公开(公告)号：US20050270444A1

公开(公告)日：2005-12-08

申请号：US10859314

申请日：2004-06-02

申请人： Michael Miller ,  Michael Murdoch ,  Paul Kane ,  Andrew Arnold ,  Serguei Endrikhovski

发明人： Michael Miller ,  Michael Murdoch ,  Paul Kane ,  Andrew Arnold ,  Serguei Endrikhovski

IPC分类号： G09G3/20 ,  G09G3/32 ,  G09G3/36 ,  G09G5/02 ,  G02F1/1335

CPC分类号： G09G3/3216 ,  G09G3/20 ,  G09G3/3225 ,  G09G3/3607 ,  G09G5/02 ,  G09G2300/0452 ,  G09G2320/02

摘要： A color display device, comprising: an array of subpixels of at least four different colors, including at least two relatively higher luminous color subpixels and at least two relatively lower luminous color subpixels, wherein the subpixels are arranged into groups forming at least two distinct types of pixels, each pixel type including the two relatively higher luminous color subpixels and at least one of the two relatively lower luminous color subpixels, and wherein the pixel types are arranged in a pattern such that the relative locations of the two relatively higher luminous color subpixels in each pixel is repeated in adjacent pixels, and the relative location of at least one of the two relatively lower luminance color subpixels is not repeated in at least one adjacent pixel. Various embodiments of the invention enable color display devices with improved image display quality, with both the appearance of jagged lines and the appearance of banding reduced simultaneously.

摘要翻译： 一种彩色显示装置，包括：至少四种不同颜色的子像素阵列，包括至少两个相对较高的发光子像素和至少两个相对较低的发光颜色子像素，其中子像素被排列成形成至少两种不同类型的组 的像素，每个像素类型包括两个相对较高的发光颜色子像素和两个相对较低的发光颜色子像素中的至少一个，并且其中像素类型被布置成使得两个相对较高的发光颜色子像素的相对位置 在相邻像素中重复每个像素，并且在至少一个相邻像素中不重复两个相对较低亮度的彩色子像素中的至少一个的相对位置。 本发明的各种实施例使得具有改善的图像显示质量的彩色显示设备能够同时缩短锯齿状线条的外观和条纹的外观。

公开(公告)号：US20050258429A1

公开(公告)日：2005-11-24

申请号：US10845038

申请日：2004-05-13

申请人： Ronald Cok ,  Michael Miller

发明人： Ronald Cok ,  Michael Miller

IPC分类号： H01L27/32 ,  H01L27/15

CPC分类号： H01L27/3213 ,  H01L27/322

摘要： A color OLED device is described having one or more pixels, at least one pixel comprising: four or more light-emitting elements, each light-emitting element comprising one or more layers of electroluminescent organic material producing a broadband light having a variable frequency-dependent luminous efficacy emission spectrum, and each light-emitting element further comprising a filter for filtering the broadband light and emitting a different color of light; wherein the different colors of light emitted by three of the light-emitting elements specify a first color gamut of the OLED device, and an additional one or more of the light-emitting elements emit at least one additional different color of light and wherein the frequency range of the filter of the additional light emitting element is matched to a portion of the broadband light frequency range having a radiant intensity greater than the radiant intensity of the frequency range of at least one of the filters of the three light-emitting elements specifying the first color gamut of the OLED device, and the additional one or more light emitting elements having luminous efficiency greater than that of at least one of the three light emitting elements specifying the first color gamut.

