公开(公告)号：USD810941S1

公开(公告)日：2018-02-20

申请号：US29580260

申请日：2016-10-06

Applicant: Edwards Lifesciences Corporation

Designer： Robert C. Taft ,  Mark Chau

公开(公告)号：US20170296336A1

公开(公告)日：2017-10-19

申请号：US15423378

申请日：2017-02-02

Applicant: Edwards Lifesciences Corporation

Inventor： Rafael Pintor ,  Mark Chau ,  Travis Zenyo Oba ,  August R. Yambao ,  Louis A. Campbell ,  Tammy Huntley ,  Qinggang Zeng ,  Carey L. Cristea ,  Faisal Kalam

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2409 ,  A61F2/243 ,  A61F2/2433 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2220/0083 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0078 ,  A61F2250/006

Abstract: A heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve has a base stent that is deployed at a treatment site, and a valve component configured to quickly connect to the base stent. The base stent may take the form of a self-or balloon-expandable stent that expands outward against the native valve with or without leaflet excision. The valve component has a non-expandable prosthetic valve and a self-or balloon-expandable coupling stent for attachment to the base stent, thereby fixing the position of the valve component relative to the base stent. The prosthetic valve may be a commercially available to valve with a sewing ring and the coupling stent attaches to the sewing ring. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment. A catheter-based system and method for deployment is provided.

公开(公告)号：US20170056176A1

公开(公告)日：2017-03-02

申请号：US15244716

申请日：2016-08-23

Applicant: Edwards Lifesciences Corporation

Inventor： Stanton J. Rowe ,  Jinny Lee ,  Philip P. Corso, JR. ,  Mark Chau ,  David L. Hauser

IPC: A61F2/24

CPC classification number: A61F2/2487 ,  A61B17/0487 ,  A61B2017/00358 ,  A61B2017/0417 ,  A61B2017/0464 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/2442 ,  A61F2/2454 ,  A61F2/246 ,  A61F2/2463 ,  A61F2/2466 ,  A61F2250/006

Abstract: The present disclosure concerns embodiments of an implantable device that are used to treat an insufficient heart valve that has been previously treated by implantation of a fixation device or an Alfieri stitch that is secured to opposing portions of the native leaflets. In one representative embodiment, an implantable device for remodeling a native mitral valve having two native leaflets and a fixation device or an Alfieri stitch secured to respective free edges of the leaflets is configured to be coupled to the fixation device or Alfieri stitch and apply a remodeling force to the native mitral valve that draws the native leaflets toward each other to promote coaptation of the leaflets.

Abstract translation: 本公开涉及可植入装置的实施例，其用于治疗先前已经通过植入固定在天然传单的相对部分的固定装置或Alfieri针迹来治疗的心脏瓣膜不足。 在一个代表性的实施例中，用于重塑具有两个天然传单的固有二尖瓣的可植入装置和固定到小叶各自的自由边缘上的固定装置或固定装置被配置成联接到固定装置或Alfieri针迹并施加重塑 对原生二尖瓣施加力量，将本地传单彼此拉开，以促进传单的接合。

公开(公告)号：US09561100B2

公开(公告)日：2017-02-07

申请号：US14684267

申请日：2015-04-10

Applicant: Edwards Lifesciences Corporation

Inventor： Rafael Pintor ,  Mark Chau ,  Travis Oba ,  August R. Yambao ,  Louis A. Campbell ,  Tammy Huntley ,  Qinggang Zeng ,  Carey L. Cristea ,  Faisal Kalam

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2409 ,  A61F2/243 ,  A61F2/2433 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2220/0083 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0078 ,  A61F2250/006

Abstract: A heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve has a base stent that is deployed at a treatment site, and a valve component configured to quickly connect to the base stent. The base stent may take the form of a self- or balloon-expandable stent that expands outward against the native valve with or without leaflet excision. The valve component has a non-expandable prosthetic valve and a self- or balloon-expandable coupling stent for attachment to the base stent, thereby fixing the position of the valve component relative to the base stent. The prosthetic valve may be a commercially available to valve with a sewing ring and the coupling stent attaches to the sewing ring. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment. A catheter-based system and method for deployment is provided.

