公开(公告)号：US20110010105A1

公开(公告)日：2011-01-13

申请号：US12887460

申请日：2010-09-21

Applicant: RAJIV SHAH ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

Inventor： RAJIV SHAH ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

IPC: G06F19/00 ,  G01R27/00

CPC classification number: G01N27/403 ,  A61B5/14532 ,  A61B5/1473 ,  A61B2560/0223 ,  A61B2562/02 ,  C12Q1/006 ,  G01N27/327 ,  G01N27/416

Abstract: A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.

公开(公告)号：USD624336S1

公开(公告)日：2010-09-28

申请号：US29315710

申请日：2009-07-16

Applicant: Peter Schultz

Designer： Peter Schultz

公开(公告)号：USD621968S1

公开(公告)日：2010-08-17

申请号：US29307611

申请日：2008-04-30

Applicant: Peter Schultz

Designer： Peter Schultz

公开(公告)号：USD619386S1

公开(公告)日：2010-07-13

申请号：US29315711

申请日：2009-07-16

Applicant: Peter Schultz

Designer： Peter Schultz

公开(公告)号：US07709604B2

公开(公告)日：2010-05-04

申请号：US11016348

申请日：2004-12-16

Applicant: Zhiwen Zhang ,  Lital Alfonta ,  Peter Schultz

Inventor： Zhiwen Zhang ,  Lital Alfonta ,  Peter Schultz

IPC: C07K14/00 ,  C12N9/00 ,  C12N15/74 ,  C07H21/02

CPC classification number: C07K14/47 ,  C12N9/93 ,  C12N15/67 ,  C12P21/02

Abstract: This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.

公开(公告)号：US20100081834A1

公开(公告)日：2010-04-01

申请号：US11814110

申请日：2006-01-09

Applicant: Hans-Georg Goebbel ,  Henning Schultz ,  Peter Schultz ,  Renate Patrascu ,  Malte Schulz ,  Meinolf Weidenbach

Inventor： Hans-Georg Goebbel ,  Henning Schultz ,  Peter Schultz ,  Renate Patrascu ,  Malte Schulz ,  Meinolf Weidenbach

IPC: C07D301/12

CPC classification number: C07D301/12 ,  Y02P20/582

Abstract: The invention relates to a process for the epoxidation of an olefin comprising (a) reacting the olefin with hydrogen peroxide in the presence of methanol as solvent in at least two reaction stages to obtain a mixture (M-a) comprising olefin oxide, unreacted olefin, methanol and water, wherein between at least two reaction stages, olefin oxide is separated by distillation; (b) separating unreacted olefin from the mixture (M-a) by distillation to obtain a mixture (M-bi) comprising at least 80 wt.-% of olefin and a mixture (M-bii) comprising methanol, water and at least 7 wt.-% of olefin oxide; (c) separating olefin oxide from the mixture (M-bii) in at least one distillation stage to obtain a mixture (M-ci) comprising at least 99 wt.-% of olefin oxide and a mixture (M-cii) comprising water and at least 55 wt.-% of methanol; (d) separating methanol from the mixture (M-cii) in at least one distillation stage to obtain a mixture (M-di) comprising at least 85 wt.-% of methanol and up to 10 wt.-% of water, and a mixture (M-dii) comprising at least 90 wt.-% of water; wherein a vapor top stream (Td) obtained from at least one distillation column used in (d), said vapor top stream (Td) comprising at least 85 wt.-% methanol, is used to operate at least partially at least one vaporizer used in at least one distillation column used in at least one of stages (a), (b) and (c).

Abstract translation: 本发明涉及烯烃的环氧化方法，其包括（a）在至少两个反应阶段中在甲醇作为溶剂的存在下使烯烃与过氧化氢反应，以获得包含烯烃氧化物，未反应的烯烃，甲醇的混合物（Ma） 和水，其中在至少两个反应阶段之间，通过蒸馏分离烯烃氧化物; （b）通过蒸馏从混合物（Ma）中分离未反应的烯烃，得到包含至少80重量％的烯烃和包含甲醇，水和至少7重量％的烯烃的混合物（M-bii）的混合物（M-bi） .-％的烯烃氧化物; （c）在至少一个蒸馏阶段从所述混合物（M-bii）分离烯烃氧化物以获得包含至少99重量％的烯烃氧化物的混合物（M-ci）和包含水的混合物（M-cii） 和至少55重量％的甲醇; （d）在至少一个蒸馏阶段中从混合物（M-cii）中分离甲醇以获得包含至少85重量％的甲醇和至多10重量％的水的混合物（M-di），以及 包含至少90重量％的水的混合物（M-dii） 其中从（d）中使用的至少一个蒸馏塔获得的蒸汽顶部流（Td），所述蒸气顶部流（Td）包含至少85重量％的甲醇，用于至少部分地使用至少一个使用的蒸发器 在（a），（b）和（c）中的至少一个中使用的至少一个蒸馏塔中。

