公开(公告)号：US09260729B2

公开(公告)日：2016-02-16

申请号：US13168833

申请日：2011-06-24

申请人： Jun Sun ,  Priti Pharkya ,  Anthony P. Burgard

发明人： Jun Sun ,  Priti Pharkya ,  Anthony P. Burgard

IPC分类号： C12P7/04 ,  C12P7/16 ,  C12N1/20 ,  C12P7/02 ,  C12N9/04 ,  C12N9/02 ,  C12N9/10 ,  C12N9/88

CPC分类号： C12P7/04 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/88 ,  C12N15/52 ,  C12P7/02 ,  C12Y101/01001 ,  C12Y101/01035 ,  C12Y102/0105 ,  C12Y203/01009 ,  C12Y203/01016 ,  C12Y402/01017

摘要： The invention provides a non-naturally occurring microbial organism having at least one exogenous gene insertion and/or one or more gene disruptions that confer production of primary alcohols. A method for producing long chain alcohols includes culturing these non-naturally occurring microbial organisms.

摘要翻译： 本发明提供了具有至少一种外源基因插入和/或一种或多种赋予伯醇生产的基因破坏的非天然存在的微生物生物。 制备长链醇的方法包括培养这些非天然存在的微生物。

公开(公告)号：US09161106B2

公开(公告)日：2015-10-13

申请号：US13524822

申请日：2012-06-15

申请人： Jun Sun ,  Junzhou Cai

发明人： Jun Sun ,  Junzhou Cai

IPC分类号： G02F1/00 ,  H04Q11/00 ,  H04L29/14 ,  H04L12/707 ,  H04L12/703

CPC分类号： H04Q11/0062 ,  H04L45/22 ,  H04L45/28 ,  H04L69/40 ,  H04Q2011/0081 ,  H04Q2011/0098

摘要： Embodiments of the present invention disclose a method for implementing shared mesh protection includes: receiving, by a first node, a message of a second type sent by a second node, where the message of the second type carries a second positive incoming sublabel allocated by the second node for a protection path of a first service and the second positive incoming sublabel is used to indicate a specified feature of recovery information of the first service; allocating, by the first node, a first positive outgoing label for the protection path of the first service based on the second positive incoming sublabel, where the first positive outgoing label corresponds to the second positive incoming sublabel; and transmitting the recovery information of the first service to the second node based on an indication of the first positive outgoing sublabel when knowing that a working path of the first service is faulty.

摘要翻译： 本发明的实施例公开了一种用于实现共享网格保护的方法，包括：由第一节点接收由第二节点发送的第二类型的消息，其中第二类型的消息携带由第二类型分配的第二正向传入子标签 用于第一服务的保护路径的第二节点和第二正输入子标签用于指示第一服务的恢复信息的指定特征; 由所述第一节点基于所述第二正进入子标签为所述第一服务的保护路径分配第一正向输出标签，其中所述第一正向输出标签对应于所述第二正向传入子标签; 以及当知道所述第一服务的工作路径有故障时，基于所述第一正向传出子标签的指示，将所述第一服务的恢复信息发送到所述第二节点。

公开(公告)号：US09054944B2

公开(公告)日：2015-06-09

申请号：US13269240

申请日：2011-10-07

申请人： Yu Wang ,  Jun Sun

发明人： Yu Wang ,  Jun Sun

IPC分类号： H04L12/28 ,  H04L12/701 ,  H04L12/717

CPC分类号： H04L45/125 ,  H04J3/1611 ,  H04J3/1652 ,  H04J2203/0098 ,  H04L45/00 ,  H04L45/42

摘要： The present invention provides a path computation method, a Path Computation Element (PCE), a node device, and a network system. The method includes: receiving a path computation request message (S201), where the path computation request message carries a network type identifier and traffic parameter constraint conditions of a path required to be computed, and the network type identifier indicates a type of a network where the path required to be computed locates; determining the network through the network type identifier, and computing the path in the network according to the traffic parameter constraint conditions (S202); and sending a path computation response message (S203), where the path computation response message carries the computed path. The problem of distinguishing and computing Traffic Engineer (TE) paths for various types of services in a multi-region convergence network is solved.

