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公开(公告)号：US20210121659A1
公开(公告)日：2021-04-29
申请号：US17142375
申请日：2021-01-06
发明人： Zhongjun WU , Bartley P. GRIFFITH , Jun DING
摘要： Disclosed is a self-expanding cannula, systems using such cannulae, and methods of their use. The cannulae may comprise single lumen cannula (“SLC”) configurations and double lumen cannula (“DLC”) configurations, and include at least a first cannula and a self-expanding wire frame attached to the first cannula. Self-expanding wire frame is automatically expandable from a compressed state (providing a reduced cannula diameter as it is moved through a patient's body to the site at which it is to be deployed) to an expanded state (which increases the diameter of the cannula to the diameter intended for its normal use). The expanded wire frame provides radial support to prevent a drainage canal (whether a patient's blood vessel or a portion of the system inserted into the patient's blood vessel) from collapsing as fluid is drained from the patient.
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公开(公告)号：US10948414B2
公开(公告)日：2021-03-16
申请号：US16000935
申请日：2018-06-06
摘要： A device and method for detecting the presence of bacteria in a sample are provided. A multi-step process for sample preparation is utilized and a microfluidic device is disclosed. The detection is performed using microfluidics and physical changes in multiple samples in differential mode.
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公开(公告)号：US20200332764A1
公开(公告)日：2020-10-22
申请号：US16851602
申请日：2020-04-17
发明人： Meilin YU , Weidong ZHU
摘要： A multi-stage hybrid Darrieus-modified-Savonius (HDMS) vertical axis wind or water turbine (VAWT) for aero-hydro energy harvesting. The HDMS VAWT can continuously harvest fluid energy, including wind and water energy, provides excellent self-starting capability, has enhanced structural stability, and a high energy harvesting efficiency.
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公开(公告)号：US20200171060A1
公开(公告)日：2020-06-04
申请号：US16629057
申请日：2018-01-26
发明人： KATHERINE L. RADTKE
IPC分类号： A61K31/683 , A61K45/06 , A61K31/506 , A61K31/675
摘要： The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting flaviviruses, filoviruses and/or coronaviruses.
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85.发明授权公开(公告)号：US10525047B2
公开(公告)日：2020-01-07
申请号：US16082325
申请日：2017-03-22
IPC分类号： A61K31/454 , A61K45/06 , A61K31/365 , A61P35/00 , G01N33/50
摘要： The present invention provides for a method of treating cancer and/or reducing proliferation of cancer cells, the method comprising administering to a subject in need of such treatment a composition comprising a PIM kinase inhibitor that exhibits changes of mRNA splicing in combination with a compound that modulates/inhibits activity of an RNA splicing factor protein. Further, changes in splicing of mRNAs and phosphorylation of RNA splicing factors can be used as biomarkers for patient responsiveness to anti-PIM treatment and also suggest effective combinatorial therapies, including synergistic combination.
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公开(公告)号：US20190394175A1
公开(公告)日：2019-12-26
申请号：US16449227
申请日：2019-06-21
发明人： Haibin ZHANG , Sisi DUAN , Yelena YESHA
摘要： A multitude of systems and methods are provided. An encryption method and system utilizing vector label input threshold encryption is included, enabling decentralized confidentiality and decentralized, fine-grained, and attributed-based access control, enabling clients to define by whom, when, and how their data is accessed. Additionally, the disclosed systems and methods can include publish/subscribe mechanisms while achieving confidentiality-preserving and decoupled publish/subscribe messaging and strong total order for publications even with crytographic access control enforced.
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公开(公告)号：US10464852B2
公开(公告)日：2019-11-05
申请号：US15593710
申请日：2017-05-12
发明人： Lee Blaney , Utsav Shashvatt
摘要： Separation methods and systems for converting high concentrations of animal wastes into nutrients and other useful products such as struvite and potassium struvite. Advantageously, the system and methods do not require the addition of external chemicals other than an acid and a base.
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88.发明授权公开(公告)号：US10435664B2
公开(公告)日：2019-10-08
申请号：US15966609
申请日：2018-04-30
发明人： Govind Rao , Yordan Kostov , Leah Tolosa , Xudong Ge , Douglas Frey
摘要： A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
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公开(公告)号：US10377810B2
公开(公告)日：2019-08-13
申请号：US15492535
申请日：2017-04-20
IPC分类号： C07K14/00 , C07K14/705 , A61K39/395 , A61K31/7088 , C07K16/00 , C07K16/28
摘要： The present invention provides for a therapeutic cancer treatment using a soluble CD80 fusion protein that binds to PDL1 and inhibits PDL1-PD1 interactions thereby overcoming PDL1-induced immune suppression and restoring T cell activation.
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公开(公告)号：US20190126996A1
公开(公告)日：2019-05-02
申请号：US16174809
申请日：2018-10-30
发明人： TONY FARQUHAR
IPC分类号： B62D35/00
摘要： The present invention relates to an air deflector configuration that can be fabricated into the construction of a new truck or trailer container or secured to the rear face of a flat rear box-like end of trucks and trailers as an attachment, with the aim of reducing aerodynamic resistance and correspondingly the fuel consumption of land vehicles used for the transportation of such containers.
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