摘要翻译： 描述了具有一个或多个像素的彩色OLED器件，至少一个像素包括：四个或更多个发光元件，每个发光元件包括一层或多层电致发光有机材料，产生具有可变频率依赖性的宽带光 发光效能发射光谱，并且每个发光元件还包括用于过滤宽带光并发射不同颜色的光的滤光器; 其中由三个发光元件发射的光的不同颜色指定OLED器件的第一色域，并且附加的一个或多个发光元件发射至少一种附加的不同颜色的光，并且其中频率 附加发光元件的滤光器的范围与具有大于三个发光元件的至少一个滤光器的频率范围的辐射强度的辐射强度的宽带光频率范围的一部分相匹配， OLED器件的第一色域，以及具有大于指定第一色域的三个发光元件中的至少一个的发光效率的附加一个或多个发光元件。

公开(公告)号：US20050234367A1

公开(公告)日：2005-10-20

申请号：US11157569

申请日：2005-06-21

申请人： Michael Miller ,  Dan Ireland

发明人： Michael Miller ,  Dan Ireland

IPC分类号： A61B10/00 ,  A61B10/02 ,  A61B17/34 ,  A61B19/00

CPC分类号： A61B10/0275 ,  A61B17/3403 ,  A61B2010/0208 ,  A61B2090/034

摘要： A biopsy instrument for use in a biopsy gun includes a hollow outer needle defining a lumen therethrough and an inner needle slidably engaged within the lumen. The inner needle defines a cavity adjacent its distal end for receiving a tissue sample. A first hub is attached to the proximal end of the inner needle, and a second hub is attached to the proximal end of the outer needle. An elongated pin having a first end and a second end is fixedly attached to the first hub at the first end of the pin. The second end is in sliding contact with the second hub so that the second hub and the pin are slideable relative to each other. A stop engagement is provided between the second end of the pin and the second hub and is configured to prevent disengagement of the outer and inner needles and to maintain a specific physical relationship between the hubs.

摘要翻译： 用于活检枪的活检器械包括限定穿过其中的腔的中空外针和可滑动地接合在内腔内的内针。 内针限定邻近其远端的腔以接收组织样本。 第一轮毂附接到内针的近端，并且第二轮毂连接到外针的近端。 具有第一端和第二端的细长销在销的第一端处固定地附接到第一毂。 第二端与第二轮毂滑动接触，使得第二轮毂和销可相对于彼此滑动。 在销的第二端和第二轮毂​​之间提供止动接合，并且构造成防止外针和内针的分离并且保持轮毂之间的特定物理关系。

公开(公告)号：US20050215939A1

公开(公告)日：2005-09-29

申请号：US11137808

申请日：2005-05-25

申请人： Jessica Lemay ,  Dane Jackson ,  Michael Miller ,  Wayne Melvin

发明人： Jessica Lemay ,  Dane Jackson ,  Michael Miller ,  Wayne Melvin

IPC分类号： A61F13/26 ,  A61F13/20

CPC分类号： A61F13/26 ,  Y10S604/904 ,  Y10T156/10 ,  Y10T156/1038

摘要： There is provided a multiple-component tampon applicator formed from at least three separate components. A fingergrip having a reduced cross-section as compared to that of the barrel may be formed such that it is a separate component or is integrally formed with a barrel component. The reduced cross-section fingergrip provides exceptional grippability to the user. The multiple components may be formed from materials including, for example, biopolymer including starches and proteins, cardboard, heat shrink plastic, paper slurry, plastic, plastic tubing, pulp slurry, pulp-molded paper, or any combinations thereof. Prior to assembly of the applicator and prior to loading the barrel component with an absorbent pledget, petals may be formed on the insertion end of the barrel using existing processes and equipment. Alternatively, a separate insertion tip component having petals may be formed. This separate component may then be connected to the barrel component either before or after an absorbent pledget is loaded into the barrel component.

公开(公告)号：US20050192421A1

公开(公告)日：2005-09-01

申请号：US10789319

申请日：2004-02-27

申请人： Frank Xu ,  Michael Miller ,  Michael Watts

发明人： Frank Xu ,  Michael Miller ,  Michael Watts

IPC分类号： C08L83/04 ,  C08L83/06

CPC分类号： B82Y10/00 ,  B82Y40/00 ,  G03F7/0002

摘要： The present invention includes a composition for a silicon-containing material used as an etch mask for underlying layers. More specifically, the silicon-containing material may be used as an etch mask for a patterned imprinted layer comprising protrusions and recessions. To that end, in one embodiment of the present invention, the composition includes a hydroxyl-functional silicone component, a cross-linking component, a catalyst component, and a solvent. This composition allows the silicon-containing material to selectively etch the protrusions and the segments of the patterned imprinting layer in superimposition therewith, while minimizing the etching of the segments in superposition with the recessions, and therefore allowing an in-situ hardened mask to be created by the silicon-containing material, with the hardened mask and the patterned imprinting layer forming a substantially planarized profile.

