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149 条记录 (耗时 0.044 秒)

    Stable preparation for the treatment of blood coagulation disorders
    81.
    发明授权
    Stable preparation for the treatment of blood coagulation disorders 失效
    稳定的治疗凝血障碍的准备

    公开(公告)号：US6017891A

    公开(公告)日：2000-01-25

    申请号：US924533

    申请日：1997-09-05

    申请人： Johann Eibl ,  Hans Peter Schwarz ,  Juergen Siekmann ,  Peter Turecek

    发明人： Johann Eibl ,  Hans Peter Schwarz ,  Juergen Siekmann ,  Peter Turecek

    IPC分类号： C12N9/64 ,  C12N9/96 ,  A61K38/00 ,  A01N57/26 ,  A61K9/127

    CPC分类号： B82Y5/00 ,  C12N9/6424 ,  C12N9/96

    摘要： The invention relates to a stable preparation which comprises a protein, such as thrombin, that is bound in and/or on (i.e., to) lipid vesicles and that was treated for the inactivation of potentially present viruses. Further, the invention relates to methods for the production of a stable preparation for the treatment of blood coagulation disorders, wherein a protein is bound in and/or on lipid vesicles, and the method comprises a step in which the protein lipid complex is subjected to a treatment for the inactivation of potentially present viruses.

    摘要翻译： 本发明涉及一种稳定的制剂，其包含结合于脂质囊泡中和/或上（即）脂质囊泡上的蛋白质，例如凝血酶，并且被处理用于灭活潜在的存在的病毒。 此外，本发明涉及生产用于治疗凝血障碍的稳定制剂的方法，其中蛋白质与脂质囊泡中和/或结合，该方法包括将蛋白质脂质复合物经受 用于灭活潜在存在的病毒的治疗。

    Method for identifying a non-anticoagulant sulfated polysaccharide which enhances blood coagulation dependence on FXI
    85.
    发明授权
    Method for identifying a non-anticoagulant sulfated polysaccharide which enhances blood coagulation dependence on FXI 有权
    鉴定增强血液凝固依赖于FXI的非抗凝血硫酸多糖的方法

    公开(公告)号：US08546096B2

    公开(公告)日：2013-10-01

    申请号：US13002501

    申请日：2009-08-21

    申请人： Michael Dockal ,  Friedrich Scheiflinger ,  Peter Turecek

    发明人： Michael Dockal ,  Friedrich Scheiflinger ,  Peter Turecek

    IPC分类号： C12Q1/56

    CPC分类号： A61K31/737 ,  A61K31/727 ,  A61K38/36 ,  A61K38/366 ,  A61K38/37 ,  A61K38/4846 ,  A61K38/4853 ,  A61K45/06 ,  G01N33/86 ,  A61K2300/00

    摘要： A method of identifying a non-anticoagulant sulfated polysaccharide (NASP) which is capable of enhancing blood coagulation in dependence of FXI, the method comprising: a) combining a blood or plasma sample having activation competent FXI with a sulfated polysaccharide and measuring the clotting or thrombin generation parameters of the blood or plasma sample; b) combining a corresponding blood or plasma sample deficient In activation competent FXI with a sulfated polysaccharide and measuring the clotting or thrombin generation parameters of the blood or plasma sample and c) comparing the clotting or thrombin generation parameters of the blood or plasma samples as determined in steps (a) and (b) with each other.

    摘要翻译： 一种鉴定能够根据FXI增强血液凝固的非抗凝血硫酸多糖（NASP）的方法，所述方法包括：a）将具有活化能力的FXI的血液或血浆样品与硫酸化多糖组合并测量凝血或 血液或血浆样品的凝血酶产生参数; b）将活化能力FXI中缺乏的相应血液或血浆样品与硫酸化多糖组合并测量血液或血浆样品的凝血酶或凝血酶产生参数; c）比较测定的血液或血浆样品的凝血酶或凝血酶产生参数 在步骤（a）和（b）中。

    Polymer-von Willebrand factor-conjugates
    86.
    发明授权
    Polymer-von Willebrand factor-conjugates 有权

    公开(公告)号：US08076463B2

    公开(公告)日：2011-12-13

    申请号：US13007208

    申请日：2011-01-14

    申请人： Friedrich Scheiflinger ,  Peter Turecek ,  Juergen Siekmann

    发明人： Friedrich Scheiflinger ,  Peter Turecek ,  Juergen Siekmann

    IPC分类号： C12P21/02 ,  C07K14/47 ,  A61K38/37

    CPC分类号： C07K14/755 ,  A61K47/60 ,  C07K14/775

    摘要： The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to at least one physiologically acceptable polymer molecule, as well as to a complex between said proteinaceous construct and at least one factor VIII (FVIII) protein. The physiologically acceptable polymer molecule can be, for instance, polyethylene glycol (PEG) or polysialic acid (PSA). Further the present invention relates to methods for prolonging the in vivo-half-life of VWF or FVIII in the blood of a mammal having a bleeding disorder associated with functional defects of or deficiencies of at least one of FVIII or VWF.

    Hydrolysable Polymeric FMOC-Linker
    90.
    发明申请
    Hydrolysable Polymeric FMOC-Linker 有权
    可水解聚合物FMOC-Linker

    公开(公告)号：US20100121034A1

    公开(公告)日：2010-05-13

    申请号：US12688461

    申请日：2010-01-15

    申请人： Peter Turecek ,  Juergen Siekmann

    发明人： Peter Turecek ,  Juergen Siekmann

    IPC分类号： C07K1/04 ,  C08B37/00 ,  C08H1/00

    CPC分类号： A61K47/61

    摘要： The invention relates to Fmoc (9-fluorenyl-methoxycarbonyl)-based polymeric conjugates. These conjugates are useful for extending the in-vivo circulation of protein and peptide drugs.

    摘要翻译： 本发明涉及Fmoc（9-芴基 - 甲氧基羰基）基聚合物共轭物。 这些缀合物可用于延长蛋白质和肽类药物的体内循环。