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114 条记录 (耗时 0.063 秒)

    Heterocyclic spiro-derivative
    81.
    发明授权
    Heterocyclic spiro-derivative 失效
    杂环螺衍生物

    公开(公告)号：US06469023B1

    公开(公告)日：2002-10-22

    申请号：US08875863

    申请日：1997-08-07

    申请人： Makoto Takemura ,  Youichi Kimura ,  Hitoshi Ohki

    发明人： Makoto Takemura ,  Youichi Kimura ,  Hitoshi Ohki

    IPC分类号： A61K3144

    CPC分类号： C07D401/04

    摘要： The present invention provides an antibacterial compound useful as medicines, animal drugs, fisheries drugs or antibacterial preservatives and to an antibacterial agent or preparation which contains the same, more particularly a compound which possesses high safety and excellent activity against a broad range of bacterial species including quinolone-resistant strains. A quinolone derivative of the following formula (I) which has a group derived from the heterocyclic spiro-compound at the 7-positioned R2 and the halogenocyclopropyl group at the N1-position, prefereably a compound of pure isomer, and an antibacterial agent containing the derivative compound.

    摘要翻译： 本发明提供了可用作药物，动物药物，渔业药物或抗菌防腐剂的抗菌化合物，以及含有该抗菌剂或抗菌剂的抗菌剂或制剂，更具体地，涉及对广泛的细菌种类具有高安全性和优异活性的化合物，包括 喹诺酮耐药株。 下述式（I）的喹啉酮衍生物，其具有衍生自7-位R2上的杂环螺环化合物和N1位上的卤代环丙基的基团，优选纯异构体的化合物和含有 衍生化合物。

    Cycloalkylaminomethylpyrrolidine derivatives
    83.
    发明授权
    Cycloalkylaminomethylpyrrolidine derivatives 失效
    环烷基氨基甲基吡咯烷衍生物

    公开(公告)号：US06194434B1

    公开(公告)日：2001-02-27

    申请号：US09171637

    申请日：1998-10-22

    申请人： Makoto Takemura ,  Youichi Kimura ,  Katsuhiro Kawakami ,  Hitoshi Ohki

    发明人： Makoto Takemura ,  Youichi Kimura ,  Katsuhiro Kawakami ,  Hitoshi Ohki

    IPC分类号： A61K3147

    CPC分类号： C07D401/04

    摘要： A quinolone derivative represented by formula (I): wherein R1 represents a cycloalkyl group; R2 represents a hydrogen atom, an amino group, a hydroxyl group, a thiol group, a halogenomethyl group, an alkyl group, an alkenyl group, an alkynyl group, or an alkoxyl group; R3 represents an amino group, a halogenomethyl group, a halogenomethoxyl group, an alkyl group, an alkenyl group, an alkynyl group, or an alkoxyl group; R4 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; R5 represents a cycloalkyl group having 3 to 6 carbon atoms; the above R1 to R5 may be substituted; X represents a halogen atom or a hydrogen atom; and Y represents a hydrogen atom, a phenyl group, an acetoxymethyl group, a pivaloyloxymethyl group, an ethoxycarbonyl group, a choline group, a dimethylaminoethyl group, a 5-indanyl group, a phthalidinyl group, a 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl group, a 3-acetoxy-2-oxobutyl group, an alkyl group having 1 to 6 carbon atoms, an alkoxymethyl group having 2 to 7 carbon atoms, or a phenylalkyl group having 1 to 6 carbon atoms in the alkyl moiety thereof, or a salt thereof. The compound exhibits high and broad antimicrobial activity against various bacteria including bacteria resistant to drugs and high safety.

    摘要翻译： 由式（I）表示的喹诺酮衍生物：其中R1表示环烷基; R2表示氢原子，氨基，羟基，硫醇基，卤代甲基，烷基，烯基，炔基或烷氧基; R3表示氨基，卤代甲基，卤代甲氧基，烷基，烯基，炔基或烷氧基; R4表示氢原子或碳原子数1〜6的烷基。 R5表示碳原子数3〜6的环烷基; 上述R 1〜R 5可以被取代; X表示卤素原子或氢原子; Y表示氢原子，苯基，乙酰氧基甲基，新戊酰氧基甲基，乙氧基羰基，胆碱基，二甲基氨基乙基，5-二氢化茚基，苯酞基，5-烷基-2-氧代 - 1,3-二氧杂环戊烯-4-基甲基，3-乙酰氧基-2-氧代丁基，碳原子数1〜6的烷基，碳原子数2〜7的烷氧基甲基或碳原子数1〜6的苯基烷基 其烷基部分的原子，或其盐。 该化合物对各种细菌（包括对药物有抗性的细菌和高安全性）具有高而广的抗菌活性。

