公开(公告)号：US08207222B2

公开(公告)日：2012-06-26

申请号：US12707410

申请日：2010-02-17

Applicant: Tilak Raj Bhardwaj ,  Manoj Kumar ,  Necraj Mehta ,  Neelima Dhingra

Inventor： Tilak Raj Bhardwaj ,  Manoj Kumar ,  Necraj Mehta ,  Neelima Dhingra

IPC: C07C203/04 ,  A61K31/167

CPC classification number: C07C233/25

Abstract: The present invention particularly relates to novel nitrate esters of paracetamol. The nitrate esters of paracetamol are prepared by reacting the paracetamol with dihaloalkyl compound and followed by reaction with silver nitrate to obtain the corresponding nitrate ester derivatives. The nitrate esters of paracetamol are useful as analgesic, anti-inflammatory agents.

Abstract translation: 本发明特别涉及新型的扑热息痛的硝酸酯。 对乙酰氨基酚的硝酸酯通过使对乙酰氨基酚与二卤烷基化合物反应，随后与硝酸银反应得到相应的硝酸酯衍生物。 对乙酰氨基酚的硝酸酯可用作止痛剂，抗炎剂。

公开(公告)号：US20120009635A1

公开(公告)日：2012-01-12

申请号：US13228833

申请日：2011-09-09

Applicant: Timothy C. Dodge ,  Manoj Kumar ,  M. Harunur Rashid ,  Fernando Valle

Inventor： Timothy C. Dodge ,  Manoj Kumar ,  M. Harunur Rashid ,  Fernando Valle

IPC: C12P17/04 ,  C07K14/24 ,  C12N1/21 ,  C12N15/31 ,  C12P7/60 ,  C12P7/58

CPC classification number: C12P7/58 ,  C07K14/24 ,  C12P7/60

Abstract: The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the inactivation of endogenous gluconate transporter genes.

Abstract translation: 本发明涉及在细菌宿主细胞中工程代谢途径，其导致用于生产抗坏血酸（ASA）中间体的增强的碳流。 特别地，本发明涉及通过增加由内源性葡萄糖酸转运蛋白基因失活产生的葡萄糖酸盐的可利用性来增加细菌细胞中ASA中间体的产生。

公开(公告)号：US07999573B2

公开(公告)日：2011-08-16

申请号：US11649746

申请日：2007-01-03

Applicant: Rajesh Narwal ,  Manoj Kumar

Inventor： Rajesh Narwal ,  Manoj Kumar

IPC: H03K19/094

CPC classification number: H03K19/018528

Abstract: An embodiment of a low-to-high-level voltage translator is proposed. This translator translates the low voltage swing signals for the core into high voltage swing signals of the I/O blocks. This translator may be particularly useful for high-speed application where the difference between the core and the I/O supply voltage is very large, e.g., the core is working at 0.8V and the I/O is working at 3.6V or higher without little or no static power dissipation. The proposed translator may give improved transition times and propagation delays as compared to conventional translators. The proposed translator may also use less hardware in comparison to other such translators.

Abstract translation: 提出了一种低电平到高电平转换器的实施例。 该转换器将芯的低电压摆幅信号转换为I / O块的高电压摆幅信号。 这种转换器对于核心和I / O电源电压差异非常大的高速应用尤其有用，例如，核心工作在0.8V，I / O工作在3.6V或更高，而没有 很少或没有静态功耗。 与传统的翻译器相比，所提出的翻译器可以提供改进的转换时间和传播延迟。 与其他这样的翻译器相比，所提出的翻译器也可以使用较少的硬件。

公开(公告)号：US20100234472A1

公开(公告)日：2010-09-16

申请号：US12707410

申请日：2010-02-17

Applicant: Tilak Raj BHARDWAJ ,  Manoj Kumar ,  Neeraj Mehta ,  Neelima Dhingra

Inventor： Tilak Raj BHARDWAJ ,  Manoj Kumar ,  Neeraj Mehta ,  Neelima Dhingra

IPC: A61K31/167 ,  C07C233/74 ,  A61P29/00

CPC classification number: C07C233/25

Abstract: The present invention particularly relates to novel nitrate esters of paracetamol. The nitrate esters of paracetamol are prepared by reacting the paracetamol with dihaloalkyl compound and followed by reaction with silver nitrate to obtain the corresponding nitrate ester derivatives. The nitrate esters of paracetamol are useful as analgesic, anti-inflammatory agents.