公开(公告)号：US20090053791A1

公开(公告)日：2009-02-26

申请号：US11978221

申请日：2007-10-26

Applicant: Peter Schultz ,  Lei Wang ,  John Christopher Anderson ,  Jason W. Chin ,  David R. Liu ,  Thomas J. Magliery ,  Eric L. Meggers ,  Ryan Aaron Mehl ,  Miro Pastrnak ,  Stephen William Santoro ,  Zhiwen Zhang

Inventor： Peter Schultz ,  Lei Wang ,  John Christopher Anderson ,  Jason W. Chin ,  David R. Liu ,  Thomas J. Magliery ,  Eric L. Meggers ,  Ryan Aaron Mehl ,  Miro Pastrnak ,  Stephen William Santoro ,  Zhiwen Zhang

IPC: C12N1/20

CPC classification number: C12P21/00 ,  C07K14/00 ,  C07K14/505 ,  C12N9/93 ,  C12N15/67 ,  C12P13/00 ,  C12P13/005 ,  C12P13/04 ,  C12P13/22 ,  C12P19/26 ,  C12P21/02

Abstract: This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.

Abstract translation: 本发明提供了用于产生蛋白质生物合成机理组分的组合物和方法，包括正交的tRNA，正交氨酰-tRNA合成酶和正向对的tRNA /合成酶。 还提供了用于识别正交对的方法。 这些组分可用于在体内将非天然氨基酸掺入蛋白质。

公开(公告)号：US20080064059A1

公开(公告)日：2008-03-13

申请号：US11664898

申请日：2005-10-20

Applicant: Peter Schultz ,  Sarah Hanson ,  Ran Xu ,  Zhiwen Zhang ,  Chi-Huey Wong

Inventor： Peter Schultz ,  Sarah Hanson ,  Ran Xu ,  Zhiwen Zhang ,  Chi-Huey Wong

IPC: C12N9/22 ,  C12N1/00 ,  C12N1/21 ,  C12P21/02 ,  C12N15/52 ,  C12N15/70

CPC classification number: C12P21/005 ,  C12N9/93 ,  C12N15/67

Abstract: Methods and compositions for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid having a N-acetylgalactosamine moiety into a protein; optionally, the N-acetylgalactosamine-containing unnatural amino acid can be further modified with additional sugars.

Abstract translation: 提供了体外和体内制备糖蛋白的方法和组合物。 一种方法包括将具有N-乙酰半乳糖胺部分的非天然氨基酸掺入蛋白质中; 任选地，含N-乙酰半乳糖胺的非天然氨基酸可以进一步用另外的糖进行改性。

公开(公告)号：US07323579B2

公开(公告)日：2008-01-29

申请号：US10884968

申请日：2004-07-07

Applicant: Hans-Georg Göbbel ,  Henning Schultz ,  Peter Schultz ,  Renate Patrascu ,  Malte Schulz ,  Meinolf Weidenbach

Inventor： Hans-Georg Göbbel ,  Henning Schultz ,  Peter Schultz ,  Renate Patrascu ,  Malte Schulz ,  Meinolf Weidenbach

IPC: C07D301/32 ,  C07D301/03 ,  B01D3/34

CPC classification number: C07D301/32

Abstract: A method of separating propylene oxide from a mixture (M) comprising 5 to 50 percent by weight propylene oxide and 50 to 85 percent by weight methanol, said method comprising (i) introducing said mixture (M) into an extractive distillation column; (ii) additionally introducing a polar solvent into said extractive distillation column; (iii) distilling propylene oxide overhead from said extractive distillation column at a bottoms temperature of from 40 to 70° C. and at a pressure of from 300 to 750 mbar.

Abstract translation: 从包含5至50重量％的环氧丙烷和50至85重量％的甲醇的混合物（M）中分离环氧丙烷的方法，所述方法包括（i）将所述混合物（M）引入萃取蒸馏塔中; （ii）另外将极性溶剂引入所述​​萃取蒸馏塔中; （iii）在40至70℃的底部温度和300至750毫巴的压力下，从所述萃取蒸馏塔中蒸馏环氧丙烷塔顶馏出物。

公开(公告)号：US20070254884A1

公开(公告)日：2007-11-01

申请号：US10577191

申请日：2004-11-10

Applicant: Shuibing Chen ,  Sheng Ding ,  Peter Schultz

Inventor： Shuibing Chen ,  Sheng Ding ,  Peter Schultz

IPC: A61K31/50 ,  A61K31/497 ,  A61K31/517 ,  A61K31/52 ,  C07D237/00 ,  C07D239/00 ,  C07D239/72 ,  C07D241/00 ,  C07D241/36 ,  C07D473/00

CPC classification number: C12N5/0696 ,  C07D473/16 ,  C07D473/24

Abstract: The present invention provides compositions and methods for dedifferentiating lineage committed mammalian cells.

Abstract translation: 本发明提供了用于去分化遗传的哺乳动物细胞的组合物和方法。