    Recording apparatus and method for forming plural dots in a pixel
    84.
    发明授权
    Recording apparatus and method for forming plural dots in a pixel 失效
    用于在像素中形成多个点的记录装置和方法

    公开(公告)号：US06106100A

    公开(公告)日：2000-08-22

    申请号：US453577

    申请日：1995-05-26

    申请人： Koji Terasawa ,  Makoto Takemura ,  Katsuyuki Yokoi

    发明人： Koji Terasawa ,  Makoto Takemura ,  Katsuyuki Yokoi

    IPC分类号： H04N1/405 ,  H04N1/52 ,  B41J2/145

    CPC分类号： H04N1/52 ,  H04N1/4051

    摘要： There is disclosed a dot forming method and a recording apparatus, suitable for unprocessed recording medium, such as plain paper having fluctuation in its ink absorbing ability, or a plastic sheet with low ink absorbing ability. At the formation of each pixel with plural dots, the dots are so distributed that they are not continuous but are mutually complementary in the transverse and longitudinal directions of the pixel and also at least in the boundary area of adjacent pixels.

    摘要翻译： 公开了适用于未加工的记录介质的点形成方法和记录装置，例如其吸墨能力波动的普通纸或具有低吸墨能力的塑料片。 在形成具有多个点的每个像素时，这些点是分布的，使得它们不是连续的，而是在像素的横向和纵向方向以及至少在相邻像素的边界区域中互补。

    Shuttle type recording apparatus
    85.
    发明授权
    Shuttle type recording apparatus 失效
    穿梭式记录装置

    公开(公告)号：US6000781A

    公开(公告)日：1999-12-14

    申请号：US901108

    申请日：1997-07-28

    申请人： Yuji Akiyama ,  Shinji Kanemitsu ,  Hiromitsu Hirabayashi ,  Makoto Takemura ,  Miyuki Fujita ,  Akitoshi Yamada

    发明人： Yuji Akiyama ,  Shinji Kanemitsu ,  Hiromitsu Hirabayashi ,  Makoto Takemura ,  Miyuki Fujita ,  Akitoshi Yamada

    IPC分类号： B41J2/01 ,  B41J2/485 ,  B41J2/51 ,  B41J3/54 ,  B41J19/18 ,  B41J2/015

    CPC分类号： B41J3/54

    摘要： In a recording apparatus for recording on a recording medium by a plurality of recording heads, a scan unit has a carriage capable of mounting the recording heads at a predetermined interval and causes the recording heads to scan corresponding divided recording areas. A record control unit causes the recording heads to conduct a first record mode to record an area of a first recording width in a direction of scan by shared recording by the recording heads of the corresponding recording areas and a second record mode to record an area of a second recording width smaller than the recording width of the first recording width by causing at least one of the recording heads to record in the corresponding divided recording area when the corresponding divided recording areas are scanned. A distance between two recording apparatus mounted at outermost positions in the arrangement of the recording heads on the carriage is not larger than a difference between the first recording width and the second recording width.

    摘要翻译： 在用于通过多个记录头在记录介质上记录的记录装置中，扫描单元具有能够以预定间隔安装记录头的托架，并使记录头扫描相应的划分的记录区域。 记录控制单元使得记录头进行第一记录模式，以通过相应记录区域的记录头的共享记录来记录扫描方向上的第一记录宽度的区域和记录第二记录模式的区域 当扫描对应的划分的记录区域时，通过使至少一个记录头记录在对应的分割记录区域中，使第二记录宽度小于第一记录宽度的记录宽度。 安装在滑架上的记录头的布置中的最外侧位置的两个记录装置之间的距离不大于第一记录宽度和第二记录宽度之间的差。

    Method and apparatus for recording information with corrected drive timing
    88.
    发明授权
    Method and apparatus for recording information with corrected drive timing 失效
    用修正的驱动定时记录信息的方法和装置

    公开(公告)号：US5988784A

    公开(公告)日：1999-11-23

    申请号：US149747

    申请日：1993-11-10

    申请人： Makoto Takemura ,  Shinji Kanemitsu ,  Makoto Kashimura ,  Shinya Matsui ,  Toshiyuki Onishi ,  Tetsuhiro Nitta ,  Yasuhiro Unosawa ,  Hajime Yoshida ,  Masaru Satou ,  Hisashi Morioka ,  Hiroshi Yoshino

    发明人： Makoto Takemura ,  Shinji Kanemitsu ,  Makoto Kashimura ,  Shinya Matsui ,  Toshiyuki Onishi ,  Tetsuhiro Nitta ,  Yasuhiro Unosawa ,  Hajime Yoshida ,  Masaru Satou ,  Hisashi Morioka ,  Hiroshi Yoshino