Abstract translation: 本发明特别涉及新型的扑热息痛的硝酸酯。 对乙酰氨基酚的硝酸酯通过使对乙酰氨基酚与二卤烷基化合物反应，随后与硝酸银反应得到相应的硝酸酯衍生物。 对乙酰氨基酚的硝酸酯可用作止痛剂，抗炎剂。

公开(公告)号：US20090248620A1

公开(公告)日：2009-10-01

申请号：US12059811

申请日：2008-03-31

Applicant: Shane Robert Vermette ,  Vijay Manguluru ,  Manoj Kumar

Inventor： Shane Robert Vermette ,  Vijay Manguluru ,  Manoj Kumar

IPC: G06F17/30

CPC classification number: G06F17/30362

Abstract: Extraction methods can interact on a common data source using identifiers that correspond to events or other actions. These identifiers can be updated, whenever appropriate, once the corresponding data has been summarized, in order to provide for multiple extraction methods to operate only on the data of interest, and obtain a lock only on the data within the scope of extraction. High water marks, such as identifiers in the sequent, can be used to further designate which data has previously been extracted. Similarly, summarization methods can interact by utilizing corresponding persistent tables in the flows for the methods, but utilizing separate intermediate tables to allow for data transformations and application of various business rules and tuning techniques. The ability to switch between different methods can accommodate business, performance, or other such needs, and can provide for the dynamic extraction and summarization of different volumes of data.

Abstract translation: 提取方法可以使用与事件或其他操作对应的标识符在公共数据源上进行交互。 一旦相应的数据已被总结，就可以适当地更新这些标识符，以便提供多种提取方法仅对感兴趣的数据进行操作，并且仅在提取范围内的数据上获得锁定。 可以使用诸如序列中的标识符的高水位标记来进一步指定先前已经提取了哪些数据。 类似地，汇总方法可以通过在方法的流中利用相应的持久表进行交互，但是利用单独的中间表来允许数据转换和应用各种业务规则和调优技术。 在不同方法之间切换的能力可以适应业务，性能或其他此类需求，并且可以提供不同数据量的动态提取和汇总。

公开(公告)号：US20090181433A1

公开(公告)日：2009-07-16

申请号：US12244702

申请日：2008-10-02

Applicant: Gopal K. Chotani ,  Manoj Kumar ,  Jeffrey P. Pucci ,  Karl J. Sanford ,  Jayarama K. Shetty

Inventor： Gopal K. Chotani ,  Manoj Kumar ,  Jeffrey P. Pucci ,  Karl J. Sanford ,  Jayarama K. Shetty

IPC: C12P19/02 ,  C12P1/00 ,  C12P7/18 ,  C12P7/58 ,  C12P7/20 ,  C12P7/46 ,  C12P7/56 ,  C12P7/02 ,  C12P17/04

CPC classification number: C12P7/56 ,  C12P7/06 ,  C12P7/10 ,  C12P7/18 ,  C12P7/20 ,  C12P7/42 ,  C12P7/44 ,  C12P7/46 ,  C12P7/58 ,  C12P7/60 ,  C12P19/02 ,  C12P2201/00 ,  Y02E50/16 ,  Y02E50/17

Abstract: The present invention provides means for the production of desired end-products of in vitro and/or in vivo bioconversion of biomass-based feed stock substrates, including but not limited to such materials as starch and cellulose. In particularly preferred embodiments, the methods of the present invention do not require gelatinization and/or liquefaction of the substrate.

Abstract translation: 本发明提供了生产基于生物质的原料基质的体外和/或体内生物转化所需的终产物的方法，包括但不限于淀粉和纤维素等材料。 在特别优选的实施方案中，本发明的方法不需要基质的凝胶化和/或液化。

公开(公告)号：US07394291B2

公开(公告)日：2008-07-01

申请号：US11615680

申请日：2006-12-22

Applicant: Rajesh Narwal ,  Manoj Kumar

Inventor： Rajesh Narwal ,  Manoj Kumar

IPC: H03K19/0175

CPC classification number: H03K19/00315

Abstract: A high voltage tolerant output buffer uses a substrate voltage control circuit to control the voltage at the substrate of the transistors in the output buffer. The circuitry of output buffer is such that the voltage between any two terminals of any of the transistors is not allowed to exceed the supply voltage of the output buffer. At the same time, the voltage at the source or drain of transistors of output buffer is not allowed to increase beyond its substrate voltage. The proposed circuit for output buffer can tolerate voltages higher than the voltage at which it is operated. The novel circuitry uses less hardware and prevents power dissipation in the circuit.

