公开(公告)号：US20070031897A1

公开(公告)日：2007-02-08

申请号：US11450696

申请日：2006-06-09

申请人： Jeffrey Johnson ,  Yun-Ping Zhou

发明人： Jeffrey Johnson ,  Yun-Ping Zhou

IPC分类号： G01N33/567 ,  C07H21/04 ,  C07K14/575

CPC分类号： C07K14/705 ,  A61K48/00 ,  G01N33/507 ,  G01N33/5088 ,  G01N33/6872 ,  G01N33/74 ,  G01N2333/62

摘要： Expression of beta-TRP is enriched in islet cells. Introduction of expression cassettes encoding beta-TRP into diabetic islet cells improved glucose-stimulated insulin production. Therefore, the invention provides methods of identifying beta-TRP modulators for treating diabetic individuals and introducing beta-TRP into islet cells

摘要翻译： β-TRP的表达富含胰岛细胞。 将编码β-TRP的表达盒引入糖尿病胰岛细胞改善了葡萄糖刺激的胰岛素产生。 因此，本发明提供鉴定用于治疗糖尿病个体并将β-TRP引入胰岛细胞的β-TRP调节剂的方法

公开(公告)号：US20070005587A1

公开(公告)日：2007-01-04

申请号：US11172464

申请日：2005-06-30

申请人： Jeffrey Johnson ,  Matthew Jeffries

发明人： Jeffrey Johnson ,  Matthew Jeffries

IPC分类号： G06F17/30

CPC分类号： G06F16/9535 ,  G06F16/24578 ,  G06F16/951

摘要： A program product and method is disclosed that rely on user interaction in the ordering of search results returned by a search engine. Each of a plurality of records in a database is associated with a user-interaction parameter that is associated with the duration of time that a user accesses a particular record of the search result. Provided that the duration of time that the user accesses the record is greater than a predetermined relevant time period, the user-interaction parameter is weighted to increase the relevance of this record in relation to records that did were not accessed for the relevant time period used in ordering the records identified in a result set generated in response to a search request.

摘要翻译： 公开了依赖于搜索引擎返回的搜索结果的排序中的用户交互的程序产品和方法。 数据库中的多个记录中的每一个与与用户访问搜索结果的特定记录的持续时间相关联的用户交互参数相关联。 如果用户访问记录的持续时间大于预定的相关时间段，则用户交互参数被加权以增加该记录与所使用的相关时间段未被访问的记录的相关性 在排序响应于搜索请求而生成的结果集中识别的记录。

公开(公告)号：US20060252100A1

公开(公告)日：2006-11-09

申请号：US11488338

申请日：2006-07-17

申请人： Jeffrey Johnson ,  Yun-Ping Zhou ,  Kimberly Marlen

发明人： Jeffrey Johnson ,  Yun-Ping Zhou ,  Kimberly Marlen

IPC分类号： G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C12N9/12 ,  A61K48/00

CPC分类号： C07K14/4747 ,  A61K38/00 ,  C12N9/12 ,  C12N9/1205 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The invention provides apoptosis signaling kinase related kinase (ASKRK) nucleic acid and polypeptide sequences and methods of using such sequences to identify modulators of ASKRK. Such modulators can be used for the treatment of diabetes or for delaying the onset of diabetes. The invention also provides methods of diagnosing diabetes or pre-diabetes and methods of making a prognosis based on the detection of ASKRK nucleic acids and proteins.

公开(公告)号：US20060246006A1

公开(公告)日：2006-11-02

申请号：US11402142

申请日：2006-04-10

申请人： Jeffrey Johnson ,  Yuko Terasawa ,  Maria Wilson

发明人： Jeffrey Johnson ,  Yuko Terasawa ,  Maria Wilson

IPC分类号： A61K49/00 ,  G01N33/567 ,  G01N33/53

CPC分类号： G01N33/6893 ,  A61K49/0004 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5023 ,  G01N33/5041 ,  G01N33/507 ,  G01N2333/914 ,  G01N2800/042

摘要： The present invention provides for methods and compositions related to the involvement of CD39L3 in insulin production.

