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318 条记录 (耗时 0.047 秒)

    Activin-A mutants
    81.
    发明授权
    Activin-A mutants 有权
    活化素-A突变体

    公开(公告)号：US07575751B2

    公开(公告)日：2009-08-18

    申请号：US11115877

    申请日：2005-04-27

    申请人： Wylie Vale ,  Craig Harrison ,  Peter Gray ,  Wolfgang Fischer ,  Senyon Choe

    发明人： Wylie Vale ,  Craig Harrison ,  Peter Gray ,  Wolfgang Fischer ,  Senyon Choe

    IPC分类号： A61K39/00 ,  C07K14/00

    CPC分类号： G01N33/5005 ,  A61K38/00 ,  C07K14/495 ,  G01N33/566 ,  G01N33/574 ,  G01N2500/00

    摘要： Members of the TGF-β superfamily control many physiologic and pathophysiologic processes in multiple tissues and signal via type II and type I receptor serine kinases. Type II activin receptors are promiscuous and known to bind 12 TGF-β ligands including activins, myostatin, BMPs and nodal. Methods are described for the screening and identification of antagonist for TGF-β superfamily members, in particular activin-A antagonist.

    摘要翻译： TGF-β超家族的成员控制多个组织中的许多生理和病理生理过程，并通过II型和I型受体丝氨酸激酶信号。 II型激活素受体是混杂的，已知结合12种TGF-β配体，包括激活素，肌生成抑制素，BMP和结节。 描述了筛选和鉴定TGF-β超家族成员，特别是激活素-A拮抗剂的拮抗剂的方法。

    METHOD OF ADMINISTRATION
    85.
    发明申请
    METHOD OF ADMINISTRATION 审中-公开
    管理方法

    公开(公告)号：US20090023805A1

    公开(公告)日：2009-01-22

    申请号：US12278046

    申请日：2007-02-12

    申请人： Anne Claire Marrast ,  Wolfgang Fischer

    发明人： Anne Claire Marrast ,  Wolfgang Fischer

    IPC分类号： A61K31/343 ,  A61P37/06

    CPC分类号： A61K31/365

    摘要： The present invention relates to the use of mycophenolic acid, a salt or prodrug thereof in immunosuppression, particularly for prevention or treatment of transplant rejection and immune-mediated and/or inflammatory diseases, wherein mycophenolic acid, the salt or the prodrug thereof is administered with an initial intensified dosage regimen.

    摘要翻译： 本发明涉及霉酚酸，其盐或前药在免疫抑制中的用途，特别是用于预防或治疗移植排斥反应和免疫介导的和/或炎性疾病，其中霉酚酸，其盐或其前药与 初始强化剂量方案。

    Preparation of new radiation-curing binders
    86.
    发明授权
    Preparation of new radiation-curing binders 有权
    新型辐射固化胶粘剂的制备

    公开(公告)号：US07381785B2

    公开(公告)日：2008-06-03

    申请号：US11080176

    申请日：2005-03-14

    申请人： Christophe Dètrembleur ,  Jan Weikard ,  Dorota Greszta-Franz ,  Wolfgang Fischer ,  Jörg Schmitz ,  Holger Mundstock

    发明人： Christophe Dètrembleur ,  Jan Weikard ,  Dorota Greszta-Franz ,  Wolfgang Fischer ,  Jörg Schmitz ,  Holger Mundstock

    IPC分类号： C08G18/78 ,  C08G18/67 ,  C08G18/16 ,  C09D175/16

    CPC分类号： C08G18/7837 ,  B33Y70/00 ,  C08G18/166 ,  C08G18/672 ,  C09D175/16 ,  C08G18/3206

    摘要： Process for preparing binders including reacting A) one or more NCO-functional compounds containing uretdione groups with B) one or more compounds containing groups capable of participating in polymerization reaction with ethylenically unsaturated compounds on exposure to actinic radiation, and contain isocyanate-reactive groups, followed by C) reaction with one or more hydroxyl-containing compounds other than B), wherein at least one of these compounds has an OH functionality of≧2, D) in the presence of one or more compounds containing phenoxide groups, as catalysts, and E) optionally auxiliaries and additives, where the reaction with compounds of component C) proceeds at least proportionally with the formation of allophanate groups and where and including binders containing allophanate groups and groups capable of participating in a polymerization reaction with ethylenically unsaturated compounds on exposure to actinic radiation, and optionally also contain NCO-reactive groups. The binders are used in coating compositions used to coat substrates.