摘要翻译： 本发明提供路径计算方法，路径计算元件（PCE），节点设备和网络系统。 该方法包括：接收路径计算请求消息（S201），其中路径计算请求消息携带要计算的路径的网络类型标识符和业务参数约束条件，并且网络类型标识符指示网络的类型， 需要计算的路径位置; 通过网络类型标识确定网络，并根据流量参数约束条件计算网络中的路径（S202）; 并发送路径计算响应消息（S203），其中路径计算响应消息携带所计算的路径。 解决了多区域融合网络中各种业务的区分和计算流量工程师（TE）路径问题。

公开(公告)号：US08907972B2

公开(公告)日：2014-12-09

申请号：US13549764

申请日：2012-07-16

申请人： Danian Zheng ,  Jun Sun ,  Satoshi Naoi

发明人： Danian Zheng ,  Jun Sun ,  Satoshi Naoi

IPC分类号： G09G5/02 ,  G06K9/34 ,  H04N1/40

CPC分类号： H04N1/40062 ,  G06K9/342 ,  G06K2209/01

摘要： An image processing device including: a local mean image generating section; a binarization image generating section configured to generate a binarization image, wherein pixels corresponding to high frequency regions and low frequency regions have a first and second grey scales, respectively; a ternarization image generating section configured to divide, based on comparison between the image and the local mean image, first grey scale regions in the binarization image into regions having the first grey scale and regions having a third grey scale; a filling section configured to recognize connected regions having the second grey scale in the ternarization image, to fill the connected regions with the first grey scale or with the third grey scale according to grey scale of pixels at boundaries of the connected regions; and a recognizing section configured to recognize strokes according to consistency of grey scale at object boundaries in the filled ternarization image.

摘要翻译： 一种图像处理装置，包括：局部平均图像生成部; 二值化图像生成部，被配置为生成二值化图像，其中分别对应于高频区域和低频区域的像素具有第一和第二灰度级; 三角化图像生成部，被配置为基于所述图像和所述局部平均图像之间的比较将所述二值化图像中的第一灰度区域划分为具有所述第一灰度级的区域和具有第三灰度级的区域; 填充部，被配置为在所述三维化图像中识别具有所述第二灰度级的连接区域，以根据所述连接区域的边界处的像素的灰度级以所述第一灰度级或所述第三灰度级填充所连接的区域; 以及识别部，被配置为根据填充的三元化图像中的对象边界处的灰度的一致性来识别笔画。

公开(公告)号：US08737743B2

公开(公告)日：2014-05-27

申请号：US13526938

申请日：2012-06-19

申请人： Jun Sun ,  Satoshi Naoi

发明人： Jun Sun ,  Satoshi Naoi

IPC分类号： G06K9/18

CPC分类号： G06K9/3208 ,  G06F17/275 ,  G06K9/344 ,  G06K2209/01

摘要： The present embodiments disclose a method of and a device for identifying the direction of characters in an image block. The method includes: performing optical character recognition processing on the image block by assuming various directions as assumed character directions, respectively, to obtain sub image blocks, recognized characters corresponding to the sub image blocks and correctness measures thereof in each of the assumed character directions; determining a language group to which the characters in the image block belong; adjusting a correctness measure corresponding to a sub image block which corresponds to a recognized character not belonging to the determined language group in each of the assumed character directions; calculating an accumulative correctness measure in each of the assumed character directions based on the adjusted correctness measure; and identifying the direction of the characters in the image block according to the accumulative correctness measures.

