公开(公告)号：US20210273734A1

公开(公告)日：2021-09-02

申请号：US17062897

申请日：2020-10-05

Applicant: Mark ZDEBLICK ,  Andrew THOMPSON ,  Aleksandr PIKELNY ,  Timothy L. ROBERTSON ,  Hooman HAFEZI

Inventor： Mark ZDEBLICK ,  Andrew THOMPSON ,  Aleksandr PIKELNY ,  Timothy L. ROBERTSON ,  Hooman HAFEZI

IPC: H04B13/00 ,  A61B5/00 ,  H01Q1/27 ,  G16H20/10 ,  H04W4/80 ,  A61B5/07 ,  A61J3/00 ,  G06K7/10 ,  A61B5/1473

Abstract: An apparatus that includes a partial power source including a first material and a second material, the partial power source configured to generate, upon contact with a conducting medium, a potential difference between the first material and the second material to provide power to a control device, and generate, using the first material and the second material, a current flow within the conducting medium, the current flow including information encoded based on a variable conductance between the first material and the second material.

公开(公告)号：US08545436B2

公开(公告)日：2013-10-01

申请号：US13336956

申请日：2011-12-23

Applicant: Timothy Robertson ,  Fataneh Omidvar ,  Yashar Behzadi ,  Lawrence Arne ,  Kenneth Rowberry ,  James Hutchison ,  Robert Leichner ,  George Savage ,  Andrew Thompson ,  Mark Zdeblick ,  Marc Kreidler ,  Hooman Hafezi ,  Robert Duck

Inventor： Timothy Robertson ,  Fataneh Omidvar ,  Yashar Behzadi ,  Lawrence Arne ,  Kenneth Rowberry ,  James Hutchison ,  Robert Leichner ,  George Savage ,  Andrew Thompson ,  Mark Zdeblick ,  Marc Kreidler ,  Hooman Hafezi ,  Robert Duck

IPC: A61M5/168

CPC classification number: A61M5/1723 ,  A61B5/0006 ,  A61B5/0028 ,  A61B5/02055 ,  A61B5/0404 ,  A61B5/04085 ,  A61B5/0428 ,  A61B5/053 ,  A61B5/11 ,  A61B5/1112 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/4094 ,  A61B2560/0209 ,  A61B2560/0412 ,  A61B2560/0468 ,  A61B2562/0219 ,  A61M5/1452 ,  A61M5/172 ,  G06F19/34 ,  G06F19/3418 ,  H04B13/005

Abstract: Receivers, which may be external or implantable, are provided. Aspects of receivers of the invention include the presence of one or more of: a high power-low power module; an intermediary module; a power supply module configured to activate and deactivate one or more power supplies to a high power processing block; a serial peripheral interface bus connecting master and slave blocks; and a multi-purpose connector. Receivers of the invention may be configured to receive a conductively transmitted signal. Also provided are systems that include the receivers, as well as methods of using the same. Additionally systems and methods are disclosed for using a receiver for coordinating with dosage delivery systems.

公开(公告)号：US08419638B2

公开(公告)日：2013-04-16

申请号：US12273503

申请日：2008-11-18

Applicant: Lawrence W. Arne ,  Olivier Colliou ,  Marc Jensen ,  Mark Zdeblick

Inventor： Lawrence W. Arne ,  Olivier Colliou ,  Marc Jensen ,  Mark Zdeblick

IPC: A61B5/00

CPC classification number: A61B5/6876 ,  A61B5/04005 ,  A61B5/053 ,  A61B5/1459 ,  A61B5/6862 ,  A61F2250/0002 ,  A61M1/3655 ,  A61M1/3656 ,  A61M1/3661 ,  A61M1/3663 ,  A61M2025/0031 ,  A61M2025/0037

Abstract: Implantable devices for evaluating body-associated fluid transport structures and methods for using the same are provided. In some instances, the implantable devices include an elongated structure with at least one hermetically sealed integrated circuit sensor stably associated therewith and a transmitter. The devices find use in a variety of different applications, including monitoring the function of various types of body-associated fluid transport structures, such as arteriovenous fistulae, vascular grafts, catheters, cerebrospinal fluid shunts, and implantable central venous access devices.

