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公开(公告)号:US5623057A
公开(公告)日:1997-04-22
申请号:US246394
申请日:1994-05-20
申请人: Stephen Marburg , Richard L. Tolman , Peter J. Kniskern , William J. Miller , Arpi Hagopian , Charlotte C. Ip , John P. Hennessey, Jr. , Dennis J. Kubek , Pamela D. Burke
发明人: Stephen Marburg , Richard L. Tolman , Peter J. Kniskern , William J. Miller , Arpi Hagopian , Charlotte C. Ip , John P. Hennessey, Jr. , Dennis J. Kubek , Pamela D. Burke
IPC分类号: A61K39/00 , A61K38/16 , A61K39/02 , A61K39/09 , A61K39/095 , A61K39/295 , A61K39/395 , A61K47/36 , A61P29/00 , C07K20060101 , C07K1/113 , C07K1/14 , C07K14/00 , C07K14/195 , C07K14/22 , C07K14/315 , C07K14/41 , C07K17/02 , C07K17/10 , C08B37/00 , C12P19/04 , C12P21/00 , C12R1/36 , C12R1/46 , A61K39/385
CPC分类号: A61K39/095 , A61K39/092 , A61K2039/6068 , A61K2039/627
摘要: A novel conjugate vaccine comprising partially hydrolyzed, highly purified, capsular polysaccharide (Ps) from Streptococcus pneumoniae bacteria (pneumococci, Pn) linked to an immunogenic carrier protein, is produced by a new process. The conjugate is useful in the prevention of pneumococcal infections. Vaccines comprising a mixture of from one to ten different pneumococcal polysaccharide-immunogenic protein (Pn-Ps-PRO) conjugates induce broadly protective recipient immune responses against the cognate pathogens from which the polysaccharide components are derived. Young children and infants younger than 2 years old, normally unable to mount a protective immune response to the Pn-Ps alone, exhibit protective immune responses upon vaccination with these Pn-Ps-PRO conjugates.
摘要翻译: 通过新方法生产包含与免疫原性载体蛋白连接的来自肺炎链球菌(Streptococcus pneumoniae)(肺炎球菌,Pn))的部分水解,高度纯化的荚膜多糖(Ps)的新型缀合疫苗。 该缀合物可用于预防肺炎球菌感染。 包含1至10种不同的肺炎球菌多糖 - 免疫原性蛋白(Pn-Ps-PRO)缀合物的混合物的疫苗诱导针对多糖成分衍生的同源病原体的广泛保护性受体免疫应答。 年龄小于2岁的幼儿和婴儿通常无法对Pn-Ps单独施加保护性免疫应答,在用这些Pn-Ps-PRO缀合物接种疫苗后,会显示出保护性的免疫应答。
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公开(公告)号:US5351326A
公开(公告)日:1994-09-27
申请号:US959610
申请日:1992-10-13
申请人: William J. Miller
发明人: William J. Miller
CPC分类号: G02B6/2856
摘要: A 1.times.N fiber optic coupler is formed by assembling a coupler preform including spacer tube means surrounded by an outer glass tube that is concentric with the spacer tube means. A first optical fiber is disposed in an axial bore in the spacer tube means, and N optical fibers are disposed within a gap between the spacer tube means and the outer tube, the first fiber and the N fibers extending through the midregion of the coupler preform. The midregion of the outer tube is heated to collapse it about the fibers, and the central portion of the midregion is stretched to reduce the diameter thereof over a predetermined length. In accordance with the invention, the spacer tube means is glued to the first optical fiber and to the outer tube.
摘要翻译: 1xN光纤耦合器通过组装耦合器预制件形成,该耦合器预制件包括由与间隔管装置同心的外部玻璃管包围的间隔管装置。 第一光纤设置在间隔管装置中的轴向孔中,并且N个光纤设置在间隔管装置和外管之间的间隙内,第一纤维和N个纤维延伸穿过联接器预成型件的中间区 。 外管的中间区被加热以将其围绕纤维折叠,并且中间区域的中心部分被拉伸以将其直径减小预定长度。 根据本发明,间隔管装置粘合到第一光纤和外管上。
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公开(公告)号:US5295205A
公开(公告)日:1994-03-15
申请号:US38244
申请日:1993-03-29
申请人: William J. Miller , Daniel A. Nolan
发明人: William J. Miller , Daniel A. Nolan
CPC分类号: G02B6/29332 , G02B6/2835 , G02B6/29352
摘要: A monolithic, environmentally stable Mach-Zehnder device is formed by threading first and second dissimilar optical fibers through the bore of a glass tube. The tube is evacuated and heated to collapse it onto the fibers. The tube is further heated and stretched at two spaced locations to form two couplers that are joined by the two optical fibers. The fibers have different propagation constants in the region between the two couplers, whereby there is a relative delay in the optical signal propagating in one of the fibers with respect to the optical signal propagating in the other fiber.