公开(公告)号：US20060215893A1

公开(公告)日：2006-09-28

申请号：US11374551

申请日：2006-03-13

申请人： Jeffrey Johnson

发明人： Jeffrey Johnson

IPC分类号： G06K9/00

CPC分类号： H04N17/00

摘要： A system and method are provided for unified visual measurement of blur and noise distortions in digital image data, the system including a processor, an input adapter in signal communication with the processor for receiving digital image data, a visual discrimination model (VDM) simulation unit in signal communication with the processor, a just noticeable difference (JND) analysis unit in signal communication with the processor, and a JND selection unit in signal communication with the processor; and the method including receiving digital image data, simulating a single-ended VDM, analyzing individual JND channels, including the responses of the highest spatial frequency channel(s), and selecting a reference JND level corresponding to low noise and blur distortions.

摘要翻译： 提供一种系统和方法，用于对数字图像数据中的模糊和噪声失真进行统一的视觉测量，该系统包括处理器，与处理器进行信号通信的输入适配器，用于接收数字图像数据，视觉辨别模型（VDM）模拟单元 与处理器进行信号通信，与处理器进行信号通信的仅有明显的差异（JND）分析单元和与处理器进行信号通信的JND选择单元; 并且该方法包括接收数字图像数据，模拟单端VDM，分析包括最高空间频率信道的响应的各个JND信道，以及选择对应于低噪声和模糊失真的参考JND电平。

公开(公告)号：US20060212486A1

公开(公告)日：2006-09-21

申请号：US11307303

申请日：2006-01-31

申请人： Peter Kennis ,  Daniel Kuokka ,  Charles Coombs ,  Stayton Addison ,  Andrew Otwell ,  Jeffrey Johnson ,  Patrick Taylor ,  Michael Lortz

发明人： Peter Kennis ,  Daniel Kuokka ,  Charles Coombs ,  Stayton Addison ,  Andrew Otwell ,  Jeffrey Johnson ,  Patrick Taylor ,  Michael Lortz

IPC分类号： G06F17/30 ,  G06F12/00

CPC分类号： G06F21/55 ,  G06F17/30569 ,  G06Q10/10 ,  G06Q30/018 ,  G06Q40/00 ,  G06Q40/025 ,  G06Q40/04

摘要： A knowledge base and methods for use in connection with a policy compliance monitoring system operative to determine exceptions to policies expressed by computer-executable policy statements. The system allows establishment, codification, and maintenance of enterprise policies, monitors electronic transactions of the enterprise from various and possibly heterogeneous data sources, detects exceptions to established policies, reports exceptions to authorized users such as managers and auditors, and/or provides a case management system for tracking exceptions and their underlying transactions. The knowledge base comprises extractor files that are utilized for extracting information from data sources for utilization in policy compliance monitoring, a mapper for normalizing data from the data sources against a system ontology and storing normalized data in a monitoring database, and computer-executable compliance policy statements used by a transaction analysis engine. The policy statements represent predetermined policies of the enterprise that apply to data stored in the monitoring database.

摘要翻译： 与政策合规监测系统有关的知识库和方法，可用于确定计算机可执行政策声明所表达的政策的例外。 该系统允许企业策略的建立，编纂和维护，监控来自各种和可能异构数据源的企业的电子交易，检测已建立的策略的异常，报告诸如管理者和审核人之类的授权用户的例外情况和/或提供案例 跟踪例外及其基础交易的管理系统。 知识库包括提取器文件，用于从数据源中提取信息以便在策略合规性监视中使用;映射器，用于对来自数据源的数据进行归一化，系统本体化，并将规范化数据存储在监视数据库中;以及计算机可执行符合性策略 事务分析引擎使用的语句。 策略语句表示适用于存储在监视数据库中的数据的企业的预定策略。