    摘要翻译： 制备粘合剂的方法包括使A）一种或多种含有脲二酮基团的NCO-官能化合物与B）一种或多种含有能够在曝光于光化辐射下参与与烯属不饱和化合物聚合反应的基团的化合物，并含有异氰酸酯反应性基团， 随后C）与除B）之外的一种或多种含羟基化合物反应，其中这些化合物中的至少一种具有> = 2的OH官能度，D）在一种或多种含有酚盐的化合物的存在下，作为催化剂 和E）任选的助剂和添加剂，其中与组分C）的化合物的反应至少与形成脲基甲酸酯基团成比例地进行，并且其中和包括含有脲基甲酸酯基团和能够与烯属不饱和化合物进行聚合反应的基团的粘合剂 暴露于光化辐射，并且任选地还含有NCO-反应性基团。 粘合剂用于涂覆基材的涂料组合物中。

    Process for the preparation of polyaddition compounds
    87.
    发明申请
    Process for the preparation of polyaddition compounds 审中-公开
    制备加聚化合物的方法

    公开(公告)号：US20070142608A1

    公开(公告)日：2007-06-21

    申请号：US11638626

    申请日：2006-12-13

    申请人： Hans Laas ,  Bernd Sojka ,  Michael Grahl ,  Josef Sanders ,  Wolfgang Fischer ,  Reinhard Halpaap

    发明人： Hans Laas ,  Bernd Sojka ,  Michael Grahl ,  Josef Sanders ,  Wolfgang Fischer ,  Reinhard Halpaap

    IPC分类号： C08G18/00

    CPC分类号： C08G18/798 ,  C08G18/0895 ,  C08G18/12 ,  C08G18/227 ,  C08G18/2825 ,  C08G18/4277 ,  C08G18/664 ,  C08G2150/20 ,  C08G18/42

    摘要： The present invention relates to a novel process for the preparation of polyaddition products, to the products obtainable by this process and to their use as starting components in the production of polyurethane plastics. The process includes the reaction of A) polyisocyanates with uretdione groups having a mean isocyanate functionality of at least 2.0, optionally with the concomitant use of B) other diisocyanates and/or polyisocyanates, different from A, in an amount of up to 70 wt. %, based on the total weight of components A) and B), with C) polyols in the molecular weight range 62-2000 having a mean functionality of at least 2.0, or mixtures of polyols and optionally D) other isocyanate-reactive monofunctional compounds in an amount of up to 40 wt. %, based on the total weight of components C) and D). An equivalent ratio of isocyanate groups to isocyanate-reactive groups of 1.8:1 to 0.6:1 is maintained in the reactants, and the reaction is carried out in the presence of at least one bismuth-containing catalyst.

    摘要翻译： 本发明涉及一种制备加聚产物的新方法，可通过该方法获得的产品及其作为聚氨酯塑料生产中起始组分的用途。 该方法包括A）多异氰酸酯与平均异氰酸酯官能度至少为2.0的脲二酮基团的反应，任选地伴随使用B）与A不同的其它二异氰酸酯和/或多异氰酸酯，其量高达70wt。 基于组分A）和B）的总重量，C）分子量范围为62-2000的平均官能度至少为2.0的多元醇，或多元醇和任选的D）混合物的其它异氰酸酯反应性单官能化合物 其量可高达40wt。 ％，基于组分C）和D）的总重量。 在反应物中保持异氰酸酯基与异氰酸酯反应性基团的当量比为1.8:1至0.6:1，反应在至少一种含铋催化剂存在下进行。

    Low-viscosity, radiation-curable urethane binder dispersions with high solids contents
    88.
    发明申请
    Low-viscosity, radiation-curable urethane binder dispersions with high solids contents 审中-公开
    低粘度，可辐射固化的聚氨酯粘合剂分散体，固体含量高

    公开(公告)号：US20060094819A1

    公开(公告)日：2006-05-04

    申请号：US11264078

    申请日：2005-11-01

    申请人： Manfred Muller ,  Richard Kopp ,  Wolfgang Fischer ,  Jan Weikard

    发明人： Manfred Muller ,  Richard Kopp ,  Wolfgang Fischer ,  Jan Weikard

    IPC分类号： C08G18/08

    CPC分类号： C09D167/07 ,  C08G18/672 ,  C08G18/673 ,  C08G63/676 ,  C08K5/13 ,  C08L67/07 ,  C08L75/16 ,  C08L2201/50 ,  C09D175/16 ,  C08L2666/20 ,  C08L2666/18

