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    Powder coating system with easily cleanable cyclone
    83.
    发明授权
    Powder coating system with easily cleanable cyclone 有权
    粉末涂料系统，易清洗旋风

    公开(公告)号：US08657933B2

    公开(公告)日：2014-02-25

    申请号：US13285452

    申请日：2011-10-31

    申请人： Larry C. Jancik ,  William C. Coomer, III ,  Greg Dawson ,  Michael Thomas ,  Francis Patrick Mohar

    发明人： Larry C. Jancik ,  William C. Coomer, III ,  Greg Dawson ,  Michael Thomas ,  Francis Patrick Mohar

    IPC分类号： B01D45/12

    CPC分类号： B01D45/16 ,  B04C5/08 ,  B05B14/45 ,  Y02P70/36

    摘要： A powder cyclone separator for use in a powder coating system is formed in two separate and separable sections. An upper section is mounted on a first frame and remains stationary. A lower section is mounted on a second frame that is movable laterally away from the first frame so that an operator has more ready access to clean interior surfaces of the upper section. Optionally, actuators may be provided to raise and lower the cyclone lower section with respect to the cyclone upper section. Optional alignment means are presented for aligning the cyclone upper and lower sections. A control mechanism may be mounted on the second frame which includes a switch that is operable to raise and lower the lower section with respect to the upper section. This design allows an operator to see and verify that virtually all internal surfaces of the cyclone have been cleaned.

    摘要翻译： 用于粉末涂料系统的粉末旋风分离器形成在两个分离的和可分离的部分中。 上部安装在第一框架上并保持静止。 下部安装在第二框架上，该第二框架可横向移动离开第一框架，使得操作者能够更容易地进入上部的干净内部表面。 可选地，可以提供致动器以相对于旋风上部升高和降低旋风下部。 呈现可选择的对准装置用于对准旋风分离器上部和下部。 控制机构可以安装在第二框架上，第二框架包括可操作以相对于上部升高和降低下部分的开关。 该设计允许操作者查看并验证旋风分离器的几乎所有内表面都已被清洁。

    FILTER WHEEL
    85.
    发明申请
    FILTER WHEEL 失效
    过滤轮

    公开(公告)号：US20130229708A1

    公开(公告)日：2013-09-05

    申请号：US13847393

    申请日：2013-03-19

    申请人： Triantafyllos Tafas ,  Michael Thomas

    发明人： Triantafyllos Tafas ,  Michael Thomas

    IPC分类号： G02B26/00 ,  G02B21/06

    CPC分类号： G02B26/008 ,  G02B7/006 ,  G02B21/06

    摘要： An improved filter wheel is disclosed, through embodiments, that comprises a plurality of reflector support structures formed as a unitized structure with a circular base member. In some embodiments, the filter wheel further comprises a plurality of light sources mounted on the filter wheel.

    摘要翻译： 通过实施例公开了一种改进的滤光轮，其包括形成为具有圆形基底构件的组合结构的多个反射器支撑结构。 在一些实施例中，滤光轮还包括安装在滤光轮上的多个光源。

    Modified messenger RNA stabilizing sequences for expressing genes in bacterial cells
    87.
    发明申请
    Modified messenger RNA stabilizing sequences for expressing genes in bacterial cells 审中-公开

    公开(公告)号：US20120301955A1

    公开(公告)日：2012-11-29

    申请号：US13584410

    申请日：2012-08-13

    申请人： Michael Thomas ,  Gloria Erichsen ,  William Widner

    发明人： Michael Thomas ,  Gloria Erichsen ,  William Widner

    IPC分类号： C12N15/113 ,  C12N15/63

    CPC分类号： C07K14/32 ,  C12N15/75

    摘要： The present invention relates to methods of producing a polypeptide having biological activity in a bacterial cell, comprising: (a) cultivating a bacterial host cell in a medium conducive for production of the polypeptide, wherein the bacterial host cell comprises a nucleic acid construct comprising a promoter region operably linked to a polynucleotide sequence encoding the polypeptide and a modified mRNA processing/stabilizing sequence located downstream of the promoter region and upstream of the ribosome binding site of the polynucleotide sequence encoding the polypeptide, wherein the modified mRNA processing/stabilizing sequence promotes higher expression of the polynucleotide sequence compared to an unmodified mRNA processing/stabilizing sequence; and (b) isolating the polypeptide having biological activity from the cultivation medium. The present invention also relates to such modified mRNA processing/stabilizing sequences, nucleic acid constructs, and bacterial host cells and to methods of obtaining such bacterial host cells.

