公开(公告)号：US11096588B2

公开(公告)日：2021-08-24

申请号：US15285634

申请日：2016-10-05

Applicant: COVIDIEN LP

Inventor： Paul Stanley Addison ,  James N. Watson ,  Dean Montgomery

IPC: A61B5/0205 ,  A61B5/021 ,  A61B5/1455 ,  A61B5/00 ,  A61B5/022

Abstract: A method for monitoring autoregulation includes, using a processor, receiving a blood pressure signal an oxygen saturation signal, and a regional oxygen saturation signal from a patient. The method also includes normalizing the regional oxygen saturation signal to correct for variation in the oxygen saturation signal based on a relationship between the oxygen saturation signal and the regional oxygen saturation signal. The method further includes determining a linear correlation between the blood pressure signal and the normalized regional oxygen saturation signal. The method still further includes providing a signal indicative of the patient's autoregulation status to an output device based on the linear correlation.

公开(公告)号：US20210193311A1

公开(公告)日：2021-06-24

申请号：US16723678

申请日：2019-12-20

Applicant: Covidien LP

Inventor： Paul S. Addison ,  Dean Montgomery ,  Andre Antunes

IPC: G16H40/40 ,  A61B5/1455 ,  A61B5/00 ,  A61B5/024 ,  A61B5/0205

Abstract: A system for continuous non-invasive blood pressure monitoring may include processing circuitry configured to determine calibration data for a continuous non-invasive blood pressure model at a calibration point, receive, from an oxygen saturation sensing device, a PPG signal at a particular time subsequent to the calibration point, derive values of the set of metrics for the patient from the PPG signal, and determine, using the continuous non-invasive blood pressure model and based at least in part on inputting the calibration data determined at the calibration point, the values of the set of metrics, and an elapsed time at the particular time since the calibration point into the continuous non-invasive blood pressure model, a blood pressure of the patient at the particular time.

公开(公告)号：US20200330049A1

公开(公告)日：2020-10-22

申请号：US16921416

申请日：2020-07-06

Applicant: Covidien LP

Inventor： Dean Montgomery ,  Paul S. Addison ,  Peter Galen

IPC: A61B5/00 ,  A61B5/1455 ,  A61B5/021

Abstract: A system for monitoring autoregulation includes an oxygen saturation sensor configured to obtain an oxygen saturation signal indicative of an oxygen saturation of a patient. The system also includes a controller having a processor configured to receive a blood pressure signal indicative of a blood pressure of the patient and the oxygen saturation signal, determine a change in the oxygen saturation signal and a change in the blood pressure signal over a period of time, and provide an indication that the patient's autoregulation is intact if the oxygen saturation changes by more than an oxygen saturation threshold and if the blood pressure changes by less than a blood pressure threshold during the period of time.

公开(公告)号：US10736578B2

公开(公告)日：2020-08-11

申请号：US15648665

申请日：2017-07-13

Applicant: COVIDIEN LP

Inventor： Dean Montgomery ,  Paul S. Addison ,  Peter Galen

IPC: A61B5/00 ,  A61B5/1455 ,  A61B5/021 ,  G16H50/30

Abstract: A system for monitoring autoregulation includes an oxygen saturation sensor configured to obtain an oxygen saturation signal indicative of an oxygen saturation of a patient. The system also includes a controller having a processor configured to receive a blood pressure signal indicative of a blood pressure of the patient and the oxygen saturation signal, determine a change in the oxygen saturation signal and a change in the blood pressure signal over a period of time, and provide an indication that the patient's autoregulation is intact if the oxygen saturation changes by more than an oxygen saturation threshold and if the blood pressure changes by less than a blood pressure threshold during the period of time.

公开(公告)号：US20200170517A1

公开(公告)日：2020-06-04

申请号：US16204061

申请日：2018-11-29

Applicant: Covidien LP

Inventor： Paul S. Addison ,  Dean Montgomery ,  Andre Antunes

IPC: A61B5/0225 ,  A61B5/021 ,  A61B5/00 ,  A61B5/11

Abstract: In some examples, devices, systems, and techniques are configured to compensate for changes in sensed blood pressure due to issues such as blood pressure sensor movement. For example, processing circuitry of a device may determine a difference value between a first blood pressure value representative of a blood pressure at a first time and a second blood pressure value representative of the blood pressure at a second time. Responsive to determining that the difference value is greater than or equal to a threshold value, the processing circuitry may generate updated blood pressure values by applying an offset value to the second blood pressure value and subsequently received blood pressure values that compensates for the difference value between the first blood pressure value and the second blood pressure value.