摘要翻译: 通过将第一和第二不同光纤穿过玻璃管的孔而形成整体式,环境稳定的马赫 - 策德尔装置。 将管抽真空并加热以使其折叠到纤维上。 将管进一步加热并在两个间隔位置拉伸以形成由两根光纤连接的两个耦合器。 纤维在两个耦合器之间的区域中具有不同的传播常数,由此相对于在另一个光纤中传播的光信号,光信号在一个光纤中传播的相对延迟。
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公开(公告)号:US5268014A
公开(公告)日:1993-12-07
申请号:US972417
申请日:1992-11-05
CPC分类号: G02B6/2835 , G02B6/2856
摘要: After a plurality of optical fibers are fused to make a fiber optic coupler, the ends thereof are glued to a substrate to provide the outwardly extending fibers with adequate pull strength. The glue can flow from the point of application toward the fused region where it can adversely affect the the device. To prevent the glue from flowing too far toward the fused region and yet permit sufficient flow to strengthen the fibers, a beam of UV light is directed onto the fibers at that predetermined point where glue flow should stop. When the glue is cured by the beam, it stops flowing. Thereafter, the remainder of the glue is cured.
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公开(公告)号:US5251276A
公开(公告)日:1993-10-05
申请号:US913622
申请日:1992-07-16
CPC分类号: G02B6/2835 , G02B6/2856 , Y10T156/1052 , Y10T156/108
摘要: A fiber optic coupler is formed by inserting a plurality of optical fibers into the longitudinal bore of a glass tube so that at least a portion of each fiber extends from at least one end of the tube. The midregion of the tube is collapsed onto the fibers, uncollapsed bore portions remaining at the tube end regions. Each bore portion is connected to the tube end surface by a funnel that facilitates the fiber insertion step. The central portion of the midregion is stretched to reduce the diameter thereof. In a first embodiment, glue is applied to the funnel. Before the glue is cured, a sufficient period of time is allowed to elapse to permit said glue to flow by capillary action between the fibers and the adjacent portion of the wall of the bore portion. The glue flows at least 3 mm into the bore portion beyond the bottom of the funnel. The glue that flows by capillary action fails to completely surround the fibers with glue. The glue is then cured. In a second embodiment, a hollow filament is inserted into the uncollapsed bore portion and a vacuum is applied to the filament. Glue, which is applied to the funnel, is drawn into the uncollapsed bore portion due to the evacuated condition thereof, thus filling the uncollapsed bore portion to the desired level.
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公开(公告)号:US4861706A
公开(公告)日:1989-08-29
申请号:US857695
申请日:1986-04-29
CPC分类号: C12Q1/706 , Y10S435/948
摘要: A quantitative assay for HAV comprises infecting at a temperature of from about 30.degree. to about 37.degree. C. a cell sheet with a dilution series of hepatitis A virus and then adding Newcastle disease virus (NDV) to the infected cell sheet and incubating the infected cell sheet in the presence of NDV at an elevated temperature for a time sufficient to permit a cytopathic effect (CPE) to become manifest, this time typically being at least about 4 days and preferably about 5 days. At an incubation temperature of from about 31.degree. to about 33.degree. C. the absence of CPE indicates the presence of HAV and the presence of CPE indicates the absence of HAV. At an incubation temperature of from about 34.degree. to about 36.degree. C. the absence of CPE indicates the absence of HAV and the presence of CPE indicates the presence of HAV.
摘要翻译: 用于HAV的定量测定包括在约30℃至约37℃的温度下感染具有稀释系列的甲型肝炎病毒的细胞片,然后向感染的细胞片中加入新城疫病毒(NDV)并孵育感染的 细胞片在NDV存在下在升高的温度下持续足以允许细胞病变效应(CPE)变得明显的时间,此时通常为至少约4天,优选约5天。 在约31℃至约33℃的温育温度下,不存在CPE表明存在HAV,而CPE的存在表明不存在HAV。 在约34℃至约36℃的培养温度下,不存在CPE表明不存在HAV,且CPE的存在表明存在HAV。
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公开(公告)号:US4753160A
公开(公告)日:1988-06-28
申请号:US123414
申请日:1987-11-20
申请人: John Baird , William J. Miller
发明人: John Baird , William J. Miller
CPC分类号: B30B15/06 , B29C45/1744 , B30B15/061
摘要: A mold press comprising a force equalizer independent of the mold platens. The force equalizer consists of a pair of plates defining a cavity therebetween. The cavity is filled with a force distributing material, such as hydraulic fluid. An opening is provided through the force equalizer to provide the extruder access to the mold plates. This opening is surrounded by a floating seal which permits movement of the equalizer plates with respect to the seal. The cavity is designed to extend beyond the chase footprint areas by an amount dictated by the size and relation of the footprint areas to one another.