    Modified messenger RNA stabilizing sequences for expressing genes in bacterial cells
    88.
    发明授权
    Modified messenger RNA stabilizing sequences for expressing genes in bacterial cells 有权
    用于在细菌细胞中表达基因的修饰的信使RNA稳定序列

    公开(公告)号：US08268586B2

    公开(公告)日：2012-09-18

    申请号：US12520072

    申请日：2007-12-19

    申请人： Michael Thomas ,  Gloria Erichsen ,  William Widner

    发明人： Michael Thomas ,  Gloria Erichsen ,  William Widner

    IPC分类号： C12P21/02

    CPC分类号： C07K14/32 ,  C12N15/75

    摘要： The present invention relates to methods of producing a polypeptide having biological activity in a bacterial cell, comprising: (a) cultivating a bacterial host cell in a medium conducive for production of the polypeptide, wherein the bacterial host cell comprises a nucleic acid construct comprising a promoter region operably linked to a polynucleotide sequence encoding the polypeptide and a modified mRNA processing/stabilizing sequence located downstream of the promoter region and upstream of the ribosome binding site of the polynucleotide sequence encoding the polypeptide, wherein the modified mRNA processing/stabilizing sequence promotes higher expression of the polynucleotide sequence compared to an unmodified mRNA processing/stabilizing sequence; and (b) isolating the polypeptide having biological activity from the cultivation medium. The present invention also relates to such modified mRNA processing/stabilizing sequences, nucleic acid constructs, and bacterial host cells and to methods of obtaining such bacterial host cells.

    摘要翻译： 本发明涉及生产在细菌细胞中具有生物活性的多肽的方法，包括：（a）在有助于产生多肽的培养基中培养细菌宿主细胞，其中细菌宿主细胞包含核酸构建体，其包含 与编码多肽的多核苷酸序列可操作地连接的启动子区和位于编码多肽的多核苷酸序列的启动子区域的下游和修饰的mRNA加工/稳定序列的修饰的mRNA加工/稳定序列，其中修饰的mRNA加工/稳定序列促进更高 与未修饰的mRNA加工/稳定序列相比，多核苷酸序列的表达; 和（b）从培养基中分离具有生物活性的多肽。 本发明还涉及这种修饰的mRNA加工/稳定序列，核酸构建体和细菌宿主细胞以及获得这种细菌宿主细胞的方法。

    Method For Managing Access To A Confined Space With Renewal Of The Atmosphere By Means Of Forced Ventilation/Extraction And The Use Of Physical Barriers That Can Be Opened In A Variable And Controlled Manner
    90.
    发明申请
    Method For Managing Access To A Confined Space With Renewal Of The Atmosphere By Means Of Forced Ventilation/Extraction And The Use Of Physical Barriers That Can Be Opened In A Variable And Controlled Manner 审中-公开
    通过强制通风/提取管理对大气更新的有限空间的管理方法和可以以可变和受控方式打开的物理障碍的使用

    公开(公告)号：US20110239670A1

    公开(公告)日：2011-10-06

    申请号：US13133675

    申请日：2009-11-23

    申请人： Carinne Kempen ,  Helmut Henrich ,  Franz Lurken ,  Serge Morel-Jean ,  Michael Thomas ,  Richard Soula

    发明人： Carinne Kempen ,  Helmut Henrich ,  Franz Lurken ,  Serge Morel-Jean ,  Michael Thomas ,  Richard Soula

    IPC分类号： F25D29/00

    CPC分类号： F25D29/001 ,  F25D3/105

    摘要： A method for managing access to a confined space which is cooled by the direct injection of a cryogenic fluid, comprising at least one system for closing the confined space, which can prevent access to said confined space and can be opened/closed to a variable and controllable degree, and a data acquisition and processing device. The device can: control the open or closed state of the closure system; set and control the degree to which the closure system is open/closed; ensure that a time delay (TP) is respected every time the closure system is closed, after which time delay the injection of cryogenic fluid into the space resumes; and, at the request of a user, implement the cycle for opening the closure system. The device determines the time that has elapsed (TE) in the closed position since the last closure cycle of the closure system and compares TE to TP. If TE=TP the device immediately authorizes the opening of the closure system. If TE>TP the device authorizes the opening of the closure system after a predefined waiting time.

    摘要翻译： 一种用于管理通过直接注入低温流体而被冷却的密闭空间的通路的方法，该方法包括至少一个闭合密闭空间的系统，该系统可防止进入所述约束空间，并能够打开/关闭变量， 可控程度，以及数据采集和处理设备。 该装置可以：控制关闭系统的打开或关闭状态; 设置和控制关闭系统打开/关闭的程度; 确保每次关闭系统关闭时延时间（TP），之后延迟将低温液体注入空间中恢复; 并且根据用户的要求，实施打开关闭系统的循环。 该设备确定自闭合系统的最后一个闭合周期以来关闭位置的时间（TE），并将TE与TP进行比较。 如果TE = TP，设备立即授权关闭系统的打开。 如果TE> TP，设备将在预定义的等待时间后授权关闭系统的打开。