公开(公告)号：US20160228247A1

公开(公告)日：2016-08-11

申请号：US15040772

申请日：2016-02-10

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Hernan Altman

IPC: A61F2/24

CPC classification number: A61F2/2409 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2230/0067 ,  A61F2230/0091 ,  A61F2250/006

Abstract: A device is in various embodiments configured to repair a native heart valve or to secure a prosthetic heart valve within a native valve of the heart of a patient. Embodiments of the device include at least an upper coil and a lower coil, where the device is configured to assume an axially expanded state where the entire upper coil is positioned on a first side of the lower coil relative to the central axis, and an axially compressed state where at least a portion of the upper coil is positioned on a second side of at least a portion of the lower coil opposite to the first side relative to the central axis.

Abstract translation: 在各种实施例中，设备被配置为修复天然心脏瓣膜或将假体心脏瓣膜固定在患者心脏的天然瓣膜内。 该装置的实施例至少包括上部线圈和下部线圈，其中该装置构造成呈现轴向扩张状态，其中整个上部线圈相对于中心轴线位于下部线圈的第一侧上，并且轴向 压缩状态，其中上部线圈的至少一部分位于相对于中心轴线的与第一侧相对的下部线圈的至少一部分的第二侧上。

公开(公告)号：US20150190225A1

公开(公告)日：2015-07-09

申请号：US14665677

申请日：2015-03-23

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Ron Sharoni ,  Tamir S. Levi ,  Emil Karapetian ,  Tri D. Tran ,  Tung T. Le

IPC: A61F2/24 ,  B23P19/04 ,  A61F2/00

CPC classification number: A61F2/2427 ,  A61B50/30 ,  A61F2/0095 ,  A61F2/243 ,  A61F2/2433 ,  A61F2002/9522 ,  B21D41/04 ,  B23P19/04 ,  B25B27/10 ,  Y10T29/53552 ,  Y10T29/53578 ,  Y10T29/5367

Abstract: A device for crimping a radially expandable and collapsible prosthetic valve comprises a coiled wire frame having a longitudinal opening extending from a proximal end to a distal end thereof The opening has a first state and a second state, the opening in the first state having a first diameter dimensioned to receive the prosthetic valve in an expanded or partially crimped configuration therein, and the opening in the second state having a second diameter dimensioned to receive the prosthetic valve in a crimped configuration. The coiled wire frame has a first end coupled to a first member and a second end coupled to a second member. The first member is movable relative to the second member to convert the coiled wire frame from the first state to the second state.

Abstract translation: 用于卷曲径向可膨胀和可折叠的人工瓣膜的装置包括具有从近端延伸到其远端的纵向开口的螺旋线框架。开口具有第一状态和第二状态，第一状态下的开口具有第一状态 直径的尺寸设计成接收处于其中的膨胀或部分卷曲构造的人造瓣膜，并且在第二状态下的开口具有第二直径，其尺寸被设计成接收处于卷曲构型的假体瓣膜。 盘绕的线框架具有联接到第一构件的第一端和联接到第二构件的第二端。 第一构件可相对于第二构件移动，以将盘绕的线框架从第一状态转换到第二状态。

公开(公告)号：US20250099240A1

公开(公告)日：2025-03-27

申请号：US18975500

申请日：2024-12-10

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： David Maimon

IPC: A61F2/24

Abstract: Reinforcement members for an outer skirt of a prosthetic heart valve are disclosed. As one example, a prosthetic heart valve can include an annular frame and an outer skirt disposed around an outer surface of the frame, the outer skirt including a sealing layer comprising an outflow edge portion secured to the frame and an inflow edge portion secured to the frame and a deformable reinforcement member attached to the sealing layer. The reinforcement member extends circumferentially along the sealing layer and is configured to extend radially outward from the frame such that the sealing layer bulges radially outward and away from the frame when the frame is radially expanded from a radially compressed state to a radially expanded state. The reinforcement member comprises a circumferentially extending row of cells or an undulating shape.

