公开(公告)号：US10105059B2

公开(公告)日：2018-10-23

申请号：US15594053

申请日：2017-05-12

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01J3/00 ,  A61B5/00 ,  A61B5/1455 ,  G01J3/10 ,  G01J3/28 ,  G01J3/453 ,  G01N21/359 ,  G01J3/14 ,  A61B5/145 ,  G01N33/15 ,  G01N33/49 ,  G01N21/3563 ,  G01N21/39 ,  G01N33/02 ,  G01N33/44 ,  G01N21/88 ,  G01J3/42 ,  G01J3/02 ,  H01S3/30 ,  G01J3/18 ,  G01M3/38 ,  G01J3/12 ,  G01N21/35 ,  G01N21/85 ,  G01N21/95 ,  H01S3/067 ,  H01S3/00

Abstract: A wearable device for measuring physiological parameters includes a light source having a plurality of semiconductor light emitting diodes (LEDs) each configured to generate an output optical beam, wherein at least a portion of the one or more optical beam wavelengths is a near-infrared wavelength. The light source is configured to increase signal-to-noise ratio by increasing light intensity for at least one of the LEDs and by increasing a pulse rate of at least one of the LEDs. A lens is configured to receive the output optical beam and to deliver a lens output beam to tissue. A detection system generates an output signal in response to the lens output beam reflected from the tissue, wherein the detection system is configured to be synchronized to the light source, and is located a different distance from a first one of the LEDs than a second one of the LEDs.

公开(公告)号：US20180120280A1

公开(公告)日：2018-05-03

申请号：US15855201

申请日：2017-12-27

Applicant: Omni Medsci, Inc.

Inventor： Mohammed N. ISLAM

IPC: G01N33/15 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/145 ,  G01J3/10 ,  G01J3/28 ,  G01J3/453 ,  G01N21/359 ,  G01N21/3563 ,  G01N21/39 ,  G01N21/88 ,  G01N33/02 ,  G01N33/44 ,  G01N33/49

CPC classification number: G01N33/15 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/0088 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/3504 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/88 ,  G01N33/02 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3513 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  H01S3/302

Abstract: A measurement system includes a light source having semiconductor sources configured to generate an input optical beam, a multiplexer configured form an intermediate optical beam from the input optical beam, fibers including a fused silica fiber configured to receive the intermediate optical beam and to form an output optical beam. The output optical beam comprises wavelengths between 700 and 2500 nanometers with a bandwidth of at least 10 nanometers. A measurement apparatus is configured to deliver the output beam to a sample to generate a spectroscopy output beam. A receiver is configured to receive and process the spectroscopy output beam to generate an output signal, wherein the receiver processing includes chemometrics or multivariate analysis methods to permit identification of materials within the sample, the light source and the receiver are remote from the sample, and the sample includes plastics or food industry goods.

公开(公告)号：US20170367585A1

公开(公告)日：2017-12-28

申请号：US15686198

申请日：2017-08-25

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. ISLAM

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/10 ,  G01J3/28 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N33/49 ,  G01N33/44 ,  G01N33/15 ,  G01N33/02 ,  G01N21/88 ,  G01J3/453 ,  G01M3/38 ,  H01S3/30 ,  G01J3/14 ,  G01J3/18

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: A wearable device for use with a smart phone or tablet includes LEDs for measuring physiological parameters by modulating the LEDs and generating a near-infrared multi-wavelength optical beam. At least one LED emits at a first wavelength having a first penetration depth and at least another LED emits at a second wavelength having a second penetration depth into tissue. The device includes lenses that deliver the optical beam to the tissue, which reflects the first and second wavelengths. A receiver is configured to capture light while the LEDs are off and while at least one of the LEDs is on and to difference corresponding signals to improve a signal-to-noise ratio of the optical beam reflected from the tissue. The signal-to-noise ratio is further increased by increasing light intensity of at least one of the LEDs. The device generates an output signal representing a non-invasive measurement on blood within the tissue.

