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124 条记录 (耗时 0.036 秒)

    Multivalent Antibodies
    81.
    发明申请
    Multivalent Antibodies 审中-公开
    多价抗体

    公开(公告)号：US20160333105A1

    公开(公告)日：2016-11-17

    申请号：US15165131

    申请日：2016-05-26

    申请人： UCB PHARMA S.A.

    发明人： Ralph Adams ,  Emma Dave ,  David Paul Humphreys

    IPC分类号： C07K16/28 ,  C07K16/18

    摘要： The present invention provides a multivalent antibody or a heavy/light chain component thereof comprising: a heavy chain comprising a constant region fragment, said constant region fragment located between two variable domains which are not a cognate pair, the heavy chain further comprising an Fc region with at least one domain selected from CH2, CH3 and combinations thereof, with the proviso that the heavy chain contains no more than one CH1 domain and only contains two variable domains, and a light chain comprising a constant region fragment located between two variable domains which are not a cognate pair, wherein said heavy and light chains are aligned to provide a first binding site formed by a first cognate pair of variable domains and a second binding site formed by a second cognate pair of variable domains.

    摘要翻译： 本发明提供了一种多价抗体或其重/轻链组分，其包含：包含恒定区片段的重链，所述恒定区片段位于不是同源对的两个可变结构域之间，所述重链还包含Fc区 其中至少一个选自CH 2，CH 3及其组合的结构域，条件是重链含有不超过一个CH1结构域并且仅含有两个可变结构域，以及包含位于两个可变结构域之间的恒定区片段的轻链， 不是同源对，其中所述重链和轻链对齐以提供由第一同源对可变结构域形成的第一结合位点和由第二同源对可变结构域形成的第二结合位点。

    Disulfide Stabilised Antibodies and Fragments Thereof
    88.
    发明申请
    Disulfide Stabilised Antibodies and Fragments Thereof 审中-公开
    二硫键稳定抗体及其片段

    公开(公告)号：US20150274810A1

    公开(公告)日：2015-10-01

    申请号：US14697092

    申请日：2015-04-27

    申请人： UCB PHARMA S.A.

    发明人： David Paul Humphreys

    IPC分类号： C07K16/00

    摘要： The present disclosure provides an antibody or antibody fragment comprising at least one Fab molecule, wherein the light chain variable region, VL and the heavy chain region, VH of the Fab molecule are linked by one or more disulfide bonds, and use of the same in treatment or prophylaxis.

    摘要翻译： 本公开内容提供了包含至少一个Fab分子的抗体或抗体片段，其中Fab分子的轻链可变区VL和重链区域VH通过一个或多个二硫键连接，并且使用它们 治疗或预防。