    摘要： The present invention relates to water-free and cosolvent-free binder compositions A) containing of a mixture of A1) at least one emulsifier-free, hydrophobic binder containing groups which can be polymerized by high-energy radiation and A2) at least one hydrophilic unsaturated polyester resin containing the reaction product of a) at least one unsaturated dicarboxylic acid and/or an anhydride thereof, b) at least one polyalkylene oxide compound having a number average molecular weight of 106 to 2000, at least 2 hydroxyl end groups and at least 2 oxyalkylene units, wherein at least 50% of the oxyalkylene units are oxyethylene units, and c) at least one hydroxy-functional compound containing at least one polymerizable unsaturated group per molecule selected from vinyl, allyl, methacrylic and acrylic groups. The present invention also relates to aqueous dispersions containing the binder compositions A), to a process for preparing an aqueous dispersion containing the binder dispersion, to a process for diluting the binder composition with tap water, to producing coatings from the aqueous dispersions and to the use of the binder compositions for preparing coating, adhesive or sealant compositions.

    摘要翻译： 本发明涉及无水和无溶剂的粘合剂组合物A），其包含A1）至少一种不含乳化剂的疏水性粘合剂，其含有能够通过高能量辐射聚合的基团和A2）至少一种亲水性 含有a）至少一种不饱和二羧酸和/或其酸酐的反应产物的不饱和聚酯树脂，b）至少一种数均分子量为106至2000的聚环氧烷化合物，至少2个羟基端基和 至少2个氧化烯单元，其中至少50％的氧化烯单元是氧化乙烯单元，和c）至少一种含有至少一个选自乙烯基，烯丙基，甲基丙烯酸和丙烯酸基团的每个分子的可聚合不饱和基团的羟基官能化合物。 本发明还涉及含有粘合剂组合物A）的水分散体，制备含有粘合剂分散体的水性分散体的方法，用于用自来水稀释粘合剂组合物的方法，从水性分散体生产涂料， 使用粘合剂组合物来制备涂料，粘合剂或密封剂组合物。

    Radiation-curing binders and a process for their preparation
    90.
    发明申请
    Radiation-curing binders and a process for their preparation 有权
    辐射固化粘合剂及其制备方法

    公开(公告)号：US20060051591A1

    公开(公告)日：2006-03-09

    申请号：US11217728

    申请日：2005-09-01

    申请人： Jan Weikard ,  Christoph Gurtler ,  Wolfgang Fischer ,  Jorg Schmitz ,  Holger Mundstock

    发明人： Jan Weikard ,  Christoph Gurtler ,  Wolfgang Fischer ,  Jorg Schmitz ,  Holger Mundstock

    IPC分类号： B32B27/00 ,  C08G18/00 ,  B29D11/00

    CPC分类号： C08G18/8175 ,  B33Y70/00 ,  C09D175/14 ,  Y10T428/31551

    摘要： The invention relates to a process for preparing binders which contain 1) allophanate groups, 2) groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation (radiation-curing groups) and 3) optionally NCO-reactive groups, by reacting at temperatures ≦130° C. A) one or more NCO-functional compounds containing uretdione groups with B) one or more compounds that contain isocyanate-reactive groups and groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation (radiation-curing groups), and then C) with one or more saturated, hydroxyl-containing compounds other than B), at least one of these compounds having an OH functionality of ≧2, in the presence of D) a catalyst containing one or more ammonium salts or phosphonium salts of aliphatic or cycloaliphatic carboxylic acids, the reaction with compounds C) taking place at least proportionally with the formation of allophanate groups. The present invention also relates to the binders obtained by the process of the invention.

    摘要翻译： 本发明涉及一种制备粘合剂的方法，其包含1）脲基甲酸酯基团，2）与烯键式不饱和化合物反应的基团与暴露于光化辐射（辐射固化基团）和3）任选的NCO-反应性基团反应的基团， A）一种或多种含有脲二酮基团的NCO-官能化合物，B）一种或多种含有异氰酸酯反应性基团的化合物和与烯键式不饱和化合物反应的基团，其在暴露于光化辐射下聚合（辐射 - 固化基团），然后C）与除了B）之外的一种或多种饱和的含羟基化合物，在D存在下，具有OH官能度> = 2的这些化合物中的至少一种，含有一种或多种 脂肪族或脂环族羧酸的铵盐或鏻盐，与化合物C）的反应至少与脲基甲酸酯基团的形成成比例地发生。 本发明还涉及通过本发明的方法获得的粘合剂。