公开(公告)号：US20170336258A1

公开(公告)日：2017-11-23

申请号：US15662527

申请日：2017-07-28

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. ISLAM

IPC: G01J3/10 ,  G01J3/02 ,  G01J3/42 ,  G02B6/293 ,  G02F1/365 ,  H01S3/067 ,  H01S3/094 ,  H01S3/30 ,  G01B9/02 ,  H01S5/14 ,  H01S5/10 ,  H01S5/00 ,  H01S5/40 ,  H01S3/102 ,  G02F1/35

CPC classification number: G01J3/108 ,  G01B9/02091 ,  G01J3/0218 ,  G01J3/0245 ,  G01J3/42 ,  G01J2003/102 ,  G01J2003/423 ,  G02B6/29349 ,  G02F1/365 ,  G02F2001/3528 ,  G02F2202/32 ,  H01S3/06725 ,  H01S3/06754 ,  H01S3/094007 ,  H01S3/094069 ,  H01S3/094076 ,  H01S3/1024 ,  H01S3/302 ,  H01S5/0064 ,  H01S5/0085 ,  H01S5/0092 ,  H01S5/1092 ,  H01S5/146 ,  H01S5/4012 ,  H01S2301/085

Abstract: A super continuum light source includes an input light source having semiconductor diodes generating an input beam having a wavelength shorter than 2.5 microns. Optical amplifiers receive the input beam and form an amplified optical beam having a spectral width. The optical amplifiers may include a cladding-pumped fiber amplifier doped with rare-earth materials. A nonlinear element may include mid-infrared fibers to receive the amplified optical beam and to broaden the spectral width of the received amplified optical beam to 100 nm or more through a nonlinear effect forming an output beam, wherein the output beam is pulsed. At least a portion of the output beam is in a mid-infrared wavelength range between 2 microns and 5 microns and at least a portion of the one or more mid-infrared fibers comprises a ZBLAN fluoride fiber coupled to a chalcogenide fiber.

公开(公告)号：US20160363482A1

公开(公告)日：2016-12-15

申请号：US15248230

申请日：2016-08-26

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. ISLAM

IPC: G01J3/10 ,  G01J3/02 ,  G01B9/02 ,  H01S3/067 ,  H01S5/00 ,  H01S5/40 ,  H01S5/14 ,  H01S3/094 ,  G01J3/42 ,  G02F1/365

CPC classification number: G01J3/108 ,  G01B9/02091 ,  G01J3/0218 ,  G01J3/0245 ,  G01J3/42 ,  G01J2003/102 ,  G01J2003/423 ,  G02B6/29349 ,  G02F1/365 ,  G02F2001/3528 ,  G02F2202/32 ,  H01S3/06725 ,  H01S3/06754 ,  H01S3/094007 ,  H01S3/094069 ,  H01S3/094076 ,  H01S3/1024 ,  H01S3/302 ,  H01S5/0064 ,  H01S5/0085 ,  H01S5/0092 ,  H01S5/1092 ,  H01S5/146 ,  H01S5/4012 ,  H01S2301/085

Abstract: A white light spectroscopy system includes a super continuum light source having an input light source including semiconductor diodes to generate an input beam having a wavelength shorter than 2.5 microns. The light source includes a cladding-pumped fiber optical amplifier to receive the input beam, and a photonic crystal fiber to receive the amplified optical beam to broaden the spectral width to 100 nm or more forming an output beam in the visible wavelength range. The output beam is pulsed with a repetition rate of 1 Megahertz or higher. The system also includes a lens and/or mirror to receive the output beam, to send the output beam to a scanning stage, and to deliver the received output beam to a sample. A detection system includes dispersive optics and narrow band filters followed by one or more detectors to permit approximately simultaneous measurement of at least two wavelengths from the sample.

Abstract translation: 白光光谱系统包括具有包括半导体二极管的输入光源的超连续光源，以产生波长短于2.5微米的输入光束。 光源包括用于接收输入光束的包层泵浦光纤放大器，以及用于接收放大的光束以将光谱宽度扩大到100nm或更大的光子晶体光纤，形成可见波长范围内的输出光束。 输出光束以1兆赫或更高的重复频率脉冲。 该系统还包括用于接收输出光束的透镜和/或反射镜，以将输出光束发送到扫描级，并将接收的输出光束传送到样品。 检测系统包括色散光学器件和窄带滤光器，随后是一个或多个检测器，以允许从样品大致同时测量至少两个波长。

公开(公告)号：US09494567B2

公开(公告)日：2016-11-15

申请号：US14650897

申请日：2013-12-17

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01J3/00 ,  G01N33/15 ,  A61B5/1455 ,  A61B5/00 ,  G01J3/10 ,  G01J3/28 ,  G01J3/453 ,  G01N21/359 ,  A61B5/145 ,  G01N33/49 ,  H01S3/30 ,  G01J3/14 ,  G01J3/18

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: Non-invasive monitoring of blood constituents such as glucose, ketones, or hemoglobin A1c may be accomplished using near-infrared or short-wave infrared (SWIR) light sources through absorbance, diffuse reflection, or transmission spectroscopy. As an example, hydro-carbon related substances such as glucose or ketones have distinct spectral features in the SWIR between approximately 1500 and 2500 nm. An SWIR super-continuum laser based on laser diodes and fiber optics may be used as the light source for the non-invasive monitoring. Light may be transmitted or reflected through a tooth, since an intact tooth and its enamel and dentine may be nearly transparent in the SWIR. Blood constituents or analytes within the capillaries in the dental pulp may be detected. The non-invasive monitoring device may communicate with a device such as a smart phone or tablet, which may transmit a signal related to the measurement to the cloud with cloud-based value-added services.

