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    Elastic filament velocity sensor
    81.
    发明授权
    Elastic filament velocity sensor 有权

    公开(公告)号：US11054290B2

    公开(公告)日：2021-07-06

    申请号：US16737442

    申请日：2020-01-08

    Applicant: The Trustees of Princeton University

    Inventor： Marcus Hultmark ,  Clay Byers ,  Matthew Fu ,  Yuyang Fan

    IPC: G01F1/28 ,  G01F1/698 ,  G01F1/20 ,  G01F1/684 ,  G01P5/02 ,  A61B5/0285

    Abstract: Disclosed is an apparatus for measuring velocity of a fluid stream via deflection of a wire filament. Also disclosed is a process for measuring velocity of a fluid stream, requiring deflecting two or more wire filaments in a fluid stream, measuring two or more resistances, and equating the velocity of the fluid stream to the result of a function of the two or more resistances. In both the apparatus and method, one wire filament must have a length dimension longer than at least one of a dimension of the wire filament in the primary sensing or transverse direction, as well as a dimension of the wire filament in the primary sensing and/or transverse direction less than 50 ⁢ ⁢ μ U ⁢ ⁢ ρ throughout a predetermined operating range.

    Fast computational phase and timing correction for multiheterodyne spectroscopy
    85.
    发明授权
    Fast computational phase and timing correction for multiheterodyne spectroscopy 有权

    公开(公告)号：US11015975B2

    公开(公告)日：2021-05-25

    申请号：US16613614

    申请日：2018-05-15

    Applicant: The Trustees of Princeton University

    Inventor： Lukasz Sterczewski ,  Jonas Westberg ,  Gerard Wysocki

    IPC: G01J3/10 ,  G01J3/427

    Abstract: Disclosed herein is an all-digital phase and timing correction procedure for coherent averaging in dual-comb and multiheterodyne spectroscopy—applicable to any dual-comb spectroscopy setup. It can account for large frequency/phase instabilities of the used sources, yielding a significant reduction of the noise pedestal and an increase in signal-to-noise ratio (SNR) of the radio frequency (RF) beat notes. This technique is computationally efficient and can be conveniently implemented either as a post-processing algorithm or in a real-time data acquisition and processing platform without the necessity of adding any additional optical elements to the dual-comb spectroscopy system. By implementing this technique, the performance of any comb- or comb-like-source-based DCS system with a sufficient degree of mutual coherence between the optical modes can be improved in terms of SNR and number of spectroscopically-usable RF beat notes. The described technique is compatible with a DC-centered RF spectrum, where the negative frequencies are folded to the positive domain to double the number of beat notes within the detector bandwidth. The technique enables coherent averaging over extended time-scales even for free-running combs, thus increasing the sensitivity of absorption and dispersion DCS measurements.

    Rapid Picocell Switching For Wireless Transit Networks
    86.
    发明申请
    Rapid Picocell Switching For Wireless Transit Networks 有权

    公开(公告)号：US20210112470A1

    公开(公告)日：2021-04-15

    申请号：US16488693

    申请日：2018-03-02

    Applicant: The Trustees of Princeton University

    Inventor： Kyle Jamieson

    IPC: H04W36/08 ,  H04W36/04

    Abstract: Disclosed is a design and implementation of a Wi-Fi based network (e.g., roadside hotspot network designed to operate at vehicular speeds and picocell, meter-sized, cells). The disclosed access points (APs) make delivery decisions to the vehicular clients they serve at millisecond-level granularities, exploiting path diversity in roadside networks. In order to accomplish this, buffer management algorithms are employed that allow participating APs to manage each other's queues, rapidly quenching each other's transmissions and flushing each other's queues. An example embodiment of the disclosed approach employs an eight-AP network alongside a nearby road, and was evaluated with mobile clients moving at up to 25 mph. Depending on mobility speed, the disclosed approach achieves a 2.4-4.7 times TCP throughput improvement over a baseline fast handover protocol that captures the state of the art in Wi-Fi roaming, the IEEE 802.11k and 802.11r standards.

    Astexin peptides
    88.
    发明授权
    Astexin peptides 有权

    公开(公告)号：US10927152B2

    公开(公告)日：2021-02-23

    申请号：US16057292

    申请日：2018-08-07

    Applicant: The Trustees of Princeton University

    Inventor： A James Link ,  Mikhail O. Maksimov

    IPC: C07K14/195 ,  A01N63/10 ,  A62D3/33 ,  C02F1/28 ,  A62D101/43 ,  C02F101/20

    Abstract: Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticcacaulis excentricus, and methods of making and using same.
    Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticcacaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.

    CRYPTIC METABOLITES AND METHOD FOR ACTIVATING SILENT BIOSYNTHETIC GENE CLUSTERS IN DIVERSE MICROORGANISMS
    89.
    发明申请
    CRYPTIC METABOLITES AND METHOD FOR ACTIVATING SILENT BIOSYNTHETIC GENE CLUSTERS IN DIVERSE MICROORGANISMS 有权

    公开(公告)号：US20210041452A1

    公开(公告)日：2021-02-11

    申请号：US16634388

    申请日：2018-07-30

    Applicant: The Trustees of Princeton University

    Inventor： Mohammad R. SEYEDSAYAMDOST ,  Fei XU ,  Yihan WU ,  Leah BUSHIN ,  Katherine Davis

    IPC: G01N33/68 ,  C07K9/00 ,  C12N1/20 ,  C12N1/38 ,  C12P19/56 ,  C12P21/00 ,  C12Q1/18

    Abstract: Microorganisms are prolific producers of natural products, a group of molecules that make up the majority of drugs approved by the FDA in the past 35 years. After decades of mining, the low-hanging fruit has been picked and so discovery of drug-like molecules from microorganisms has come to a near-halt. The reason for this lack of productivity is that most biosynthetic pathways that give rise to natural products are not active under typical laboratory growth conditions. These so-called ‘cryptic’ or ‘silent’ pathways are a major source of new bioactive molecules and methods that reliably activate them could have a profound impact on drug discovery. Disclosed herein is a rapid genetics-free method for eliciting and detecting cryptic metabolites using an imaging mass spectrometry-based approach. An organism of choice is challenged with elicitors from a small molecule library. The molecules elicited are then imaged by mass spec, which allows for rapid identification of cryptic metabolites. These are then isolated and characterized. Employing the disclosed approach activated production of cryptic glycopeptides from an actinomycete bacterium. The molecules that result, the keratinimicins and keratinicyclins, are metabolites with important structural features. At least two of these, keratinimicins B and C, are highly bioactive against several pathogenic strains. This approach will allow for rapid activation and identification of cryptic metabolites from diverse microorganisms in the future.

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