公开(公告)号：US20060145300A1

公开(公告)日：2006-07-06

申请号：US10905486

申请日：2005-01-06

申请人： Douglas Coolbaugh ,  Stephen Furkay ,  Jeffrey Johnson ,  Robert Rassel

发明人： Douglas Coolbaugh ,  Stephen Furkay ,  Jeffrey Johnson ,  Robert Rassel

IPC分类号： H01L29/93 ,  H01L21/20

CPC分类号： H01L29/93

摘要： A semiconductor structure comprising a hyperabrupt junction varactor with a compensated cathode contact as well as a method of fabricating the same are disclosed. The method includes a single implant mask which is used in forming the subcollector/cathode, collector/well and hyperabrupt junction.

摘要翻译： 公开了一种半导体结构，其包括具有补偿的阴极接触的超级连接变容二极管及其制造方法。 该方法包括用于形成子集电极/阴极，集电极/阱和超破裂结的单个注入掩模。

公开(公告)号：US20060122120A1

公开(公告)日：2006-06-08

申请号：US11200809

申请日：2005-08-10

申请人： Jeffrey Johnson ,  Thor Stein

发明人： Jeffrey Johnson ,  Thor Stein

IPC分类号： A61K38/10 ,  A61K38/08 ,  A61K38/06 ,  C07K7/08 ,  C07K7/06

CPC分类号： A61K38/07 ,  A61K38/08 ,  A61K38/10 ,  C07K5/1021 ,  C07K7/06 ,  C07K7/08 ,  C07K14/4711

摘要： The invention provides methods and materials related to inhibiting the effects of Aβ such as neuronal cell death and tau phosphorylation. For example, the invention provides polypeptides, compositions containing polypeptides, transgenic animals, and methods for preventing an Aβ effect (e.g., neuronal cell death in a mammal).

摘要翻译： 本发明提供了与抑制Aβ的作用相关的方法和材料，例如神经元细胞死亡和tau磷酸化。 例如，本发明提供了多肽，含有多肽的组合物，转基因动物和用于预防Abeta效应（例如哺乳动物神经元细胞死亡）的方法。

公开(公告)号：US20060075041A1

公开(公告)日：2006-04-06

申请号：US10954638

申请日：2004-09-30

申请人： Lauren Nicole Antonoff ,  Deven Gulab Hariyani ,  Jeffrey Johnson ,  Khai Ong ,  Hani Saliba ,  Stephen Matlock

发明人： Lauren Nicole Antonoff ,  Deven Gulab Hariyani ,  Jeffrey Johnson ,  Khai Ong ,  Hani Saliba ,  Stephen Matlock

IPC分类号： G06F15/16

CPC分类号： H04L67/28 ,  H04L67/2852

摘要： Systems and methods for detecting and removing metadata and hidden information from a file. A system can include a review module to identify metadata and hidden information, and a scrubber module for removing the metadata and hidden information from the file. The scrubber module can remove the metadata and hidden information automatically or upon prompting the user. The file can be a file attached to an electronic mail. The file can also be a file uploaded to a server.

公开(公告)号：US20060000629A1

公开(公告)日：2006-01-05

申请号：US10882571

申请日：2004-07-01

申请人： Jeffrey Johnson ,  Syed Karim

发明人： Jeffrey Johnson ,  Syed Karim

IPC分类号： H01J15/00

CPC分类号： H02G3/088

摘要： Moisture-resistant flange structures and side assemblies are for an outdoor electrical enclosure adapted to be mounted in an opening, for example, in the wall of a building. The moisture-resistant flange structures include flange elements disposed on side members of the outdoor electrical enclosure without having an aperture extending through the flange element and not having a passageway extending between the flange element and the side member into the opening. The moisture-resistant side assemblies include at least one adjustable generally L-shaped flange element coupled to the first and second side members by fasteners extending through elongated apertures in the adjustable flange elements. Extensions coupled to the side members overlap a portion of each side member and a portion of at least one of the at least one generally L-shaped adjustable flange elements and the elongated aperture extending therethrough.