公开(公告)号：US20090299447A1

公开(公告)日：2009-12-03

申请号：US11917992

申请日：2006-06-30

申请人： Marc Jensen ,  Olivier Colliou ,  Benedict Costello ,  Mark Zdeblick ,  Todd Thompson ,  George Savage ,  Andrew Thompson

发明人： Marc Jensen ,  Olivier Colliou ,  Benedict Costello ,  Mark Zdeblick ,  Todd Thompson ,  George Savage ,  Andrew Thompson

IPC分类号： A61N1/05

CPC分类号： A61N1/0587

摘要： Minimally invasive deployable epicardial array devices are provided. The devices include deployable platform comprising two or more effectors, such as sensors and actuators, where the devices are configured to be deployed at an epicardial location via a minimally invasive, e.g., sub-xiphoid approach. In embodiments of the present invention, at least one area of the electrode patch is an electrical control area that comprises a series of effectors, e.g., sensors and/or electrodes. Other embodiments provide localized physical constraint and dynamic mechanical stimulation of the heart to effectuate physical and biological responses. Still other embodiments provide both of these functions. Also provided are methods of using the devices, as well as systems and kits that include the devices.

摘要翻译： 提供微创可部署的心外阵列器件。 这些装置包括包括两个或更多个效应器（诸如传感器和致动器）的可展开平台，其中装置被配置成经由微创例如亚剑突方法部署在心外膜位置。 在本发明的实施例中，电极贴片的至少一个区域是包括一系列效应器例如传感器和/或电极的电控制区域。 其他实施例提供心脏的局部物理约束和动态机械刺激以实现物理和生物反应。 其他实施例提供这两个功能。 还提供了使用这些设备的方法，以及包括设备的系统和套件。

公开(公告)号：US20060131036A1

公开(公告)日：2006-06-22

申请号：US11266973

申请日：2005-11-04

申请人： Scott Franson ,  Kenneth Vos ,  Thomas Winebrenner ,  Andrew Thompson

发明人： Scott Franson ,  Kenneth Vos ,  Thomas Winebrenner ,  Andrew Thompson

IPC分类号： A62C37/08

CPC分类号： A62C37/09 ,  A62C37/14

摘要： A pendant sprinkler head includes a sprinkler body, with an orifice that forms an inlet and an outlet. A deflector is movably supported by a deflector support assembly and is movable between a retracted position wherein the deflector is adjacent the outlet and an extended position where the deflector is spaced from the outlet. At least a portion of the deflector support assembly is located in the orifice when the deflector is in its retracted position.

摘要翻译： 吊顶喷头包括具有形成入口和出口的孔口的喷洒器主体。 偏转器由偏转器支撑组件可移动地支撑并且可在缩回位置之间移动，其中偏转器邻近出口和延伸位置，其中偏转器与出口间隔开。 当偏转器处于其缩回位置时，偏转器支撑组件的至少一部分位于孔中。

公开(公告)号：US20050092344A1

公开(公告)日：2005-05-05

申请号：US10913982

申请日：2004-08-05

申请人： Patrick Mooney ,  Andrew Thompson

发明人： Patrick Mooney ,  Andrew Thompson

IPC分类号： A45C11/26 ,  A45D1/00 ,  A45D7/04

CPC分类号： A45D1/00 ,  A45C11/26 ,  A45D2001/002

摘要： A flexible heat resistant mat for use with a heated hair styling device, the mat being made of a fibrous material of which the fibres are capable of withstanding a temperature in excess of 225° C., wherein air spaces between the fibres give the material a sufficiently low thermal conductivity to permit a styling device having a temperature in excess of 200° C. to be supported on the mat for more than at least 10 minutes while resting on a surface capable of withstanding a temperature of about 70° C. without damage to the surfaces.