公开(公告)号：US10463292B2

公开(公告)日：2019-11-05

申请号：US15293610

申请日：2016-10-14

Applicant: COVIDIEN LP

Inventor： Paul Stanley Addison ,  James N. Watson ,  Dean Montgomery

IPC: A61B5/00 ,  A61B5/1455 ,  A61B5/02 ,  A61B5/026 ,  A61B5/0205 ,  A61B5/021 ,  G16H50/20 ,  G16H40/63 ,  G16H50/30 ,  G16H20/40

Abstract: A system configured to monitor autoregulation includes a medical sensor configured to be applied to a patient and to generate a regional oxygen saturation signal. The system includes a controller having a processor configured to receive the regional oxygen saturation signal and a blood pressure signal and to determine a cerebral oximetry index (COx) based on the blood pressure signal and the regional oxygen saturation signal. The processor is also configured to apply a data clustering algorithm to cluster COx data points over a range of blood pressures, identify a first cluster of COx data points that corresponds to an intact autoregulation zone for the patient, and provide a first output indicative of the intact autoregulation zone for the patient.

公开(公告)号：US20180338731A1

公开(公告)日：2018-11-29

申请号：US15980235

申请日：2018-05-15

Applicant: Covidien LP

Inventor： Paul S. Addison ,  Dean Montgomery

IPC: A61B5/00 ,  A61B5/0205 ,  G16H50/20

Abstract: In some examples, a device includes processing circuitry configured to receive first and second signals indicative of first and second physiological parameters and determine a trendline function based on values of first and second physiological parameters. The processing circuitry is further configured to determine transformed values of the first physiological parameter based on the trendline function. The processing circuitry is configured to determine correlation coefficient values for the transformed values of the first physiological parameter and the values of the second physiological parameter. The processing circuitry is further configured to determine a limit of autoregulation of the patient based on the correlation coefficient values. The processing circuitry is configured to determine an autoregulation status based on the estimate of the limit of autoregulation and output, for display, an indication of the autoregulation status.

公开(公告)号：US20160367197A1

公开(公告)日：2016-12-22

申请号：US15184305

申请日：2016-06-16

Applicant: COVIDIEN LP

Inventor： Paul S. Addison ,  Dean Montgomery ,  James N. Watson

IPC: A61B5/00 ,  A61B5/0205 ,  A61B5/145

CPC classification number: A61B5/7246 ,  A61B5/02007 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/02108 ,  A61B5/022 ,  A61B5/0261 ,  A61B5/0295 ,  A61B5/14546 ,  A61B5/14551 ,  A61B5/14553 ,  A61B5/6803 ,  A61B5/7221 ,  A61B5/7264 ,  A61B5/7282 ,  A61B2505/03 ,  A61B2562/0233

Abstract: A method for monitoring autoregulation includes, using a processor, receiving a blood pressure signal, a regional oxygen saturation signal, and a blood volume signal from a patient. The method also includes determining a first linear correlation between the blood pressure signal and the regional oxygen saturation signal and determining a second linear correlation between the blood pressure signal and the blood volume signal. The method also includes determining a confidence level associated with the first linear correlation based at least in part on the second linear correlation and providing a signal indicative of the patient's autoregulation status to an output device based on the linear correlation and the confidence level.

Abstract translation: 用于监测自动调节的方法包括使用处理器从患者接收血压信号，区域氧饱和度信号和血液体积信号。 该方法还包括确定血压信号和区域氧饱和度信号之间的第一线性相关性，并确定血压信号与血容量信号之间的第二线性相关。 该方法还包括至少部分地基于第二线性相关性来确定与第一线性相关性相关联的置信水平，并且基于线性相关性和置信水平向输出设备提供指示患者自动调节状态的信号。

公开(公告)号：US20160345913A1

公开(公告)日：2016-12-01

申请号：US15146548

申请日：2016-05-04

Applicant: COVIDIEN LP

Inventor： Dean Montgomery ,  Paul S. Addison

IPC: A61B5/00 ,  A61B5/1455 ,  A61B5/0205

CPC classification number: A61B5/7275 ,  A61B5/0205 ,  A61B5/14553 ,  G06F19/00

Abstract: A method for monitoring autoregulation includes receiving a blood pressure signal and a regional oxygen saturation signal from a patient. The method also includes determining one or more pairs of linear correlation lines between the blood pressure signal and the regional oxygen saturation signal based on one or more bins. Each of the one or more bins includes one or more regional oxygen saturation values derived from the regional oxygen saturation signal. The method also includes determining a value indicative of the patient's autoregulation status based on a first pair of linear correlation lines selected from the one or more pairs of linear correlation lines and providing a signal indicative of the patient's autoregulation status to an output device.

Abstract translation: 用于监测自动调节的方法包括从患者接收血压信号和区域氧饱和度信号。 该方法还包括基于一个或多个箱来确定血压信号和区域氧饱和度信号之间的一对或多对线性相关线。 一个或多个箱体中的每一个包括从区域氧饱和度信号导出的一个或多个区域氧饱和度值。 所述方法还包括基于从所述一对或多对线性相关线中选择的第一对线性相关线来确定指示所述患者的自动调节状态的值，并向输出设备提供指示患者的自动调节状态的信号。