摘要翻译: 一种模压机,包括独立于模板的力均衡器。 力平衡器由一对在其间限定空腔的板组成。 空腔中充满了力分布材料,如液压油。 通过力均衡器提供开口以提供挤出机进入模板。 该开口被浮动密封件包围,允许均衡器板相对于密封件移动。 该空腔被设计成延伸超过追踪足迹区域的量,其大小和足迹区域彼此之间的关系。
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88.
公开(公告)号:US4351982A
公开(公告)日:1982-09-28
申请号:US216435
申请日:1980-12-15
CPC分类号: H04L9/302 , H04L9/3033 , H04L2209/08 , H04L2209/12
摘要: A public-key data encryption system employing RSA public-key data encryption including a message encrypter capable of encrypting messages using a non-secret encryption key, a transmitter-receiver coupled to the message encrypter which transmits or receives an encrypted message to or from a remote location, the transmitter-receiver also being coupled to a decrypter capable of decrypting a received encrypted message using a decryption key which is a secret input to the decrypter, and an encryption-decryption key generator, including a microprocessor or other large-scale integrated circuit or circuits formed to generate a sequence of prime numbers beginning with a selected known prime number having a length relatively short with respect to the desired length of the last in the sequence of prime numbers, and which is constructed to form the sequence of prime numbers in the form hP+1 where P is the preceding prime number in the sequence, and to test hP+1 for primality by first determining if hP+1 has a GCD of 1 with x, wherein x is a composite number consisting of the product of all known prime numbers less than or equal to a pre-selected known prime number and if the GCD is not equal to 1, incrementing h to form a new hP+1 to be tested for a GCD equal to 1, and when a GCD is found to be 1, performing the primality tests to determine whether 2.sup.hP .ident.1 [mod (hP+1)] and 2.sup.h .notident.1 [mod (hP+1)], and if either 2.sup.hP .notident.1 [mod (hP+1)] or 2.sup.h .ident.1 [mod (hP+1)] further incrementing h and so on until a prime is found in this manner and then determining if the length of the prime number is of or greater than the desired length. If the hP+1 which has been determined to be prime is not of the desired length, hP+1 is placed in the sequence of prime numbers and a new h selected to be used to find the next prime number in the sequence in accordance with the above described procedure by forming a new hP+1 in which P is the previously determined prime number in the sequence of prime numbers. When a prime number in the sequence of prime numbers is found which is of the desired length it is input into the encryption-decryption key generator for generating the RSA public-key encryption and decryption keys.
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公开(公告)号:US4017601A
公开(公告)日:1977-04-12
申请号:US623184
申请日:1975-10-16
IPC分类号: G01N33/576 , A61K39/29 , C12Q1/70 , A61K39/12
CPC分类号: A61K39/29 , A61K39/12 , A61K2039/5252 , A61K2039/575 , C12N2770/32434
摘要: Hepatitis A antigen obtained from the stools of patients infected with hepatitis A (infectious hepatitis) virus has been found to be usable in fast, simple assays for hepatitis A antibody and thus usable in diagnosis of hepatitis A disease, and for the preparation of hepatitis A vaccine.
摘要翻译: 已经发现从感染甲型肝炎(感染性肝炎)病毒的患者的粪便获得的甲型肝炎抗原可用于甲型肝炎抗体的快速,简单的测定中,因此可用于诊断甲型肝炎疾病和用于制备甲型肝炎 疫苗。
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公开(公告)号:US08824852B2
公开(公告)日:2014-09-02
申请号:US13407257
申请日:2012-02-28
IPC分类号: G02B6/00
CPC分类号: G02B6/4471 , G02B6/4403 , G02B6/483
摘要: A cable clamp assembly and a cable clamp method for a flat fiber optic cable are disclosed. The assembly includes a wedge-shaped outer shell with a bottom wall having a friction inner surface with a longitudinal central recess formed therein. The flat fiber optic cable resides within the interior of the outer shell and is supported by the friction inner surface. A shim having two parallel rows of protrusions fits within the interior of the outer shell with the protrusions being in contact with the fiber optic cable. The assembly includes a wedge insert having two outer ridges that substantially align with the two rows of protrusions. When the wedge insert matingly engages the outer shell, the outer ridges press down on the protrusions, which in turn press down on the fiber optic cable mainly at the locations where longitudinal dielectric strength members reside.
摘要翻译: 公开了一种用于扁平光缆的电缆夹组件和电缆夹紧方法。 组件包括楔形外壳,其具有底壁,所述底壁具有形成在其中的纵向中心凹部的摩擦内表面。 扁平光缆位于外壳的内部并由摩擦内表面支承。 具有两个平行的突起的垫片装配在外壳的内部中,突起与光纤电缆接触。 组件包括楔形插入物,其具有两个与两排突起物基本对准的外脊。 当楔形插入件配合地接合外壳时,外脊下压到突起上,突起又主要在纵向介电强度构件所在的位置压在光纤电缆上。
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