公开(公告)号：US08412347B2

公开(公告)日：2013-04-02

申请号：US12514045

申请日：2009-04-29

Applicant: Mark Zdeblick

Inventor： Mark Zdeblick

IPC: A61N1/00

CPC classification number: A61N1/056 ,  A61N1/048 ,  A61N1/0488 ,  A61N1/378

Abstract: A charge pump is provided in the same integrated circuit chip as a control means which permits selectively connecting any of one or more electrodes with conductors along a lead. The charge pump derives about two volts from a one-volt supply, and becomes stable within a few tens of microseconds. The charge pump may be composed of three doublers—the first generating timing signals for the second and third doublers, with the second and third doublers working out of phase with each other.

Abstract translation: 电荷泵设置在与控制装置相同的集成电路芯片中，该控制装置允许选择性地将一个或多个电极中的任一个与导体沿导线连接。 电荷泵从一伏电源产生约两伏特，并在几十微秒内稳定。 电荷泵可以由三个倍增器组成，即第二和第三倍增器的第一产生定时信号，第二和第三倍增器彼此相位异相。

公开(公告)号：US20120277813A1

公开(公告)日：2012-11-01

申请号：US13536702

申请日：2012-06-28

Applicant: Mark Zdeblick

Inventor： Mark Zdeblick

IPC: A61N1/36

CPC classification number: A61N1/36146 ,  A61N1/056 ,  A61N1/36185 ,  A61N1/3686

Abstract: System, device and method of variable pacing and stimulation are provided. In one example device, one or more lead integrated circuits may programmably control one or more variability parameters. One or more electrodes may provide electrical stimulation. Each electrode may be individually addressable by at least one of the lead integrated circuits and controlled by at least one variability parameter. Electrodes may be intentionally shorted together during time intervals that fall between times of stimulus, so as to dissipate potentials that might otherwise persist and cause electrode degradation.

Abstract translation: 提供可变起搏和刺激的系统，装置和方法。 在一个示例性设备中，一个或多个引线集成电路可编程地控制一个或多个可变性参数。 一个或多个电极可以提供电刺激。 每个电极可以由至少一个引线集成电路单独寻址并由至少一个可变性参数控制。 在刺激时间之间的时间间隔内，电极可能被故意地短路在一起，以消散可能会持续并导致电极降解的电位。

公开(公告)号：US20120022341A1

公开(公告)日：2012-01-26

申请号：US13260081

申请日：2011-01-28

Applicant: Mark Zdeblick

Inventor： Mark Zdeblick

IPC: A61B5/00

CPC classification number: A61B5/0408 ,  A61B5/061 ,  A61B5/07 ,  A61B5/681 ,  A61J7/0481 ,  A61J2200/30 ,  A61J2205/60 ,  A61K9/20 ,  G06F19/00 ,  G06F19/3456 ,  H04B13/005

Abstract: Sensing is carried out from locations at considerable remove from the stomach. Cooperating sensor electronics are placed at each of two wrists of the patient. The potential discomfort and inconvenience of an abdominal patch are reduced or eliminated. And alternative power sources become available.

Abstract translation: 从相当大的胃部移除的位置进行感测。 合作的传感器电子设备放置在患者的两只手腕的每一个上。 减轻或消除腹部贴片的潜在不适和不便。 并且替代电源变得可用。

公开(公告)号：US20120016211A1

公开(公告)日：2012-01-19

申请号：US13243759

申请日：2011-09-23

Applicant: George Savage ,  Hooman Hafezi ,  Olivier Colliou ,  Mark Zdeblick ,  Angela Strand

Inventor： George Savage ,  Hooman Hafezi ,  Olivier Colliou ,  Mark Zdeblick ,  Angela Strand

IPC: A61B5/07

CPC classification number: A61B5/053 ,  A61B5/04884 ,  A61B5/073 ,  A61B5/1107 ,  A61B5/14539 ,  A61B5/42 ,  A61B5/6861 ,  A61B2560/0214 ,  A61B2560/0242 ,  G06F19/00

Abstract: Portable electroviscerography systems are provided. Aspects of the systems include a body-associated receiver and an ingestible identifier unit, both of which are configured to detect visceral electrical signals. The system communicates with an extra-corporeal data processor configured to receive data from the body-associated receiver and generate and electroviscerogram from the received data. Also provided are methods of producing electroviscerograms using systems of the present invention.

