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公开(公告)号:US20230021837A1
公开(公告)日:2023-01-26
申请号:US17779900
申请日:2020-11-25
发明人: Anu MATHEW , Mingyue WANG , Christopher CAMPBELL , Katarzyna HAYNESWORTH , Nikhil PADMANABHAN , Martin STENGELIN , Paridhi GUPTA , Rashmi SRIRAM
IPC分类号: G01N33/564 , G01N33/543
摘要: The invention relates to assay methods and kits for assessing autoimmune diseases in a human subject. In embodiments, the present disclosure provides assay methods and kits for diagnosing a subject with or predicting that a subject will develop Type 1 diabetes. In embodiments, the present disclosure provides assay methods and kits for assessing responsiveness of a subject having Type 1 diabetes to treatment with alefacept. In embodiments, the present disclosure provides assay methods and kits for diagnosing a subject with systemic lupus erythematosus. In embodiments, the present disclosure provides assay methods and kits for determining if a subject is at risk of a systemic lupus erythematosus flare. In embodiments, the present disclosure provides assay methods and kits for diagnosing a subject with celiac disease.
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公开(公告)号:US20230184768A1
公开(公告)日:2023-06-15
申请号:US17997267
申请日:2021-04-30
发明人: Jacob N. WOHLSTADTER , George SIGAL , Anu MATHEW , James WILBUR , Jeffery DEBAD , Christopher CAMPBELL , Hans BIEBUYCK , Priscilla KRAI , Alan KISHBAUGH , Leonid DZANTIEV , Christopher SHELBURNE , Pu LIU , Paul GOODWIN
IPC分类号: G01N33/569 , G01N33/68
CPC分类号: G01N33/56983 , G01N33/6854 , G01N2333/11 , G01N2333/165 , G01N2469/20
摘要: The invention relates to methods and kits for detecting a virus, e.g., a respiratory virus such as a coronavirus, in a biological sample. The invention also relates to methods and kits for detecting and/or quantifying biomarkers, e.g., antibody biomarkers against a viral antigen; inflammatory and/or tissue damage response biomarkers; and/or extracellular vesicles in response to a viral infection.
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公开(公告)号:US20240347167A1
公开(公告)日:2024-10-17
申请号:US18595584
申请日:2024-03-05
申请人: MESO SCALE TECHNOLOGIES, LLC. , THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
发明人: William F. BLAKELY , Eli N. GLEZER , John H. KENTEN , Sudeep KUMAR , Anu MATHEW , Natalia I. OSSETROVA , George SIGAL
CPC分类号: G16H20/40 , G01N27/3273 , G01N33/6893 , G01N35/00 , G01T1/00 , G01T1/02 , G01N2333/70535 , G01N2333/70578 , G01N2800/40 , G01N2800/60
摘要: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
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公开(公告)号:US20220003766A1
公开(公告)日:2022-01-06
申请号:US17246360
申请日:2021-04-30
发明人: Jacob N. WOHLSTADTER , George SIGAL , Anu MATHEW , Anastasia AKSYUK , David ROUTENBERG , Martin STENGELIN , John KENTEN , Timothy J. BREAK , Seth B. HARKINS , Michael TSIONSKY
IPC分类号: G01N33/569 , C12Q1/70
摘要: The invention relates to methods and kits for detecting a virus, e.g., a respiratory virus such as a coronavirus, in a biological sample. The invention also relates to methods and kits for detecting and/or quantifying biomarkers, e.g., antibody biomarkers against a viral antigen; inflammatory and/or tissue damage response biomarkers; and/or extracellular vesicles in response to a viral infection.
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公开(公告)号:US20210349104A1
公开(公告)日:2021-11-11
申请号:US17246364
申请日:2021-04-30
申请人: Meso Scale Technologies, LLC. , The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人: Jacob N. WOHLSTADTER , George SIGAL , Anu MATHEW , James WILBUR , Jeffery DEBAD , Christopher CAMPBELL , Hans BIEBUYCK , Priscilla KRAI , Alan KISHBAUGH , Leonid DZANTIEV , Christopher SHELBURNE , Pu LIU , Paul GOODWIN , Adrian MCDERMOTT , Sarah O'CONNELL , Sandeep NARPALA
IPC分类号: G01N33/68
摘要: The invention relates to methods and kits for detecting a virus, e.g., a respiratory virus such as a coronavirus, in a biological sample. The invention also relates to methods and kits for detecting and/or quantifying biomarkers, e.g., antibody biomarkers against a viral antigen; inflammatory and/or tissue damage response biomarkers; and/or extracellular vesicles in response to a viral infection.
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