申请号：US17849917

申请日：2022-06-27

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： John KENTEN ,  George SIGAL ,  Alexander K. TUCKER-SCHWARTZ

IPC: G01N21/64 ,  C07F15/00 ,  C12Q1/6816 ,  G01N21/66 ,  G01N33/533 ,  G01N33/58

Abstract: The invention relates to methods, compositions, kits, and assay systems for assay signal amplification. Also provided herein is a signal amplification reagent, wherein the signal amplification reagent is an antibody or antigen-binding fragment thereof.

公开(公告)号：US20220404360A1

公开(公告)日：2022-12-22

申请号：US17749716

申请日：2022-05-20

Applicant: Meso Scale Technologies, LLC.

Inventor： George SIGAL ,  Seth B. HARKINS ,  Timothy J. BREAK

IPC: G01N33/569 ,  C12Q1/6818 ,  G16B25/10 ,  G16B30/00

Abstract: The invention relates to methods and kits for determining a SARS-CoV-2 strain in a sample. The invention also provides methods and kits for detecting a single nucleotide polymorphism (SNP) in a target nucleic acid, wherein the target nucleic acid is a SARS-CoV-2 nucleic acid. The invention further provides methods and kits for detecting one or more antibody biomarkers in a sample.

公开(公告)号：US20220341843A1

公开(公告)日：2022-10-27

申请号：US17733036

申请日：2022-04-29

Applicant: Meso Scale Technologies, LLC.

Inventor： Nicholas ANDERSON ,  Jeffery DEBAD ,  Eli N. GLEZER ,  Sudeep KUMAR ,  Noel LAWRENCE ,  Kenneth PAGE ,  George SIGAL ,  Sharon WEST

IPC: G01N21/05 ,  G01N21/69 ,  G01N21/76 ,  B01L3/00 ,  G01N21/03 ,  G01F23/02 ,  G01F23/292 ,  G01N1/10

Abstract: Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, thy reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.

公开(公告)号：US20220161968A1

公开(公告)日：2022-05-26

申请号：US17534773

申请日：2021-11-24

Applicant: Meso Scale Technologies, LLC. ,  Merrill's Packaging, Inc.

Inventor： Nataliya Lavrykova-Marrain ,  Jonathan Vu Tran ,  Kevin Scott

IPC: B65D25/10 ,  B65D43/16 ,  B65D85/44

Abstract: The disclosure is directed to a package for containing a plurality of substantially rectangular assay plates, each plate having a peripheral flange. In one embodiment, the package comprises a cavity having extending therein one or more sloped buttress elements spaced across at least a portion of a top corner, and one or more adjacent protrusions extending from the bottom and at least partially up one or both sidewalls, each set of protrusions forming grooves therebetween into which fit the flanges of respective assay plates. The package can comprise a transparent polymer through which product information located on the assay plates can be read or scanned.

公开(公告)号：US20220145363A1

公开(公告)日：2022-05-12

申请号：US17453991

申请日：2021-11-08

Applicant: MESO SCALE TECHNOLOGIES, LLC. ,  The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. ,  The United States of America,as represented by the Secretary,Department of Health and Human Services

Inventor： Christopher CAMPBELL ,  Kimbra KENNEY ,  Jessica GILL

IPC: C12Q1/686 ,  C12Q1/6853 ,  G01N27/327 ,  G01N21/76

Abstract: The invention relates to methods and kits for assessing brain injury, e.g., traumatic brain injury resulting from blast exposure. The invention provides methods of quantifying the amount of phosphorylated tau or total tau in a biological sample. The invention further provides a method of determining the number of blast exposures experienced by a subject. Also provided herein are kits for detecting phosphorylated tau or total tau in a biological sample.

公开(公告)号：US20220018785A1

公开(公告)日：2022-01-20

申请号：US17363758

申请日：2021-06-30

Applicant: Meso Scale Technologies, LLC.

Inventor： Alexander K. TUCKER-SCHWARTZ ,  George SIGAL

IPC: G01N21/76 ,  G01N33/58 ,  G01N33/543

Abstract: The invention relates to novel compositions comprising an electrochemiluminescence (ECL) co-reactant. In embodiments, the composition further comprises an ionic component, a surfactant, or combination thereof. In embodiments, the ECL co-reactant is triethanolamine (TEA), tert-butyldiethanolamine (tBDEA), methyldibutylethanolamine (MDEA), 3-[Bis-(2-hydroxy-ethyl)-amino]-propane-1-sulfonic acid (DEA-PS), or a combination thereof. Methods of using the compositions and kits comprising the compositions are also provided herein.

公开(公告)号：US20220003766A1

公开(公告)日：2022-01-06

申请号：US17246360

申请日：2021-04-30

Applicant: Meso Scale Technologies, LLC.

Inventor： Jacob N. WOHLSTADTER ,  George SIGAL ,  Anu MATHEW ,  Anastasia AKSYUK ,  David ROUTENBERG ,  Martin STENGELIN ,  John KENTEN ,  Timothy J. BREAK ,  Seth B. HARKINS ,  Michael TSIONSKY

IPC: G01N33/569 ,  C12Q1/70

Abstract: The invention relates to methods and kits for detecting a virus, e.g., a respiratory virus such as a coronavirus, in a biological sample. The invention also relates to methods and kits for detecting and/or quantifying biomarkers, e.g., antibody biomarkers against a viral antigen; inflammatory and/or tissue damage response biomarkers; and/or extracellular vesicles in response to a viral infection.

公开(公告)号：US20210382043A1

公开(公告)日：2021-12-09

申请号：US17287341

申请日：2019-10-23

Applicant: Meso Scale Technologies, LLC.

Inventor： David ROUTENBERG ,  Alexander K. TUCKER-SCHWARTZ ,  Sigal SHACHAR

IPC: G01N33/543 ,  C12Q1/6834 ,  C12N15/10

Abstract: The invention relates to method and kits for highly specific isolation of surface marker displaying agents by targeting at least two surface markers. The invention further relates to methods and kits for analyzing surface marker displaying agents and their contents.