Abstract translation: 高耐压输出缓冲器使用衬底电压控制电路来控制输出缓冲器中的晶体管的衬底上的电压。 输出缓冲器的电路使得任何晶体管的任何两个端子之间的电压不允许超过输出缓冲器的电源电压。 同时，输出缓冲器的晶体管的源极或漏极的电压不允许超过其衬底电压。 所提出的用于输出缓冲器的电路可以容忍高于其工作电压的电压。 新颖的电路使用更少的硬件并防止电路中的功耗。

公开(公告)号：US20080019956A1

公开(公告)日：2008-01-24

申请号：US11492294

申请日：2006-07-24

Applicant: Manoj Kumar

Inventor： Manoj Kumar

IPC: A61K38/54

CPC classification number: C11D3/386 ,  A01N63/02 ,  A01N65/00 ,  A01N2300/00 ,  A01N63/04

Abstract: Described herein is a composition for removing biofilm from surfaces. The composition is an enzyme mixture having at least three enzymes and resulting in the removal of at least 40% biofilm from the surface.

Abstract translation: 本文描述的是用于从表面除去生物膜的组合物。 该组合物是具有至少三种酶的酶混合物，并且从表面除去至少40％的生物膜。

公开(公告)号：US20070298474A1

公开(公告)日：2007-12-27

申请号：US11879260

申请日：2007-07-16

Applicant: Manoj Kumar ,  Fernando Valle ,  Veronique Dartois ,  James Hoch

Inventor： Manoj Kumar ,  Fernando Valle ,  Veronique Dartois ,  James Hoch

IPC: C12P7/02

CPC classification number: C12P7/60

Abstract: A method for enhancing a host cell's biosynthetic production of 2-KLG is described. Such method comprises selecting a host cell that has an at least partially intracellular synthetic pathway which utilizes 2,5-DKG to produce 2-KLG; increasing the transport of said 2,5-DKG into said host cell while maintaining the integrity of the host cell; culturing the host cell to produce said 2,5-DKG; and producing 2-KLG. The transport of the 2,5-DKG is increased by transforming into the host cell DNA encoding for one or more enzymes transporting the 2,5-DKG into the host cell.

Abstract translation: 描述了增强宿主细胞2-KLG生物合成生产的方法。 这种方法包括选择具有至少部分细胞内合成途径的宿主细胞，其利用2,5-DKG产生2-KLG; 增加所述2,5-DKG进入所述宿主细胞的同时保持宿主细胞的完整性; 培养宿主细胞以产生所述2,5-DKG; 并生产2-KLG。 通过将编码一种或多种将2,5-DKG转运到宿主细胞的酶的宿主细胞DNA转化成2,5-DKG的转运来增加。

公开(公告)号：US20060099245A1

公开(公告)日：2006-05-11

申请号：US10514674

申请日：2002-05-21

Applicant: Manoj Kumar ,  Naresh Talwar ,  Rajeev Raghuvanshi ,  Ashok Rampal

Inventor： Manoj Kumar ,  Naresh Talwar ,  Rajeev Raghuvanshi ,  Ashok Rampal

IPC: A61K9/48 ,  A61K9/64 ,  A61K9/22 ,  A61K31/403

CPC classification number: A61K9/0065 ,  A61K9/2866 ,  A61K9/4891

Abstract: The present invention relates to an oral drug delivery system with biphasic release characteristics comprising a porous matrix comprising at least one drug substance, sugar(s), a release retarding polymer, gas generating components and optionally, pharma-ceuti-cally acceptable auxiliary components wherein the pharmaceutical composition further comprises a coating of said drug substance. The pharmaceutical composi-tion, either in the form of pellets (multiparticulate or single unit dosage form), beads, granules, capsules or tablets, is retained in the stomach while selectively delivering the drug(s) at gastrointestinal levels and upper parts of the small intestine over an extended period of time. The release of the drug from the said pharmaceutical composition is characterized by a biphasic release profile of the drug substance, which exhibits both immediate and controlled release characteristics.

Abstract translation: 本发明涉及具有双相释放特征的口服药物递送系统，其包含多孔基质，其包含至少一种药物物质，糖，缓释聚合物，气体产生组分和任选的药物可接受的辅助成分，其中 药物组合物还包含所述药物的涂层。 以颗粒形式（多颗粒或单一单位剂型），珠粒，颗粒，胶囊或片剂的药物组合物保留在胃中，同时选择性地将药物在胃肠水平和 小肠在较长时间内。 药物从所述药物组合物的释放的特征在于药物物质的双相释放曲线，其表现出立即和控制释放特征。