Abstract translation: 提供便携式电视摄影系统。 系统的方面包括身体相关联的接收器和可摄取的识别器单元，它们都配置成检测内脏电信号。 该系统与配置成从身体相关联的接收器接收数据并从接收到的数据生成电视图的外部数据处理器进行通信。 还提供了使用本发明的系统生产电视图的方法。

公开(公告)号：US20120007734A1

公开(公告)日：2012-01-12

申请号：US13180516

申请日：2011-07-11

Applicant: Jeffrey Berkman ,  Mark Zdeblick ,  Patricia Johnson ,  Hooman Hafezi ,  Jonathan Withrington

Inventor： Jeffrey Berkman ,  Mark Zdeblick ,  Patricia Johnson ,  Hooman Hafezi ,  Jonathan Withrington

IPC: G08B1/08

CPC classification number: A61B5/073 ,  A61B5/0002 ,  A61B5/0008 ,  A61B5/036 ,  A61B5/0538 ,  A61B5/14539 ,  A61B5/4839 ,  A61B5/7285 ,  A61B2560/0214 ,  A61B2562/18 ,  A61J3/007 ,  H01Q1/273

Abstract: The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can also measure the conditions of the environment surrounding the system.

Abstract translation: 本发明的系统包括不同材料形式的导电元件，电子元件和部分电源。 当与导电流体接触时，产生电压电位并且电源完成，这激活了系统。 电子部件控制不同材料之间的电导，以产生独特的当前签名。 该系统还可以测量系统周围环境的状况。

公开(公告)号：US08055345B2

公开(公告)日：2011-11-08

申请号：US12202150

申请日：2008-08-29

Applicant: Haifeng Li ,  Mark Zdeblick ,  Lawrence Arne ,  Yafei Bi ,  Nilay Jani ,  Jonathan Withrington

Inventor： Haifeng Li ,  Mark Zdeblick ,  Lawrence Arne ,  Yafei Bi ,  Nilay Jani ,  Jonathan Withrington

IPC: A61N1/00

CPC classification number: A61N1/37288 ,  A61N1/025

Abstract: Various aspects of the present invention enable robust, reliable control functionality for effectors present on intraluminal, e.g., vascular leads, as well as other types of implantable devices. Aspects of the invention include implantable integrated circuits that have self-referencing and self-clocking signal encoding, and are capable of bidirectional communication. Also provided by the invention are effector assemblies that include the integrated circuits, as well as implantable medical devices, e.g., pulse generators that include the same, as well as systems and kits thereof and methods of using the same, e.g., in pacing applications, including cardiac resynchronization therapy (CRT) applications.

Abstract translation: 本发明的各个方面对存在于管腔内（例如血管引线）以及其它类型的可植入装置的效果器提供了鲁棒且可靠的控制功能。 本发明的方面包括具有自参考和自时钟信号编码并且能够进行双向通信的可植入集成电路。 本发明还提供了包括集成电路的效应器组件以及可植入的医疗装置，例如包括其的脉冲发生器，以及其系统和套件，以及使用该装置的方法，例如在起搏应用中， 包括心脏再同步治疗（CRT）应用。

公开(公告)号：US20110257491A1

公开(公告)日：2011-10-20

申请号：US12530431

申请日：2008-03-07

Applicant: Timothy Robertson ,  Mark Zdeblick

Inventor： Timothy Robertson ,  Mark Zdeblick

IPC: A61B5/07 ,  A61M5/00 ,  H01Q1/08

CPC classification number: H01Q7/00 ,  A61B5/0031 ,  A61B5/0205 ,  A61B5/073 ,  A61B5/1104 ,  A61B2562/08 ,  H01Q1/08 ,  H01Q21/20

Abstract: Deployable antennas for in-body devices, such as implantable and ingestible devices, are provided. Aspects of the in-body deployable antennas of the invention include antennas configured to go from a first configuration to a second configuration following placement in a living body, e.g., via ingestion or implantation. Embodiments of the in-body devices are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.

Abstract translation: 提供用于体内器件的可部署天线，例如可植入和可摄取的设备。 本发明的体内可展开天线的方面包括配置成在放置在生物体中（例如通过摄取或植入）之后从第一配置转到第二配置的天线。 身体内装置的实施例被配置为在与目标生理部位接触时发出可检测信号。 还提供了制造和使用本发明的装置的方法。