Abstract translation: 通过吸收，漫反射或透射光谱可以使用近红外或短波红外（SWIR）光源实现对血液成分如葡萄糖，酮或血红蛋白A1c的非侵入性监测。 作为示例，水 - 碳相关物质如葡萄糖或酮在SWIR中在约1500和2500nm之间具有不同的光谱特征。 可以使用基于激光二极管和光纤的SWIR超连续激光器作为非侵入性监测的光源。 光可以通过牙齿传播或反射，因为完整的牙齿及其牙釉质和牙质在SWIR中可能几乎是透明的。 可以检测牙髓中毛细血管内的血液成分或分析物。 非侵入式监测设备可以与诸如智能电话或平板电脑的设备进行通信，智能电话或平板电脑可以使用基于云的增值业务将与测量相关的信号传输到云。

公开(公告)号：US09400215B2

公开(公告)日：2016-07-26

申请号：US14715960

申请日：2015-05-19

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G02B6/00 ,  G01J3/42 ,  H01S3/30 ,  G01J3/10 ,  G01B9/02 ,  G01J3/02 ,  H01S5/00 ,  H01S5/10 ,  H01S5/14 ,  G02F1/35 ,  H01S3/067 ,  H01S3/094 ,  H01S3/102

CPC classification number: G01J3/108 ,  G01B9/02091 ,  G01J3/0218 ,  G01J3/0245 ,  G01J3/42 ,  G01J2003/102 ,  G01J2003/423 ,  G02B6/29349 ,  G02F1/365 ,  G02F2001/3528 ,  G02F2202/32 ,  H01S3/06725 ,  H01S3/06754 ,  H01S3/094007 ,  H01S3/094069 ,  H01S3/094076 ,  H01S3/1024 ,  H01S3/302 ,  H01S5/0064 ,  H01S5/0085 ,  H01S5/0092 ,  H01S5/1092 ,  H01S5/146 ,  H01S5/4012 ,  H01S2301/085

Abstract: A diagnostic system includes a semiconductor light emitter(s) configured to generate an input beam having a wavelength shorter than about 2.5 microns. An optical amplifier(s) configured to receive a portion of the input beam communicates an intermediate beam to an output end of the optical amplifier. An optical fiber(s) configured to receive a portion of the intermediate beam forms an output beam with an associated wavelength. A subsystem having lenses or mirrors receives a received portion of the output beam and delivers a delivered portion of the output beam to a sample. The delivered portion has a temporal duration greater than approximately 30 picoseconds and a repetition rate between continuous wave and Megahertz or higher. A time averaged intensity of the delivered portion is less than approximately 50 MW/cm2. A light detection system collects and analyzes a fraction of the delivered portion that reflects or transmits from the sample.

Abstract translation: 诊断系统包括配置成产生具有短于约2.5微米的波长的输入束的半导体光发射器。 被配置为接收输入光束的一部分的光放大器将中间光束传送到光放大器的输出端。 配置成接收中间波束的一部分的光纤形成具有相关波长的输出波束。 具有透镜或反射镜的子系统接收输出光束的接收部分并将输出光束的传送部分传送到样品。 传送部分具有大于约30皮秒的时间持续时间和连续波与兆赫兹或更高之间的重复频率。 输送部分的时间平均强度小于约50MW / cm 2。 光检测系统收集和分析从样品反射或透射的传送部分的一部分。

公开(公告)号：US20150305627A1

公开(公告)日：2015-10-29

申请号：US14651367

申请日：2013-12-17

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. ISLAM

IPC: A61B5/00

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: A system and method for using near-infrared or short-wave infrared (SWIR) sources such as lamps, thermal sources, LED's, laser diodes, super-luminescent laser diodes, and super-continuum light sources for early detection of dental caries measure transmission and/or reflectance. In the SWIR wavelength range, solid, intact teeth may have a low reflectance or high transmission with very few spectral features while a carious region exhibits more scattering, so the reflectance increases in amplitude. The spectral dependence of the transmitted or reflected light from the tooth may be used to detect and quantify the degree of caries. Instruments for applying SWIR light to one or more teeth may include a C-clamp design, a mouth guard design, or hand-held devices that may augment other dental tools. The measurement device may communicate with a smart phone or tablet, which may transmit a related signal to the cloud, where additional value-added services are performed.