摘要翻译： 本发明包括用作下层的蚀刻掩模的含硅材料用组合物。 更具体地，含硅材料可以用作包括突起和凹陷的图案化印记层的蚀刻掩模。 为此，在本发明的一个实施方案中，组合物包括羟基官能的硅氧烷组分，交联组分，催化剂组分和溶剂。 该组合物允许含硅材料与图案化压印层的突起和段的叠加选择性地蚀刻，同时最小化与凹陷叠加的段的蚀刻，并且因此允许形成原位硬化的掩模 通过含硅材料，硬化的掩模和图案化的压印层形成基本平坦化的轮廓。

公开(公告)号：US20050172199A1

公开(公告)日：2005-08-04

申请号：US10772034

申请日：2004-02-03

申请人： Michael Miller ,  Lyman Horne ,  W. Willes ,  Douglas Grover

发明人： Michael Miller ,  Lyman Horne ,  W. Willes ,  Douglas Grover

IPC分类号： G08C25/02 ,  H04L1/08 ,  H04L1/16 ,  H04L1/18

CPC分类号： H04L1/188 ,  H04L1/08 ,  H04L1/16 ,  H04L1/1819

摘要： A data networking system designed to provide efficient yet reliable transportation of data across a time division multiplexed network. This invention allows for redundantly sending and resending of segments in a dynamic manner. In addition, segments are fragmented, resized and sent with low overhead due to dynamic header sizes, segment sizes, forward error correction, and cyclic redundancy checks. The result is a very adaptive network that meets the demanding requirements of networks such as power line and wireless while still being able to transport data for voice, audio, video, computer, control, and the like.

摘要翻译： 一种数据网络系统，旨在通过时分复用网络提供高效可靠的数据传输。 本发明允许以动态方式冗余地发送和重新发送段。 另外，由于动态报头大小，段大小，前向纠错和循环冗余检查，段被分段，调整大小并以低开销发送。 结果是一个非常适合的网络，满足诸如电力线和无线等网络的苛刻要求，同时仍然能够传输语音，音频，视频，计算机，控制等数据。

公开(公告)号：US20050099426A1

公开(公告)日：2005-05-12

申请号：US10703748

申请日：2003-11-07

申请人： Bruno Primerano ,  Michael Miller ,  Michael Murdoch

发明人： Bruno Primerano ,  Michael Miller ,  Michael Murdoch

IPC分类号： G09G3/20 ,  G09G3/32 ,  G09G5/02 ,  H04N1/60

CPC分类号： H04N1/6022 ,  G09G3/20 ,  G09G3/3208 ,  G09G5/02 ,  G09G2300/0452 ,  G09G2320/02

摘要： A method for transforming three color input signals (R, G, B) corresponding to three gamut defining color primaries to four color output signals (R′, G′, B′, W) corresponding to the gamut defining color primaries and one additional color primary W for driving a display having emitters that emit light corresponding to the to the four color output signals including calculating a common signal value S as a function F1 of the three color input signals (R,G,B) for a current and neighboring pixels; determining a final common signal value S′ based upon the common signals for the current and neighboring pixels; calculating the three color signals (R′,G′,B′) by calculating a value of a function F2 of the final common signal value S′ and adding it to each of the three color input signals (R,G,B); and calculating the output signal W as a function F3 of the final common signal value S′.