Abstract translation: 提供了可以在手术过程中快速且容易地植入的心脏瓣膜假体。 假体瓣膜具有部署在治疗部位的基部支架和构造成快速连接到基部支架的阀部件。 基底支架可以采取自体或球囊扩张的支架的形式，其在具有或不具有小叶切除的情况下相对于天然瓣膜向外扩张。 阀部件具有不可扩张的假体瓣膜和用于附接到基底支架的自支撑或球囊扩张的联接支架，由此固定阀部件相对于基底支架的位置。 人造瓣膜可以是市售的，具有缝合环的阀门，并且联接支架附接到缝合环。 该系统特别适用于在常规开心手术环境中快速部署心脏瓣膜。 提供了基于导管的系统和部署方法。

公开(公告)号：US09510946B2

公开(公告)日：2016-12-06

申请号：US14011598

申请日：2013-08-27

Applicant: Edwards Lifesciences Corporation

Inventor： Mark Chau ,  Travis Oba ,  Sergio Delgado ,  Robert C. Taft ,  Stanton J. Rowe ,  Alexander H. Cooper

IPC: A61F2/24

CPC classification number: A61F2/2436 ,  A61F2/2412 ,  A61F2/243 ,  A61F2/2433 ,  A61F2/2442 ,  A61F2/2445 ,  A61F2/2454 ,  A61F2/2457 ,  A61F2/246 ,  A61F2/2463 ,  A61F2/2466 ,  A61F2230/0069 ,  A61F2250/0003

Abstract: This disclosure pertains generally to prosthetic devices and related methods for helping to seal native heart valves and prevent or reduce regurgitation therethrough, as well as devices and related methods for implanting such prosthetic devices. In some cases, a spacer having a single anchor can be implanted within a native heart valve. In some cases, a spacer having dual anchors can be implanted within a native heart valve. In some cases, devices can be used to extend the effective length of a native heart valve leaflet.

公开(公告)号：US20160338826A1

公开(公告)日：2016-11-24

申请号：US15227238

申请日：2016-08-03

Applicant: Edwards Lifesciences Corporation

Inventor： Mark Chau ,  Marlowe E. Patterson ,  Seung-Beom Yi ,  Stephen C. Geist ,  Travis Zenyo Oba

IPC: A61F2/24

CPC classification number: A61F2/2412 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/2445 ,  A61F2/246 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2230/0069 ,  A61F2250/006 ,  A61F2250/0063

Abstract: A prosthetic apparatus for implantation in a native mitral valve includes a main body for placement within the native mitral annulus. The main body is compressible to a radially compressed state for delivery into the heart and is self-expandable from the compressed state to a radially expanded state for implantation. A valve structure is mounted within a lumen of the main body and preferably forms three leaflets made of pericardium. An atrial sealing member is disposed along an atrial portion of the main body and ventricular anchors are coupled to a ventricular portion of the main body. The atrial sealing member impedes the flow of blood between the main body and the native annulus. The ventricular anchors are positioned outside the main body for capturing native mitral valve leaflets between the main body and the ventricular anchors.

Abstract translation: 用于植入天然二尖瓣的假体装置包括用于放置在天然二尖瓣环内的主体。 主体可压缩到径向压缩状态，用于输送到心脏中，并且可以从压缩状态自扩张到用于植入的径向扩张状态。 阀结构安装在主体的内腔中，优选形成由心包制成的三个传单。 心房密封构件沿着主体的心房部分设置，并且心室锚固件联接到主体的心室部分。 心房密封件妨碍主体和天然环之间的血液流动。 心室锚定位于主体外部，用于捕获主体和心室锚之间的原生二尖瓣小叶。

公开(公告)号：US20160331523A1

公开(公告)日：2016-11-17

申请号：US15154578

申请日：2016-05-13

Applicant: Edwards Lifesciences Corporation

Inventor： Mark Chau ,  David M. Taylor ,  Alexander J. Siegel ,  Christopher J. Olson ,  Sergio Delgado ,  Alexander H. Cooper ,  Lauren R. Freschauf ,  Asher L. Metchik ,  Matthew T. Winston ,  Cristobal R. Hernandez ,  Emil Karapetian ,  Bao Khuu ,  Eric Dixon

IPC: A61F2/24

Abstract: In one representative embodiment, an implantable prosthetic device comprises a spacer body portion configured to be disposed between native leaflets of a heart, and an anchor portion configured to secure the native leaflets against the spacer body portion, wherein the prosthetic device is movable between a compressed configuration, in which the spacer body portion is radially compressed and is axially spaced relative to the anchor portion, and an expanded configuration, in which the spacer body portion expands radially outwardly relative to the compressed configuration and overlaps at least a portion of the anchor portion.