    IPC分类号： B41J2/05 ,  B41J2/175 ,  B41J25/308 ,  B41J25/34

    CPC分类号： B41J2/1752 ,  B41J2/04503 ,  B41J2/04551 ,  B41J2/04553 ,  B41J2/04563 ,  B41J2/04573 ,  B41J2/0458 ,  B41J25/308 ,  B41J25/34

    摘要： Ink jet recording encounters deviations in the position at which a recorded dot is applied due to changes in the distance from the recording head to a recording medium, the carriage movement speed and the ink discharge speed or the like. When bidirectional recording is performed while moving the carriage having the recording head mounted thereon, deviations of the recorded dot may occur in the forward and rearward recording operations. The present invention is arranged in such a manner that values for correcting the deviations occurring in bidirectional recording and corresponding to the changes of the distance from the recording head to a recording medium, the carriage movement speed and the ink discharge speed or the like are previously stored. A drive signal, the timing of which has been corrected with the correction value, is used to operate the apparatus so that high-quality recordings free from deviations occurring in the bidirectional recording operation are obtained. The present invention disclosed a recording apparatus having a plurality of recording heads mounted on a carriage thereof, the recording apparatus being arranged in such a manner that the carriage movement speed is detected to determine the recording timing of the plural recording heads to prevent the deviation of dots formed by the plural recording heads due to the changes in the moving speed caused by changes in the environment of the apparatus to record high quality images.

    摘要翻译： 由于从记录头到记录介质的距离的变化，滑架移动速度和喷墨速度等，喷墨记录遇到记录点被施加的位置的偏差。 当在安装有记录头的托架移动时执行双向记录时，记录点的偏离可能在前后记录操作中发生。 本发明以如下方式布置：用于校正双向记录中发生的偏差并对应于从记录头到记录介质的距离的变化，滑架移动速度和排墨速度等的值 存储。 使用校正值校正其定时的驱动信号来操作该装置，从而获得没有在双向记录操作中出现的偏差的高质量记录。 本发明公开了一种具有安装在其滑架上的多个记录头的记录装置，该记录装置以检测滑架运动速度的方式布置以确定多个记录头的记录定时，以防止 由于由设备的环境变化引起的移动速度的变化，由多个记录头形成的点以记录高质量图像。

    Carbapenem derivatives
    89.
    发明授权
    Carbapenem derivatives 失效
    卡巴培南衍生物

    公开(公告)号：US5583218A

    公开(公告)日：1996-12-10

    申请号：US601142

    申请日：1996-02-13

    申请人： Makoto Takemura ,  Toshiyuki Nishi ,  Hiroshi Susaki ,  Youhei Ishida ,  Hiroko Koda ,  Takeshi Hayano

    发明人： Makoto Takemura ,  Toshiyuki Nishi ,  Hiroshi Susaki ,  Youhei Ishida ,  Hiroko Koda ,  Takeshi Hayano

    IPC分类号： C07D477/20 ,  C07D519/00 ,  C07D519/06 ,  C07D487/01

    CPC分类号： C07D477/20

    摘要： Carbapenem derivatives of formula (I): ##STR1## wherein (a) R.sub.1 is a hydrogen atom, an alkyl group of from 1 to 6 carbon atoms, a hydroxy-lower alkyl group or a protected hydroxy-lower alkyl group of from 1 to 6 carbon atoms in its alkyl moiety, (b) COOR.sub.2 is a carboxyl group, a carboxylate anion or a protected carboxyl group, (c) R.sub.3 is an alkyl group of from 1 to 6 carbon atoms and (d) R.sub.4 is a substituted or unsubstituted heterobicyclic group of formula (II): ##STR2## in which the partial structure ##STR3## is a 5- or 6-membered, saturated or unsaturated, nitrogen-containing heterocycle containing 1 to 4 hereto atoms each selected from the group consisting of oxygen, sulfur and nitrogen, at least one hetero atom being nitrogen, and is which R.sub.5 and R.sub.6 each is a hydrogen atom or an appropriate substituent, any isomeric form thereof, and pharmacologically acceptable salts thereof are potent and stable antimicrobial agents.

    摘要翻译： 式（I）的碳青霉烯衍生物：其中（a）R 1是氢原子，1至6个碳原子的烷基，羟基 - 低级烷基或被保护的羟基 - 低级烷基 （b）COOR2是羧基，羧酸根阴离子或受保护的羧基，（c）R3是1-6个碳原子的烷基，（d）R4是 取代或未取代的式（II）的杂双环基团：其中部分结构“IMAGE”是每个含有1至4个原子的5或6元饱和或不饱和的含氮杂环， 选自氧，硫和氮，至少一个杂原子是氮，R5和R6各自是氢原子或适当的取代基，其任何异构形式及其药理学上可接受的盐是有效和稳定的 抗菌剂。