摘要翻译： 将对应于三个色域定义颜色原色的三色输入信号（R，G，B）变换为与定义颜色原色的色域对应的四色输出信号（R'，G'，B'，W）的一种方法， 用于驱动具有发射与四色输出信号相对应的光的显示器的显示器W，包括计算用于当前和相邻的三色输入信号（R，G，B）的函数F 1的公共信号值S 像素; 基于当前和相邻像素的公共信号确定最终公共信号值S'; 通过计算最终公共信号值S'的函数F 2的值并将其相加到三个颜色输入信号（R，G，B）中的每一个来计算三色信号（R'，G'，B'）， ; 并计算输出信号W作为最终公共信号值S'的函数F 3。

公开(公告)号：US20050085513A1

公开(公告)日：2005-04-21

申请号：US10963711

申请日：2004-10-14

申请人： Erkan Baloglu ,  Michael Miller ,  Ravi Chari

发明人： Erkan Baloglu ,  Michael Miller ,  Ravi Chari

IPC分类号： A61K31/337 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07D305/14 ,  C07D407/12 ,  C07D407/14 ,  C07D409/12 ,  A61K31/4025 ,  A61K31/4433 ,  C07D45/02

CPC分类号： C07D407/12 ,  A61K31/337 ,  C07D305/14 ,  C07D407/14 ,  C07D409/12 ,  Y02A50/423 ,  Y02A50/491

摘要： Included within the scope of the present invention are potent taxanes and taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a link, and (B) a pharmaceutically acceptable carrier, diluent or excipient is also included. A method for inducing cell death in selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent is included as well.

摘要翻译： 包括在本发明范围内的有效的紫杉烷类和含有连接基团的紫杉烷类。 还包括细胞毒性剂，其包含与细胞结合剂连接的一种或多种紫杉烷类。 一种用于在所选细胞群体中诱导细胞死亡的治疗组合物，包括：（A）细胞毒性量的一种或多种通过连接体与细胞结合剂共价结合的紫杉烷，和（B）药学上可接受的载体，稀释剂或赋形剂 。 还包括诱导选择的细胞群体中的细胞死亡的方法，包括使靶细胞或含有靶细胞的组织与有效量的包含与细胞结合剂连接的一种或多种紫杉烷的细胞毒性试剂接触。

公开(公告)号：US20050065393A1

公开(公告)日：2005-03-24

申请号：US10984164

申请日：2004-11-09

申请人： Michael Miller

发明人： Michael Miller

IPC分类号： A61B17/34 ,  A61M36/12 ,  A61N5/10 ,  A61N5/00

CPC分类号： A61M37/0069 ,  A61N5/1007 ,  A61N5/1027 ,  A61N2005/1011

摘要： The present invention provides devices for depositing objects into tissue of an animal. The devices include a cannula having a proximal end and an opposite distal end insertable into tissue and defining an exit aperture. The cannula has a sidewall between the distal and proximal ends and defines a passageway in communication with the exit aperture. A distal retaining tab extends from an inner surface of the cannula and is positioned across at least a portion of the passageway adjacent the exit aperture. The distal tab has a first closed position blocking the passageway and a second open position wherein the tab is urged towards the sidewall to allow an object to pass. The tab is resilient to return to the first position after the object passes the tab. In some embodiments, the invention also includes a proximal retaining tab adjacent the proximal end of the cannula and positionable to block a portion of the passageway. The invention also a stylet that is slidable within the passageway to urge the objects out through the exit aperture.

摘要翻译： 本发明提供了用于将物体沉积到动物组织中的装置。 这些装置包括具有近端和相对的远端插入到组织中并限定出口孔的插管。 套管在远端和近端之间具有侧壁，并且限定与出口孔连通的通道。 远侧保持突出部从套管的内表面延伸并且位于与出口孔相邻的通道的至少一部分上。 远端突片具有阻挡通道的第一关闭位置和第二打开位置，其中突片朝向侧壁被推动以允许物体通过。 标签弹性回到对象通过标签后的第一个位置。 在一些实施例中，本发明还包括邻近套管的近端并且可定位成阻挡通道的一部分的近侧保持突出部。 本发明还提供一种可在通道内滑动以便通过出口孔推动物体的探针。