公开(公告)号：US12186184B2

公开(公告)日：2025-01-07

申请号：US17657732

申请日：2022-04-01

Applicant: Edwards Lifesciences Corporation

Inventor： Liron Tayeb ,  Eran Goldberg ,  David Maimon ,  Adi Carmi ,  Arie Tylis ,  Ralph Schneider ,  Mohammad Jafari ,  Hengchu Cao ,  Eitan Atias

IPC: A61F2/24 ,  A61F2/88 ,  A61F2/90

Abstract: An expandable docking station includes an annular valve seat having an end, an annular outer wall comprising struts disposed around the valve seat, and links that connect the end of the annular valve seat to the annular outer wall. Each of the links extends from the struts of the annular outer wall directly toward a longitudinal axis that runs longitudinally through a center of the docking station, and to a corresponding one of a plurality of circumferentially spaced axially extending legs at least partially defining the annular valve seat. The outer wall is configured to conform to an interior shape of a blood vessel, when expanded inside the blood vessel, such that the outer wall can expand in multiple locations to conform to multiple bulges of the blood vessel and can contract in multiple locations to conform to multiple narrowed regions of the blood vessel.

公开(公告)号：US20240358511A1

公开(公告)日：2024-10-31

申请号：US18767778

申请日：2024-07-09

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： David Maimon ,  Liron Tayeb ,  Eran Goldberg

IPC: A61F2/24 ,  A61F2/95 ,  A61M25/00

CPC classification number: A61F2/2439 ,  A61F2/2427 ,  A61F2/2433 ,  A61M25/0023 ,  A61F2/9517 ,  A61M2025/0024

Abstract: The active introducer sheath systems disclosed herein are expanded by activating a translation mechanism at the handle. The sheath has an inner cylindrical structure of comingled fixed and mobile elongate rods bound together by an attachment line. Activating the translation mechanism causes the mobile rods to move axially with respect to the fixed rods, changing the internal tension in the attachment line. Increased tension draws the fixed and mobile rods closer together, decreasing the diameter of the cylindrical structure. Decreased tension in the attachment line enables the fixed and mobile rods to move apart, increasing the diameter of the cylindrical structure. A prosthetic device, such as a prosthetic heart valve, can be routed through the expanded sheath and to the implantation site. During implantation, the sheath can be contracted back to its original outer diameter, and expanded again for retrieval of the delivery apparatus.

公开(公告)号：US12083012B2

公开(公告)日：2024-09-10

申请号：US17824411

申请日：2022-05-25

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Boaz Manash ,  Eyal Leiba ,  Ziv Yohanan ,  Yair A. Neumann ,  Anatoly Dvorsky ,  Jonathan Bar-Or ,  Oren Cohen ,  Ofir Witzman ,  Liron Tayeb ,  Elazar Levi Schwarcz ,  Noam Miller ,  Tomer Saar

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/243 ,  A61F2220/0041 ,  A61F2250/001 ,  A61F2250/0069

Abstract: An assembly can comprise a prosthetic valve comprising a radially expandable and compressible frame and a rotatable screw connected to the frame, where the screw comprises a screw head having an annular bore with internal threads, and where the screw is rotatable to radially expand the frame. The assembly further comprises a delivery apparatus releasably coupled to the screw, the delivery apparatus comprising a first shaft and a first head disposed at an end of the first shaft, the first head comprising external threads configured to engage with the internal threads of the screw head, and a second shaft that is coaxial with and surrounds the first shaft, the second shaft comprising a second head disposed at an end of the second shaft. The second head is configured to releasably engage with an exterior surface of the screw head and rotate the screw.