Abstract translation: 在一个代表性的实施例中，可植入假体装置包括被配置为设置在心脏的天然传播单元之间的间隔体本体部分和被配置成将天然传单固定在间隔体主体部分上的锚固部分，其中假体装置可在压缩 配置，其中间隔件主体部分被径向压缩并且相对于锚定部分轴向间隔开，并且展开构造，其中间隔件主体部分相对于压缩构造径向向外扩张并且与锚定部分的至少一部分重叠 。

公开(公告)号：US20160317290A1

公开(公告)日：2016-11-03

申请号：US15204874

申请日：2016-07-07

Applicant: Edwards Lifesciences Corporation

Inventor： Mark Chau ,  Travis Zenyo Oba ,  Sergio Delgado ,  Robert C. Taft

IPC: A61F2/24

CPC classification number: A61F2/2436 ,  A61F2/2412 ,  A61F2/243 ,  A61F2/2433 ,  A61F2/2442 ,  A61F2/2445 ,  A61F2/2454 ,  A61F2/2457 ,  A61F2/246 ,  A61F2/2463 ,  A61F2/2466 ,  A61F2230/0069 ,  A61F2250/0003

Abstract: This disclosure pertains generally to prosthetic devices and related methods for helping to seal native heart valves and prevent or reduce regurgitation therethrough, as well as devices and related methods for implanting such prosthetic devices. In some cases, a spacer having a single anchor can be implanted within a native heart valve. In some cases, a spacer having dual anchors can be implanted within a native heart valve. In some cases, devices can be used to extend the effective length of a native heart valve leaflet.

Abstract translation: 本公开总体上涉及用于帮助密封天然心脏瓣膜并防止或减少反流的假体装置和相关方法，以及用于植入这种假体装置的装置和相关方法。 在一些情况下，具有单个锚的间隔物可以植入天然心脏瓣膜内。 在一些情况下，具有双重锚的间隔物可以植入天然心脏瓣膜内。 在某些情况下，可以使用装置来延长天然心脏瓣膜小叶的有效长度。

公开(公告)号：US20150320553A1

公开(公告)日：2015-11-12

申请号：US14801713

申请日：2015-07-16

Applicant: Edwards Lifesciences Corporation

Inventor： Mark Chau ,  Marlowe E. Patterson ,  Seung-Beom Yi ,  Stephen C. Geist ,  Travis Oba

IPC: A61F2/24

CPC classification number: A61F2/2412 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/2445 ,  A61F2/246 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2230/0069 ,  A61F2250/006 ,  A61F2250/0063

Abstract: A prosthetic apparatus configured for implantation in the native mitral valve region of the heart includes a main body that is self-expandable from a compressed state to a radially expanded state. The prosthetic apparatus comprises at least one ventricular anchor coupled to the main body and disposed outside of the main body for capturing a native valve leaflet between the anchor and an outer surface of the main body. In one preferred method of implantation, the prosthetic apparatus is rotated within the native mitral valve region such that a portion of the anchor moves horizontally behind adjacent chordae for anchoring the prosthetic apparatus in the native mitral valve.

Abstract translation: 构造成用于植入心脏的天然二尖瓣区域的假体装置包括从压缩状态向径向展开状态自扩张的主体。 假体装置包括耦合到主体并且设置在主体外部的至少一个心室锚，用于捕获锚固体和主体的外表面之间的天然瓣膜。 在一种优选的植入方法中，假体装置在天然二尖瓣区域内旋转，使得锚的一部分水平地移动到相邻的腱索之后，以将假体装置锚定在天然二尖瓣中。

公开(公告)号：US20150230919A1

公开(公告)日：2015-08-20

申请号：US14622460

申请日：2015-02-13

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Mark Chau ,  David M. Taylor ,  Alexander J. Siegel ,  Stanton J. Rowe ,  Bao Khuu ,  Yoon H. Kwon

IPC: A61F2/24

CPC classification number: A61F2/246 ,  A61B17/0487 ,  A61B2017/00243 ,  A61B2017/0488 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2457 ,  A61F2/2463 ,  A61F2/2466

Abstract: In a representative embodiment, an implantable prosthetic heart valve device comprises an elongated body having first and second end portions, the body being configured to be implanted around a native leaflet of a heart valve such that the first end portion is on an atrial side of the leaflet and the second end portion is on a ventricular side of the leaflet and such that the body can coapt with and move away from an opposing native leaflet during operation of the heart valve. The device can further comprises a fastener configured to be mounted on a suture that extends from one of the first or second end portions, through the native leaflet and through the other of the first or second end portions such that the body is secured to the native leaflet.

Abstract translation: 在代表性的实施例中，可植入假体心脏瓣膜装置包括具有第一和第二端部的细长体，所述主体被配置为围绕心脏瓣膜的天然小叶植入，使得第一端部位于心脏瓣膜的心房侧 小叶，并且第二端部位于小叶的心室侧，并且使得在心脏瓣膜的操作期间，身体可以与相对的天然小叶相配合并移开。 该装置还可包括紧固件，该紧固件被配置成安装在从第一或第二端部中的一个延伸穿过天然小叶并通过第一或第二端部中的另一个的缝合线，使得主体固定到本地 传单。