公开(公告)号：US20050059666A1

公开(公告)日：2005-03-17

申请号：US10970216

申请日：2004-10-21

申请人： Michael Miller

发明人： Michael Miller

IPC分类号： A61K31/18 ,  A61K31/506 ,  A61P1/04 ,  A61P11/06 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P25/28 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07D401/14 ,  C07D403/06 ,  C07D409/14 ,  C07D417/14 ,  A61K31/496 ,  A61K31/4545 ,  C07D43/14

CPC分类号： C07D401/14 ,  A61K31/18 ,  A61K31/506 ,  A61K45/06 ,  C07D403/06 ,  C07D409/14 ,  C07D417/14 ,  A61K2300/00

摘要： Compounds of the formula or a pharmaceutically acceptable salt or isomer thereof, wherein: Q, X and Z are CH or N; R, R4-R7 and R13 are H or alkyl; R1 is H, alkyl, fluoroalkyl, R9-arylalkyl, R9-heteroarylalkyl, alkyl-SO2—, cycloalkyl-SO2—, fluoroalkyl-SO2—, R9-aryl-SO2—, R9-heteroaryl-SO2-, N(R22)(R23)—SO2—, alkyl-C(O)—, cycloalkyl-C(O)—, fluoroalkyl-C(O)—, R9-aryl-C(O)—, NH-alkyl-C(O)— or R9-aryl-NH—C(O)—; R2 is H and R3 is H, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, R9-aryl, R9-arylalkyl, R9-heteroaryl, or R9-heteroarylalkyl, and when X and Z are each CH, R3 is alkoxy, R9-aryloxy, R9-heteroaryloxy, alkylC(O)O—, alkylaminoC(O)O—, alkylC(O)NR13—, alkylOC(O)NR13— or alkylaminoC(O)NR13—; or R2 and R3 together are ═O, ═NOR10, ═N—NR11R12 or ═CH-alkyl; R8 is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenymethyl, alpha-substituted benzyl or alpha-substituted heteroarylmethyl; R9-R12 are as defined; are disclosed for the treatment of HIV, solid organ transplant rejection, graft v. host disease, inflammatory diseases, atopic dermatitis, asthma, allergies or multiple sclerosis, as well as pharmaceutical compositions and combinations with antiviral or anti-inflammatory agents.

摘要翻译： 下式的化合物或其药学上可接受的盐或异构体，其中：Q，X和Z是CH或N; R 4，R 4 -R 7和R 13是H或烷基; R 1是H，烷基，氟烷基，R 9 - 芳基烷基，R 9 - 杂芳基烷基，烷基-SO 2 - ，环烷基-SO 2 - ，氟烷基-SO 2 - ，R 9 - 芳基-SO 2 - R 9 - 杂芳基-SO 2 - ，N（R 22）（R 23）-SO 2 - ，烷基-C（O） - ，环烷基-C（O） - ，氟烷基-C（O） ，R 9 - 芳基-C（O） - ，NH-烷基-C（O） - 或R 9 - 芳基-NH-C（O） - ; R 2是H，R 3是H，烷基，烷氧基烷基，环烷基，环烷基烷基，R 9 - 芳基，R 9 - 芳基烷基，R 9 - 杂芳基或R 9 - 杂芳基烷基 当X和Z各自为CH时，R 3为烷氧基，R 9 - 芳氧基，R 9 - 杂芳氧基，烷基C（O）O-，烷基氨基C（O）O-，烷基C（O）NR 烷基OC（O）NR 13 - 或烷基氨基C（O）NR 13 - ; 或R 2和R 3一起为= O，= NOR 10，= N-NR 11或= CH-烷基; R 8是取代的苯基，取代的杂芳基，萘基，芴基，二苯甲基，α-取代的苄基或α-取代的杂芳基甲基; R 9 -R 12定义如上; 被公开用于治疗HIV，实体器官移植排斥，移植物抗宿主病，炎性疾病，特应性皮炎，哮喘，过敏或多发性硬化，以及药物组合物和与抗病毒或抗炎剂的组合。