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公开(公告)号：US20220185828A1
公开(公告)日：2022-06-16
申请号：US17688122
申请日：2022-03-07
Applicant: California Institute of Technology
Inventor： Anton Toutov , Kerry Betz , Alexey Fedorov , Brian M. Stoltz , Wenbo Liu , Robert H. Grubbs
IPC: C07F7/08 , C07D209/12
Abstract: The present disclosure describes methods for silylating aromatic derivatives, comprising the use of hydrosilanes and potassium hydroxide.
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公开(公告)号：US11224655B2
公开(公告)日：2022-01-18
申请号：US16431605
申请日：2019-06-04
Inventor： Robert H. Grubbs , Marshall Leedy Stoller , Hoyong Chung , Alissa M. Fitzgerald , Thomas W. Kenny , Renee M. Thomas
Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.
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公开(公告)号：US20210198291A1
公开(公告)日：2021-07-01
申请号：US17192129
申请日：2021-03-04
Applicant: California Institute Of Technology
Inventor： Anton A. Toutov , Kerry N. Betz , Andrew M. Romine , Robert H. Grubbs
IPC: C07F7/10
Abstract: The present disclosure is directed to hydrosilyl amines and fluorosilyl amines and methods of making the same.
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公开(公告)号：US10995105B2
公开(公告)日：2021-05-04
申请号：US16997226
申请日：2020-08-19
Applicant: California Institute Of Technology
Inventor： Anton A. Toutov , Kerry N. Betz , Andrew M. Romine , Robert H. Grubbs
IPC: C07F7/10
Abstract: The present disclosure is directed at methods of forming an N—Si silyl bond, the method comprising contacting an organic substrate comprising an aromatic amine having at least one N—H bond with a mixture comprising of (a) at least one hydrosilane and (b) at least one hydroxide or alkoxide, under conditions sufficient to form the N—Si bond. The disclosure is further directed to the compositions involved in these methods and the products that result therefrom.
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公开(公告)号：US10919917B2
公开(公告)日：2021-02-16
申请号：US16705408
申请日：2019-12-06
Applicant: California Institute of Technology
Inventor： Anton Toutov , Kerry Betz , Alexey Fedorov , Brian M. Stoltz , Wenbo Liu , Robert H. Grubbs
IPC: C07F7/08 , C07D209/12
Abstract: The present disclosure describes methods for silylating heteroaromatic derivatives, comprising the use of hydrosilanes and potassium hydroxide.
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Patent Agency Ranking
公开(公告)号：US10781221B2
公开(公告)日：2020-09-22
申请号：US16244637
申请日：2019-01-10
Applicant: California Institute of Technology
Inventor： Anton A. Toutov , Kerry N. Betz , Andrew M. Romine , Robert H. Grubbs
IPC: C07F7/10
Abstract: The present disclosure is directed at methods of forming an N—Si silyl bond, the method comprising contacting an organic substrate comprising an aromatic amine having at least one N—H bond with a mixture comprising of (a) at least one hydrosilane or hydrosiloxane and (b) at least one hydroxide or alkoxide, under conditions sufficient to form the N—Si bond. The disclosure is further directed to the compositions involved in these methods and the products that result therefrom.
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公开(公告)号：US20200061157A1
公开(公告)日：2020-02-27
申请号：US16546272
申请日：2019-08-20
Inventor： Robert H. Grubbs , Daniel M. Schwartz
Abstract: Disclosed herein include methods, kits, formulations, and compositions for increasing choroidal or retinal perfusion or promoting non-leaking or minimally-leaking choroidal or retinal revascularization in a subject in need thereof. An effective amount of an angiogenesis factor (e.g., a pro-angiogenic factor and/or a vascular maturation factor) can be administered to the subject.
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公开(公告)号：US10513531B2
公开(公告)日：2019-12-24
申请号：US16159298
申请日：2018-10-12
Applicant: California Institute Of Technology
Inventor： Anton Toutov , Kerry Betz , Alexey Fedorov , Brian M. Stoltz , Wenbo Liu , Robert H. Grubbs
IPC: C07F7/08 , C07D209/12
Abstract: The present disclosure describes novel silylated heteroaromatic derivatives, including those prepared by methods comprising the use of hydrosilanes and at least one strong base, the definition of strong base now also including hydroxide, especially KOH.
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公开(公告)号：US10125153B2
公开(公告)日：2018-11-13
申请号：US15804275
申请日：2017-11-06
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Anton Toutov , Kerry Betz , Alexey Fedorov , Brian M. Stoltz , Wenbo Liu , Robert H. Grubbs
IPC: C08G75/00 , C07F7/08 , C07D209/12
Abstract: The present invention describes chemical systems and methods for silylating N—H bonds of aliphatic amines, said system or method comprising or consisting essentially of a mixture of (a) at least one organosilane and (b) at least one hydroxide, especially KOH, said system being preferably, but not necessarily substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to replace an N—H bond with a silyl N—Si bond.
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90.发明授权公开(公告)号：US10035806B2
公开(公告)日：2018-07-31
申请号：US15286983
申请日：2016-10-06
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Melanie A. Yen , Harry B. Gray , Robert H. Grubbs , Joshua Palmer
IPC: C07D487/22 , A61K31/409 , C07F5/00
CPC classification number: C07D487/22 , C07F5/003
Abstract: The present invention is directed to derivatized corroles, methods of making and using the same as imaging and therapeutic agents. In certain embodiments, the corroles are compounds having a Structure (I-H) and (I-M): where R1, R2, R3, and R4 are independently —F or —N(H)—(CH2)m—Y, provided that at least one of R1, R2, R3, and R4 is —N(H)—(CH2)m—Y, and m and Y are described herein.
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