摘要翻译： 本实施例公开了一种用于识别图像块中的字符的方向的方法和装置。 该方法包括：通过假设各个方向作为假定的字符方向，分别对图像块执行光学字符识别处理，以获得子图像块，对应于子图像块的识别字符及其在每个假定字符方向上的正确性度量; 确定图像块中的字符属于的语言组; 在每个假定的字符方向上调整对应于对应于不属于所确定的语言组的识别字符的子图像块的正确性度量; 基于所调整的正确性度量，计算每个假设字符方向中的累积正确性度量; 并根据累积的正确性度量来识别图像块中的字符的方向。

公开(公告)号：US08703152B2

公开(公告)日：2014-04-22

申请号：US12996166

申请日：2009-06-03

申请人： Jun Sun

发明人： Jun Sun

IPC分类号： A61K39/112 ,  A61K39/00 ,  A61K39/38 ,  A61K39/02 ,  A61K45/00 ,  A61K47/00 ,  A61K38/16 ,  A61K38/00

CPC分类号： A61K38/164 ,  A61K48/00 ,  C07K14/255 ,  C12N15/85 ,  C12N2830/008 ,  Y02A50/481

摘要： Methods and products are disclosed for treating an inflammatory intestinal disease in a mammalian subject in need thereof, or preventing or reducing a symptom of inflammatory intestinal disease. These method include administering to the subject a therapeutically effective dose of (i) an isolated AvrA protein or polypeptide fragment thereof or (ii) a nucleic acid molecule encoding the isolated AvrA protein or polypeptide fragment. Preferred inflammatory intestinal diseases include Inflammatory Bowel Disease, Celiac Disease, and gastroenteritis.

摘要翻译： 公开了用于治疗有需要的哺乳动物受试者的炎性肠道疾病或预防或减轻炎症性肠病的症状的方法和产品。 这些方法包括向受试者施用治疗有效剂量的（i）分离的AvrA蛋白或其多肽片段或（ii）编码分离的AvrA蛋白或多肽片段的核酸分子。 优选的炎症性肠病包括炎症性肠病，腹腔疾病和胃肠炎。

公开(公告)号：US08637286B2

公开(公告)日：2014-01-28

申请号：US13011818

申请日：2011-01-21

申请人： Anthony P. Burgard ,  Robin E. Osterhout ,  Jun Sun ,  Priti Pharkya

发明人： Anthony P. Burgard ,  Robin E. Osterhout ,  Jun Sun ,  Priti Pharkya

IPC分类号： C12N9/00 ,  C12N1/20

CPC分类号： C12P7/42 ,  C12N9/0008 ,  C12N9/0095 ,  C12P7/04 ,  C12P7/16 ,  C12P7/18 ,  C12P7/52 ,  Y02E50/10

摘要： A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing theses non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce a product having acetyl-CoA as a building block. Another non-naturally occurring microbial organism includes at least one exogenous nucleic acid encoding an enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, thereby increasing the yield of redox-limited products via carbohydrate-based carbon feedstock. A method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen includes culturing this organism for a sufficient period of time to produce a product.

摘要翻译： 非天然存在的微生物体包括具有还原性TCA或Wood-Ljungdahl途径的微生物生物体，其中至少一种编码这些途径酶的外源核酸以足够的量表达以增强通过乙酰辅酶A的碳通量。 通过乙酰辅酶A增强碳通量的方法包括在条件和足够的时间段内培养这些非天然存在的微生物，以产生具有乙酰辅酶A作为结构单元的产物。 另一种非天然存在的微生物生物体包括至少一种编码以足够量表达的酶的外源核酸，以增强在一氧化碳或氢气存在下还原当量的可用性，从而通过碳水化合物 - 碳原料。 在一氧化碳或氢气存在下增强还原当量的可用性的方法包括在足够的时间内培养该生物体以产生产物。

公开(公告)号：US08445244B2

公开(公告)日：2013-05-21

申请号：US13011788

申请日：2011-01-21

申请人： Anthony P. Burgard ,  Robin E. Osterhout ,  Jun Sun ,  Priti Pharkya

发明人： Anthony P. Burgard ,  Robin E. Osterhout ,  Jun Sun ,  Priti Pharkya

IPC分类号： C12N9/00 ,  C12N1/20

CPC分类号： C12P7/42 ,  C12N9/0008 ,  C12N9/0095 ,  C12P7/04 ,  C12P7/16 ,  C12P7/18 ,  C12P7/52 ,  Y02E50/10

摘要： A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing theses non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce a product having acetyl-CoA as a building block. Another non-naturally occurring microbial organism includes at least one exogenous nucleic acid encoding an enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, thereby increasing the yield of redox-limited products via carbohydrate-based carbon feedstock. A method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen includes culturing this organism for a sufficient period of time to produce a product.