公开(公告)号：US12070388B2

公开(公告)日：2024-08-27

申请号：US18138651

申请日：2023-04-24

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： David Maimon ,  Liron Tayeb ,  Eran Goldberg

IPC: A61F2/24 ,  A61M25/00 ,  A61F2/95

CPC classification number: A61F2/2439 ,  A61F2/2427 ,  A61F2/2433 ,  A61M25/0023 ,  A61F2/9517 ,  A61M2025/0024

Abstract: The active introducer sheath systems disclosed herein are expanded by activating a translation mechanism at the handle. The sheath has an inner cylindrical structure of comingled fixed and mobile elongate rods bound together by an attachment line. Activating the translation mechanism causes the mobile rods to move axially with respect to the fixed rods, changing the internal tension in the attachment line. Increased tension draws the fixed and mobile rods closer together, decreasing the diameter of the cylindrical structure. Decreased tension in the attachment line enables the fixed and mobile rods to move apart, increasing the diameter of the cylindrical structure. A prosthetic device, such as a prosthetic heart valve, can be routed through the expanded sheath and to the implantation site. During implantation, the sheath can be contracted back to its original outer diameter, and expanded again for retrieval of the delivery apparatus.

公开(公告)号：US20240189100A1

公开(公告)日：2024-06-13

申请号：US18582897

申请日：2024-02-21

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： David Maimon ,  Boaz Manash ,  Eyal Leiba ,  Ziv Yohanan ,  Yair A. Neumann ,  Anatoly Dvorsky ,  Jonathan Bar-Or ,  Oren Cohen ,  Ofir Witzman ,  Liron Tayeb ,  Elazar Levi Schwarcz ,  Noam Miller ,  Tomer Saar

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/243 ,  A61F2220/0041 ,  A61F2250/001 ,  A61F2250/0069

Abstract: A method can comprise deploying a prosthetic valve with a delivery apparatus, where the prosthetic valve comprises a frame and a rotatable screw connected to the frame, and where the screw comprises a screw head having an annular bore with internal threads. The delivery apparatus is releasably coupled to the screw and can comprise a first shaft and a first head disposed at an end of the first shaft, the first head comprising external threads releasably engaged with the internal threads of the screw head, and a second shaft that is coaxial with and surrounds the first shaft, the second shaft comprising a second head disposed at an end of the second shaft, the second head releasably engaged with an exterior surface of the screw head. Deploying the valve includes radially expanding the prosthetic valve by rotating the screw with the delivery apparatus.

公开(公告)号：US20240099836A1

公开(公告)日：2024-03-28

申请号：US18531385

申请日：2023-12-06

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： David Maimon ,  Tamir S. Levi ,  Ziv Yohanan ,  Anatoly Dvorsky

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2002/8483

Abstract: Devices, assemblies, and methods for displacement of leaflets surrounding a prosthetic valve, such as native leaflets or host leaflets of a previously-implanted prosthetic valve, during valve implantation procedures are disclosed herein. As one example, a valve assembly can include a prosthetic valve and a leaflet engagement frame coupled to the frame of the prosthetic valve. The leaflet engagement frame can include a plurality of engagement frame struts defining one or more rungs, and a plurality of spikes that extend in a distal direction from a first rung of struts of the leaflet engagement frame. The distally extending spikes are configured to engage with one or more native or host leaflets positioned outside the valve assembly when the valve assembly is in a partially expanded state, and to distally fold the engaged native or host leaflets when the valve assembly is further expanded.

公开(公告)号：US20230414348A1

公开(公告)日：2023-12-28

申请号：US18459319

申请日：2023-08-31

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： David Maimon ,  Melissa Fusari ,  Tamir S. Levi

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2230/0069

Abstract: An implantable prosthetic valve may comprise a valve body having a proximal end, a distal end, an outer surface, and an inner surface facing a flow channel, and a skirt including a first level forming at least a portion of the outer surface of the valve body and configured to be thromboresistant and a second level forming at least a portion of the outer surface of the valve body and configured to allow tissue ingrowth with the second level. A plurality of prosthetic valve leaflets may be positioned within the flow channel and extend inward from the inner surface of the valve body.