Abstract translation: 使用近红外或短波红外（SWIR）源的系统和方法，例如灯，热源，LED，激光二极管，超发光激光二极管和超连续光源，用于早期检测龋齿测量传输 和/或反射率。 在SWIR波长范围内，固体，完整的牙齿可能具有低反射率或高透射率，光谱特征非常少，而龋齿区域表现出更多的散射，因此反射率增加。 来自牙齿的透射光或反射光的光谱依赖性可用于检测和量化龋齿的程度。 将SWIR光应用于一个或多个牙齿的仪器可以包括可以增加其它牙科工具的C形夹设计，口罩设计或手持式装置。 测量设备可以与智能电话或平板电脑进行通信，智能电话或平板电脑可以向云进行相关信号的传输，其中执行附加的增值业务。

公开(公告)号：US20150247756A1

公开(公告)日：2015-09-03

申请号：US14715960

申请日：2015-05-19

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. ISLAM

IPC: G01J3/42 ,  G01J3/02 ,  G01J3/10

CPC classification number: G01J3/108 ,  G01B9/02091 ,  G01J3/0218 ,  G01J3/0245 ,  G01J3/42 ,  G01J2003/102 ,  G01J2003/423 ,  G02B6/29349 ,  G02F1/365 ,  G02F2001/3528 ,  G02F2202/32 ,  H01S3/06725 ,  H01S3/06754 ,  H01S3/094007 ,  H01S3/094069 ,  H01S3/094076 ,  H01S3/1024 ,  H01S3/302 ,  H01S5/0064 ,  H01S5/0085 ,  H01S5/0092 ,  H01S5/1092 ,  H01S5/146 ,  H01S5/4012 ,  H01S2301/085

Abstract: A diagnostic system includes a semiconductor light emitter(s) configured to generate an input beam having a wavelength shorter than about 2.5 microns. An optical amplifier(s) configured to receive a portion of the input beam communicates an intermediate beam to an output end of the optical amplifier. An optical fiber(s) configured to receive a portion of the intermediate beam forms an output beam with an associated wavelength. A subsystem having lenses or mirrors receives a received portion of the output beam and delivers a delivered portion of the output beam to a sample. The delivered portion has a temporal duration greater than approximately 30 picoseconds and a repetition rate between continuous wave and Megahertz or higher. A time averaged intensity of the delivered portion is less than approximately 50 MW/cm2. A light detection system collects and analyzes a fraction of the delivered portion that reflects or transmits from the sample.

Abstract translation: 诊断系统包括配置成产生具有短于约2.5微米的波长的输入束的半导体光发射器。 被配置为接收输入光束的一部分的光放大器将中间光束传送到光放大器的输出端。 被配置为接收中间波束的一部分的光纤形成具有相关波长的输出波束。 具有透镜或反射镜的子系统接收输出光束的接收部分并将输出光束的传送部分传送到样品。 传送部分具有大于约30皮秒的时间持续时间和连续波与兆赫兹或更高之间的重复频率。 输送部分的时间平均强度小于约50MW / cm 2。 光检测系统收集和分析从样品反射或透射的传送部分的一部分。

公开(公告)号：US20250009233A1

公开(公告)日：2025-01-09

申请号：US18891970

申请日：2024-09-20

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. ISLAM

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61C1/00 ,  A61C19/04 ,  G01J3/02 ,  G01J3/10 ,  G01J3/12 ,  G01J3/14 ,  G01J3/18 ,  G01J3/28 ,  G01J3/42 ,  G01J3/453 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3504 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/95 ,  G01N33/02 ,  G01N33/15 ,  G01N33/44 ,  G01N33/49 ,  G16H40/67 ,  G16Z99/00 ,  H01S3/00 ,  H01S3/067 ,  H01S3/30

Abstract: A remote sensing system comprises a time-of-flight sensor including an array of near-infrared laser diodes comprising Bragg reflectors and pulsed with durations approximately 0.5 to 2 nanoseconds whose light is directed to an object. The detection system comprises a photodiode array coupled to a processor, and the time-of-flight measurement is calculated from the temporal distribution of photons reflected from the object. The sensor is coupled to an optical system comprising an active illuminator with a plurality of light emitting diodes and a camera system configured to be synchronized to the illuminator. Furthermore, the sensor is coupled to a light sensing system comprising a multi-wavelength filter to separate incoming ambient light into a series of wavelength bands, and a detector array configured to capture some of the wavelength bands to generate a color output. The processor may be configured to control the active illuminator based on the received color output.