摘要翻译： 非天然存在的微生物体包括具有还原性TCA或Wood-Ljungdahl途径的微生物生物体，其中至少一种编码这些途径酶的外源核酸以足够的量表达以增强通过乙酰辅酶A的碳通量。 通过乙酰辅酶A增强碳通量的方法包括在条件和足够的时间段内培养这些非天然存在的微生物，以产生具有乙酰辅酶A作为结构单元的产物。 另一种非天然存在的微生物生物体包括至少一种编码以足够量表达的酶的外源核酸，以增强在一氧化碳或氢气存在下还原当量的可用性，从而通过碳水化合物 - 碳原料。 在一氧化碳或氢气存在下增强还原当量的可用性的方法包括在足够的时间内培养该生物体以产生产物。

公开(公告)号：US20130065279A1

公开(公告)日：2013-03-14

申请号：US13436811

申请日：2012-03-30

申请人： Mark J. BURK ,  Anthony P. Burgard ,  Robin E. Osterhout ,  Jun Sun ,  Priti Pharkya

发明人： Mark J. BURK ,  Anthony P. Burgard ,  Robin E. Osterhout ,  Jun Sun ,  Priti Pharkya

IPC分类号： C12P7/40 ,  C12N1/15 ,  C12P19/40 ,  C12P7/62 ,  C12P7/42 ,  C12N1/21 ,  C12N1/19

CPC分类号： C12P7/40 ,  C12P7/42 ,  C12P7/62 ,  C12P19/32

摘要： The invention provides a non-naturally occurring microbial organism having a methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a methacrylic acid pathway. The invention additionally provides a method for producing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate. The method can include culturing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a methacrylic acid pathway enzyme in a sufficient amount to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate, under conditions and for a sufficient period of time to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate.

摘要翻译： 本发明提供具有甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯途径的非天然存在的微生物生物。 微生物生物体含有编码甲基丙烯酸途径中的酶的至少一种外源核酸。 本发明另外提供了生产甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯的方法。 该方法可以包括培养产生甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯的微生物，其中微生物生物体表达至少一种编码甲基丙烯酸途径酶的外源核酸，其量足以产生甲基丙烯酸， 甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯在条件下和足够的时间以产生甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯。

公开(公告)号：US20130022271A1

公开(公告)日：2013-01-24

申请号：US13525736

申请日：2012-06-18

申请人： Jun Sun ,  Satoshi Naoi

发明人： Jun Sun ,  Satoshi Naoi

IPC分类号： G06K9/18

CPC分类号： G06K9/3208 ,  G06K9/344 ,  G06K2209/01

摘要： The embodiments disclose a method of and a device for identifying direction of characters in image block. The method includes: performing optical character recognition processing on the image block by assuming various directions as assumed character directions to obtain sub image blocks, recognized characters and correctness measures in each assumed direction; in sub image blocks in the assumed directions with a 180° mutual relation, searching for a minimum matching pair; when there is one sub image block in each assumed direction in a minimum matching pair and recognized characters belonging to the minimum matching pair are the same rotation invariant character or belong to the same rotation invariant character pair, adjusting their correctness measures to the same; calculating an accumulative correctness measure in each assumed direction based on the adjusted results; and identifying the direction of the characters in the image block according to the accumulative correctness measures.

摘要翻译： 实施例公开了用于识别图像块中的字符的方向的装置和方法。 该方法包括：通过假设各种方向作为假定的字符方向对图像块执行光学字符识别处理，以在每个假定方向上获得子图像块，识别的字符和正确性度量; 在具有180°相互关系的假设方向上的子图像块中，搜索最小匹配对; 当在最小匹配对中的每个假定方向上存在一个子图像块时，属于最小匹配对的识别字符是相同的旋转不变字符或属于相同的旋转不变字符对，将它们的正确性度量调整到相同; 根据调整结果计算每个假设方向的累积正确度; 并根据累积的正确性度量来识别图像块中的字符的方向。