摘要翻译： 一种用于加热头发定型装置的柔性耐热垫，该垫由纤维材料制成，纤维材料能够承受超过225℃的温度，其中纤维之间的空气间隔使材料a 足够低的热导率，以允许具有超过200℃的温度的造型装置在搁置在能够耐受约70℃的温度的表面上而不被损坏的情况下被支撑在垫上多于至少10分钟 到表面。

公开(公告)号：US20050042713A1

公开(公告)日：2005-02-24

申请号：US10479868

申请日：2002-06-07

申请人： Andrew Thompson ,  Christian Hamon ,  Thomas Neumann

发明人： Andrew Thompson ,  Christian Hamon ,  Thomas Neumann

IPC分类号： C07D495/04 ,  C07K1/113 ,  C07K1/12 ,  C12Q1/37 ,  G01N30/88 ,  G01N33/68 ,  C12P21/06 ,  C07K14/47

CPC分类号： G01N33/6848 ,  C07K1/12 ,  C07K1/128 ,  G01N33/6821

摘要： Provided is a method for characterising a polypeptide or a population of polypeptides, which method comprises the steps of: (a) optionally reducing disulphide linkages in the polypeptides, if they are present and capping free thiols in the polypeptides, if they are present; (b) contacting a sample comprising one or more polypeptides with a cleavage reagent which cleaves one or more polypeptides on the C-terminal side of a lysine residue to produce peptide fragments; (c) optionally deactivating the cleavage reagent; (d) contacting the sample with a lysine reactive agent to cap ε-amino groups; (e) removing those peptides having capped ε-amino groups; and (f) recovering the C-terminal peptides.

摘要翻译： 提供了表征多肽或多肽群体的方法，该方法包括以下步骤：（a）如果它们存在，任选地还原多肽中的二硫键，如果它们存在则任选地还原多肽中的无帽硫醇; （b）使包含一种或多种多肽的样品与裂解试剂接触，所述切割试剂在赖氨酸残基的C末端侧切割一个或多个多肽以产生肽片段; （c）任选地使切割试剂失活; （d）使样品与赖氨酸反应剂接触以将ε-氨基封端; （e）去除具有封端的ε-氨基的那些肽; 和（f）回收C末端肽。

公开(公告)号：US20050042676A1

公开(公告)日：2005-02-24

申请号：US10479855

申请日：2002-06-07

申请人： Christian Hamon ,  Andrew Thompson ,  Karsten Kuhn ,  Thomas Neumann ,  Richard Joubert ,  Robert Johnstone ,  Gunier Schmidt

发明人： Christian Hamon ,  Andrew Thompson ,  Karsten Kuhn ,  Thomas Neumann ,  Richard Joubert ,  Robert Johnstone ,  Gunier Schmidt

IPC分类号： C07D213/71 ,  C07D215/36 ,  C07D239/38 ,  C07D241/18 ,  C07D251/58 ,  C07K1/107 ,  C07K1/12 ,  C12Q1/02 ,  C12Q1/37 ,  G01N33/68 ,  G01N33/53

CPC分类号： G01N33/6848 ,  C07K1/12 ,  G01N33/6821

摘要： Provided is a method for characterising a polypeptide or a population of polypeptides, which method comprises the steps of: (a) contacting a sample comprising one or more polypeptides with a lysine reactive agent to cap ε-amino groups; (b) optionally reacting the sample of polypeptides with an amine reactive reagent to block α-amino groups; (c) digesting the sample of polypeptides with a cleavage reagent to produce peptide fragments; (d) optionally deactivating the cleavage reagent; (e) removing those peptides having uncapped or unblocked amino groups; and (f) recovering the N-terminal peptides.

摘要翻译： 提供了表征多肽或多肽群体的方法，该方法包括以下步骤：（a）将包含一种或多种多肽的样品与赖氨酸反应剂接触以将ε-氨基封端; （b）任选地使多肽样品与胺反应试剂反应以阻断α-氨基; （c）用裂解试剂消化多肽样品以产生肽片段; （d）任选地使切割试剂失活; （e）除去具有未封端或未封闭的氨基的那些肽; 和（f）回收N-末端肽。